DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and Khc-73

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster

Alignment Length:	2360	Identity:	502/2360 - (21%)
Similarity:	837/2360 - (35%)	Gaps:	787/2360 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ASSIQVCIKVRP-----CEPGLTSLWQVKERRSI--------HLADSHAEPYVFDYVF------D 51
            :..|:|.::|||     .|.....:.:::::::|        .:.....:.:.||:.|      |
  Fly     3 SDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPED 67

  Fly    52 EGASNQE-VFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQIS 115
            |..::|| |||.:.:.|:....||:|..|||||||.|||:|||||.:::.|::.....::|..|:
  Fly    68 ENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIA 132

  Fly   116 SET--ERDFLLRVGYIEIYNEKIYDLLNKK--NQDLKIHESGNGIVNV------NCEECIITSEV 170
            :::  |..:.:.|.|:||||||::|||:.|  .|.||:.|.     ||      ...:..:||..
  Fly   133 NKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREH-----NVMGPYVDGLSQLAVTSYQ 192

  Fly   171 DLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHS---DDDAVIQSVLNLVDLAGSE 232
            |:..|:..|||.|||..||||..||||||:|.:::....:|.:   ..:.|  |.::||||||||
  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKV--SRMSLVDLAGSE 255

  Fly   233 RADQTGARGARLKEGGHINKSLLFLSNVIKSLSE------NADNRFTNYRDSKLTRILQASLGGN 291
            ||.:|||.|.|||||.:|||||..|..||..|::      :.:::|..||||.||.:|:.:||||
  Fly   256 RAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGN 320

  Fly   292 AFTSIICTIKPSI--MEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLK------ 348
            :.|.::.||.||.  .||:.|||.:|.|||:|.....||| ..:|.:::.|..|::.|:
  Fly   321 SRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNE-DPNARIIRELRHEVETLRSMLKHA 384

  Fly   349 ---------DKLAEEER-------------------KNENQQKVEHL-----ERQIKHDMHK--- 377
                     |||||.|.                   :||.||.:|.:     ...||.:.:|
  Fly   385 TGSPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYL 449

  Fly   378 ---------------------IICGHSLSDKGQQKRRRTWCPTASGSHLELAETG--------TT 413
                                 :|.|.::|  |||            ..::|:..|        |.
  Fly   450 VNLNADPSLNELLVYYLKDRTLIGGRTIS--GQQ------------PDIQLSGLGIQPEHCVITI 500

  Fly   414 EDRIDQFPKVSHL-PKPV-----FFHTSNA--------GKR--WD-------NIPKTINILGSLD 455
            ||        |.| .:||     |.:.|.|        |.|  |.       |.||:.|
  Fly   501 ED--------SGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNN------ 551

  Fly   456 IGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQ---DLQM 517
               .|...||...||:.||:...|.::::..|:           ..|:.|...:.|.|   |.|:
  Fly   552 ---TSMCASEPQTPAQLIDYNFARDEIMQNELS-----------NDPIQTAIARLERQHEEDKQV 602

  Fly   518 FTSLEKHFEVECEEVQGLKEKLAEVT-----AQRDNLEQESL----------AEK---ERYDALE 564
              :|||..:....:.|.|:..|:..|     |..|.|....:          .||   ||.:...
  Fly   603 --ALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFR 665

  Fly   565 KEVTSLRADNEAANSKISE---LEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDDL 626
            :.:..|:.|...|||.:.|   |.|            |:|.:....:..:......|...|....
  Fly   666 RSLGQLKTDIMRANSLVQEANFLAE------------EMEKKTKFSVTLQIPPANLSPNRRRGAF 718

  Fly   627 LS--ALLEKES-------TIESLQKSL--------------------DNL-TRDVLRNSKEGHML 661
            :|  |:|.|.:       |:|.|:..|                    ||. .:|....|:|.|.|
  Fly   719 VSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLDEDNAKPQDPFYESQENHNL 783

  Fly   662 ---------------------SIAPEQEDIAGDSICNKCEELEKLIADLESKKNSCECDQLRLEI 705
                                 .|..:|.::||    ....|:|::...:...:   .|:.:....
  Fly   784 IGVANIFLEVLFHDVKLDYHTPIISQQGEVAG----RLQVEIERIAGQMPQDR---MCESVSESS 841

  Fly   706 VSVRDKLES-VESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGI- 768
            ...||:.:. |:...|..:..:..|...    ...||.|...|.|.        ..|..|:..:
  Fly   842 GDSRDEYDDPVDPTSNQITCRVTIKCAS----GLPLSLSNFVFCQY--------TFWGHQEMVVP 894

  Fly   769 -----TTLHE-----KHEHVQEKYQKLQEEYEQLESRARSASSAE--------FQRLQN-DNTKF 814
                 :|.|:     |.||.|:....:.||:  ||.....|.|.|        |.:.:. :..:.
  Fly   895 VINAESTAHDQNMVFKFEHTQDFTVTINEEF--LEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQ 957

  Fly   815 QADIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLME 879
            ||...||.:|..|....:                  ||..:|.||..|.|...          :|
  Fly   958 QAKARSLVDRWAELSRKI------------------ELWVEIHELNDNGEYSP----------VE 994

  Fly   880 SVQENDALREEIKQRPTSHVEESMRSSGISSDFDEQKQDINLLHQFVQ-------LSESVQQIEL 937
            ....|:.|                 :.||......|::.:|:..:.||       :.:|:..:.:
  Fly   995 VTNRNEVL-----------------TGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAI 1042

  Fly   938 QHHSGISRLFRANQMKLDQSEPGLKLCLESAEYIEED-----NRQSDATEPICLKGFLKRHRFQI 997
            ...:..|||    |..||             .|.|||     .:.|:|
  Fly  1043 GSVTVRSRL----QRPLD-------------SYQEEDLTVLREKWSEA----------------- 1073

  Fly   998 KRLSQEHVDMGEEKRLLDIISQLEQEIEEKSALMEATEATINEMREQMTNLESALLEKSVIINKV 1062
                     :|..::.||  .|::..|:::            |..||....|.:|:.:.|.:.
  Fly  1074 ---------LGRRRQYLD--QQIQMLIKKE------------EKNEQERERELSLVHQWVSLT-- 1113

  Fly  1063 EDYQRQIESLEKQNAEMTMVYEELQDRVTRESSMSESLLRVPPDEDTLPGCPTS---PSRREQEV 1124
                      |::||.:                       ||.....:||.|.|   ||..|..|
  Fly  1114 ----------EERNAVL-----------------------VPAPGSGIPGAPASWEPPSGMEPHV 1145

  Fly  1125 ATLKTSITELQSQVSDLKAELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDED--- 1186
            ..|..::..     .||.|:..|.    :|....|..:.:  :|...:..:::: |..||:|
  Fly  1146 PVLFLNLNG-----DDLSAQNTND----ELSVAGINSILS--KEHGHKFYTLQI-LQHLDKDVCC 1198

  Fly  1187 -TKQKQELLDRQAQKLSDDLCLIDQLQKKNAQLVEQYHKATESLSLADAKPDQILLSSQYDSQIE 1250
             ......:.|.||         ::::.:.|.::   |.....::.|:...|..::|..:....|:
  Fly  1199 VASWDSSMHDSQA---------LNRVTEANERV---YLILRTTVRLSHPAPMDLVLRKRLSINIK 1251

  Fly  1251 KLNQLLNAAKDELHDVRRIKDDEI---SALRMEFLLQI-----ETNEKENQAKFYAELQETK--- 1304
            | .|.|.   |.|...|.::.:..   |.:..|.:..|     |..::|:.|:..|...:..
  Fly  1252 K-GQTLT---DRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGDDCSASD 1312

  Fly  1305 -----DRYESNVAELKEKLLQVEETLSSVTVRCQAELEALKSAHKENISQAVEERNNLIVQHQAE 1364
                 ::|...|:.: |.:|.::....:|.|:   |||   :||.:.:|
  Fly  1313 GETYIEKYTRGVSAV-ESILTLDRLRQNVAVK---ELE---TAHGQPLS---------------- 1354

  Fly  1365 METIRETLKNKLAEASTQQSKMEDAFRAEINEVRATLMEQLNQTKEDRDKGASKLEEVKKTLEQM 1429
               :|:|:.                                       ....|::.....::|.:
  Fly  1355 ---MRKTVS---------------------------------------VPNFSQIMRFDASMESL 1377

  Fly  1430 INGGRVMSDTIAELEKTKAEQDLAVNKLTKDNIELEKQCSKTQEQLQMESLTRDQISF-----EI 1489
            :|.||  |::.|:|..:...     ||.|...          ........:.|.:.||     ..
  Fly  1378 LNVGR--SESFADLNNSALG-----NKFTPAG----------HSPAGAGGVIRSRHSFGGKGSSD 1425

  Fly  1490 EAHIKKLELIVASSKK----RIIELEEKCDQQVLELDKCRLEKLSLESEIQKANSEHSCTMEKLQ 1550
            ::..|...:...::.|    |:..|.|:.......||:        |.|...::||::...|:.:
  Fly  1426 DSPGKAFGIASPATSKLLGMRMTTLHEEPLGGHRSLDE--------EPEDSYSDSEYAAEYEQER 1482

  Fly  1551 ELQAEMKVLSNRNEKEKCDFETKLETFTFKITDLEEVLKEAQHKVILYDDLVSQHERLKICLAEA 1615
            :....|...|.....:..|          ...|                  ||.|.. :..|:..
  Fly  1483 QQNKSMATRSRLTASKTMD----------SFMD------------------VSSHSN-QSYLSYT 1518

  Fly  1616 NELSSNLQKKVMSLHTELIDS--QKGISSRDVEINELREELKAAMDAKATASAEQMTLVTQ---- 1674
            :..::|: |.:..|.|..:.|  ..|..|:.|..|.|..|..|:|.:.:.........|..
  Fly  1519 SSANANM-KHLTGLATLSMSSSTSSGYGSQAVSCNNLSNEDIASMRSMSIDETPDFDRVNSNSPP 1582

  Fly  1675 ---------LKD-----VEERMANQAEK----FTREAANLKGSINELLLKLNSMQETKDMLESGN 1721
                     |||     ::|:...||:|    ||.....|:.|.|               .:|.:
  Fly  1583 NRQARVNPFLKDMPKAKIQEQPEQQAKKLQEAFTHPLEQLESSQN---------------AQSDD 1632

  Fly  1722 EELKEQLRNSQNLRNMLDEESKMCISLKEKLVKLEDAKTSLEQQLRDNKSEIYQRHTELTKEVEL 1786
            :|..:..:|:.|..::::|...:            .::|.||:.:...||:     ||...:.:.
  Fly  1633 DECAQLPKNNNNNLDLVNEPKPL------------SSQTDLEESMSQPKSK-----TEFATDNQN 1680

  Fly  1787 GRNRIGELTKKCEELCSDLENSDQIRLDLQETKEQLKK-----------TLENNLGWQQKVDEVT 1840
            |.....||:...|:|   ||....:|.:|...|...:|           ::.||.....:...:.
  Fly  1681 GNRSSDELSHSSEDL---LEGDGIVREELPAGKVVRRKKSNTQPPSNGNSINNNNNGTTQAPRIN 1742

  Fly  1841 RECEKLRFD-----------MQSKEVQNESKVQELI---------------------------SE 1867
            ......:.:           ..|.||..|||..||:                           :|
  Fly  1743 HRASVAKMEGLAAYLDSSIMTSSTEVDEESKDVELVLPEWIVVGESVLIRPYNTSGVIRFVGTTE 1807

  Fly  1868 CE-------ELRSTLKSKEAS------FQSE-KESMDRTISSLLEDKRNLEEKLCSA----NDIV 1914
            .:       ||.:.....:.|      ||.: |..|......|:.|||....:...|    |.|.
  Fly  1808 FQPGAWIGVELDTPTGKNDGSVKGVQYFQCKPKHGMFVRSDKLMLDKRGKAMRAYKAAEKSNSIS 1872

  Fly  1915 AKLETEIAALRPRKSLDRNPVPRKSITFESEIRKNRRISVHDERRQSYWNDVREFGIMTDPVDNN 1979
            .::.|.:..     |:.|:.....|:...:.. ...:.| |..:|   |.:.|:..:.|......
  Fly  1873 KEMSTSMTG-----SMTRSKSRGDSLNLSARKXLYPKCS-HQLQR---WTNCRQSTVATSSQPAT 1928

  Fly  1980 CN-------CAELNSKLQDC 1992
            |:       .|:.||..:.|
  Fly  1929 CHRLRATSGAADANSHGKKC 1948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	137/360 (38%)
		Motor_domain	8..321	CDD:277568	136/353 (39%)
		Smc	<680..1449	CDD:224117	144/824 (17%)
		TMPIT	779..>867	CDD:285135	22/96 (23%)
		Smc	1042..1910	CDD:224117	171/986 (17%)
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	137/361 (38%)
		KISc	6..359	CDD:214526	137/359 (38%)
		Kinesin_assoc	356..468	CDD:292801	21/112 (19%)
		FHA	446..546	CDD:238017	22/121 (18%)
		KIF1B	741..786	CDD:289208	9/44 (20%)
		DUF3694	<1196..1252	CDD:289256	9/67 (13%)
		CAP_GLY	1786..1850	CDD:279625	8/63 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437760
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2883
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.870