DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and Kif18a

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	XP_038961378.1	Gene:	Kif18a / 362186	RGDID:	1561740	Length:	886	Species:	Rattus norvegicus

Alignment Length:	1054	Identity:	249/1054 - (23%)
Similarity:	413/1054 - (39%)	Gaps:	292/1054 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IQVCIKVRPCEPGLTSLWQVKERRSIHLADSHA---EP--------------------------- 43
            ::|.::|||..   |....|:..:.:|:.|.|.   :|
  Rat    12 MKVVVRVRPEN---TKEKAVQFHKVVHVVDKHILVFDPKQEEISFFHRKKTTNFDITKRQNKDLK 73

  Fly    44 YVFDYVFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAK 108
            :|||.||||.::..|||:...|.|:|:.:.|:|.|:||||.|.||||:||:|....||||.|...
  Rat    74 FVFDAVFDETSTQMEVFEHTTKPILHSFLNGYNCTVFAYGATGSGKTHTMLGSTAEPGVMYLTML 138

  Fly   109 EIFQQISS-ETERDFLLRVGYIEIYNEKIYDLLNKKN--------------QDLKIHESGNGIVN 158
            ::|:.:.. :.|::....|.|:|:|||:|.|||....              |.|.:|:.
  Rat   139 DLFKCMDEVKDEKECSTAVSYLEVYNEQIRDLLTNSGPLAVREDAQKGVVVQGLTLHQP------ 197

  Fly   159 VNCEECIITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVL 223
                    .|..::|:||..|||.||...|:||..||||||:|:|.:..:....|.:..|..:.:
  Rat   198 --------KSSEEILQLLDNGNKNRTQHPTDMNAASSRSHAVFQIYLRQQDKTASINQNVHIAKM 254

  Fly   224 NLVDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSE-NADNRFTNYRDSKLTRILQAS 287
            :|:||||||||..:|.:|.|..||.:||||||.|.|||.:|:: ...|:...||:|||||:|:.|
  Rat   255 SLIDLAGSERASISGTKGTRFVEGTNINKSLLALGNVINALADTKRRNQHIPYRNSKLTRLLKDS 319

  Fly   288 LGGNAFTSIICTIKPSIM--EESQSTLSFATRAKKIR----------IKPQVNEMVSDATMMKRL 340
            ||||..|.:|..:.||.:  :::.:||.:|.|||.|:          :...:::.|....|.|
  Rat   320 LGGNCQTIMIAAVSPSSLFYDDTYNTLKYANRAKDIKSSQLKSNVVNLSSHISQYVKICNMQK-- 382

  Fly   341 EREIKVLKDKLAEEERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHL 405
             .||.:||:||    :..|.|:.:..     ::|..|::  ||
  Rat   383 -AEILMLKEKL----KAYEGQKALTD-----RNDCAKLV--HS---------------------- 413

  Fly   406 ELAETGTTEDR-IDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLP 469
                  ..||: |::|.::                        :|.|..     ....:.:|:|.
  Rat   414 ------NVEDKEIERFQEI------------------------LNCLFQ-----NREGMRQEYLK 443

  Fly   470 AECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQG 534
            .|.:                             |..:::|.....     ...|..|:.|.|
  Rat   444 VEML-----------------------------LKENELKSSYHQ-----QCHKQIEMMCSE--- 471

  Fly   535 LKEKLAEVTAQRDNLEQESLAEKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIME 599
              :||.:.|.:||:          |.:.|:.....|....|....:..|....|..::..||::.
  Rat   472 --DKLEKATCRRDH----------RLEKLKSNRCVLEKKKEEMLKQFDENTNWLHRVESEMRLLG 524

  Fly   600 VENQVAVGLEFEFEAH-----KKSSKLRVDDL--LSALLEKE--STIESLQKSLDNLTRDVLRNS 655
            ....:..||..:...|     .|..|.::..:  |:||.|::  .|...|...|..|.:...|..
  Rat   525 QNGDIPEGLNKDLHCHHLHLQNKDLKTQMGHMMTLAALQEQQHGQTEAVLNALLPVLRKQYWRLK 589

  Fly   656 KEGHMLSIAPEQEDIAGDSICNKCEELEKLIADLESKKNSCECDQLR-------------LEIVS 707
            :.|  ||.|....|.         :::|.|:   |.||.....||..             |....
  Rat   590 ETG--LSNAAFDSDF---------KDIEHLV---ERKKVVAWADQTAEHSNQSDVPGTSLLMTFP 640

  Fly   708 VRDKLESVESAFNLASSEII----QKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGI 768
            ....::|:....:::...|:    |:.|..:.:...|.........|.||....|...:..|..:
  Rat   641 QLGPIQSIPCCSSMSDPSILKITPQRRTKRKLIPSPLKVKHTQKSALSERTQLNDSFSKELQPIV 705

  Fly   769 TTLHEKHEHVQEKYQKLQEEYEQLESRARSASSAEFQRLQNDN--------------TKFQADIA 819
            .|..:....||:....|        :||.|.|:    ...|||              |:.:..:.
  Rat   706 YTPEDSRRTVQDLSPPL--------ARASSHSA----NGMNDNSLKALCRTESPLSRTECKEGLY 758

  Fly   820 SLN---ERLEEAQNMLTE-VQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLMES 880
            |.:   :.::..:|.|.| :.:|:||:.  |:::.....|.                 |..:..|
  Rat   759 STSAICDGIKSLKNNLPEPLPSSKSTLH--RVESSSFPTKD-----------------SRSVSTS 804

  Fly   881 VQENDALREEIKQR-----PTSHVE-ESMRSSGISSDFDEQKQDINLLHQFVQLSESVQQIELQH 939
            |....|:....|::     .||... :|..|.|::....:....:.|:.: .:|....::...:.
  Rat   805 VPSYMAMTTAAKRKWKFMSSTSDASLKSDESCGLAKRIRQDNSSVKLIRE-NRLRVGYKKTTNKT 868

  Fly   940 HSGISRLFRANQMK 953
            :|.:.|.||.|..|
  Rat   869 NSNMLRKFRRNTSK 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	130/376 (35%)
		Motor_domain	8..321	CDD:277568	129/359 (36%)
		Smc	<680..1449	CDD:224117	57/315 (18%)
		TMPIT	779..>867	CDD:285135	19/105 (18%)
		Smc	1042..1910	CDD:224117
Kif18a	XP_038961378.1	KISc_KIP3_like	11..355	CDD:276821	129/359 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810