DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cmet and Klp59C

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_611759.1	Gene:	Klp59C / 37671	FlyBaseID:	FBgn0034824	Length:	626	Species:	Drosophila melanogaster

Alignment Length:	366	Identity:	123/366 - (33%)
Similarity:	192/366 - (52%)	Gaps:	47/366 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NASSIQVCIKVRPCE--------------PGLTSLWQVKERRSIHLA---DSHAEPYVFDYVFDE 52
            |...|.||::.||..              |...:|...:.|:.::|.   ::|:  :.|||||||
  Fly   184 NCHQIMVCVRKRPLRRKELADREQDVVSIPSKHTLVVHEPRKHVNLVKFLENHS--FRFDYVFDE 246

  Fly    53 GASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNP--------GVMVLAAKE 109
            ..||..|::..|:.::.....|...|.||||||.|||||||.|  |.|        |:..:|||:
  Fly   247 ECSNATVYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGG--QFPGRHQSSMDGIYAMAAKD 309

  Fly   110 IFQQISSETERDFLLRV--GYIEIYNEKIYDLLNKKNQDLKIHESGNGIVN-VNCEECIITSEVD 171
            :|..:.:.......|:|  .:.|||..:::|||......|::.|..|..|. |...:..:.:..:
  Fly   310 VFSTLKTVPYNKLNLKVYCSFFEIYGTRVFDLLMPGKPQLRVLEDRNQQVQVVGLTQNPVQNTAE 374

  Fly   172 LLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSER-AD 235
            :|.||.|||..||.|.|:.|.:||||||:|:|::.|...:.      :....:|:||||:|| ||
  Fly   375 VLDLLELGNSVRTSGHTSANSKSSRSHAVFQIVLRSAAGEK------LHGKFSLIDLAGNERGAD 433

  Fly   236 QTGA-RGARLKEGGHINKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQAS-LGGNAF-TSII 297
            .:.| |..|| ||..||||||.|...|::|...:.:  ..:|.||||::|:.| :||... |.:|
  Fly   434 NSSADRQTRL-EGSEINKSLLVLKECIRALGRQSSH--LPFRGSKLTQVLRDSFIGGKKVKTCMI 495

  Fly   298 CTIKPSI--MEESQSTLSFATRAKKIRIKPQVNEMVSDATM 336
            ..|.|.:  :|.:.:||.:|.|.|::.::...::.:.||.:
  Fly   496 AMISPCLHSVEHTLNTLRYADRVKELSVESIPSKRMPDANL 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	120/353 (34%)
		Motor_domain	8..321	CDD:277568	120/346 (35%)
		Smc	<680..1449	CDD:224117
		TMPIT	779..>867	CDD:285135
		Smc	1042..1910	CDD:224117
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	119/344 (35%)
Klp59C	NP_611759.1	Kinesin	193..520	CDD:278646	116/339 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437835
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930