Protein Alignment cmet and unc-104

DIOPT Version :9

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Alignment Length: 1912
• Identity: 443/1912 - (23%)
• Similarity: 735/1912 - (38%)
• Gaps: 544/1912 - (28%)

  Fly     7 SSIQVCIKVRPCEPGLTSLWQVKERRSI-----------------HLADSHAEPYVFDYVF---- 50
            ||::|.::|||    ..|....:|.:.|                 :.:|| .:.:.|||.:
  Fly     2 SSVKVAVRVRP----FNSREIARESKCIIEMAGATTAITNPKVPPNTSDS-VKRFNFDYSYWSHD 61

  Fly    51 --DEGASNQE-VFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMG--DEQNPGVMVLAAKEI 110
              |...|.|. |:..:.:.::.....|:|..|||||||.:||:|||||  :||..|::.:..|::
  Fly    62 HHDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGRQEEQQEGIIPMICKDL 126

  Fly   111 FQQISSETERD---FLLRVGYIEIYNEKIYDLLNKKNQ-DLKIHES---GNGIVNVNCEECIITS 168
            |.:| .:||.|   :.:.|.|:|||.|::.||||.||: :|::.|.   |..:.:::  :..:|.
  Fly   127 FTRI-QDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLS--KLAVTD 188

  Fly   169 EVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSD---HSDDDAVIQSVLNLVDLAG 230
            ..|:..|:..|||.|||..|||||.||||||:|.|....|:.|   :...:.|  |.::||||||
  Fly   189 YQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKV--SKISLVDLAG 251

  Fly   231 SERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADNR-------FTNYRDSKLTRILQASL 288
            |||||.|||:|.|||||.:|||||..|..||.:|:|.|..:       |..||||.||.:|:.:|
  Fly   252 SERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENL 316

  Fly   289 GGNAFTSIICTIKPSIM--EESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKL 351
            |||:.|::|..|.|:.:  :|:.|||.:|.|||:|..|..||| .::|.:::.|:.||:.|:|.|
  Fly   317 GGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNE-DANAKLIRELKEEIQKLRDLL 380

  Fly   352 AEE--------------------ERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTW 396
            ..|                    :.:|.|....|....|::.. .|:|.  .|::..::|.:||
  Fly   381 KAEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQAS-EKLIA--ELNETWEEKLKRT- 441

  Fly   397 CPTASGSHLEL------AETGTT--EDRIDQ---FPKVS----------HLPKPVFFH----TSN 436
                  ..:.:      ||.|..  ||.|..   .||.:          :|.:.:.::    .:.
  Fly   442 ------EEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTR 500

  Fly   437 AGKRWDNIPKTINILGSLDIGT----ESNSISEEFLP-AECIDFGSPR----PDVLKPMLTIRQL 492
            .|....|:|:.|.:.||..:..    |:.:.:...|| .:.|.:.:.|    |:|||....:
  Fly   501 LGTHEANVPQDIQLSGSHILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRV--- 562

  Fly   493 PDLPLTPKGPL---TTDKIKKEIQDLQMFTSLEKHFEVE-------------CE--EVQGLKEKL 539
                :..|..:   |..:..:|::| ::.|..|...|||             ||  |.||:..|
  Fly   563 ----ILGKNHVFRFTNPEQARELRD-KIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLK- 621

  Fly   540 AEVTAQRDNLEQESLAEK---------------ERYDALEKEVTSLRADNEAANSKISE---LEE 586
            ||:..:.||||::...||               .|.|||:|:|..........:|...|   .||
  Fly   622 AEMKKRLDNLEEQYKREKLQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEE 686

  Fly   587 KLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDDLL-SALLEKESTIES--LQKSLD--- 645
            .:.|...................|....:.:.:.|| |||. :|:..||:...|  |:|.:.
  Fly   687 DVYTNPMYESCWTAREAGLAAWAFRKWRYHQFTSLR-DDLWGNAIFLKEANAISVELKKKVQFQF 750

  Fly   646 NLTRDVLRNSKEGHMLS-IAP-EQEDIAGDSICNKCEELEKLIA-DLESKKNSCECDQLRLEIVS 707
            .|..|.|.:.....:.| :|| .|||..|....:|     .|:| ::...||.. .....||  .
  Fly   751 TLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSK-----TLVAVEVTDTKNGA-THHWSLE--K 807

  Fly   708 VRDKLESVESAFNLAS--SEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITT 770
            :|.:||.:...:|:.|  |.::...:..|.||..:|......|| |.:...|:...::::..:|.
  Fly   808 LRYRLELMRQIYNVESPPSSMLFDTSGMEALSGWISPPSQHPGQ-QAQLLPLEPPVESERGRLTL 871

  Fly   771 LH-----EKHEHVQEKYQKLQEEYEQLESRARSASSAEFQ-----------------RLQNDNTK 813
            .:     ::.|.::|.|....|         .|.:|.::.                 |:...:..
  Fly   872 ANLIPSRQRLELMREMYHNEAE---------MSPTSPDYNVESLTGGDPFYDRFPWFRMVGRSFI 927

  Fly   814 FQAD----------IASLNERLE-------EAQNMLTE---------------VQNSESTVEKLR 846
            :.::          :|.:|||.:       ..|.:|.|               |.|.:....|.|
  Fly   928 YLSNLLYPVPLVHKVAIVNERGDVRGYLRIAVQPVLDEESIDFNNGVKQSARLVFNEDDAKPKYR 992

  Fly   847 -----------IQNHELTAKIKELETNFEEMQREYDCLSNQLMESVQENDALREEIKQRPTSHVE 900
                       |.|..|.:|::|||          |..|.:.::|...::.  .|..:.|..|::
  Fly   993 ALNEKDDVQRYIDNGGLDSKLEELE----------DVDSGRGIDSNSASEC--HENSEEPGEHLQ 1045

  Fly   901 ES---------MRSSGISSDFDEQKQDINLLHQF--------VQLSESVQQIELQHHSGISRLFR 948
            ..         ::::||.:::.:.....|.||:.        |:.|.|...:...|...|:
  Fly  1046 VGKEFTFRVTVLQATGIGAEYADIFCQFNFLHRHEEAFSTEPVKNSASGAPLGFYHVQNIT---- 1106

  Fly   949 ANQMKLDQSEPGLKLCLESAEYIEEDNRQSDATEPICLK--GFLKRHRFQIKRLSQEHVDMGEEK 1011
                        :.:.....||::        |:||..|  |..:.|... |...|:.|.....:
  Fly  1107 ------------VPVTKSFIEYLK--------TQPIMFKIFGHYQTHPLH-KDAKQDFVSRPPPR 1150

  Fly  1012 RLLDIISQLEQEIEEK--SALMEATEATINEMREQMTNLESALLEKS-----VIINKVED----- 1064
            |:|.....:.|.:...  ..|..|..:|:....:.:...|...|..:     .::...:|
  Fly  1151 RMLPPSIPISQPVRSPKFGPLPCAPTSTVLAKHDVLVWFEICELAPNGEYVPSVVEHSDDLPCRG 1215

  Fly  1065 -------YQRQIESLEKQNAEMTMVYEELQD--------------RVTRESSMSE-------SLL 1101
                   .||:|        .:|:|:|...:              |.|.|||..:       ||.
  Fly  1216 LFLLHQGIQRRI--------RITIVHEPTTEVKWKDINELVVGRIRNTPESSDEQDEDACVLSLG 1272

  Fly  1102 RVPPDEDTLPGCPTSPSRREQEVATLKTSI--TELQSQVSD--------LKA--ELENHLR-QIQ 1153
            ..|.:...:||...|..|.|   |...:|:  :.|.::||.        |.|  ||||..| .|.
  Fly  1273 LFPGEALEVPGDDRSFYRFE---AAWDSSLHNSALLNRVSQGGETIYITLSAYLELENCARPAII 1334

  Fly  1154 LKD------GNIARLQTDFEEMSERCLSMEVRLAELDEDTKQKQELLDRQAQKLSDDLCLIDQLQ 1212
            .||      |..||..   ....:...|.:.|..|.:..|...:..|.|.::..|..   :.:.|
  Fly  1335 TKDLSMVIYGRDARTG---PRSLKHLFSGQYRNPEANRLTGVYELALRRASEAGSPG---VQRRQ 1393

  Fly  1213 KKNAQLVEQYHKATESLSLADAKPDQILLSSQYDSQIEKLNQL---------------------- 1255
            ::.......|.:..|:|.....:.|.::...|:  ::|||.:|
  Fly  1394 RRVLDTSSTYVRGEENLHGWRPRGDSLIFDHQW--ELEKLTRLEEVGRMRHLLLLRERLGMDTNP 1456

  Fly  1256 --------------LNAAKDELHDV------RRIKDDEISALRMEFLLQIETNEKENQAKFYAEL 1300
                          ..||...:|.|      ..:||.:      :.:.:.|.|::|....... |
  Fly  1457 NPTTKTEKDVCNLAARAATSPVHMVIPQSPQTPVKDPQ------QIIPEREYNQREQDLMLKC-L 1514

  Fly  1301 QETKDRY---ESNVAELKEKLLQVEETLSSVTVRCQAELEALKSAHKENISQAVEERNNLIVQHQ 1362
            :..:.||   |:|..:.:..:...:|..:.:||.|              ||....|.|..:::
  Fly  1515 KLVQGRYTKSEANDTQTQSDVSPSDEGCADMTVSC--------------ISSNSMENNKFVIR-- 1563

  Fly  1363 AEMETIRETLKNKLAEA---------STQQSKMEDAFRAEINEVRATLMEQLNQTKEDRDKGASK 1418
                  |.......|:|         :||.:.....:..|:.|:|                 .|.
  Fly  1564 ------RRLCSPDRADAPNGWEAPAPATQPALPLRLYVPELEEIR-----------------VSP 1605

  Fly  1419 LEEVKKTLEQMINGG----------RVMSDTIAELEKTKAEQDLAVNKLTKDNIELEKQCSKTQE 1473
            :...|..|..:.:||          |.....|...||...|:  ||..|...::|    ||:.|
  Fly  1606 VVARKGLLNVLEHGGSGWKKRWVIVRRPYVFIYRSEKDPVER--AVLNLATAHVE----CSEDQ- 1663

  Fly  1474 QLQMESLTRDQISFEIEAHIKKLELIVASSKKRIIELEEKCDQQVLE-----------LDKCRLE 1527
                            .|.:|........:|.|...|:...|::|.:           ..|.||.
  Fly  1664 ----------------AAMVKIPNTFSVVTKHRGYLLQTLGDKEVHDWLYAINPLLAGQIKSRLA 1712

  Fly  1528 KLSLE------SEIQKANSEHSCTMEK 1548
            :.:||      |:||..|:.::.:..|
  Fly  1713 RRTLEPASQTASQIQATNAANANSASK 1739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	140/364 (38%)
		Motor_domain	8..321	CDD:277568	138/357 (39%)
		Smc	<680..1449	CDD:224117	175/978 (18%)
		TMPIT	779..>867	CDD:285135	24/147 (16%)
		Smc	1042..1910	CDD:224117	121/645 (19%)
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	141/365 (39%)
		KISc	3..358	CDD:214526	140/364 (38%)
		Kinesin_assoc	355..498	CDD:292801	30/153 (20%)
		FHA	475..574	CDD:238017	17/105 (16%)
		KIF1B	878..923	CDD:289208	7/53 (13%)
		DUF3694	1246..1347	CDD:289256	29/103 (28%)
		PH_KIFIA_KIFIB	1602..1704	CDD:269939	25/141 (18%)
		PH	1607..1700	CDD:278594	23/115 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437958
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2883
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.870