Protein Alignment cmet and KIF15

DIOPT Version :10

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: XP_016862373.1
• Gene: KIF15 / 56992
• HGNCID: 17273
• Length: 1411
• Species: Homo sapiens
• Alignment Length: 1632
• Identity: 408/1632 - (25%)
• Similarity: 718/1632 - (43%)
• Gaps: 413/1632 - (25%)

  Fly     3 AKNASSIQVCIKVRP--------------CEPGLTSLWQVKERRSIHLADSHAEP--YVFDYVFD 51
            :....:|:|.:::||              |...|:|       .|:.| .|:.||  :.||:|.|
Human    21 SNEGDAIKVFVRIRPPAERSGSADGEQNLCLSVLSS-------TSLRL-HSNPEPKTFTFDHVAD 77

  Fly    52 EGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNP-------GVMVLAAKE 109
            ...:.:.||..:||.||.:||.|:||||||||||.||||:||||..::.       ||:..:.:.
Human    78 VDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRSFEY 142

  Fly   110 IFQQISSETE-----RDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHES-GNGIVNVNCEECIITS 168
            :|..|..|.|     :.||.:..:||||||:|||||:..:..|.:.|. ..|:..|...|.::||
Human   143 LFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSASAGLYLREHIKKGVFVVGAVEQVVTS 207

  Fly   169 EVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQ-SVLNLVDLAGSE 232
            ..:..::|..|.:.|.|..|:||..||||||:|.|.|||  .:.|::...|: |:||||||||||
Human   208 AAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIES--MEKSNEIVNIRTSLLNLVDLAGSE 270

  Fly   233 RADQTGARGARLKEGGHINKSLLFLSNVIKSLSE--NADNRFTNYRDSKLTRILQASLGGNAFTS 295
            |...|.|.|.||||.|:||:||..|..||.:|.:  |...|...|||||||.:|:.||||||.|:
Human   271 RQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKTA 335

  Fly   296 IICTIKPS--IMEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAE----- 353
            ||..:.|.  ...|:.|||:||.|||.|:.|..|||  .....:.:|:.|:|.||::|||
Human   336 IIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNE--DTQGNVSQLQAEVKRLKEQLAELASGQ 398

  Fly   354 ---EERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTED 415
               |.....:::|..::| ..:..|       ....|.:|:::                  :..:
Human   399 TPPESFLTRDKKKTNYME-YFQEAM-------LFFKKSEQEKK------------------SLIE 437

  Fly   416 RIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRP 480
            ::.|...:: |.|..|..::....::    :...|:....:..||..   .|||.|.....|
Human   438 KVTQLEDLT-LKKEKFIQSNKMIVKF----REDQIIRLEKLHKESRG---GFLPEEQDRLLS--- 491

  Fly   481 DVLKPMLTIR-QLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTA 544
            ::...:.|:| |:...|...|..:....:::|.:.|::...:::..|::.:.:..|::..:|::.
Human   492 ELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQTIAKLEKAFSEISG 556

  Fly   545 -QRDNLEQESLAEKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVENQVAVGL 608
             ::.:..|:..:.|     .:|| ..|.|:.|...:::.:::.:|:..||
Human   557 MEKSDKNQQGFSPK-----AQKE-PCLFANTEKLKAQLLQIQTELNNSKQ--------------- 600

  Fly   609 EFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGD 673
              |:|..|:.::.|       .||.||.::||||:..|| .::|..:|       |.::::::
Human   601 --EYEEFKELTRKR-------QLELESELQSLQKANLNL-ENLLEATK-------ACKRQEVS-- 646

  Fly   674 SICNKCEELEKLIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKATDCERLSK 738
                   :|.|:.|:....||          ::.:.:.|.::|:| .....:||...|...:|..
Human   647 -------QLNKIHAETLKLKN----------VMWIYNDLFNLENA-GFFPIQIITTPTKAYQLHS 693

  Fly   739 ----ELSTSQNAFGQL----------------------QERYDALDQQWQAQQAGITTLHEKHEH 777
                :||....:||.|                      ::.::|:.::.:..|..::.|..|.:.
Human   694 RPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKLDE 758

  Fly   778 VQEKYQKLQEEYEQLESRARSASSAEFQRL----QNDNTKFQADIAS----LNERLEEAQN---- 830
            .:.|..|||:..::||..     |.:.|.|    :.|.||.|.::.|    |.::|:|.|.
Human   759 EEHKNLKLQQHVDKLEHH-----STQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDF 818

  Fly   831 MLTEVQ-------------------------NSESTVEK--------------LRIQNHELTAKI 856
            :.:||.                         |.|....|              ||::|.:|....
Human   819 LKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESK 883

  Fly   857 KELETNFEEMQR----EYDCLSNQLMESVQENDALREEIKQRPTSHVEESMRSSGISSDFDEQKQ 917
            ..|:.:::.:|.    |.|.||..|....:||:.|:.::.........|..|::.:|..|:|.|:
Human   884 ACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKE 948

  Fly   918 DINLLHQFVQLSESVQQIELQHHSGISRLFRANQMKLDQSEPGLKLCLESAEYIEEDNRQSDATE 982
              |...:.:::.|:|:| |.|..:.......|...||::|    .|..|......|.:|.||
Human   949 --NSSKEILKVLEAVRQ-EKQKETAKCEQQMAKVQKLEES----LLATEKVISSLEKSRDSD--- 1003

  Fly   983 PICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQEIEEKSALMEATEATINEMREQMTN 1047
                                       :|.:.|:::|::   |.::::.|.|| ||:.:::::.:
Human  1004 ---------------------------KKVVADLMNQIQ---ELRTSVCEKTE-TIDTLKQELKD 1037

  Fly  1048 L----ESALL---EKSVIINKVE-DYQRQIESLE----KQNAEMTMVYEELQ------DRVTRES 1094
            :    .|||:   |..|:|.|.| |.....|:|.    .::.|..|:.|:|.      :.:|..|
Human  1038 INCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEAS 1102

  Fly  1095 SMSESLLRVPPDEDTLPGCPTSPSRREQEVATLKTSITELQSQVSDLKAELENHLRQIQLKDGNI 1159
            .....||:                ..::|:...:..|.|||.:::..|.|:|....:...|   :
Human  1103 KKHSGLLQ----------------SAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFK---M 1148

  Fly  1160 ARLQTDFEEMSERCLS------MEVRLAELDEDTKQKQELLDRQAQKLSDDLCLIDQLQK----K 1214
            .:|:...:..:|...|      .:..||:|.|  .|:||:.|.:|.|.|.: .|:.:|.:    |
Human  1149 RQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLE--TQEQEIEDGRASKTSLE-HLVTKLNEDREVK 1210

  Fly  1215 NAQLVEQYHKATESLSLADAKPDQILLSSQYDSQIEKLNQLLNAAKDELHDVRRIKDDEISALRM 1279
            ||:::....:..|.        :.:.|.||   |:.:.|.||   :.:|.|::|
Human  1211 NAEILRMKEQLREM--------ENLRLESQ---QLIEKNWLL---QGQLDDIKR----------- 1250

  Fly  1280 EFLLQIETNEKENQAKFYAELQETKDRYESNVAELKEKLLQVEETLSSVTVRCQAELEALKSAHK 1344
                     :|||..:.:.:.|:.|:..|.::.|...|...|||.|     :.:|:||.::||
Human  1251 ---------QKENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEML-----KMKADLEEVQSA-- 1299

  Fly  1345 ENISQAVEERNNLIVQHQAEMETIRETLKNKLAEASTQQSKMEDAFRAEINEVRATLMEQLNQTK 1409
                           .:..|||.:|.|  :::....|.:||   ||: |..::|:.|.|..
Human  1300 ---------------LYNKEMECLRMT--DEVERTQTLESK---AFQ-EKEQLRSKLEEMY---- 1339

  Fly  1410 EDRDKGASKLEEVKKTLEQMI--NGGRVMSDTIAELEKTKAEQDL-----AVNKLTKDNIELEKQ 1467
            |:|::.:.::|.::|.:|.:.  ||            |....|:|     .|.:|.|:|:.|.::
Human  1340 EERERTSQEMEMLRKQVECLAEENG------------KLVGHQNLHQKIQYVVRLKKENVRLAEE 1392

  Fly  1468 CSKTQEQ 1474
            ..|.:.:
Human  1393 TEKLRAE 1399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	Motor_domain	8..321	CDD:473979	146/346 (42%)
		SMC_prok_B	539..1431	CDD:274008	211/1003 (21%)
		SMC_prok_B	1137..1926	CDD:274008	81/355 (23%)
		YhaN	1717..2182	CDD:443752
KIF15	XP_016862373.1	KISc_KLP2_like	25..373	CDD:276824	151/359 (42%)
		SMC_N	<371..643	CDD:481474	64/348 (18%)
		SMC_prok_B	<579..1362	CDD:274008	205/968 (21%)