DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and Kif6

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_796026.2	Gene:	Kif6 / 319991	MGIID:	1098238	Length:	802	Species:	Mus musculus

Alignment Length:	908	Identity:	233/908 - (25%)
Similarity:	406/908 - (44%)	Gaps:	203/908 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SIQVCIKVRPC----EPGLTSLWQVKERRSIH---------LAD----SHAEPYVFDY--VFDEG 53
            :||:..:|:|.    :.|:.|:  .::.:..|         |||    :..|.|.|.:  :||:.
Mouse     5 TIQIFARVKPTVRKQQQGIYSI--DEDEKLTHSLEIVLPRDLADGFVNNKRESYKFKFQRIFDQE 67

  Fly    54 ASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQ---NPGVMVLAAKEIFQQIS 115
            |..:.:|:.:||.:..:.:.|:||||||||||.||||:|:.|..:   :.|::......||:|:.
Mouse    68 AKQEIIFEIIAKPVAESTLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTLSYIFEQLQ 132

  Fly   116 SETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIV------NVNCEECII---TSEVD 171
            .::.:.:...:.|:|||||..||||:.:::..|:.:.....:      |::.:...:   |:|.:
Mouse   133 KDSSKIYTTHISYLEIYNECGYDLLDPRHEASKLEDLPKVTILEDPDQNIHLKNLSLHQATTEEE 197

  Fly   172 LLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQ 236
            .|.||.||:..|.:.||.||:.|:|||.||.:.:.|::...:   .|..:.|:|||||||||..:
Mouse   198 ALNLLFLGDTNRMIAETPMNQASTRSHCIFTVHLSSKEPGSA---TVRHAKLHLVDLAGSERVSK 259

  Fly   237 TGARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTI- 300
            ||..|..|.|..:||.||.:|..||.:|||....... ||:|.:|.:|:.|||||..|::|.|:
Mouse   260 TGVGGLLLTEAKYINLSLHYLEQVIIALSEKHRTHIP-YRNSMMTSVLRDSLGGNCMTTMIATLS 323

  Fly   301 --KPSIMEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKL--AEEERKNENQ 361
              |.:| :||.||..||.|...|:.:..:||.:....|:.||::||:.||.:|  |..|::.|..
Mouse   324 LEKRNI-DESISTCRFAQRVALIKNEAILNEEIDPRLMIVRLQKEIEDLKAELAMATGEQRTEAL 387

  Fly   362 QKVE----------HLERQ-------IKHDMHKI-ICGHS----LSDKGQQKRRRTWCPTASGSH 404
            .:.|          :||.|       :..||.|| .|.|.    |:||      :|...|.|...
Mouse   388 TEAELLQLEKLIASYLEDQDPESRLEVGADMRKIHHCFHHFKKLLNDK------KTLENTVSSES 446

  Fly   405 LELAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLP 469
            ...|......|  :::.|:..|.           |:.||   .||||  :::..:....:::.|.
Mouse   447 TRQACQEPLRD--EEYTKLLGLL-----------KQRDN---EINIL--VNMLKKEKKKTQDALQ 493

  Fly   470 AECIDFGSPRPDVLKPMLTIRQLPDLPLTP--KGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEV 532
            ...::....||....|.  |...|.:|.||  ..|..|       |||    |:.:|......:.
Mouse   494 NSSLEKSDTRPPQNSPF--IAGSPAVPRTPFSSAPSHT-------QDL----SICRHRSSLLHKK 545

  Fly   533 QGLKEKLAEVTAQRDNLEQESLAEKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRI 597
            .|::|::             ||..:|.::..:::    .||:..       :|:....|||  |.
Mouse   546 TGMREEM-------------SLGRQEAFEIFKRD----HADSVT-------IEDNKQVLKQ--RF 584

  Fly   598 MEVENQVAVGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLS 662
            .|.:   |:| |...||..|..:|:  |.::            |:.|..:...:..|:    :.:
Mouse   585 SEAK---ALG-ESINEARSKIGQLK--DAIN------------QRHLQQVALGISENT----VPA 627

  Fly   663 IAPEQEDIAGDSICNKCEELEKLIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEII 727
            ..|:.::             |||.|.||.:|...:...:.|:.:.|              ..|.:
Mouse   628 STPDPQE-------------EKLRAQLEEEKGRYKTAFMHLKALKV--------------EIEHL 665

  Fly   728 QKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKHEHVQEKYQKL-QEEYEQ 791
            |...|..::            :||:.::|    |.|::|....::....::|:..:.. |::..|
Mouse   666 QLLMDKAKV------------KLQKEFEA----WWAEEATSLQVNSPATNLQDAVKPFPQQDQAQ 714

  Fly   792 LESRARSASSAEFQRLQNDNTKFQADIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHELTA 854
            |.|:..|      :.|:.:|...:.::...|.| ....:.....|:.|.:..::.:|:..|::
Mouse   715 LLSKKSS------RDLEVENGAGRLEVCDRNAR-RILPSPCPNQQSQEPSGSRVLVQDRPLSS 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	120/353 (34%)
		Motor_domain	8..321	CDD:277568	119/346 (34%)
		Smc	<680..1449	CDD:224117	32/176 (18%)
		TMPIT	779..>867	CDD:285135	14/77 (18%)
		Smc	1042..1910	CDD:224117
Kif6	NP_796026.2	KISc_KIF9_like	5..343	CDD:276826	119/344 (35%)
		Kinesin	11..345	CDD:278646	117/340 (34%)
		Cob_adeno_trans	<350..>408	CDD:294596	17/57 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900