DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and KIF5C

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_004513.1	Gene:	KIF5C / 3800	HGNCID:	6325	Length:	957	Species:	Homo sapiens

Alignment Length:	1231	Identity:	308/1231 - (25%)
Similarity:	495/1231 - (40%)	Gaps:	377/1231 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SIQVCIKVRPCEP-----GLTSLWQVKERRSIHLADSHAEPYVFDYVFDEGASNQEVFDRMAKHI 67
            ||:|..:.||...     |...:.:.|...::.:  ...:|||||.|.....:.::|::..||.|
Human     8 SIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVI--GQGKPYVFDRVLPPNTTQEQVYNACAKQI 70

  Fly    68 VHACMQGFNGTIFAYGQTSSGKTYTMMG---DEQNPGVMVLAAKEIFQQISSETER-DFLLRVGY 128
            |...::|:|||||||||||||||:||.|   |.|..|::...|.:||..|.|..|. :|.::|.|
Human    71 VKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFHIKVSY 135

  Fly   129 IEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCEECIITSEVDLLRLLCLGNKERTVGETNMNE 192
            .|||.:||.|||:....:|.:||..|.:..| .|.|..::|..:::.::..|...|.|..|||||
Human   136 FEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMNE 200

  Fly   193 RSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHINKSLLFL 257
            .|||||:||.|.|   |.::.:.:..:...|.||||||||:..:|||.||.|.|..:|||||..|
Human   201 HSSRSHSIFLINI---KQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSAL 262

  Fly   258 SNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPSIMEESQ--STLSFATRAKK 320
            .|||.:|:|..... ..|||||:|||||.|||||..|:|:....||:..|::  |||.|..|||.
Human   263 GNVISALAEGTKTH-VPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKT 326

  Fly   321 IRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQKV-EHLERQIKHDMHKIICGHSL 384
            |:....||           ||...:..|.|..:|:.||:..:.| :|||.::..
Human   327 IKNTVSVN-----------LELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNR----------- 369

  Fly   385 SDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTIN 449
                       |   .:|..:...|..:.:|:.:..|                   .||.|...|
Human   370 -----------W---RNGEAVPEDEQISAKDQKNLEP-------------------CDNTPIIDN 401

  Fly   450 ILGSL-DIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQ 513
            |...: .|.||.....:|.:.:                 ..|||.|         ..|:|.::.|
Human   402 IAPVVAGISTEEKEKYDEEISS-----------------LYRQLDD---------KDDEINQQSQ 440

  Fly   514 DLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKER-YDALEKEVTSLRADNEAA 577
                                 |.|||.:....:|.|    ||...| |:.:::|:|.|:.:||||
Human   441 ---------------------LAEKLKQQMLDQDEL----LASTRRDYEKIQEELTRLQIENEAA 480

  Fly   578 NSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDD-LLSALLEKESTIESLQ 641
            ..::.|:.:.|..|               .:.::.::.:...|.|.:: |...|.:|.:|:.:.|
Human   481 KDEVKEVLQALEEL---------------AVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQ 530

  Fly   642 KSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIADLESKKNSCECDQLRLEIV 706
            :.|..|                                :||..     ..||.:.|...|.|:
Human   531 RELSQL--------------------------------QELSN-----HQKKRATEILNLLLK-- 556

  Fly   707 SVRDKLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTL 771
                                     |...:...:.|:.                       :.||
Human   557 -------------------------DLGEIGGIIGTND-----------------------VKTL 573

  Fly   772 HEKHEHVQEKY-------QKLQEEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNERLEEAQ 829
            .:.:..::|::       .|::.|.:.|.:|::...||:    .:.|.|..|     :||
Human   574 ADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQ----MDSNRKMNA-----SER----- 624

  Fly   830 NMLTEVQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLMESVQENDALREEIKQR 894
                     |....:|.|..||  ||||.|....:.|:::    ..||.||   .|:|.||:.:
Human   625 ---------ELAACQLLISQHE--AKIKSLTDYMQNMEQK----RRQLEES---QDSLSEELAK- 670

  Fly   895 PTSHVEESMRSSGISSDFDEQKQDINLLHQFVQLSESVQQIELQHHSGISRLFRANQMKLDQSEP 959
              ...:|.|                   |:.     |.|..|.:|   ::||..|.:||
Human   671 --LRAQEKM-------------------HEV-----SFQDKEKEH---LTRLQDAEEMK------ 700

  Fly   960 GLKLCLESAEYIEEDNRQSDATEPICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQ-- 1022
                  ::.|...|.:|::              |:.|:.||..|   :.|:::::|.|..|.|
Human   701 ------KALEQQMESHREA--------------HQKQLSRLRDE---IEEKQKIIDEIRDLNQKL 742

  Fly  1023 EIEEKSALMEATEATINEMREQMTNLESALLEKSVIIN-KVEDYQRQIESLEKQNAEMTMVYEEL 1086
            ::|::....:..:..|.:...:|.      |||.:::| |.|..:..::.||:..:........|
Human   743 QLEQEKLSSDYNKLKIEDQEREMK------LEKLLLLNDKREQAREDLKGLEETVSRELQTLHNL 801

  Fly  1087 -----QDRVTRESSMSESLLRVPPDEDTLPGCPTSPSRREQEVATLKTS---ITELQSQV----S 1139
                 ||..||.....|.      |.|...|    .:.::|:::.|:.:   :|::..|:    :
Human   802 RKLFVQDLTTRVKKSVEL------DNDDGGG----SAAQKQKISFLENNLEQLTKVHKQLVRDNA 856

  Fly  1140 DLKAELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDE----DTKQKQELLDR 1196
            ||:.||              .:|:......:||..::|..|.|..|    |.|:.|:.:||
Human   857 DLRCEL--------------PKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQEVDR 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	138/331 (42%)
		Motor_domain	8..321	CDD:277568	137/324 (42%)
		Smc	<680..1449	CDD:224117	107/543 (20%)
		TMPIT	779..>867	CDD:285135	22/94 (23%)
		Smc	1042..1910	CDD:224117	38/172 (22%)
KIF5C	NP_004513.1	KISc_KHC_KIF5	6..327	CDD:276820	137/324 (42%)
		Microtubule-binding	174..315		66/144 (46%)
		Smc	<460..801	CDD:224117	99/539 (18%)
		PRK03918	<715..>916	CDD:235175	49/222 (22%)
		Globular	859..956		14/59 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..957
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910