DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and Klp68D

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	923	Identity:	228/923 - (24%)
Similarity:	377/923 - (40%)	Gaps:	283/923 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAKN-----ASS------IQVCIKVRPC-----------------EPGLTSLWQV----KERRS 33
            ||||:     .||      :||.::.||.                 ..|:..|..|    ||:|.
  Fly     1 MSAKSRRPGTGSSQTPNECVQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRK 65

  Fly    34 IHLADSHAEPYVFDYVFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTM---MG 95
            :         :.:|..:|..|:...::..:...:|.:.::||||.|||||||.:|||:||   .|
  Fly    66 V---------FTYDAAYDASATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRG 121

  Fly    96 DEQNPGVMVLAAKEIFQQISSETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNVN 160
            :::..|::....::|:..|:......||:.|.|:|||.|::.|||...::.|::.|.|:|:...|
  Fly   122 NDELMGIIPRTFEQIWLHINRTENFQFLVDVSYLEIYMEELRDLLKPNSKHLEVRERGSGVYVPN 186

  Fly   161 CEECIITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNL 225
            .......|..|:::::.:|||.||||.|||||.||||||||.|.||   ...::.:.:....|||
  Fly   187 LHAINCKSVEDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIE---MCDTETNTIKVGKLNL 248

  Fly   226 VDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGG 290
            :|||||||..:|||...||||...||.:|..|.|||.:|:|::.:  ..||||||||:||.||||
  Fly   249 IDLAGSERQSKTGASAERLKEASKINLALSSLGNVISALAESSPH--VPYRDSKLTRLLQDSLGG 311

  Fly   291 NAFTSIICTIKPS--IMEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAE 353
            |:.|.:|..|.||  ...|:.:||.:|:|||.|:.:|..||...||.:
  Fly   312 NSKTIMIANIGPSNYNYNETLTTLRYASRAKSIQNQPIKNEDPQDAKL----------------- 359

  Fly   354 EERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRID 418
                .|.|:::|.|:|.|                |.|:::|
  Fly   360 ----KEYQEEIERLKRLI----------------GPQQQQR------------------------ 380

  Fly   419 QFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVL 483
                                                         ||:.:.|:       :..|.
  Fly   381 ---------------------------------------------SEKQVTAK-------KQRVK 393

  Fly   484 KPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECE----EVQGLKEKLAEVTA 544
            ||                  ..:.:.||:.|....:::|:..|.:.:    |.:..||..|||..
  Fly   394 KP------------------KKETVTKEMSDSLQVSTIEQPVEDDSDPEGAESESDKENEAEVAK 440

  Fly   545 QRDNLEQESLAEKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVENQVAVGLE 609
            ..:.||:|                  |.:|....:|::|||.:|....:.:.....|.|:.:..:
  Fly   441 SNEELERE------------------RVENSKLAAKLAELEGQLVRGGKNLLDTYSERQIELEKK 487

  Fly   610 FEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDS 674
            ....|.:|..::.:...|.  |::|:|:|..::                   :::.|||......
  Fly   488 LVEIAERKKREIEIQQQLE--LQEETTLEIRER-------------------NVSLEQEVELKKR 531

  Fly   675 ICNKCEELEKLIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKATDCERLSKE 739
            ..:||  ..|.:| |:.:.|.|:.|.        ...|..:|    :|.:|::::      |.::
  Fly   532 KLSKC--YAKYLA-LQQELNDCKSDH--------NQDLRELE----MAQNELVKE------LKRQ 575

  Fly   740 L---------STSQNAFGQLQERYDALDQQWQAQQAGITT-------LHEKHEHVQEKYQKLQEE 788
            |         ...|..:  .|.:||...::|:.....:.|       ...|......:.::...|
  Fly   576 LLIIDNFVPIEVKQRLY--TQAKYDEEQEEWKFSSMSLPTPPGGDGKFSSKRPVSHPQRRRPTSE 638

  Fly   789 YEQLESRARSASSAEFQRLQNDNTKFQADI------------ASLNERLEEAQNMLT-----EVQ 836
            |...|:::.|.||..|:.....|.:.:...            |||...|  ||.|.|     ::.
  Fly   639 YALQEAKSNSPSSLRFKSENIVNYELEMPCRTTQEYRTPKVSASLQAVL--AQAMQTGGDDIDIV 701

  Fly   837 NSESTVEKLRIQN 849
            :|.:...:.|::|
  Fly   702 DSHTNSLRSRLEN 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	131/351 (37%)
		Motor_domain	8..321	CDD:277568	129/344 (38%)
		Smc	<680..1449	CDD:224117	38/203 (19%)
		TMPIT	779..>867	CDD:285135	19/88 (22%)
		Smc	1042..1910	CDD:224117
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	128/339 (38%)
		KISc	20..351	CDD:214526	130/344 (38%)
		GBP_C	<479..576	CDD:303769	25/138 (18%)
		coiled coil	547..558	CDD:293879	3/18 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438006
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840