DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and kif3cb

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_001017849.2	Gene:	kif3cb / 550547	ZFINID:	ZDB-GENE-080709-4	Length:	759	Species:	Danio rerio

Alignment Length:	741	Identity:	227/741 - (30%)
Similarity:	348/741 - (46%)	Gaps:	170/741 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KNASSIQVCIKVRPC---EPGLTS---------LWQVKERRSIHLADSHAEPYVFDYVFDEGASN 56
            |.:.:::|.::.||.   |..:..         |.||..|.. ..:.|..:.:.||.|:|..:..
Zfish    17 KKSEAVKVVVRCRPLNKKEEAMNQERIVEVDVRLGQVSVRNP-KSSGSLVKSFTFDAVYDVSSKQ 80

  Fly    57 QEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMG---DEQNPGVMVLAAKEIFQQISSET 118
            .|::|...|.::.:.:.||||||||||||.:||||||.|   |.:..||:..:.:.||.|||...
Zfish    81 NELYDYACKPLIDSVLLGFNGTIFAYGQTGTGKTYTMEGVPTDPETRGVIPNSFQHIFTQISRSQ 145

  Fly   119 ERDFLLRVGYIEIYNEKIYDLLNK-KNQDLKIHESGNGIVNVNCEECIITSEV-DLLRLLCLGNK 181
            .:.:|:||.|||||.|:|.|||.| .|:.|::.|:....|.|....|::|..: ::..::.|||:
Zfish   146 NQQYLVRVSYIEIYQEEIRDLLCKDNNKKLELKENPELGVYVKDLSCVVTKNIKEIEHVMNLGNQ 210

  Fly   182 ERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKE 246
            .|:||.|.||||||||||||.|.||..:.....:|.:....||:||||||||..:||.:|.|.||
Zfish   211 SRSVGFTKMNERSSRSHAIFVITIECSEMGIDGEDHIRVGKLNMVDLAGSERQSKTGVQGRRFKE 275

  Fly   247 GGHINKSLLFLSNVIKSLSENADNRFTN--YRDSKLTRILQASLGGNAFTSIICTIKPS--IMEE 307
            ...||.||..|.|||.:|   .|.:.|:  ||||||||:||.||||||.|.::.|:.|:  ..:|
Zfish   276 AAKINLSLSALGNVISAL---VDGKSTHVPYRDSKLTRLLQDSLGGNAKTVMVATVGPASCYYDE 337

  Fly   308 SQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEER----KNENQQKVEHLE 368
            :.:||.:|.|||.|:.||::||...|| :::..:.||..||.:|  |||    |...:||...|
Zfish   338 TLTTLRYANRAKNIKNKPKINEDPKDA-LLREFQEEIARLKAQL--EERGMLAKERRRQKRNSL- 398

  Fly   369 RQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRID-----QFPKVSHLPK 428
             ::|..|          ..|:.:..|.       ..:|:.||...|...|     |..|.|...|
Zfish   399 -RMKRSM----------SSGEVETPRI-------GEVEVVETVREESVEDYWWKQQMAKTSANYK 445

  Fly   429 PVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLP 493
            |                         ||..:...::|:.
Zfish   446 P-------------------------DISRKLGMVNEKV-------------------------- 459

  Fly   494 DLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKE 558
                     .|.:::.||.|.::  ..:||:..:|.:.:.|.|..:.....|:..||...|...|
Zfish   460 ---------KTVEELLKEQQAME--NMIEKYKAMESKLLVGGKNIIDHTNEQQKMLELTRLEIAE 513

  Fly   559 RYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKS---SK 620
            : |..|:|:..|..:.:   .:..||:|..|||:|               |.||:..|..   ||
Zfish   514 Q-DRKEREMQQLMFEQD---EETIELKETFSTLQQ---------------EVEFKTKKLRKFYSK 559

  Fly   621 LR-----VDDLLSALLEKESTIESLQKSLDNLTRD------VLRNSKEGHMLSIAPEQEDIAGDS 674
            |:     :.|:::   |..:..:.|:::::.|||:      ::.|       .|.||::    :.
Zfish   560 LQLVRSEIGDIIN---EHVTMRQELEQTMNELTREMKFKNLIIEN-------FIPPEEK----NK 610

  Fly   675 ICNKC-----EELEKLIADLESKKNS 695
            |.|:.     |:..|::..|.|:.||
Zfish   611 IINRLHFDSEEDQWKVLPLLPSENNS 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	143/340 (42%)
		Motor_domain	8..321	CDD:277568	140/333 (42%)
		Smc	<680..1449	CDD:224117	6/16 (38%)
		TMPIT	779..>867	CDD:285135
		Smc	1042..1910	CDD:224117
kif3cb	NP_001017849.2	KISc_KIF3	20..351	CDD:276822	140/334 (42%)
kif3cb	NP_001017849.2	KISc	21..358	CDD:214526	143/340 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910