Protein Alignment cmet and cos

DIOPT Version :10

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: NP_477092.1
• Gene: cos / 35653
• FlyBaseID: FBgn0000352
• Length: 1201
• Species: Drosophila melanogaster
• Alignment Length: 1383
• Identity: 255/1383 - (18%)
• Similarity: 475/1383 - (34%)
• Gaps: 515/1383 - (37%)

  Fly    39 SHAEPYVFDYVFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNP--- 100
            :||.|        ..:|.::|:.:....::...::||:.::..|||...||:||:.|:.|:|
  Fly   139 THALP--------SSSSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLT 195

  Fly   101 ----GVMVLAAKEIFQQISSETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNVNC 161
                ||:.|..::||..||...||.:.:.||::||....:.|||              |:.|::|
  Fly   196 DSTEGVVQLCVRDIFSHISLHPERTYAINVGFVEICGGDVCDLL--------------GMGNIHC 246

  Fly   162 EECIITSEVD-LLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQ---SV 222
                  :.|| :...|.:|...|         :|..:|.:|.:.:|.:   ....:.::|   |.
  Fly   247 ------TNVDAVFHWLQVGLSAR---------QSLPAHTLFTLTLEQQ---WVSKEGLLQHRLST 293

  Fly   223 LNLVDLAGSER-ADQTGARGARLKEGGHINKSLLFLSNVIKSLSE----NADNRFTNYRDSKLTR 282
            .:..||.|:|| .||        ..|..::..|..|..||.:|::    ...|....|..:.||.
  Fly   294 ASFSDLCGTERCGDQ--------PPGRPLDAGLCMLEQVISTLTDPGLMYGVNGNIPYGQTTLTT 350

  Fly   283 ILQASLGGNAFTSIICTIKP--SIMEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIK 345
            :|:.|.||.|.|.:|..:.|  ..:.|:...|.||.:.:.:|....:|....|.||:.:....:
  Fly   351 LLKDSFGGRAQTLVILCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSDDNTMIVQPAEPV- 414

  Fly   346 VLKDKLAEEERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAET 410
                                                                |.::.|...|::.
  Fly   415 ----------------------------------------------------PESNSSAGPLSQA 427

  Fly   411 GTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDF 475
            |..::                |....|..:|..:                 ..:.|.|.::.||
  Fly   428 GPGDN----------------FGLQFAASQWSKL-----------------VTNAEGLFSKLID- 458

  Fly   476 GSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLA 540
                                     ..|.|:..|::|:: .:|      .:.||||.      |:
  Fly   459 -------------------------SKLITEVEKEQIEE-WLF------LKQECEEC------LS 485

  Fly   541 EVTAQRDNLEQESLAEKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVENQVA 605
            ...|.|...:...:.|.|.    .::|.|..|::|:.||                   :.||
  Fly   486 STEAMRQQKQLVPILEAEE----PEDVNSEAANSESPNS-------------------DNEN--- 524

  Fly   606 VGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTR--DVLRNSKEGHMLSIAPEQE 668
               :.:.|:|:.....:::.|:....:|...: .|:|..:.|::  ..:..|::..:.:..||:.
  Fly   525 ---DTDNESHRPDLDDKIESLMEEFRDKTDAL-ILEKHAEYLSKHPKAVMQSQDREIEAQPPEEN 585

  Fly   669 DIAGDSICNKCEELEKLIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQ----- 728
               ||                 .:|            ||:..:..||:...:|:::|:..
  Fly   586 ---GD-----------------DRK------------VSIGSRRRSVQPGASLSTAELAMLNRVA 618

  Fly   729 -----KATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKHEHVQEKYQKLQEE 788
                 ...|.|.:...|.:|..         :.:.|...|..|....:    |.:|:|.:||..|
  Fly   619 SQQPPPPIDPESVVDPLESSSG---------EGIRQAALAAAAATAPI----EQLQKKLRKLVAE 670

  Fly   789 YEQLESRARSASSAEFQRLQNDNTKFQADIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHELT 853
            .|..:.:.|                      .:.|.::..||::.|:..:..|....:.:.|:..
  Fly   671 IEGKQRQLR----------------------EIEETIQVKQNIIAELVKNSDTRSHAKQRFHKKR 713

  Fly   854 AKIKELETNFEEMQREYDCLSNQLMESVQENDALREEIKQRPTSHVEESMRSSGISSDFDEQKQD 918
            ||          ::.|.|....||.:::         ::.|..|.:|   |.:.|....:.:.:|
  Fly   714 AK----------LEAECDKAKKQLGKAL---------VQGRDQSEIE---RWTTIIGHLERRLED 756

  Fly   919 INLLHQFVQLSESVQQIELQHHSGISRLFRANQMKLDQSEPGLKLCLESAEYIEEDNRQSDATEP 983
            ::               .::|.:|               |.|.|
  Fly   757 LS---------------SMKHIAG---------------ESGQK--------------------- 770

  Fly   984 ICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQEIEEKSAL---MEATEATINEMREQM 1045
                         :|:|.|   .:||.::..|   .|::::.::..|   |||..|.:.|.||..
  Fly   771 -------------VKKLQQ---SVGESRKQAD---DLQKKLRKECKLRCQMEAELAKLRESRETG 816

  Fly  1046 TNLESALLEKSVIINKVEDYQRQIESLEKQNAEMTMVYEELQDRVTRESSMSESLLRVPPDEDTL 1110
            ..|..|.       ...|...||:::::.:...:..:..|..|.:..:
  Fly   817 KELVKAQ-------GSPEQQGRQLKAVQARITHLNHILREKSDNLEEQ----------------- 857

  Fly  1111 PGCPTSPSRREQEVATLKTSITELQSQVSDLKAELENHLRQIQLKDGNIARLQTDFEEMSERCLS 1175
            ||    |.::|    ||:..|..|:. ..||..|                          |||
  Fly   858 PG----PEQQE----TLRHEIRNLRG-TRDLLLE--------------------------ERC-- 885

  Fly  1176 MEVRLAELDEDTKQKQELLDRQAQKL---SDDLCLID-QLQKKNAQLVEQYHKATESLSLADAKP 1236
                  .||...|:.:.|..::.:||   .:.:..|| .::.||..:..  |::.::       .
  Fly   886 ------HLDRKLKRDKVLTQKEERKLLECDEAIEAIDAAIEFKNEMITG--HRSIDT-------S 935

  Fly  1237 DQILLSSQYDSQIEKLNQLLNAAKDELHDVRRIKDDEISALRMEFLLQIETNEKENQAKFYAELQ 1301
            |:|        |.||..|:|.|.      :.|:..:|:..|..::..:: .:.:::..|.  |||
  Fly   936 DRI--------QREKGEQMLMAR------LNRLSTEEMRTLLYKYFTKV-IDLRDSSRKL--ELQ 983

  Fly  1302 ETKDRYESNVAELKEKLLQVEETLSSVTVRCQAELEALKSAHKENISQAVEERNNLIVQHQAEME 1366
            ..:...|.:..|.||::|       |..|| ||.||.              |||.:::|.|.||:
  Fly   984 LVQLERERDAWEWKERVL-------SNAVR-QARLEG--------------ERNAVLLQRQHEMK 1026

  Fly  1367 TIRETLKNKLAEASTQQS 1384
             :...|::...|.|...:
  Fly  1027 -LTLMLRHMAEETSASSA 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	Motor_domain	8..321	CDD:473979	76/299 (25%)
		SMC_prok_B	539..1431	CDD:274008	154/865 (18%)
		SMC_prok_B	1137..1926	CDD:274008	54/252 (21%)
		YhaN	1717..2182	CDD:443752
cos	NP_477092.1	Kinesin	140..389	CDD:459720	76/296 (26%)
		SMC_N	660..>999	CDD:481474	95/545 (17%)