DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and klp-20

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_497178.1	Gene:	klp-20 / 3565057	WormBaseID:	WBGene00002230	Length:	646	Species:	Caenorhabditis elegans

Alignment Length:	725	Identity:	199/725 - (27%)
Similarity:	325/725 - (44%)	Gaps:	196/725 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KNASSIQVCIKVRP---------------CEPGLTSLWQVKERRSIHLAD-SHAEP---YVFDYV 49
            :.|..::|.::.||               |.         .|.:::::.. |..:|   :.||.|
Worm     2 EGAEKVKVVVRCRPISTTEKLQGHKIAVTCN---------DEEKAVNIKSLSQEDPPRTFYFDAV 57

  Fly    50 FDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGD---EQNPGVMVLAAKEIF 111
            |........|::..|:.||...::|:||||||||||.:|||:||.||   .:..|::..:...||
Worm    58 FSPNTDQMTVYNVAARPIVENVLKGYNGTIFAYGQTGTGKTFTMAGDLEPVEMRGIIPNSFAHIF 122

  Fly   112 QQISS-ETERDFLLRVGYIEIYNEKIYDLLNK-KNQDLKIHESGN-GIVNVNCEECIITSEVDLL 173
            ..|:. :.:..||:||.|:|||||:|.|||:| .|.:|:|.|..: |:...|.....:.:...:.
Worm   123 DHIAKCQHDTTFLVRVSYLEIYNEEIRDLLSKDHNGNLEIKERPDVGVYVRNLSNPTVENASKMQ 187

  Fly   174 RLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTG 238
            .|:..|:|.|.||.|.||..||||||:|.:.|||.:     :..|.|..|.|||||||||..:||
Worm   188 ALMEFGSKNRKVGATAMNLESSRSHAMFTVTIESCR-----NGLVTQGKLQLVDLAGSERQSKTG 247

  Fly   239 ARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTN--YRDSKLTRILQASLGGNAFTSIICTIK 301
            |:|.||||...||.||..|.|||.||   .|.:.|:  ||:|||||:||.|||||:.|.:|..:.
Worm   248 AQGERLKEAAKINLSLSTLGNVISSL---VDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMIANVG 309

  Fly   302 PSI--MEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQKV 364
            |:.  .:|:.|||.:|.|||.|:...::||...|| .:::.:.||:.|: |:.:||...:::.:.
Worm   310 PATYNYDETLSTLRYANRAKNIQNVAKINEDPKDA-QLRKFQLEIEALR-KILDEENPGDDENQE 372

  Fly   365 EHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKP 429
            |..|.:::.           .:...:|:|:                 ..|:|:
Worm   373 EAWEAKMQE-----------REVEMEKKRK-----------------ILEERV------------ 397

  Fly   430 VFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPD 494
                                          ::::::|
Worm   398 ------------------------------NSAVNDE---------------------------- 404

  Fly   495 LPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQ-------- 551
                     .|.::.||:.:          .|.|.::.:...|||      |..||:
Worm   405 ---------ETHRLVKEMME----------NEAELKKARSEHEKL------RSKLEKIEKKLIVG 444

  Fly   552 -ESLAEKERYDALEKEVTSLRADN-EAANSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEA 614
             |:|.||     :|::...|..:| |...||..|...:....::|...:|:|.:.:   ..:.||
Worm   445 GENLLEK-----VEEQAKLLEVNNKELEQSKFQEAHLRTQLEERTAVKVEIEERYS---SLQEEA 501

  Fly   615 HKKSSKLR--VDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICN 677
            ..||.|::  .::|..|..|.:...|..|:.::.:..|:.:..|| .:|:||...|.|..:.:
Worm   502 FVKSKKIKKVSNELKDARAELKDLEEDHQRQVEAMLDDIRQLRKE-LLLNIAIIDEYIPVEHV-- 563

  Fly   678 KCEELEKLIA 687
              |.:||.::
Worm   564 --ELIEKYVS 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	135/348 (39%)
		Motor_domain	8..321	CDD:277568	134/341 (39%)
		Smc	<680..1449	CDD:224117	3/8 (38%)
		TMPIT	779..>867	CDD:285135
		Smc	1042..1910	CDD:224117
klp-20	NP_497178.1	Motor_domain	5..331	CDD:328930	134/342 (39%)
klp-20	NP_497178.1	SMC_N	<325..>569	CDD:330553	67/381 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910