DRSC/TRiP Functional Genomics Resources

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Protein Alignment cmet and kif18a

DIOPT Version :9

Sequence 1:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster
Sequence 2:NP_956533.1 Gene:kif18a / 393209 ZFINID:ZDB-GENE-040426-862 Length:895 Species:Danio rerio


Alignment Length:925 Identity:244/925 - (26%)
Similarity:408/925 - (44%) Gaps:181/925 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SSIQVCIKVRPCEPGLTSLWQVKE-----RRSIHLADSHA---EP-------------------- 43
            |.::|.::|||...        ||     ::.:|:.|:|.   :|                    
Zfish     8 SHVKVVVRVRPLND--------KEKDGNFKKVVHVVDNHMLVFDPKEEEVTFFRGQRVGNRDVRK 64

  Fly    44 -------YVFDYVFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPG 101
                   :|||.||.|.:|..|||:...|.||...:.|:|.|:||||.|.:|||:||:|...:||
Zfish    65 RANKDLKFVFDSVFGEESSQIEVFENTTKAIVDGVLNGYNCTVFAYGATGAGKTHTMLGTSNSPG 129

  Fly   102 VMVLAAKEIFQQIS-SETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESG-NGIVNVNCEEC 164
            ||.|..||:|.::. .:.::.|.:...|:|:|||:|.|||.... .|.:.|.| ||:|.......
Zfish   130 VMFLTMKELFARMDLIKEDKVFNVAFSYLEVYNEQIRDLLTNSG-PLAVREDGSNGVVVQGLTLH 193

  Fly   165 IITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLA 229
            ...|...:|..|..||:.||...|:||..||||||:|:|.:..:....|.:..|..:.::|:|||
Zfish   194 QPKSAEHILEALDYGNRNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASLNPNVRVAKMSLIDLA 258

  Fly   230 GSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTN--YRDSKLTRILQASLGGNA 292
            |||||..|..:||||:||.:||:|||.|.|||.:|: |...:.|:  ||||||||:|:.|||||.
Zfish   259 GSERASATNTKGARLREGANINRSLLALGNVINTLA-NPKCKKTHIPYRDSKLTRLLKDSLGGNC 322

  Fly   293 FTSIICTIKPSIM--EESQSTLSFATRAKKIRIKPQVNEMVSD------ATMMKRLEREIKVLKD 349
            .|.:|..:.||.:  |::.:||.:|.|||:|:...:.|.|..|      |.:.::.:.||.:||.
Zfish   323 RTVMIANVSPSSLSYEDTHNTLKYANRAKEIKSTLRSNVMSLDSHIGQYAIICEKQKAEIVMLKQ 387

  Fly   350 KLAE-EERKNE-------NQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLE 406
            ||.| ||||.|       :.||....|: :...:..:     .||:.:.::          .||:
Zfish   388 KLKEYEERKAEAPALNPISIQKRAEFEK-MSESLRSV-----FSDRLKLRK----------EHLD 436

  Fly   407 LAETGTTEDRIDQFPKVS-HLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPA 470
            : |....|.|:....:.| |....:||..:.|.:......:.:..|.|     ....:.:..:.:
Zfish   437 I-EKQLNESRLTMRHRESWHQQSLIFFPDNKAERATCKYERKLASLKS-----HQEHLQQRLMES 495

  Fly   471 E-CIDFGSPRPDVLKPMLTIRQLP-DLPLTPKGPLTTDKIKKEIQ--DLQM-FTSLEKHFE---- 526
            | |......         .:.::. ::.|......|.:::|||:|  .||: .:.|::|.|    
Zfish   496 EKCFQENEG---------WLHRIENEMKLLGHDGHTPEELKKELQCHQLQLQISDLQQHMEHMSH 551

  Fly   527 -VECEEVQGL-KEKLAEV---TAQRDNLEQESLA---EKERYDALEKEVTSLR----ADNEAANS 579
             :..::.:.. ..||...   |.:|.:|..::::   :...::.||:.|...|    ||.|.|..
Zfish   552 LISVQDQENTHTHKLVNALLSTCRRQHLALKAMSADGDGSEWEELERLVHRERAVVWADQEKAED 616

  Fly   580 KISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLR----------------VDDLLS 628
            |..:.....:.|:..:....:.:..:.....|....:.|.:||                .:.:|.
Zfish   617 KRDDSGIGSTHLRPILSFSHLVSHQSTPCSSEKHTRRTSQRLRPTHSSKDCGPHHQVAEAEGVLK 681

  Fly   629 ALLEKESTIESLQKSLDNLT--------RDVLRNSKEGHM-LSIAPEQE-------------DI- 670
            ..:.::.::...:...|...        :||||  :||.. |...||.:             || 
Zfish   682 KPIRRKLSVSPAKLDGDGPVLSHHPPDLQDVLR--QEGMFPLQFTPEGQPHTSSIFDPNSTIDIG 744

  Fly   671 -------AGDSICNKCEE-----LEKLIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLAS 723
                   |..:|....|:     |:.|.|:..:|..:      ||||.|:.|...|..|...:.|
Zfish   745 HIEDPTGANATIILSPEDPGRSTLQALRANNANKPAN------RLEIPSLLDLRRSKPSYMAMTS 803

  Fly   724 SEIIQKATDCERLSKELSTSQNAFGQLQERYDALD--QQWQAQQAGITTLHEKHEHVQEKYQKLQ 786
            :...::..:|..:.||.|:...|....:.:.|..:  :..:.::.|:::.:|....|.....  :
Zfish   804 AAQGKRKLNCSSIGKEDSSQAMAAAPKRIKRDPCEASKPLRIRRLGVSSENEPSRRVVRSVS--E 866

  Fly   787 EEYEQLESRARSASS 801
            ....||..|....||
Zfish   867 GNLHQLGRRKHKLSS 881

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cmetNP_524993.3 KISc 8..328 CDD:214526 135/360 (38%)
Motor_domain 8..321 CDD:277568 134/353 (38%)
Smc <680..1449 CDD:224117 28/129 (22%)
TMPIT 779..>867 CDD:285135 5/23 (22%)
Smc 1042..1910 CDD:224117
kif18aNP_956533.1 KISc 9..354 CDD:214526 134/354 (38%)
KISc_KIP3_like 9..353 CDD:276821 134/353 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0242
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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