Protein Alignment cmet and kif5c

DIOPT Version :9

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: NP_001116747.1
• Gene: kif5c / 565563
• ZFINID: ZDB-GENE-081105-14
• Length: 985
• Species: Danio rerio
• Alignment Length: 1162
• Identity: 289/1162 - (24%)
• Similarity: 503/1162 - (43%)
• Gaps: 266/1162 - (22%)

  Fly    10 QVCIKV----RPCEP-----GLTSLWQVKERRSIHLADSHAEPYVFDYVFDEGASNQEVFDRMAK 65
            :.|:||    ||...     |...:.:.|...::.:|   .:||:||.|.....:.::|:|..||
Zfish     6 ECCVKVMCRFRPLNESEINRGDKYIPKFKGEDTVVIA---GKPYIFDRVLPPNTTQEQVYDTCAK 67

  Fly    66 HIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNP---GVMVLAAKEIFQQISSETER-DFLLRV 126
            .||...:.|:|||||||||||||||:||.|...|.   |::...|::||:.|.|..|. :|.::|
Zfish    68 QIVKDVLDGYNGTIFAYGQTSSGKTHTMEGQLHNAQLMGIIPRIAQDIFEHIYSMDENLEFHIKV 132

  Fly   127 GYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCEECIITSEVDLLRLLCLGNKERTVGETNM 190
            .|.|||.:||.|||:....:|.:||..|.:..| .|.|..::|..|::.::..|...|.|..|||
Zfish   133 SYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPFVKGCTERFVSSPEDVMDVIDEGKANRHVAVTNM 197

  Fly   191 NERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHINKSLL 255
            ||.|||||:||.|.|   |.::.:.:..:...|.||||||||:..:|||.|:.|.|..:|||||.
Zfish   198 NEHSSRSHSIFLINI---KQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGSVLDEAKNINKSLS 259

  Fly   256 FLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPSIMEESQ--STLSFATRA 318
            .|.|||.:|:|..... ..|||||:|||||.|||||..|:|:....||:..|::  |||.|..||
Zfish   260 ALGNVISALAEGTKTH-VPYRDSKMTRILQDSLGGNCRTTIVICCSPSVYNEAETKSTLMFGQRA 323

  Fly   319 KKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQ-KVEHLERQIKHDMHKIICGH 382
            |.|:....||           :|...:..|.|..:|:.|..|.: .::.||.::|.
Zfish   324 KTIKNTVSVN-----------MELTAEEWKKKYEKEKEKTRNLKIIIQRLENELKR--------- 368

  Fly   383 SLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKT 447
                         |                                          ::.:.:|
Zfish   369 -------------W------------------------------------------RKGETVP-- 376

  Fly   448 INILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEI 512
            :|       ...||..|:....|..||..:|.|:.|                     :|..|.:.
Zfish   377 VN-------EQHSNKESKNCEAAPVIDTSAPPPEPL---------------------SDAEKTQY 413

  Fly   513 QDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKER-YDALEKEVTSLRADNEA 576
            ::|  ...|.:..:.:.:|: ....:|||...|:...:.|.||...| |:.:::::..|:.:||.
Zfish   414 EEL--INDLYQQLDDKDDEI-NQHSQLAEDLKQQMVDQDELLASTRRDYEKIQEDLNRLQRENET 475

  Fly   577 ANSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDDLLS-ALLEKESTIESL 640
            |..::.|:.:.|..|               .:.::.::|:...|.:.::.|| .|::|.|.:..:
Zfish   476 AKEEVKEVLQALEEL---------------AVNYDQKSHEVEEKSKTNNQLSDELVQKSSALAGV 525

  Fly   641 QK---SLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIADLESKKNSCE--CDQ 700
            ::   ||..|:....|.|.|  :||:........|..|.....:|.:|...:|.:.....  ..:
Zfish   526 ERDLSSLKELSEHHRRRSAE--ILSLLLRDLCEIGSVIALNDHKLSELNGGMEEEFTMARLFISK 588

  Fly   701 LRLEIVSVRDKLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQ 765
            ::.|:.|:.::.:.:||    ..|:.::|....|   |||::.|....|.|.:..:|....|..:
Zfish   589 MKSEVKSLVNRSKQLES----TQSDTMRKMQANE---KELASCQMLISQHQAKIKSLTDYMQNME 646

  Fly   766 AGITTLHEKHEHVQEKYQKLQEEYEQLE-----------SRARSA---SSAEFQRLQNDNTKFQA 816
            .....|.|.|:.:.|:..||..|....|           ||.:.|   ..|..|::::.....|.
Zfish   647 QKKRQLEESHDSLTEELAKLHAEERMHEVSVLDKEKEHMSRMQDAEEMKKALEQQMESHRETHQK 711

  Fly   817 DIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLMESV 881
            .::.|.:.:||.|.:|.|          |:..|..|..:.|:|.:::|::|:|......:|.:.:
Zfish   712 QLSRLRDEIEEKQRILDE----------LKDVNQALELEQKKLMSDYEKLQQEDQKKDERLQKLL 766

  Fly   882 ---QENDALREEIKQRPTSHVEESMRSSGISSDFDEQKQDINLLHQFVQLSESVQQIELQHHSGI 943
               ::.:..:|::|     .:||::            .:::..||...:|  .:|.|.
Zfish   767 FLNEKKEQAKEDLK-----GLEETV------------AKELQTLHDLRKL--FIQDIN------- 805

  Fly   944 SRLFRANQMKLDQSEPGLKLCLESAEYIEEDNRQSDATEPICLKGFLKRHRFQIKRLSQEHVDMG 1008
            :|:.|:  ::||..|.|..|..:......|:|          |:...|.|    |:|..::.|:.
Zfish   806 NRIGRS--VELDTDESGGSLAQKQKIIFLENN----------LEQLTKVH----KQLVHDNADLR 854

  Fly  1009 EEKRLLDIISQLEQEIEEKSALMEATEATINEMREQMTNLESALLEKSVIINKVEDYQRQIESLE 1073
            .|      :.:||:.:...:..::..|:.:.|.:      |||:.::       :.||::::.::
Zfish   855 CE------LPKLEKRLRATAERVKILESALREAK------ESAMRDR-------KKYQQEVDRIK 900

  Fly  1074 KQNAEMTMVYEELQDRVTRESSMSESL--------LRVPPDEDTLPGCPTSPSRREQ 1122
            :      ::..:.|.|....:.:::.:        ....|......|.| ||.|..|
Zfish   901 E------VIRAKNQSRRNHTAQIAKPIRAGHHHPVASASPGHSVRGGTP-SPRRHHQ 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	138/333 (41%)
		Motor_domain	8..321	CDD:277568	137/326 (42%)
		Smc	<680..1449	CDD:224117	90/470 (19%)
		TMPIT	779..>867	CDD:285135	23/101 (23%)
		Smc	1042..1910	CDD:224117	14/89 (16%)
kif5c	NP_001116747.1	KISc_KHC_KIF5	6..326	CDD:276820	137/326 (42%)
		Kinesin	14..326	CDD:278646	134/318 (42%)
		GBP_C	<638..766	CDD:303769	31/137 (23%)
		PKK	656..804	CDD:289257	35/176 (20%)
		coiled coil	733..744	CDD:293879	3/10 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910