Protein Alignment cmet and KIF5C

DIOPT Version :10

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: NP_004513.1
• Gene: KIF5C / 3800
• HGNCID: 6325
• Length: 957
• Species: Homo sapiens
• Alignment Length: 1231
• Identity: 308/1231 - (25%)
• Similarity: 495/1231 - (40%)
• Gaps: 377/1231 - (30%)

  Fly     8 SIQVCIKVRPCEP-----GLTSLWQVKERRSIHLADSHAEPYVFDYVFDEGASNQEVFDRMAKHI 67
            ||:|..:.||...     |...:.:.|...::.:  ...:|||||.|.....:.::|::..||.|
Human     8 SIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVI--GQGKPYVFDRVLPPNTTQEQVYNACAKQI 70

  Fly    68 VHACMQGFNGTIFAYGQTSSGKTYTMMG---DEQNPGVMVLAAKEIFQQISSETER-DFLLRVGY 128
            |...::|:|||||||||||||||:||.|   |.|..|::...|.:||..|.|..|. :|.::|.|
Human    71 VKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFHIKVSY 135

  Fly   129 IEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCEECIITSEVDLLRLLCLGNKERTVGETNMNE 192
            .|||.:||.|||:....:|.:||..|.:..| .|.|..::|..:::.::..|...|.|..|||||
Human   136 FEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMNE 200

  Fly   193 RSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHINKSLLFL 257
            .|||||:||.|.|   |.::.:.:..:...|.||||||||:..:|||.||.|.|..:|||||..|
Human   201 HSSRSHSIFLINI---KQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSAL 262

  Fly   258 SNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPSIMEESQ--STLSFATRAKK 320
            .|||.:|:|..... ..|||||:|||||.|||||..|:|:....||:..|::  |||.|..|||.
Human   263 GNVISALAEGTKTH-VPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKT 326

  Fly   321 IRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQKV-EHLERQIKHDMHKIICGHSL 384
            |:....||           ||...:..|.|..:|:.||:..:.| :|||.::..
Human   327 IKNTVSVN-----------LELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNR----------- 369

  Fly   385 SDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTIN 449
                       |   .:|..:...|..:.:|:.:..|                   .||.|...|
Human   370 -----------W---RNGEAVPEDEQISAKDQKNLEP-------------------CDNTPIIDN 401

  Fly   450 ILGSL-DIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQ 513
            |...: .|.||.....:|.:.:                 ..|||.|         ..|:|.::.|
Human   402 IAPVVAGISTEEKEKYDEEISS-----------------LYRQLDD---------KDDEINQQSQ 440

  Fly   514 DLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKER-YDALEKEVTSLRADNEAA 577
                                 |.|||.:....:|.|    ||...| |:.:::|:|.|:.:||||
Human   441 ---------------------LAEKLKQQMLDQDEL----LASTRRDYEKIQEELTRLQIENEAA 480

  Fly   578 NSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDD-LLSALLEKESTIESLQ 641
            ..::.|:.:.|..|               .:.::.::.:...|.|.:: |...|.:|.:|:.:.|
Human   481 KDEVKEVLQALEEL---------------AVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQ 530

  Fly   642 KSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIADLESKKNSCECDQLRLEIV 706
            :.|..|                                :||..     ..||.:.|...|.|:
Human   531 RELSQL--------------------------------QELSN-----HQKKRATEILNLLLK-- 556

  Fly   707 SVRDKLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTL 771
                                     |...:...:.|:.                       :.||
Human   557 -------------------------DLGEIGGIIGTND-----------------------VKTL 573

  Fly   772 HEKHEHVQEKY-------QKLQEEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNERLEEAQ 829
            .:.:..::|::       .|::.|.:.|.:|::...||:    .:.|.|..|     :||
Human   574 ADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQ----MDSNRKMNA-----SER----- 624

  Fly   830 NMLTEVQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLMESVQENDALREEIKQR 894
                     |....:|.|..||  ||||.|....:.|:::    ..||.||   .|:|.||:.:
Human   625 ---------ELAACQLLISQHE--AKIKSLTDYMQNMEQK----RRQLEES---QDSLSEELAK- 670

  Fly   895 PTSHVEESMRSSGISSDFDEQKQDINLLHQFVQLSESVQQIELQHHSGISRLFRANQMKLDQSEP 959
              ...:|.|                   |:.     |.|..|.:|   ::||..|.:||
Human   671 --LRAQEKM-------------------HEV-----SFQDKEKEH---LTRLQDAEEMK------ 700

  Fly   960 GLKLCLESAEYIEEDNRQSDATEPICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQ-- 1022
                  ::.|...|.:|::              |:.|:.||..|   :.|:::::|.|..|.|
Human   701 ------KALEQQMESHREA--------------HQKQLSRLRDE---IEEKQKIIDEIRDLNQKL 742

  Fly  1023 EIEEKSALMEATEATINEMREQMTNLESALLEKSVIIN-KVEDYQRQIESLEKQNAEMTMVYEEL 1086
            ::|::....:..:..|.:...:|.      |||.:::| |.|..:..::.||:..:........|
Human   743 QLEQEKLSSDYNKLKIEDQEREMK------LEKLLLLNDKREQAREDLKGLEETVSRELQTLHNL 801

  Fly  1087 -----QDRVTRESSMSESLLRVPPDEDTLPGCPTSPSRREQEVATLKTS---ITELQSQV----S 1139
                 ||..||.....|.      |.|...|    .:.::|:::.|:.:   :|::..|:    :
Human   802 RKLFVQDLTTRVKKSVEL------DNDDGGG----SAAQKQKISFLENNLEQLTKVHKQLVRDNA 856

  Fly  1140 DLKAELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDE----DTKQKQELLDR 1196
            ||:.||              .:|:......:||..::|..|.|..|    |.|:.|:.:||
Human   857 DLRCEL--------------PKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQEVDR 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	Motor_domain	8..321	CDD:473979	137/324 (42%)
		SMC_prok_B	539..1431	CDD:274008	133/686 (19%)
		SMC_prok_B	1137..1926	CDD:274008	17/68 (25%)
		YhaN	1717..2182	CDD:443752
KIF5C	NP_004513.1	KISc_KHC_KIF5	6..327	CDD:276820	137/324 (42%)
		Microtubule-binding	174..315		66/144 (46%)
		PRK03918	<412..907	CDD:235175	145/766 (19%)
		Khc_CBD_cc	836..905	CDD:467880	19/82 (23%)
		Globular	859..956		14/59 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	911..957