DRSC/TRiP Functional Genomics Resources

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Protein Alignment cmet and KIF7

DIOPT Version :9

Sequence 1:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster
Sequence 2:XP_011519833.1 Gene:KIF7 / 374654 HGNCID:30497 Length:1384 Species:Homo sapiens


Alignment Length:1459 Identity:327/1459 - (22%)
Similarity:565/1459 - (38%) Gaps:426/1459 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 IQVCIKVRP------------C---EPGLTSLWQVKERRSIHLADSHAEPYVFDYVFDEGASNQE 58
            ::|.::|||            |   ||||..:...::|.           :.|..|..|.|..:.
Human    57 VRVALRVRPLLPKELLHGHQSCLQVEPGLGRVTLGRDRH-----------FGFHVVLAEDAGQEA 110

  Fly    59 VFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTM--------MGDEQNPGVMVLAAKEIFQQIS 115
            |:....:.::.|..:|||.|:||||||.|||||||        :.|||  |::..|..|.|:.|.
Human   111 VYQACVQPLLEAFFEGFNATVFAYGQTGSGKTYTMGEASVASLLEDEQ--GIVPRAMAEAFKLID 173

  Fly   116 SETERDFLLRVGYIEIYNEKIYDLL--NKKNQDLKIHESGNG-IVNVNCEECIITSEVDLLRLLC 177
            .....|.|:.|.|:|:|.|:..|||  ...::|:::.|...| :|....:|..:....::|.||.
Human   174 ENDLLDCLVHVSYLEVYKEEFRDLLEVGTASRDIQLREDERGNVVLCGVKEVDVEGLDEVLSLLE 238

  Fly   178 LGNKERTVGETNMNERSSRSHAIFKIIIESR-----KSDHSDDDAVIQSVLNLVDLAGSERADQT 237
            :||..|..|.|::|..|||||.:|.:.:|.|     :........::.|..:.||||||||..:|
Human   239 MGNAARHTGATHLNHLSSRSHTVFTVTLEQRGRAPSRLPRPAPGQLLVSKFHFVDLAGSERVLKT 303

  Fly   238 GARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTN--YRDSKLTRILQASLGGNAFTSIICTI 300
            |:.|.||||...||.|||.|.|||.:|.: ...|.::  |||||:||||:.||||||.|.:|..:
Human   304 GSTGERLKESIQINSSLLALGNVISALGD-PQRRGSHIPYRDSKITRILKDSLGGNAKTVMIACV 367

  Fly   301 KPSI--MEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQK 363
            .||.  .:|:.:||::|:||:.||.:..||..                     .|.||..|.   
Human   368 SPSSSDFDETLNTLNYASRAQNIRNRATVNWR---------------------PEAERPPEE--- 408

  Fly   364 VEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPK 428
                                               ||||:.      |....|.:  .::.|   
Human   409 -----------------------------------TASGAR------GPPRHRSE--TRIIH--- 427

  Fly   429 PVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLP 493
                    .|:|... |.|.:...::.:|            |||..:.:........:..::..|
Human   428 --------RGRRAPG-PATASAAAAMRLG------------AECARYRACTDAAYSLLRELQAEP 471

  Fly   494 DLPLTPKGPLTTDKIKKEIQD-----------LQMFTSLEKHFE---VECEEVQGL--------K 536
            .||         ....::::|           |...:..:...|   ||.:..||.        .
Human   472 GLP---------GAAARKVRDWLCAVEGERSALSSASGPDSGIESASVEDQAAQGAGGRKEDEGA 527

  Fly   537 EKLAEVTAQRDNLEQES---LAEKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIM 598
            ::|..:..|...||:|:   ||..|  ||:|:  ..|::|      ::.|.:|::..|:..:.::
Human   528 QQLLTLQNQVARLEEENRDFLAALE--DAMEQ--YKLQSD------RLREQQEEMVELRLRLELV 582

  Fly   599 -------------------------------------------------------EVENQVAVGL 608
                                                                   :|.|....|.
Human   583 RPGWGGPRLLNGLPPGSFVPRPHTAPLGGAHAHVLGMVPPACLPGDEVGSEQRGEQVTNGREAGA 647

  Fly   609 EFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLRN--SKEGHMLSIAPEQEDIA 671
            |...|.::..|.      .||..|:|...|...:...:|.|:.:.|  .:.|......||::   
Human   648 ELLTEVNRLGSG------SSAASEEEEEEEEPPRRTLHLRRNRISNCSQRAGARPGSLPERK--- 703

  Fly   672 GDSICNKCEELEKLIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKATDCERL 736
            |..:|  .|||:..|....:...|    :.|   |..|....:..|.:.||.::  ||..:   |
Human   704 GPELC--LEELDAAIPGSRAVGGS----KAR---VQARQVPPATASEWRLAQAQ--QKIRE---L 754

  Fly   737 SKELSTSQNAFGQL---QERYDALDQQWQAQQAGITTLHEKHEHVQEKYQKLQEEYEQLESRARS 798
            :..:...:...|:|   .:...||::|...:   |..|.::.|.|:.:..:.|.:..:||.: ..
Human   755 AINIRMKEELIGELVRTGKAAQALNRQHSQR---IRELEQEAEQVRAELSEGQRQLRELEGK-EL 815

  Fly   799 ASSAEFQRLQNDNTKFQADIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHELTAKIKELETNF 863
            ..:.|..|||           ....|:..||:.:..::..:...|:|...:.:...:::|||.|.
Human   816 QDAGERSRLQ-----------EFRRRVAAAQSQVQVLKEKKQATERLVSLSAQSEKRLQELERNV 869

  Fly   864 EEMQREYDCLSNQLMESVQENDALREEIKQRPTSHVEESMRSSGISSDFDEQKQDINLLHQFVQL 928
            :.|:::...|..:|.|..::...|..|:.:|                                  
Human   870 QLMRQQQGQLQRRLREETEQKRRLEAEMSKR---------------------------------- 900

  Fly   929 SESVQQIELQHHSGISRL------FRANQMKLDQSEPGLKLCLESAEYIEEDNRQSDATEPICLK 987
            ...|:::||:|......|      ..|.|.|......|..:.||..:.|||              
Human   901 QHRVKELELKHEQQQKILKIKTEEIAAFQRKRRSGSNGSVVSLEQQQKIEE-------------- 951

  Fly   988 GFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQEIEEKSALMEATEATINEMREQMTNLESAL 1052
                    |.|.|.||...:.:::|.|:   :|.:|:.::.|::...||    :.::.|.|||..
Human   952 --------QKKWLDQEMEKVLQQRRALE---ELGEELHKREAILAKKEA----LMQEKTGLESKR 1001

  Fly  1053 LEKSVIINKVEDYQR---QIESLEKQNAEMTMVYEELQDRVTRESSMSESLLRVPPDEDTLPGCP 1114
            |..|..:|  ||..|   ::|.|||:.:|.:       .::.:.|:.|:..:|...|        
Human  1002 LRSSQALN--EDIVRVSSRLEHLEKELSEKS-------GQLRQGSAQSQQQIRGEID-------- 1049

  Fly  1115 TSPSRREQEVATLKTSITELQSQVSDLKAELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVR 1179
               |.|:::.:.||.            :.|::..|||..|......|.....:|..|   :::..
Human  1050 ---SLRQEKDSLLKQ------------RLEIDGKLRQGSLLSPEEERTLFQLDEAIE---ALDAA 1096

  Fly  1180 LAELDEDTKQKQELLDRQAQKLSD-DLCLIDQL-----QKKNAQLVEQYHKATESLSLADAKPDQ 1238
            :...:|....:|.:|...|..||. ::.|:.:|     .:..|.|.:.:.|.   ::|.:.:..|
Human  1097 IEYKNEAITCRQRVLRASASLLSQCEMNLMAKLSYLSSSETRALLCKYFDKV---VTLREEQHQQ 1158

  Fly  1239 ILLSSQYDSQIEKLNQL---LNAAKDELHDVRRIKDDEISALRMEFLLQIETNEKENQAKFYAEL 1300
            .:..|:.:.|:|:..:|   |..|              :...|:|...|:...:||::......|
Human  1159 QIAFSELEMQLEEQQRLVYWLEVA--------------LERQRLEMDRQLTLQQKEHEQNMQLLL 1209

  Fly  1301 QETKD-----------RYESNVAELKEKL 1318
            |:::|           :||:.:..|:::|
Human  1210 QQSRDHLGEGLADSRRQYEARIQALEKEL 1238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cmetNP_524993.3 KISc 8..328 CDD:214526 127/353 (36%)
Motor_domain 8..321 CDD:277568 125/346 (36%)
Smc <680..1449 CDD:224117 134/671 (20%)
TMPIT 779..>867 CDD:285135 16/87 (18%)
Smc 1042..1910 CDD:224117 62/300 (21%)
KIF7XP_011519833.1 KISc 56..397 CDD:214526 127/353 (36%)
KISc_KIF4 56..391 CDD:276823 125/347 (36%)
TPP_enzymes <541..615 CDD:294952 13/83 (16%)
FAM184 774..993 CDD:292293 56/296 (19%)
Utp11 891..1069 CDD:295201 53/272 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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