DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cmet and KIF22

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	XP_024306038.1	Gene:	KIF22 / 3835	HGNCID:	6391	Length:	723	Species:	Homo sapiens

Alignment Length:	711	Identity:	187/711 - (26%)
Similarity:	301/711 - (42%)	Gaps:	186/711 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IQVCIKVR------------PCEPGLTSLWQVKERRSIHLAD--SHAE--PYVFDYVFDEGASNQ 57
            ::|.:::|            ||..|:.|.       |:.:|:  :|.|  .|.||..:.|.::.|
Human    44 VRVAVRLRPFVDGTAGASDPPCVRGMDSC-------SLEIANWRNHQETLKYQFDAFYGERSTQQ 101

  Fly    58 EVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSE--TER 120
            :::....:.|:...::|.|.::.|||.|.:|||:||:|..:.|||:..|..::.|....|  ..|
Human   102 DIYAGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQPGVIPRALMDLLQLTREEGAEGR 166

  Fly   121 DFLLRV--GYIEIYNEKIYDLLNKKNQDLKIHESGNG-IVNVNCEECIITSEVDLLRLLCLGNKE 182
            .:.|.|  .|:|||.||:.|||:..:.||.|.|...| |:.....:..|:|..|..|.....::.
Human   167 PWALSVTMSYLEIYQEKVLDLLDPASGDLVIREDCRGNILIPGLSQKPISSFADFERHFLPASRN 231

  Fly   183 RTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEG 247
            ||||.|.:|:|||||||:..:.::.|  :........:..|.|:||||||...:||.:|.||||.
Human   232 RTVGATRLNQRSSRSHAVLLVKVDQR--ERLAPFRQREGKLYLIDLAGSEDNRRTGNKGLRLKES 294

  Fly   248 GHINKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPS--IMEESQS 310
            |.||.||..|..|:.:|::....  ..||||||||:||.||||:|.:.:|..|.|.  ...::.|
Human   295 GAINTSLFVLGKVVDALNQGLPR--VPYRDSKLTRLLQDSLGGSAHSILIANIAPERRFYLDTVS 357

  Fly   311 TLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQKVEHLERQIKHDM 375
            .|:||.|:|::..:|..||.:....:.          ..||:::|
Human   358 ALNFAARSKEVINRPFTNESLQPHALG----------PVKLSQKE-------------------- 392

  Fly   376 HKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKR 440
                    |....:.||.|                |..|:.|..       |:|:....| |.::
Human   393 --------LLGPPEAKRAR----------------GPEEEEIGS-------PEPMAAPAS-ASQK 425

  Fly   441 WDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGP--- 502
            ...:.|    |.|:|                        |.:|:.:|::.:|    |..:|.
Human   426 LSPLQK----LSSMD------------------------PAMLERLLSLDRL----LASQGSQGA 458

  Fly   503 --LTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKERYDALEK 565
              |:|.|.::.:   .|.|..||..|:|     .||.|..|       ||.:.||:|    |.||
Human   459 PLLSTPKRERMV---LMKTVEEKDLEIE-----RLKTKQKE-------LEAKMLAQK----AEEK 504

  Fly   566 E--------------VTSLRADNEAANSKISELEEKLST-------LKQTMRIMEVENQVAVGLE 609
            |              ||..:...:|....:..::|:.::       ||...|..::|:..|:
Human   505 ENHCPTMLRPLSHRTVTGAKPLKKAVVMPLQLIQEQAASPNAEIHILKNKGRKRKLESLDAL--- 566

  Fly   610 FEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDI 670
               |..:|:     :|.....:..|......||.||.|.....|:.:.  :..|.|::..:
Human   567 ---EPEEKA-----EDCWELQISPELLAHGRQKILDLLNEGSARDLRS--LQRIGPKKAQL 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	118/341 (35%)
		Motor_domain	8..321	CDD:277568	117/334 (35%)
		Smc	<680..1449	CDD:224117
		TMPIT	779..>867	CDD:285135
		Smc	1042..1910	CDD:224117
KIF22	XP_024306038.1	KISc_KID_like	43..366	CDD:276827	116/332 (35%)
KIF22	XP_024306038.1	ComEA	<596..632	CDD:333350	4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810