DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cmet and kif1ab

DIOPT Version :9

Sequence 1:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster
Sequence 2:XP_009296795.1 Gene:kif1ab / 566766 ZFINID:ZDB-GENE-070912-480 Length:1799 Species:Danio rerio


Alignment Length:2195 Identity:467/2195 - (21%)
Similarity:785/2195 - (35%) Gaps:703/2195 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SSIQVCIKVRPC---EPGLTSLW---------------QVKERRSIHLAD----SHAEPYVFDYV 49
            :|::|.::|||.   |.|..|..               |.||.:|.:. |    ||..|...:| 
Zfish     4 ASVKVAVRVRPFNSREIGKDSKCIIQMSGNTTTILNPKQPKENKSFNF-DYSYWSHTTPEDVNY- 66

  Fly    50 FDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMG--DEQNPGVMVLAAKEIFQ 112
                |..::|:..:.:.::....:|:|..|||||||.:||:|||||  ::...|::.|..:::|.
Zfish    67 ----ACQKQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQEGIIPLLCEDLFT 127

  Fly   113 QISSETERD--FLLRVGYIEIYNEKIYDLLNKKNQ-DLKIHE---SGNGIVNVNCEECIITSEVD 171
            :|:...:.:  :.:.|.|:|||.|::.||||.||: :|::.|   .|..:.:::  :..:||..|
Zfish   128 KINDNNDNNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLMGPYVEDLS--KLAVTSYND 190

  Fly   172 LLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQ-SVLNLVDLAGSERAD 235
            :..|:..|||.|||..|||||.||||||:|.||...::.|:..::...: |.::|||||||||||
Zfish   191 IQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKQHDNDSENTTEKVSKISLVDLAGSERAD 255

  Fly   236 QTGARGARLKEGGHINKSLLFLSNVIKSLSE--NADNR---------FTNYRDSKLTRILQASLG 289
            .|||:|.|||||.:|||||..|..||.:|:|  :|.|:         |..||||.||.:|:.:||
Zfish   256 STGAKGTRLKEGANINKSLTTLGKVISALAEMDSAPNKNKKKKKVESFIPYRDSVLTWLLRENLG 320

  Fly   290 GNAFTSIICTIKPSIM--EESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKL- 351
            ||:.|:::..:.|:.:  :|:.|||.:|.|||:||....:||..:: .:::.|:.|:..|||.| 
Zfish   321 GNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNN-RLVRELKEEVARLKDLLY 384

  Fly   352 ----------------------AEEERKN------------------------------------ 358
                                  |..:|.:                                    
Zfish   385 AQGLGDIIENLSNYKANISSIQAVNQRGDFSTVTNAMTGMSPSPSLSALTSRVGSISSLHDRIMF 449

  Fly   359 --ENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTT--ED--RI 417
              .:::.:|.|:     :..|||.  .|::..::|.|||.........| |||.|..  ||  .:
Zfish   450 SPGSEEAIERLK-----ETEKIIA--ELNETWEEKLRRTEAIRMEREAL-LAEMGVAMREDGGTV 506

  Fly   418 DQF--PKVSHL----PKPVFFH--------------TSNAGKRWDNI-------------PKTIN 449
            ..|  .|..||    ..|:...              ..:|..|.|.:             ..|.|
Zfish   507 GVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITKVGREDASSRQDIVLSGHFIKDEHCIFTSTTN 571

  Fly   450 ILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTI-------------------RQLPDL 495
            .:|...:..|....:|.::..:.:    ..|.|||....|                   |:....
Zfish   572 AIGEGTVVLEPCEGAETYVNGKRV----TEPTVLKSGNRIIMGKSHVFRFNDPEQARQDRERTPC 632

  Fly   496 PLTPKGPLTTDKIKKEI---------QDL-QMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLE 550
            ..||..|:.....::|:         |:: |....||..:..|.||...|             ||
Zfish   633 ADTPVEPVDWAFAQRELLEKQGIDMKQEMDQRLQELEDQYRKEREEASNL-------------LE 684

  Fly   551 QESLAEKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAH 615
            |:.|..:.:.:||:|:|.| |...|....: .|||:::...|:       |.::|:....::..:
Zfish   685 QQRLDYESKLEALQKQVNS-RYYPETTEEE-EELEDEVPWTKR-------ETELALWAFRKWRFY 740

  Fly   616 KKSSKLRVDDLL--SALLEKESTIES--LQKSLD---NLTRDVLRNSKEGHMLSIAPEQEDIAGD 673
            :.:| ||  |||  :|:..||:...|  |:|.:.   .|..|.|          .:|...|:...
Zfish   741 QFTS-LR--DLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTL----------YSPLPPDLLPP 792

  Fly   674 SICNKCEELEK-------LIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKAT 731
            ||   .::.||       :..:::.:||.                                  ||
Zfish   793 SI---AKDREKRLFPRTIVAVEVQDQKNG----------------------------------AT 820

  Fly   732 DCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKHEHVQEKYQKLQEEYE--QLES 794
            ....|.|           |::|.|.:.:.:.......:|..|..:|:........:.:.  :|..
Zfish   821 HYWTLDK-----------LRQRLDLMREMYDRAAEVPSTAVEDCDHIMSGGDPFYDRFPWFRLVG 874

  Fly   795 RARSASSAEFQRLQNDNTKFQADIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHELTAKIKEL 859
            |....::...:|:..         .:|:..|.:..:.:||:.: |....|:.::..||.....|:
Zfish   875 RTPILNTCMSERMSG---------LTLSPTLSDPDSDITELAD-ERHYGKVEVEEEELEDLDDEI 929

  Fly   860 --ETNFEEMQREYDCLSNQLMESVQENDALREEIKQRPTSHVEESMRSSGIS---SDFDEQKQDI 919
              |.|..|:.||         |...::|.:.|              |..|:|   ..|.::....
Zfish   930 FVEDNGSELGRE---------EEEDDDDGVGE--------------RCPGVSDGQDPFYDRWPLF 971

  Fly   920 NLL-HQFVQLSESVQQIELQHHSGISRLFRANQMKLDQSEPGLKLCLESAEYIEEDNRQSDATEP 983
            :|: ..||.||..:..:.|.|...|            .||.|.                      
Zfish   972 SLVGRAFVYLSNLLYPVPLVHRVAI------------VSEKGE---------------------- 1002

  Fly   984 ICLKGFLKRHRFQIKRLS--QEHVDMGEEKRLLDI--ISQLEQEIEEKSALMEATEATINEMREQ 1044
              :||||   |..::.:|  :|..|.|...|....  ||..:|..|:..     |||..:.|.:.
Zfish  1003 --VKGFL---RVAVQAISADEEAPDYGSGVRQSGTAKISFEDQAFEKFQ-----TEACTSGMSQT 1057

  Fly  1045 MTNLESALLEKSVIINKVEDYQRQIESLEKQNAEMTMVYEELQDRVTRESSMSESLLRVPPDEDT 1109
            .|:               |:..|.:|. |.||:|:.:..:|:.:..                   
Zfish  1058 HTS---------------EEELRIVEG-EGQNSELGLSADEVNNNT------------------- 1087

  Fly  1110 LPGCPTSPSRREQEVATLKTSITELQSQVSD--LKAELENHLRQIQLKDGNIARLQTDFEEMSER 1172
               |..||                   .:||  ||..||..|...|.|.....::.::|      
Zfish  1088 ---CLVSP-------------------DISDSPLKGVLECPLDVTQDKSLQHLKIGSNF------ 1124

  Fly  1173 CLSMEVRLAELDEDTKQKQELLDRQAQKLS----DDLCLIDQLQKKNAQLVEQ------------ 1221
                ..|:..|             ||..:|    |..|..:.:.:.:.....:            
Zfish  1125 ----TFRVTVL-------------QASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLG 1172

  Fly  1222 -YH------KATES-LSLADAKPDQILLSSQYDSQIEKLNQLLNAAKDELHDVRRIKDDEISALR 1278
             ||      :.|:| :....::|....:...|..|     ......||.:..:|        .:|
Zfish  1173 FYHVQNITVEVTKSFVEYIKSQPIVFEVFGHYQKQ-----PFPPLCKDLISSLR--------PMR 1224

  Fly  1279 MEFLLQIETNEKENQAKFYAELQETKDRYESNVAELKEKLLQVEETLSSVTVRCQAELEALKSAH 1343
            .:|...:..::.....|.     .|..|..:.....|..|:...|.       |:.|      |:
Zfish  1225 RQFPRVMPLSKPVPATKL-----STLARSTAGPCHCKYDLMAFFEI-------CELE------AN 1271

  Fly  1344 KENISQAVEERNNL-----IVQHQAEMETIRETLKNKLAEASTQQSKMEDAFRAEINEVRATLME 1403
            .:.|...|:.|..:     .:.||.....|..|:.:            |.....|..||:..::.
Zfish  1272 GDYIPAVVDHRGGMPCHGTFLLHQGIQRRITVTIAH------------ETGNDIEWKEVKELVIG 1324

  Fly  1404 QLNQTKE-DR---DKGASKL-----EEVKKTLEQMINGGRVMSD--TIAELE---KTKAEQDLAV 1454
            ::..|.| |.   |.....|     ..::.|.:..::.|   ||  |....|   .:.....|.:
Zfish  1325 RIRNTPEADETIIDPNILSLNILSSNYIRPTYDDRVSLG---SDHRTFYRFEAAWDSSMHNSLLL 1386

  Fly  1455 NKLTKDNIELEKQCSKTQEQLQMESLTRDQI---SFEIEAHIKKLELIVASSKKRIIE------L 1510
            |::|...   ||........|:||:.|:..:   .|.:..:.:..:|..:.|.:.:..      |
Zfish  1387 NRVTPYG---EKIYITLSAYLEMENCTQPTVVTKDFCMVFYSRDAKLPASRSIRNLFSTGAFRPL 1448

  Fly  1511 EEKCDQQVLELDKCRLEKLSLESEIQKANSEHSCTMEKLQELQAEMKVLSNRNEKEKC------- 1568
            |..|...|.||..|.|..:.            |..|::.:....:..|...|.|:...       
Zfish  1449 ESNCVTGVYELSLCHLADIG------------SPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSD 1501

  Fly  1569 ----DFETKLETFTFKITDLEEVLKEAQHKVILYDD-----LVSQHERLKICLAEANELSSNLQK 1624
                |.:.:||    |::.|:|| ::.:|.::|.:.     |:.|.......|.::.:.:|.:..
Zfish  1502 SLILDHQWELE----KLSLLQEV-EKTRHYLLLREKLEASLLLGQDSFYGKDLLDSPKANSPMIS 1561

  Fly  1625 KVMSLHTELIDSQKGISSRDVEINELREELKAAMDAKATASAEQMTLVTQLKDVEERMANQAEKF 1689
            .||||         |:.|.    ||.:.||.|                   |.|...|    ..|
Zfish  1562 PVMSL---------GLDSP----NERQRELAA-------------------KCVRLLM----HTF 1590

  Fly  1690 TREAANLKGSINELLLKLNSMQETKDMLESGNEELKEQLRNSQNLRNMLDEESKMCISLKEKLVK 1754
            .|:.:.:..|::|..|...|....:|.:.|....|               ..|..|.||.:....
Zfish  1591 NRQYSQVSSSLSESKLSEISASLLRDSVTSPLSSL---------------TPSSTCPSLLDGHYS 1640

  Fly  1755 LE----DAKTSLEQQLRDNKSEIYQRHTELTKEVELGRNRIGELTKKCEELCSDLENSDQIRLDL 1815
            .:    :|.:.......|..|.|.::                      ...|:.:.|..:||:..
Zfish  1641 TDLRGAEANSGASSPDLDPFSPIERK----------------------PRTCTFIPNIQEIRVSP 1683

  Fly  1816 QETKEQLKKTLE-NNLGWQQKVDEVTRECEKL---RFDMQSKEVQNESKVQELISE--------- 1867
            ..:|:.....|| :..||.::...|.|....|   ..|...:.:.|.|..|...||         
Zfish  1684 IVSKKGYLHFLEPHTSGWVKRYIVVRRPYVYLYRSERDYVERAIINLSSAQVEYSEDHHTLMRAP 1748

  Fly  1868 -----CEELRSTLKSKEASFQSEKESMD----------RTISSLLEDKRN 1902
                 |.|.|:.|    ....::||..|          .||.|.|..:::
Zfish  1749 NTFTVCTEHRNIL----LQATNDKEMHDWLYAFNPLLAGTIRSKLSRRKS 1794

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cmetNP_524993.3 KISc 8..328 CDD:214526 136/363 (37%)
Motor_domain 8..321 CDD:277568 134/356 (38%)
Smc <680..1449 CDD:224117 139/832 (17%)
TMPIT 779..>867 CDD:285135 15/91 (16%)
Smc 1042..1910 CDD:224117 170/963 (18%)
kif1abXP_009296795.1 KISc_KIF1A_KIF1B 4..361 CDD:276816 136/364 (37%)
KISc 5..361 CDD:214526 136/363 (37%)
Kinesin_assoc 358..538 CDD:292801 32/188 (17%)
FHA 515..618 CDD:238017 16/106 (15%)
ATP-synt_B <647..696 CDD:304375 13/61 (21%)
KIF1B 828..874 CDD:289208 7/45 (16%)
DUF3694 1320..1428 CDD:289256 21/113 (19%)
PH_KIFIA_KIFIB 1680..1782 CDD:269939 22/105 (21%)
PH 1685..1778 CDD:278594 21/96 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2883
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.030

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