DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and Kif3b

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_001099999.1	Gene:	Kif3b / 296284	RGDID:	1306815	Length:	747	Species:	Rattus norvegicus

Alignment Length:	794	Identity:	224/794 - (28%)
Similarity:	356/794 - (44%)	Gaps:	191/794 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KNASSIQVCIKVRPCEPGLTSLWQVKERRSIH--LAD----------------SHAEP--YVFDY 48
            |::.|::|.::.||...        ||:.:.:  :.|                ||..|  :.||.
  Rat     5 KSSESVRVVVRCRPMNG--------KEKAAAYDKVVDVDVKLGQVSVKNPKGTSHEMPKTFTFDA 61

  Fly    49 VFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTM---MGDEQNPGVMVLAAKEI 110
            |:|..|...|::|...:.:|.:.:|||||||||||||.:||||||   .||.:..||:..:...|
  Rat    62 VYDWNAKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGVRGDPEKRGVIPNSFDHI 126

  Fly   111 FQQISSETERDFLLRVGYIEIYNEKIYDLLNK-KNQDLKIHESGNGIVNVNCEECIITSEV-DLL 173
            |..||....:.:|:|..|:|||.|:|.|||:| :.:.|::.|..:..|.|......:|..| ::.
  Rat   127 FTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVKDLSSFVTKSVKEIE 191

  Fly   174 RLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTG 238
            .::.:||:.|:||.|||||.||||||||.|.:|..:.....::.:....|||||||||||..:||
  Rat   192 HVMNVGNQNRSVGATNMNEHSSRSHAIFVITVECSEVGLDGENHIRVGKLNLVDLAGSERQAKTG 256

  Fly   239 ARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTN--YRDSKLTRILQASLGGNAFTSIICTIK 301
            |:|.||||...||.||..|.|||.:|   .|.:.|:  ||||||||:||.||||||.|.::..:.
  Rat   257 AQGERLKEATKINLSLSALGNVISAL---VDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVG 318

  Fly   302 PSI--MEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKL------------- 351
            |:.  :||:.:||.:|.|||.|:.||:|||...|| :::..:.||..||.:|
  Rat   319 PASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDA-LLREFQEEIARLKAQLEKRSIGRRKRREK 382

  Fly   352 ----------AEEERK----------------NENQQKVEHLERQIKHDMHKIICGHSL------ 384
                      .|||.:                .|.|:|:|..:|.|..| |.::....:
  Rat   383 RREGGGSGGGGEEEEEEGEEGEEEGDDKDDYWREQQEKLEIEKRAIVED-HSLVAEEKMRLLKEK 446

  Fly   385 SDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTIN 449
            ..|.:..||........|:.::..|:           |:....|.:..||:
  Rat   447 EKKMEDLRREKDAAEMLGAKIKAMES-----------KLLVGGKNIVDHTN-------------- 486

  Fly   450 ILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQD 514
                     |...|.|:           .|.::.:.....|::..         ..:...:|..:
  Rat   487 ---------EQQKILEQ-----------KRQEIAEQKRREREIQQ---------QMESRDEETLE 522

  Fly   515 L-QMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKERYDALEKEVT---------- 568
            | :.:|||::..:::.::::.|..||..|.|:..:|::|.:.|::..:..:.|:|
  Rat   523 LKETYTSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTRELKLKHLII 587

  Fly   569 ----SLRADNEAANSKISELEEKLSTLKQTMRIMEVENQ-------VAVGLEFEFEAHKKSS--- 619
                .|...|:..|....:.||....|....|:   |||       .|||.:.....|.:.|
  Rat   588 ENFIPLEEKNKIMNRSFFDDEEDHWKLHPITRL---ENQQMMKRPVSAVGYKRPLSQHARMSMMI 649

  Fly   620 ----KLRVDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCE 680
                :.|.::::...|:..|          ..|||.     ||.  :|:|:.: .|.|:.....:
  Rat   650 RPEPRYRAENIMLLELDMPS----------RTTRDY-----EGP--AISPKVQ-AALDAALQDED 696

  Fly   681 ELEKLIADLESKKN 694
            |::...:..||..|
  Rat   697 EIQVDASSFESTAN 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	142/348 (41%)
		Motor_domain	8..321	CDD:277568	139/341 (41%)
		Smc	<680..1449	CDD:224117	4/15 (27%)
		TMPIT	779..>867	CDD:285135
		Smc	1042..1910	CDD:224117
Kif3b	NP_001099999.1	KISc_KIF3	8..340	CDD:276822	139/342 (41%)
Kif3b	NP_001099999.1	Smc	<352..>614	CDD:224117	52/317 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910