Protein Alignment cmet and cos

DIOPT Version :9

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: NP_001260765.1
• Gene: cos / 35653
• FlyBaseID: FBgn0000352
• Length: 1201
• Species: Drosophila melanogaster
• Alignment Length: 1412
• Identity: 275/1412 - (19%)
• Similarity: 507/1412 - (35%)
• Gaps: 445/1412 - (31%)

  Fly    39 SHAEPYVFDYVFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNP--- 100
            :||.|        ..:|.::|:.:....::...::||:.::..|||...||:||:.|:.|:|
  Fly   139 THALP--------SSSSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLT 195

  Fly   101 ----GVMVLAAKEIFQQISSETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNVNC 161
                ||:.|..::||..||...||.:.:.||::||....:.|||              |:.|::|
  Fly   196 DSTEGVVQLCVRDIFSHISLHPERTYAINVGFVEICGGDVCDLL--------------GMGNIHC 246

  Fly   162 EECIITSEVD-LLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQ---SV 222
                  :.|| :...|.:|...|         :|..:|.:|.:.:|.:   ....:.::|   |.
  Fly   247 ------TNVDAVFHWLQVGLSAR---------QSLPAHTLFTLTLEQQ---WVSKEGLLQHRLST 293

  Fly   223 LNLVDLAGSER-ADQTGARGARLKEGGHINKSLLFLSNVIKSLSE----NADNRFTNYRDSKLTR 282
            .:..||.|:|| .||        ..|..::..|..|..||.:|::    ...|....|..:.||.
  Fly   294 ASFSDLCGTERCGDQ--------PPGRPLDAGLCMLEQVISTLTDPGLMYGVNGNIPYGQTTLTT 350

  Fly   283 ILQASLGGNAFTSIICTIKP--SIMEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIK 345
            :|:.|.||.|.|.:|..:.|  ..:.|:...|.||.:.:.:|....:|....|.||:.:....:
  Fly   351 LLKDSFGGRAQTLVILCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSDDNTMIVQPAEPV- 414

  Fly   346 VLKDKLAEEERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAET 410
                                                                |.::.|...|::.
  Fly   415 ----------------------------------------------------PESNSSAGPLSQA 427

  Fly   411 GTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDF 475
            |..::                |....|..:|..:                 ..:.|.|.::.||
  Fly   428 GPGDN----------------FGLQFAASQWSKL-----------------VTNAEGLFSKLID- 458

  Fly   476 GSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLA 540
                                     ..|.|:..|::|:: .:|      .:.||||.      |:
  Fly   459 -------------------------SKLITEVEKEQIEE-WLF------LKQECEEC------LS 485

  Fly   541 EVTAQRDNLEQESLAEKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVENQVA 605
            ...|.|...:...:.|.|.    .::|.|..|::|:.||                   :.||
  Fly   486 STEAMRQQKQLVPILEAEE----PEDVNSEAANSESPNS-------------------DNEN--- 524

  Fly   606 VGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTR--DVLRNSKEGHMLSIAPEQE 668
               :.:.|:|:.....:::.|:....:|...: .|:|..:.|::  ..:..|::..:.:..||:.
  Fly   525 ---DTDNESHRPDLDDKIESLMEEFRDKTDAL-ILEKHAEYLSKHPKAVMQSQDREIEAQPPEEN 585

  Fly   669 DIAGD----SICNKCEELEKLIADLESKKNSCECDQLR----------LEIVSVRDKLESVESAF 719
               ||    ||.::...::.     .:..::.|...|.          ::..||.|.|||
  Fly   586 ---GDDRKVSIGSRRRSVQP-----GASLSTAELAMLNRVASQQPPPPIDPESVVDPLES----- 637

  Fly   720 NLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKHEHVQEKYQK 784
              :|.|.|::|.    |:...:|:  ...|||::...|..:.:.:|   ..|.|..|.:|.|...
  Fly   638 --SSGEGIRQAA----LAAAAATA--PIEQLQKKLRKLVAEIEGKQ---RQLREIEETIQVKQNI 691

  Fly   785 LQEEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNERL----------EEAQNMLTEVQNSE 839
            :.|..:..::|:.:.     ||......|.:|:.....::|          .|.:...|.:.:.|
  Fly   692 IAELVKNSDTRSHAK-----QRFHKKRAKLEAECDKAKKQLGKALVQGRDQSEIERWTTIIGHLE 751

  Fly   840 STVEKLRIQNH---ELTAKIKELETNFEEMQREYDCLSNQLMESVQENDALREEI----KQRPTS 897
            ..:|.|....|   |...|:|:|:.:..|.:::.|.|..:|.:..:....:..|:    :.|.|.
  Fly   752 RRLEDLSSMKHIAGESGQKVKKLQQSVGESRKQADDLQKKLRKECKLRCQMEAELAKLRESRETG 816

  Fly   898 HVEESMRSSGISSDFDEQKQDINLLHQFVQLSESVQQIELQHHSGISRLFRANQMKLDQSEPGLK 962
              :|.:::.|.......|.:.:              |..:.|   ::.:.|.....|:: :||
  Fly   817 --KELVKAQGSPEQQGRQLKAV--------------QARITH---LNHILREKSDNLEE-QPG-- 859

  Fly   963 LCLESAEYIEEDNRQSDATEPICL--KGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQEIE 1025
              .|..|.:..:.|....|..:.|  :..|.|...:.|.|:|:     ||::||        |.:
  Fly   860 --PEQQETLRHEIRNLRGTRDLLLEERCHLDRKLKRDKVLTQK-----EERKLL--------ECD 909

  Fly  1026 EKSALMEATEATINEMREQMTNLESALLEKSVIINKVEDYQRQIESLEKQNAEMTMVYEELQDRV 1090
            |   .:||.:|.|....|.:|.                  .|.|::               .||:
  Fly   910 E---AIEAIDAAIEFKNEMITG------------------HRSIDT---------------SDRI 938

  Fly  1091 TRESSMSESLLRVPPDEDTLPGCPTSPSRREQEVATLKTSITELQSQVSDLKAELENHLRQIQLK 1155
            .||......:.|:              :|...|  .::|.:.:..::|.||:    :..|:::|:
  Fly   939 QREKGEQMLMARL--------------NRLSTE--EMRTLLYKYFTKVIDLR----DSSRKLELQ 983

  Fly  1156 DGNIARLQTDFEEMSERCLSMEVRLAELDEDTKQKQELLDRQAQ-KLSDDLCLIDQLQKKNAQLV 1219
            ...:.| :.|..|..||.||..||.|.|:.:  :...||.||.: ||:  |.|....::.:|...
  Fly   984 LVQLER-ERDAWEWKERVLSNAVRQARLEGE--RNAVLLQRQHEMKLT--LMLRHMAEETSASSA 1043

  Fly  1220 EQYHKATESLSLADAKPDQILLSSQYDSQIE----KLNQLLNAAK--------DELHDVRRIKDD 1272
            ....:|.....:  |.|.|......||...:    ....|:.|.|        |      :.||.
  Fly  1044 SYGERALAPACV--APPVQASSDFDYDHFYKGGGNPSKALIKAPKPMPTGSALD------KYKDK 1100

  Fly  1273 EISALRMEFLLQIETNEKENQAKFYAELQETKDRYES--------NVAELKEKLLQVEETLSSVT 1329
            |..:.|..|            |||:     ...||.|        :.||....|::...|.::.|
  Fly  1101 EQRSGRNIF------------AKFH-----VLTRYASAAAAGSSGSTAEESTALIESTTTATATT 1148

  Fly  1330 VRC-------QAELEALKSAHKENI---------SQAVEERNNLIVQ 1360
            ...       :.:.:||.|...|.:         ::...::|.:|:|
  Fly  1149 TSTTTTGAVGKVKDKALVSFRPEQLKRLMPAPTATKVTRQKNKIIIQ 1195

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	77/306 (25%)
		Motor_domain	8..321	CDD:277568	76/299 (25%)
		Smc	<680..1449	CDD:224117	147/747 (20%)
		TMPIT	779..>867	CDD:285135	20/100 (20%)
		Smc	1042..1910	CDD:224117	70/356 (20%)
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	76/297 (26%)
		SPEC	657..856	CDD:295325	41/225 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437874
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930