DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and CG5004

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_573195.1	Gene:	CG5004 / 32698	FlyBaseID:	FBgn0260748	Length:	1247	Species:	Drosophila melanogaster

Alignment Length:	899	Identity:	173/899 - (19%)
Similarity:	312/899 - (34%)	Gaps:	278/899 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 FAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETERDFLLRV-----------GYIEIYN 133
            :|.|..|:|..:.:   ..|..:.    ||..||...:..:|.|.:|           |.::||:
  Fly   219 YAKGVGSNGGYWNV---PSNAAIY----KEQHQQQHQQAPQDLLTKVNNDRYDRYPKAGGLQIYS 276

  Fly   134 EKIYDLLNKKNQDLKIHESGNGIVNVNCEECIITSEVDLLRLLCLGNKERTVGETNMNERSSRSH 198
                  :|..|.|:     .||....|.......:|::.:..:|....:|.....:.:..||.|.
  Fly   277 ------MNGVNSDI-----NNGPATGNNSGTGGGAELEDMLKICTEYADRNNSMPSTHNVSSTSS 330

  Fly   199 AIFKIIIESR-KSDHS----------DDDAVIQSVLNL-----------VDLAGSERADQTGA-- 239
            .....|:::| |::.|          ...|.:.|..|:           |.|.|..|.:..|.
  Fly   331 ITSSPIVQNRIKTNGSLPRDKNKSPFPQQAGVASSANISLLSSSSGYENVRLLGPNRVEINGQIH 395

  Fly   240 RGARLKEGGH---INKSLLFLSNVIKSLSENADNRFTNYRDSKL------TRILQASLG------ 289
            ..|...:||.   ::.:.|..:..:::..||.:...:.....|.      |:|....:.
  Fly   396 VPASAGDGGSSSGVSSNALAPTAAVRASHENLNQNHSATTGGKYVPQSPRTKIRTNCMSPKKDVS 460

  Fly   290 -GNAFTSIICTIKPSIMEESQSTLSFATRAKKIRI-----------KPQVNEMVSDATMMKRLER 342
             ||||.   ..|.|..:..|    :..:.:|.|.|           .|..|:......:.|..||
  Fly   461 FGNAFA---LAISPPPLASS----AVVSTSKPIPIPSMVKPPLAPKPPAPNQQRDYEQLFKSFER 518

  Fly   343 EIKVLKDKLAEEERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLEL 407
            :.:.| |::...:|.|:|   :.:|.                                  .:|:.
  Fly   519 KQQQL-DRMVPAKRSNKN---INNLT----------------------------------LNLQS 545

  Fly   408 AETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAEC 472
            .|:.|      |.||.|..|.|.              |::|::              |:....|.
  Fly   546 VESQT------QSPKPSRKPAPA--------------PRSIHL--------------EQRQRREL 576

  Fly   473 IDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKE 537
            |.    |...||     |:|.:||  |...:...::|...|.|....|...       ::|.|:.
  Fly   577 IQ----RRKQLK-----RELAELP--PSAGIEGLELKLGEQPLAPSASPRL-------QLQALQN 623

  Fly   538 KLAEVTAQRDN---LEQESLAE-KERYDALEKEVTSLRA-----DNEAANSKISELEEKLSTLKQ 593
            ::..:.|||:.   :|:...|: |:..:..:.::..|||     .|.|.      |:|:|..:.:
  Fly   624 RVCRLEAQRNATRVMEENQQAKLKQSIEIKQDQLKKLRAMLKQKPNNAC------LKEELQLVCE 682

  Fly   594 TMRIMEVENQVAVGLEFEF------------EAHKKSSKLRVDDLLSALL-------EKESTIES 639
            :   :|.:.:....|||::            |..::..:|.::..|:||.       |:..:..|
  Fly   683 S---LESDRKTFEDLEFQYFEEESEHHASHEEFKRQEQRLMLEAELAALRIQIGPDEEEPGSPTS 744

  Fly   640 LQKSLDNLTRDVLRNSKEGHMLSIAPE---QEDIAGDSICNKCEELEKLIADLESKK-------- 693
            ...:..||...|:..|..|....:.|:   |||:...|:........|:.|:..:.|
  Fly   745 PGSTGSNLVNGVMSQSLFGSAELLCPKRRNQEDLMSKSVNENMFYNHKIEANTSTPKRLPLQLFE 809

  Fly   694 ----NSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKATDCERLSK-----ELSTSQNAFGQ 749
                .|||.....|.:...|.::..:|..        :....|.:|..|     .:|.||.|..:
  Fly   810 DLAGGSCEQISFNLSLQGDRFEVNPLERR--------VPSQDDIDRSCKVANDAPISASQGASTK 866

  Fly   750 LQERYDALDQQWQ---AQQAGITTLHEK----------HEHVQEKY----QKLQEEYEQLESRAR 797
            :.:....:::..:   |||......||:          |:..:.:|    |:..|:..||||.|.
  Fly   867 IFDSIMEIERNRKLLLAQQGHQVIEHERQKMYDLKKKSHDEARTQYLLSTQQSMEQQRQLESDAN 931

  Fly   798 SASSAE-FQRLQNDNTKFQADIASLNERLEE---------AQNMLTEVQNSEST 841
            ....|: |::         .::..||::..|         |.:....|||.:||
  Fly   932 GGKDAKLFEK---------TELQKLNQKPGEPVDDQVQKIAGDKENNVQNRKST 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	59/309 (19%)
		Motor_domain	8..321	CDD:277568	56/291 (19%)
		Smc	<680..1449	CDD:224117	41/206 (20%)
		TMPIT	779..>867	CDD:285135	19/77 (25%)
		Smc	1042..1910	CDD:224117
CG5004	NP_573195.1	FHA	41..104	CDD:278899
		PH-like	1142..1242	CDD:302622
		PH	1143..1237	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437960
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930