DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and Kif3C

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	701	Identity:	202/701 - (28%)
Similarity:	304/701 - (43%)	Gaps:	204/701 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ASSIQVCIKVRPCEPGLTSLWQVKERRSIHLAD---------------SHAEPYVFDYVFDEGAS 55
            :.:|:|.::.||...      ..|||...::.:               |..:.::||.|::....
  Fly     2 SENIKVVVRCRPMNQ------TEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTD 60

  Fly    56 NQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDE---QNPGVMVLAAKEIFQQISSE 117
            .:.::|.|...:|.:.::|:||||||||||..|||:||.|||   .:.|::......||::||..
  Fly    61 TEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMT 125

  Fly   118 TERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVN---------------------VNC 161
            |...:|..|.|:|||||:|.|||||       :|:.| ::|                     ||.
  Fly   126 TNVRYLALVTYLEIYNERIRDLLNK-------NENTN-VINHFLKELPGIGVSVPTLTTQPVVNA 182

  Fly   162 EECIITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHS-DDDA---VIQSV 222
            .:|     .|.|.   .|||.|....|.||:.|||||.||.|.:|.....:| ..||   :.:..
  Fly   183 NQC-----YDWLH---FGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGK 239

  Fly   223 LNLVDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQAS 287
            |:|||||||||..:|||:|.||||...||.||..|.|||.||.: ...:...:|||||||:||.|
  Fly   240 LSLVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD-GKAKHVPFRDSKLTRLLQDS 303

  Fly   288 LGGNAFTSIICTIKPSIM--EESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDK 350
            ||||..|.:|..|.|:.:  :|:.|||.:|:|||.|..||::||...|| .:::.:.||..||..
  Fly   304 LGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDA-RLRQYQNEILYLKRM 367

  Fly   351 LAEEER-KNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTE 414
            |.|.:: .|:|            :|.:|||
  Fly   368 LQESQQIINKN------------NDPNKII----------------------------------- 385

  Fly   415 DRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPR 479
                      ..|..:..||        |:..|.|:                    :.||.|...
  Fly   386 ----------KSPLKIIQHT--------NMNSTKNV--------------------QIIDLGRNC 412

  Fly   480 PDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLE--KHFEVECEEVQG--LKEK-L 539
            ....|...:|...|:.||.        :.|:|:| ||..:.::  |...:..|.:..  |||| :
  Fly   413 KASFKTNNSILTKPNFPLI--------QSKEEVQ-LQARSRIDLIKRSLIGGERIHDFELKEKHM 468

  Fly   540 AEVTAQRDNLEQESLA----EKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEV 600
            |...|.:.:|...::|    :.|..|.|:....::..:.:..|..|.:.:||:..|:     |||
  Fly   469 ARKYAAQRHLSAIAIALSRVKCEDRDLLQGHYATITQEIDIKNDYIRKCKEKIKMLE-----MEV 528

  Fly   601 ENQVAVGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTRDV 651
            .:     |..||:                 |::|..::.::    ||.|.|
  Fly   529 SD-----LNSEFQ-----------------LDREDYLDEIR----NLGRQV 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	137/364 (38%)
		Motor_domain	8..321	CDD:277568	134/357 (38%)
		Smc	<680..1449	CDD:224117
		TMPIT	779..>867	CDD:285135
		Smc	1042..1910	CDD:224117
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	134/358 (37%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	132/351 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437713
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840