DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and Morc3

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_001038994.2	Gene:	Morc3 / 338467	MGIID:	2136841	Length:	942	Species:	Mus musculus

Alignment Length:	1136	Identity:	210/1136 - (18%)
Similarity:	398/1136 - (35%)	Gaps:	334/1136 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   429 PVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLP----AECIDFGSPRPDVLKPMLTI 489
            |.|.||::....|                           |    ||.|| .:..|||....:.|
Mouse    16 PKFLHTNSTSHTW---------------------------PFSAVAELID-NAYDPDVNAKQIWI 52

  Fly   490 RQ--LPD---LPLTPKG-PLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKL-----AEVT 543
            .:  :.|   |..|..| .:|.||:.|.:.                   .|..:|:     ..|.
Mouse    53 DKTVISDHICLTFTDNGNGMTADKLHKMLS-------------------FGFSDKVTMNGHVPVG 98

  Fly   544 AQRDNLEQESLAEKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQT-MRIMEVENQVAVG 607
            ...:..:..|:       .|.|:......:.|..:         :..|.|| :.:::.|: |.|.
Mouse    99 LYGNGFKSGSM-------RLGKDAMVFTKNGETMS---------VGFLSQTYLEVIKAEH-VVVP 146

  Fly   608 LEFEFEAHKKSSKLRVDDL-LSALLEKESTIESLQKSLDNL--------TRDVLRN--------- 654
            : ..|..|::...|..... |:|:|| .|...:.||.|..|        ||.::.|
Mouse   147 I-VTFNKHRQMINLTESKASLAAILE-HSLFSTEQKLLAELNAIMGKKGTRIIIWNLRSYKNATE 209

  Fly   655 ---SKEGHMLSIAPEQEDIAGDSICNKCEELEKLIADLE-SKKNSCECDQL--RLEIVSVRDKLE 713
               .|:.:.:.|..:.::.||.....|.|.::::..:.: |.:..|....|  |::|:....|::
Mouse   210 FDFEKDKYDIRIPEDLDETAGRKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIIIRGQKVK 274

  Fly   714 SVESAFNLASSEIIQKATDCERLSKELSTSQNAFG---QLQERYDALDQQWQAQQAGITTLHEKH 775
            :     .|.|..:.....|..|......|.:..||   :.::.|            ||...|:
Mouse   275 T-----QLVSKSLAYIERDVYRPKFLTRTVRITFGFNCRNKDHY------------GIMMYHK-- 320

  Fly   776 EHVQEKYQKLQEEYEQLESRARSASSA-------EFQRLQNDNTK--------FQADIASLNERL 825
                   .:|.:.||::..:.::.:..       |...|:..:.|        ::..|.:|.|:|
Mouse   321 -------NRLIKAYEKVGCQLKANNMGVGVVGIIECNFLKPTHNKQDFDYTNEYRLTILALGEKL 378

  Fly   826 EEAQNMLTEVQNSESTVEKLRIQN-----------HELTAKIKELETNFEEMQREYDCLSN---- 875
            .:..|.:...:|:|..| .|.:::           .:...|.::|....:::..::.|.:|
Mouse   379 NDYWNEMKVKKNAEYPV-NLPVEDIQKRPDQTWVQCDACLKWRKLPDGIDQLPEKWYCSNNPDPQ 442

  Fly   876 ----QLMESVQENDALRE--EIKQRPTSHVEESMRSSGISSDFDEQKQDIN--LLHQ-------F 925
                ::.|..::.|.:..  |...:.||.....:|...|......|   ||  ||:|       |
Mouse   443 FRNCEVPEEPEDEDLVHPTYEKTYKKTSKERFRIRQPEILPRILPQ---INPELLYQTSVSSQSF 504

  Fly   926 VQLSESVQQIELQHHSGISRLFRANQMKLDQSEPGLKLCLESAEYIEEDNRQSDATEP--ICLKG 988
            ..:.|||.:   .|.|.::..|.|..:.|:.:.|                    |:||  ..:|.
Mouse   505 SPVKESVPR---PHLSEVTSPFAARIINLNLASP--------------------ASEPENSSMKR 546

  Fly   989 FLKRH----RFQIKRLSQEHVDMGEEKRLLD---IISQLEQEIEEKSALMEATEATIN---EMRE 1043
            .|..|    ..:.:|||...|:....|...|   ||      :||.|....|.:..:.   |::.
Mouse   547 KLGVHSSILNAKTRRLSNPPVENSSYKNDDDEDVII------LEENSTPKPAVDLEVKSDIEVKS 605

  Fly  1044 QMTNLESALLEKSVIINKVEDYQRQIESLEKQNAEMTMVYEELQD----RVTRESSMSESLLRVP 1104
            :.::.|.:.:...::.:.....|....|.....::..:......|    .|.:|.||.|. :.|.
Mouse   606 EQSHTEQSGIHVDLVSSPKPCVQASSTSTSTSRSDPGITVSTQTDAPGLTVKKEESMEED-MGVR 669

  Fly  1105 PDEDTLPGCPTSPSRRE---QEVATLKTSITELQSQVSDLKAELENHLRQIQLKDGNIARLQTDF 1166
            ....||....|....:|   :.|......:.||:|::..:..|.:::.||.|:....|..||...
Mouse   670 NGTATLSCVGTEAKVQETSAESVDATSHQLQELRSELLVVTQERDDYKRQCQMFTDQIQVLQQRL 734

  Fly  1167 EEMSERCLSMEVRLAELDEDTKQKQELLDRQAQKLSDDLCLIDQLQKKNAQLVEQYHKATESLSL 1231
            .||:::|:                                      ||     |:.|::||:
Mouse   735 LEMNDKCV--------------------------------------KK-----EKCHQSTET--- 753

  Fly  1232 ADAKPDQILLSSQYDSQIEKLNQLLNAAKDELHDVRRIKDDEISALRMEFLLQIETNEKENQAKF 1296
                 |.:.|....:.|.|.|:.|.:..:..|.::.|:| .:.|||:     |:::...:
Mouse   754 -----DAVFLLDSVNGQAESLDHLGSQYQQALQEIERLK-RQCSALQ-----QVKSECSQ----- 802

  Fly  1297 YAELQETKDRYESNVAELKEKLLQVEETLSSVTVRCQAELEALKS------AHKENISQAVEERN 1355
             |...|:|...:....:|.:...|::        :|..|.:..|:      ..|.:|....||.
Mouse   803 -ASCTESKSEVDEMAVQLDDVFRQLD--------KCTIERDQYKNEVQLLEIEKSHIHSQCEEL- 857

  Fly  1356 NLIVQHQAEMETIRETLKNKLAEASTQQSKMED------------AFRAEINEVRATLMEQLNQT 1408
                  |.|:|.::.|.:...|:.||..:..|.            :.|..:.::.|.::..|:..
Mouse   858 ------QTEVEQLKSTGQQAAADGSTASNAEEPVSYVDGESLKLRSLRVNVGQLLAMIVPDLDLQ 916

  Fly  1409 KEDRDKGASKLEEVKKTLEQMINGGRVMSDT 1439
            :.:.|     ::.|.:.|.|::.....:|.|
Mouse   917 QVNYD-----VDVVDEILGQVVEQMSEISST 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526
		Motor_domain	8..321	CDD:277568
		Smc	<680..1449	CDD:224117	155/848 (18%)
		TMPIT	779..>867	CDD:285135	17/113 (15%)
		Smc	1042..1910	CDD:224117	76/423 (18%)
Morc3	NP_001038994.2	HATPase_c	29..>136	CDD:294057	27/142 (19%)
		Nuclear matrix binding. /evidence=ECO:0000250\|UniProtKB:Q14149	326..353		3/26 (12%)
		zf-CW	409..446	CDD:284831	4/36 (11%)
		RNA binding. /evidence=ECO:0000250\|UniProtKB:Q14149	503..594		28/119 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..654		3/30 (10%)
		bZIP	<698..721	CDD:304365	6/22 (27%)
		Prefoldin	768..875	CDD:298833	26/133 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7544
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950