DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and Klp3A

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster

Alignment Length:	1544	Identity:	330/1544 - (21%)
Similarity:	553/1544 - (35%)	Gaps:	544/1544 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAKNASSIQVCIKVRPCEPGLTSLWQVKERRSIHLADSHA------------EPYVFDYVFDEG 53
            ||:::.|.:.|.::|||       |.|.:..|...:|...:            |.|.::||||..
  Fly     1 MSSEDPSCVAVALRVRP-------LVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDID 58

  Fly    54 ASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGD------EQNPGVMVLAAKEIFQ 112
            .|.:::|:...:..|...:.|:|.||.|||||.|||||| ||.      :.:.||:..|..:||.
  Fly    59 DSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYT-MGTAFNGVLDDHVGVIPRAVHDIFT 122

  Fly   113 QISS-ETERDFLLRVGYIEIYNEKIYDLLNKKNQD---LKIHESGNGIVNVNCEECIITSEVDLL 173
            .|:. ::|..|.:...::|:|.|:.|||.:.|.:|   :.|.|..|.|:.....|.::||...:.
  Fly   123 AIAEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMPGLTELVVTSAQQVT 187

  Fly   174 RLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTG 238
            ..|..|:..|.|..|.|||.||||||||.:.:.:.|.|  ...:|..|..||||||||||..:|.
  Fly   188 DHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLD--GKQSVTTSRFNLVDLAGSERCSKTL 250

  Fly   239 ARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPS 303
            |.|.|.|||.:|||.||.|.|||.:|.......:..||.|||||:||.|||||:.|.:|..:.|:
  Fly   251 ASGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPA 315

  Fly   304 --IMEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQKVEH 366
              .:.|:.|||.:|.||.:|:.||.||        :.....|:.:|||.:
  Fly   316 DYNVAETLSTLRYADRALQIKNKPVVN--------LDPHAAEVNMLKDVI--------------- 357

  Fly   367 LERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVF 431
                                   ||.|           :||...|.....:
  Fly   358 -----------------------QKLR-----------VELLSGGKMSSSL-------------- 374

  Fly   432 FHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLP 496
                            |:.:|:..:|.         :|.|....||
  Fly   375 ----------------ISAVGAAGLGA---------IPCEESLAGS------------------- 395

  Fly   497 LTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKERYD 561
                                         .....|:|.|||::..:..:...|:||  ..:...|
  Fly   396 -----------------------------MANAAEIQRLKEQVRTLQDRNRKLQQE--LHQSLLD 429

  Fly   562 ALEKEVTSLRAD--NEAANSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVD 624
            ..|||:.:..|:  ::...|.:|||:.||...:|
  Fly   430 LTEKEMRAHIAEQAHDKLRSHVSELKNKLDQREQ------------------------------- 463

  Fly   625 DLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIADL 689
                |....|:|      :.||..||.
  Fly   464 ----AQFGNENT------NGDNEMRDF-------------------------------------- 480

  Fly   690 ESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERY 754
                 |...:::.:|:...:::|||             |.....:|||....|
  Fly   481 -----SLLVNRVHVELQRTQEELES-------------QGHESRQRLSSRSHT------------ 515

  Fly   755 DALDQQWQAQQAGITTLHEK-HEHVQEKYQKLQEEYEQLESRARSASSAEFQRLQNDNTKFQADI 818
                   :..::|...:||. |.|        .|||                  .|....|..::
  Fly   516 -------EGGESGGDEVHEMLHSH--------SEEY------------------TNKQMNFAGEL 547

  Fly   819 ASLNERLEEAQNMLTEVQNSESTVE------KLRIQNHELTAKIKELETNFEEMQREYDCLSNQL 877
            .::|.:|:..|.:...:..:.|.::      |||:.|.    ||.:||....::.
  Fly   548 RNINRQLDLKQELHERIMRNFSRLDSDDEDVKLRLCNQ----KIDDLEAERRDLM---------- 598

  Fly   878 MESVQENDALREEIKQRPTSHVEESMRSSGISSDF-DEQKQDINLLHQFVQLSESVQQIELQHHS 941
                   |.||             :::|..||:.. :|:::.:.||.|  ::|:..:::
  Fly   599 -------DQLR-------------NIKSKDISAKLAEERRKRLQLLEQ--EISDLRRKL------ 635

  Fly   942 GISRLFRANQMKLDQSEPGLKLCLESAEYIEEDNRQSDATEPICLKGFLKRHRFQIKRLSQEHVD 1006
                :.:||.:|:...|                                   |.:|:.||.|...
  Fly   636 ----ITQANLLKIRDKE-----------------------------------REKIQNLSTEIRT 661

  Fly  1007 MGEEKRLLDIISQLEQEIEEKSALMEATEATINEMREQMTNLESALLEKSVIINKVEDYQRQIES 1071
            |.|.|  :.:|..:..|.|:........|..:.:::.:...::|.::.:..:.:|    |||:
  Fly   662 MKESK--VKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSK----QRQV-- 718

  Fly  1072 LEKQNAEMTMVYEELQDRVTRESSMSESLLRVPPDEDTLPGCPTSPSR------REQEVATLKTS 1130
            |:::..|.....:.|:|.:.|::|......:...:..:..|...:.::      ||.|:......
  Fly   719 LKRKCEEALAANKRLKDALERQASAQAQRHKYKDNGGSAAGSSNANAKTDSWVDRELEIILSLID 783

  Fly  1131 ITELQSQVSDLKAELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDEDTKQKQELLD 1195
            ......|:.:.:|.:.||...:|                              .|.|....|..:
  Fly   784 AEHSLEQLMEDRAVINNHYHLLQ------------------------------QEKTSDPAEAAE 818

  Fly  1196 RQAQKLSDDLCLIDQLQKKNAQLVEQYHKATESLSLADAKPDQILLSSQYDSQIEKLNQLLNAAK 1260
             ||:.|:.   |.::|:.:|||:.:...|               :..:..||:|..|.:    ..
  Fly   819 -QARILAS---LEEELEMRNAQISDLQQK---------------VCPTDLDSRIRSLAE----GV 860

  Fly  1261 DELHDVRRIKDDEISALRMEFLLQIETNEKENQAKFYAELQETKDRYESNVAELKEKLLQVEETL 1325
            ..|.:.|.:...         ||:....::..||....|.:.|.|       ||:.:||..::..
  Fly   861 QSLGESRTVSKQ---------LLKTLVQQRRLQASSLNEQRTTLD-------ELRAQLLDAQQQE 909

  Fly  1326 SSVTVRCQAELEALKSAHKENI---SQAVEERNNLIVQHQAEMETIRETLKNKLAEASTQQSKME 1387
            .:.:.|    |..|:|.|:|.:   .:|.||:.:::::          |...:.|||   :|..|
  Fly   910 DAASKR----LRLLQSQHEEQMLAQQRAYEEKVSVLIR----------TANQRWAEA---RSPAE 957

  Fly  1388 DAFRAEINEVRATLMEQLNQTKED-RDKGASKLEEVKKTLE------QMINGGR--VMSDT---- 1439
            |..|.:|.|...:..|.|.|..:. |.|..||.:.||...:      |:::|..  |:||.
  Fly   958 DQQRNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQDLDDSFQIVDGNETVVLSDVSDDP 1022

  Fly  1440 --IAELEKTK-------------AEQDLAVNKLTKDNIELEKQCSKTQE 1473
              :....|:|             .:||..|..|...:|:.....|.|::
  Fly  1023 DWVPSTSKSKRIQSDSRNVISPPEKQDANVTSLGNSSIQSLNSTSATED 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	131/343 (38%)
		Motor_domain	8..321	CDD:277568	128/336 (38%)
		Smc	<680..1449	CDD:224117	143/813 (18%)
		TMPIT	779..>867	CDD:285135	17/93 (18%)
		Smc	1042..1910	CDD:224117	91/469 (19%)
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	129/338 (38%)
		Kinesin	14..335	CDD:278646	127/330 (38%)
		Smc	<396..>994	CDD:224117	161/916 (18%)
		FlaC	522..633	CDD:225888	32/172 (19%)
		TCR	1075..1110	CDD:281618
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437985
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840