Protein Alignment cmet and kif5aa

DIOPT Version :9

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: NP_001186705.1
• Gene: kif5aa / 566086
• ZFINID: ZDB-GENE-070912-141
• Length: 1033
• Species: Danio rerio
• Alignment Length: 1151
• Identity: 300/1151 - (26%)
• Similarity: 494/1151 - (42%)
• Gaps: 246/1151 - (21%)

  Fly    44 YVFDYVFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMG---DEQNPGVMVL 105
            |.||.||....:.::|::..||.||...:.|:|||||||||||||||:||.|   |.|..|::..
Zfish    47 YAFDRVFPTNTTQEQVYNTCAKQIVKDVLGGYNGTIFAYGQTSSGKTHTMEGNLHDPQQMGIIPR 111

  Fly   106 AAKEIFQQISSETER-DFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCEECIITS 168
            .|::||..|.|..|. :|.::|.|.|||.|||.|||:....:|.:||..|.:..| .|.|..::|
Zfish   112 IAEDIFNHIFSMDENLEFHIKVSYFEIYMEKIRDLLDVTKTNLSVHEDKNRVPYVKGCTERFVSS 176

  Fly   169 EVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSER 233
            ..:::.::..|...|.|..|||||.|||||:||.|.|   |.:|.:.:..:...|.||||||||:
Zfish   177 PEEVMDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINI---KQEHVETEQKLCGKLYLVDLAGSEK 238

  Fly   234 ADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIIC 298
            ..:|||.||.|.|..:|||||..|.|||.:|:|...:. ..|||||:|||||.|||||..|::..
Zfish   239 VSKTGAAGAVLDEAKNINKSLSALGNVISALAEGTKSH-VPYRDSKMTRILQDSLGGNCRTTMFI 302

  Fly   299 TIKPSIME--ESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLERE---IKVLKD---KLAEEE 355
            ...||...  |::|||.|..|||.|:....:|..::.....::.|:|   .|.|:|   :|..|.
Zfish   303 CCSPSSYNDAETKSTLMFGQRAKTIKNTASINLELTAEQWKRKYEKEKEKNKSLRDSMQRLELEL 367

  Fly   356 RKNENQQKVEHLERQIKHDMHKIICGHSLS---DKG-QQKRRRTWCPTASGSHLELAETGTTEDR 416
            |:..|.:||...| |...|:.|:......|   :|. :::|.|......|...:.::|    |:|
Zfish   368 RRWRNGEKVPETE-QTDADVVKLDVSEETSLDNEKSCERQRERERDSDTSSIVVRISE----EER 427

  Fly   417 IDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPD 481
            .....::..|.:.:           |:....||:...|     ...:.|:.|..:.: ..|.|.|
Zfish   428 QKYEEEIRKLYRQL-----------DDKDDEINLQCQL-----VEKLKEQILDQDEL-LASTRGD 475

  Fly   482 VLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEV-QGLKEKLAEVTAQ 545
                                   :||::.|:..||..:...|   .|..|| |.|:|.......:
Zfish   476 -----------------------SDKVQTELGRLQTESESAK---AEVREVLQALEELAVNYDQK 514

  Fly   546 RDNLEQESLAEKERYDALEKEVTSLRADNEAANSKISELEEKLSTL-----KQTMRIMEVENQVA 605
            ...:|::||..|:..:.|..::.:|           .|||.:|:.:     :|..||.:|.|.:.
Zfish   515 SQEVEEKSLHNKQLAEQLSHKMANL-----------MELEAELAQMQEVSSQQRKRIADVLNGLM 568

  Fly   606 VGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDI 670
            ..|. ||.:...:.:|::...:|..:|:|.|:..|                  ::..|..|.:
Zfish   569 KDLS-EFSSIVGNGELKLPVEISGAIEEEFTVARL------------------YISKIKSEVK-- 612

  Fly   671 AGDSICNKCEELEKLIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEII--QKATDC 733
               |:..:|.:||.:         ..||.:          |:|  |::..|:|.:::  |.....
Zfish   613 ---SMVKRCRQLENM---------QLECHR----------KME--ETSRELSSCQLLISQHEAKI 653

  Fly   734 ERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKHEHVQE--KYQKLQEEYEQLESRA 796
            ..|::.:...:....||::.||||.::       :.||.....||.|  ..:|...|.:..::..
Zfish   654 RSLTEYMQNVEQKKRQLEDNYDALSEE-------LYTLQNSESHVAELDGGEKADREADGKKAAV 711

  Fly   797 RSASSAEFQRLQNDNTKFQADIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHELTAKIKELET 861
            |.|..||.:         |..::.|.:.:.|.|.::.|:.:          :|..|..::..:.:
Zfish   712 RPALHAESR---------QTQLSRLRDEINEKQRLIDELTD----------KNQALELELAHVRS 757

  Fly   862 NFEEMQREYDCLSNQLMESVQENDALREEIKQRPTSHVEESMRSSGISSDFDEQKQDINLLHQFV 926
            :|..::.:.|..|           |..|::..:...|              ::.|||:.
Zfish   758 SFSNLKLQDDSKS-----------ACLEQMSFQQERH--------------EQSKQDLK------ 791

  Fly   927 QLSESVQQIELQHHSGISRLF---RANQMKLDQSEPGLKLCLESAEYIEEDNRQSDATEPICLKG 988
            .|.|:|.: |||....:.:||   ...::|            :|:|...:|:..|:..:...  .
Zfish   792 GLEETVAR-ELQTLHNLRKLFVQDLTTRVK------------KSSEIGPDDSGGSNTQKQKI--S 841

  Fly   989 FLKRHRFQI----KRLSQEHVDM-----GEEKRLLDIISQLEQEIEEKSALMEATEATINEMREQ 1044
            ||:.:..|:    |:|.:::.|:     ..||||.   |..|:....::||.:|.:..:|:.|..
Zfish   842 FLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLR---STAERVRALETALKDAKQGAMNDRRRY 903

  Fly  1045 MTNLESALLEKSVIINKVEDYQRQIESLEKQNAEMTMVYEELQDRVTRESSMSESLLRVPPDEDT 1109
            ...:|           ::.|..|....|.:.||............||..|..|.|:.|.     :
Zfish   904 QQEVE-----------RIRDAMRLRYPLRRPNAAQIAKPVRPGHHVTATSPTSFSVTRA-----S 952

  Fly  1110 LPGCPTSPSR--------REQEVATLKTSITELQSQVSDLKAELEN 1147
            .|....|.:|        ..|:..|:..|.......:|....::||
Zfish   953 KPATSYSNARFLQDEKMENSQKTNTVGYSTVRSIDILSSCPLDVEN 998

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	131/290 (45%)
		Motor_domain	8..321	CDD:277568	130/283 (46%)
		Smc	<680..1449	CDD:224117	95/492 (19%)
		TMPIT	779..>867	CDD:285135	15/89 (17%)
		Smc	1042..1910	CDD:224117	22/114 (19%)
kif5aa	NP_001186705.1	KISc_KHC_KIF5	7..327	CDD:276820	130/283 (46%)
		KISc	9..334	CDD:214526	131/290 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910