Protein Alignment cmet and kif18a

DIOPT Version :10

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: NP_956533.1
• Gene: kif18a / 393209
• ZFINID: ZDB-GENE-040426-862
• Length: 895
• Species: Danio rerio
• Alignment Length: 925
• Identity: 244/925 - (26%)
• Similarity: 408/925 - (44%)
• Gaps: 181/925 - (19%)

  Fly     7 SSIQVCIKVRPCEPGLTSLWQVKE-----RRSIHLADSHA---EP-------------------- 43
            |.::|.::|||...        ||     ::.:|:.|:|.   :|
Zfish     8 SHVKVVVRVRPLND--------KEKDGNFKKVVHVVDNHMLVFDPKEEEVTFFRGQRVGNRDVRK 64

  Fly    44 -------YVFDYVFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPG 101
                   :|||.||.|.:|..|||:...|.||...:.|:|.|:||||.|.:|||:||:|...:||
Zfish    65 RANKDLKFVFDSVFGEESSQIEVFENTTKAIVDGVLNGYNCTVFAYGATGAGKTHTMLGTSNSPG 129

  Fly   102 VMVLAAKEIFQQIS-SETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESG-NGIVNVNCEEC 164
            ||.|..||:|.::. .:.::.|.:...|:|:|||:|.|||.... .|.:.|.| ||:|.......
Zfish   130 VMFLTMKELFARMDLIKEDKVFNVAFSYLEVYNEQIRDLLTNSG-PLAVREDGSNGVVVQGLTLH 193

  Fly   165 IITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLA 229
            ...|...:|..|..||:.||...|:||..||||||:|:|.:..:....|.:..|..:.::|:|||
Zfish   194 QPKSAEHILEALDYGNRNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASLNPNVRVAKMSLIDLA 258

  Fly   230 GSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTN--YRDSKLTRILQASLGGNA 292
            |||||..|..:||||:||.:||:|||.|.|||.:|: |...:.|:  ||||||||:|:.|||||.
Zfish   259 GSERASATNTKGARLREGANINRSLLALGNVINTLA-NPKCKKTHIPYRDSKLTRLLKDSLGGNC 322

  Fly   293 FTSIICTIKPSIM--EESQSTLSFATRAKKIRIKPQVNEMVSD------ATMMKRLEREIKVLKD 349
            .|.:|..:.||.:  |::.:||.:|.|||:|:...:.|.|..|      |.:.::.:.||.:||.
Zfish   323 RTVMIANVSPSSLSYEDTHNTLKYANRAKEIKSTLRSNVMSLDSHIGQYAIICEKQKAEIVMLKQ 387

  Fly   350 KLAE-EERKNE-------NQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLE 406
            ||.| ||||.|       :.||....|: :...:..:     .||:.:.::          .||:
Zfish   388 KLKEYEERKAEAPALNPISIQKRAEFEK-MSESLRSV-----FSDRLKLRK----------EHLD 436

  Fly   407 LAETGTTEDRIDQFPKVS-HLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPA 470
            : |....|.|:....:.| |....:||..:.|.:......:.:..|.|     ....:.:..:.:
Zfish   437 I-EKQLNESRLTMRHRESWHQQSLIFFPDNKAERATCKYERKLASLKS-----HQEHLQQRLMES 495

  Fly   471 E-CIDFGSPRPDVLKPMLTIRQLP-DLPLTPKGPLTTDKIKKEIQ--DLQM-FTSLEKHFE---- 526
            | |......         .:.::. ::.|......|.:::|||:|  .||: .:.|::|.|
Zfish   496 EKCFQENEG---------WLHRIENEMKLLGHDGHTPEELKKELQCHQLQLQISDLQQHMEHMSH 551

  Fly   527 -VECEEVQGL-KEKLAEV---TAQRDNLEQESLA---EKERYDALEKEVTSLR----ADNEAANS 579
             :..::.:.. ..||...   |.:|.:|..::::   :...::.||:.|...|    ||.|.|..
Zfish   552 LISVQDQENTHTHKLVNALLSTCRRQHLALKAMSADGDGSEWEELERLVHRERAVVWADQEKAED 616

  Fly   580 KISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLR----------------VDDLLS 628
            |..:.....:.|:..:....:.:..:.....|....:.|.:||                .:.:|.
Zfish   617 KRDDSGIGSTHLRPILSFSHLVSHQSTPCSSEKHTRRTSQRLRPTHSSKDCGPHHQVAEAEGVLK 681

  Fly   629 ALLEKESTIESLQKSLDNLT--------RDVLRNSKEGHM-LSIAPEQE-------------DI- 670
            ..:.::.::...:...|...        :||||  :||.. |...||.:             ||
Zfish   682 KPIRRKLSVSPAKLDGDGPVLSHHPPDLQDVLR--QEGMFPLQFTPEGQPHTSSIFDPNSTIDIG 744

  Fly   671 -------AGDSICNKCEE-----LEKLIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLAS 723
                   |..:|....|:     |:.|.|:..:|..:      ||||.|:.|...|..|...:.|
Zfish   745 HIEDPTGANATIILSPEDPGRSTLQALRANNANKPAN------RLEIPSLLDLRRSKPSYMAMTS 803

  Fly   724 SEIIQKATDCERLSKELSTSQNAFGQLQERYDALD--QQWQAQQAGITTLHEKHEHVQEKYQKLQ 786
            :...::..:|..:.||.|:...|....:.:.|..:  :..:.::.|:::.:|....|.....  :
Zfish   804 AAQGKRKLNCSSIGKEDSSQAMAAAPKRIKRDPCEASKPLRIRRLGVSSENEPSRRVVRSVS--E 866

  Fly   787 EEYEQLESRARSASS 801
            ....||..|....||
Zfish   867 GNLHQLGRRKHKLSS 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	Motor_domain	8..321	CDD:473979	134/353 (38%)
		SMC_prok_B	539..1431	CDD:274008	61/326 (19%)
		SMC_prok_B	1137..1926	CDD:274008
		YhaN	1717..2182	CDD:443752
kif18a	NP_956533.1	KISc_KIP3_like	9..353	CDD:276821	134/353 (38%)
		SMC_N	<345..572	CDD:481474	53/257 (21%)