Protein Alignment cmet and Klp98A

DIOPT Version :10

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Alignment Length: 1384
• Identity: 334/1384 - (24%)
• Similarity: 563/1384 - (40%)
• Gaps: 355/1384 - (25%)

  Fly     7 SSIQVCIKVRP---------------CEPGLTSLWQVKER-RSIHLA--DSHAEPYVFDY---VF 50
            ||::|.::|||               .|...|.|  :|.| :||..|  |:|.: :.|||   .|
  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRL--LKPRLQSIRDAGRDNHHD-FTFDYSYWSF 63

  Fly    51 D----EGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIF 111
            |    ..|:.::|:..:...:|....:|:|..:||||||.||||:||||...|||::....:|:|
  Fly    64 DAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELF 128

  Fly   112 --QQISSETERDFLLRVGYIEIYNEKIYDLL--NKKNQDLKIHESGN-GIVNVNCEECIITSEVD 171
              .::..|:...:.....|:|||||::.|||  ......|::.|..: |....|..:..::...:
  Fly   129 ARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDE 193

  Fly   172 LLRLLCLGNKERTVGETNMNERSSRSHAIFKI-IIESRKSDHSDDDAVIQSVLNLVDLAGSERAD 235
            :...:..||.:||...||||:.||||||||.| .:::...:....:.|  |.::||||||||||:
  Fly   194 IQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETV--SKIHLVDLAGSERAN 256

  Fly   236 QTGARGARLKEGGHINKSLLFLSNVIKSLSE------------------NADNR--FTNYRDSKL 280
            .|||.|.|||||.||||||:.|.:||.:|:|                  .|..|  :..||||.|
  Fly   257 ATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSIL 321

  Fly   281 TRILQASLGGNAFTSIICTIKPS--IMEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLERE 343
            |.:|:.|||||:.|.:|..:.|:  ...|:.|||.:|.|||.|..||.||| .::..:::.|..|
  Fly   322 TWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNE-DTNVKLIRELREE 385

  Fly   344 IKVLKDKLA-------------EEERKNENQQKV-------------EHLERQ------------ 370
            |..||..||             .:.:|.|.|:||             ..|:.|
  Fly   386 INKLKSMLAGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQKSLGLRKSGVGV 450

  Fly   371 -----------IKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSH-------LELAETGTTEDRI 417
                       |.:|:...:..:||.: |:         |..||.       :|||..|......
  Fly   451 VLDSEMPHLIGIHNDVTTGVTLYSLKE-GE---------TRIGSEDADVAQDIELAGDGIRAQHC 505

  Fly   418 DQFPK---VSHLPKPVFFHTSNAGKRWDNI-----PKTIN-----ILGSLDIGTESNSISEEFLP 469
            ..|.|   |:..|.|:       .:.|.|.     ||.|:     :||..:|...:|       |
  Fly   506 SIFLKGGVVTLHPWPL-------AQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNN-------P 556

  Fly   470 AECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQG 534
            ||..                                 |::|::...|:..|
  Fly   557 AEAA---------------------------------KLRKDLSRSQLDMS-------------- 574

  Fly   535 LKEKLAEVTAQRDNLEQESLAEKE----RYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTM 595
               :|:.:|:.::||...|:...|    .|...|::....|..:........|..:.|.|::..:
  Fly   575 ---RLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIENAL 636

  Fly   596 RIMEVENQVAVGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHM 660
            :.:.||                  ::::.|.....:.|             ||.:::|
  Fly   637 KQLNVE------------------RVQMHDQYKTKVRK-------------LTEELIR------- 663

  Fly   661 LSIAPEQEDIAGDSICNKCEELEKLIA--DL---ESKKNSCECDQLRLEIVSVRDKLESVESAFN 720
                .|||::.|..:.| |.| ::|||  |:   |......:.|.:..:|.:.:.:|:|.:..|:
  Fly   664 ----LEQEEMDGLQLLN-CRE-QELIARKDMLLWEKNNEKVQIDIVCRQISAFQTQLDSKKRDFS 722

  Fly   721 LASSEIIQKATDCERLSK-----ELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKHEHVQE 780
            ...::.:|:..||.:|.:     |..|..|....||.. |:||  ..|.|....|:...:|.:
  Fly   723 EYVAKELQELQDCGKLDEMGMKIEEGTPLNDELLLQVS-DSLD--LFAAQFIKDTVRRNNEEI-- 782

  Fly   781 KYQKLQEEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNERLEEAQNMLTEVQNSESTVEKL 845
              :||.|:..:.| |..:||:.:..::.....:.||.:..|  |||.|::      .:||...:.
  Fly   783 --RKLDEQIAEKE-RILNASTTKIAKVDETMLEIQAQLERL--RLERAES------EAESQAMRA 836

  Fly   846 RIQNHELTAKIKELETNFEEMQREYDCLSNQLMESVQENDALREEIKQRPTSHVEESMRS--SGI 908
            :.||.:|....|.:.|:....:.: |...:...|:.......:..:....:..:.|..:|  |..
  Fly   837 KKQNMKLQLGNKSMSTSTSTNEAD-DVSKSDTYETCDTFHTAQSNLSLVSSPTITEGQQSPLSNC 900

  Fly   909 SSDFDEQKQDINLLHQFVQLSESVQQIELQHHSGISRLFRANQMKL--DQSEPGLKLCLESAEYI 971
            |.|.:::.:|.    :...||.|.::......:|.|....:..:.:  ..|.|.   |..|::.|
  Fly   901 SCDAEDEAEDT----RKDDLSGSSEETSRTCTAGPSSGSGSGSVGIGGSGSAPS---CTPSSQAI 958

  Fly   972 EEDNRQSDATEPICL---------KGFLKRHRFQIKRLSQEHVDMG-----EEKRLLDI------ 1016
            ..|:       .:||         .|.|..:: |..|.|.|  |.|     |..|..|:
  Fly   959 MSDS-------GVCLDSRNQAILQNGHLNNYK-QAVRTSDE--DTGSCSSCELGRHSDVARPYCP 1013

  Fly  1017 ISQLEQEI-EEKSALMEATEATIN--EMREQMTNLESALLEKSVI------INKVEDYQRQIESL 1072
            :..|.::| .:|:.:|:..|..:|  ::.|.:.:|:.  |::..|      :..|:|.:...:..
  Fly  1014 LHSLRRKIAAQKALIMKNLETDLNKAQLDEHIADLQD--LQRRYIQMEQEMLQSVQDLEAHAQCC 1076

  Fly  1073 EKQNAEMTMVYEELQDRVTRESSMSESLLRVPPDEDTLPGCPTS-PSRRE----QEVATLKTSIT 1132
            ..:.:.|...| ||...:.|.|.||.:.:.....:...|....| ||.||    :...|:.:.:.
  Fly  1077 ADERSGMERQY-ELASSIMRSSVMSPTSMEESTSQIYSPSMTRSCPSMREFPEGEHFITIPSFVM 1140

  Fly  1133 ELQSQVSDLKAELENHLRQIQLKDG--NIARLQTDFEEM---SERCLS----------MEVRLAE 1182
            ....:.:..:.|:     :|.|.||  ||.|..:.|.|:   .:.|..          .|:..:.
  Fly  1141 RGAGKQTHYEYEV-----RIALPDGKLNILRRYSRFRELHLCMKHCYGAKISALPFPRRELFASN 1200

  Fly  1183 LDEDTKQKQELLDRQAQKL 1201
            .:...|.::.||:...::|
  Fly  1201 SEPVAKHRRRLLELYLRRL 1219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	Motor_domain	8..321	CDD:473979	132/365 (36%)
		SMC_prok_B	539..1431	CDD:274008	148/730 (20%)
		SMC_prok_B	1137..1926	CDD:274008	16/80 (20%)
		YhaN	1717..2182	CDD:443752
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	136/373 (36%)
		Kinesin_assoc	370..478	CDD:465047	21/109 (19%)
		FHA_KIF16	449..556	CDD:438760	26/130 (20%)
		SMC_N	624..>864	CDD:481474	65/300 (22%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	17/94 (18%)