DRSC/TRiP Functional Genomics Resources

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Protein Alignment cmet and Kif21b

DIOPT Version :9

Sequence 1:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster
Sequence 2:XP_006249915.1 Gene:Kif21b / 289397 RGDID:1306206 Length:1635 Species:Rattus norvegicus


Alignment Length:1489 Identity:335/1489 - (22%)
Similarity:566/1489 - (38%) Gaps:453/1489 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSAKNASSIQVCIKVRPCEPGLTSLWQVKERRSIHLADSHAEPYVFDYVFDEGASNQEVFDRMAK 65
            :|.:......:|..|.|.||            .:.|....|  :.:|:|||.....::::.....
  Rat    19 LSKEKIEGCHICTSVTPGEP------------QVLLGKDKA--FTYDFVFDLDTWQEQIYSTCVS 69

  Fly    66 HIVHACMQGFNGTIFAYGQTSSGKTYTM------MGDEQNPGVMVLAAKEIFQQISSETER---- 120
            .::..|.:|:|.|:.|||||.:||||||      :..|:..|::..|...:|:.|.....|    
  Rat    70 KLIEGCFEGYNATVLAYGQTGAGKTYTMGTGFDTVTSEEEQGIIPRAIAHLFRGIDERKRRAQEQ 134

  Fly   121 -----DFLLRVGYIEIYNEKIYDLLNK--------KNQDLKIHESGN-GIVNVNCEECIITSEVD 171
                 :|.:...::|:|||:|.||.:.        :..::||||..| ||........:|.|:.:
  Rat   135 GVTGPEFKVSAQFLELYNEEILDLFDSTRDPDARHRRSNIKIHEDANGGIYTTGVTSRLINSQEE 199

  Fly   172 LLRLLCLGNKERTVGETNMNERSSRSHAIFKI-IIESRKSDHSDDDAVIQSVLNL---------- 225
            |::.|..|...||...|.||.:||||||||.| :.:.|..  :..|.|.::|..|          
  Rat   200 LIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRVC--AQPDLVNETVTGLPDGTAPTGTE 262

  Fly   226 ----------VDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADN-RFTNYRDSK 279
                      ||||||||..:|||.|.|.|||..||..||.|.|||.:|.:.:.. ....|||||
  Rat   263 YETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDQSKKVVHVPYRDSK 327

  Fly   280 LTRILQASLGGNAFTSIICTIKPSIME--ESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLER 342
            |||:||.|||||:.|.:|..:.||..:  |:.:||.:|.||:.|:.|..||:   |.|     .:
  Rat   328 LTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVVVNQ---DKT-----SQ 384

  Fly   343 EIKVLKDKLAEEERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLEL 407
            :|..|:.::|..:                                                 :||
  Rat   385 QISALRAEIARLQ-------------------------------------------------MEL 400

  Fly   408 AETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAEC 472
            .|                         ..||||         ::|  :.|.|..|          
  Rat   401 ME-------------------------YKAGKR---------VIG--EDGAEGYS---------- 419

  Fly   473 IDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKE 537
                    |:.:                                                     
  Rat   420 --------DLFR----------------------------------------------------- 423

  Fly   538 KLAEVTAQRDN--LEQESLAEKERYDALEKEVTSLRADNEAAN---SKISELEEKLSTLKQTMRI 597
              .....|::|  |.....|.:|..||:...||.|.  ::.||   :|..:..|.:..|      
  Rat   424 --ENAMLQKENGALRLRVKAMQEAIDAINNRVTQLM--SQEANLLLAKAGDGNEAIGAL------ 478

  Fly   598 MEVENQVAVGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLS 662
              ::|.:.                .:::|.:.|||.|:..|||::|   |:|...||.   :.|.
  Rat   479 --IQNYIR----------------EIEELRTKLLESEAMNESLRRS---LSRASARNP---YSLG 519

  Fly   663 IAPEQEDIAGDSICNKCEELEKLIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEII 727
            .:|......|                                     ....|:|.|     ||:|
  Rat   520 ASPAGPAFGG-------------------------------------SPASSMEDA-----SEVI 542

  Fly   728 QKA-TDCERLSK-------ELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKHEHVQEKYQK 784
            ::| .|.|||.|       :.|..:.||     :..|..||..:::   |..:|..|..:|:.:.
  Rat   543 RRAKQDLERLKKKEVRQRRKSSPEKEAF-----KKRAKLQQENSEE---TDENEAEEEEEERDES 599

  Fly   785 LQEEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNERLEEAQNMLTEVQNSESTVEKLRIQN 849
            ..||.|..:|.:..:........:.....||||:|.|...:|..|.::.|::||:..::.|:   
  Rat   600 GCEEEEDEDSGSEESLVDSDSDPEEKEVNFQADLADLTCEIEIKQKLIDELENSQRRLQTLK--- 661

  Fly   850 HELTAKIKELETNFEEMQREYDCLSNQLMESVQENDALREEIKQRPTSHVEESMRSSGISSDFDE 914
            |:...|:..|:....:.|.|.|    ::::::...:...||             :::.|.:|:::
  Rat   662 HQYEEKLILLQNKIRDTQLERD----RVLQNLSTMECYTEE-------------KANKIKADYEK 709

  Fly   915 QKQDINLLHQFVQLSESVQQIELQHHSGISRLFRANQMKLDQSEPGLKLCLESAEYIEEDNRQSD 979
            :.:::|...|.:|.::......|::.|...|..:..|.::.:.:.. |:.|......|:..|:..
  Rat   710 RLREMNRDLQKLQAAQKEHARLLKNQSRYERELKKLQTEVAEMKKA-KVALMKQMREEQQRRRLV 773

  Fly   980 AT----EPICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQEIEEKSALME----ATEA 1036
            .|    |...||...:|..|||:.|.       .:||..:|:  |.::.:|.|||..    .:|.
  Rat   774 ETKRNREIAQLKKEQRRQEFQIRALE-------SQKRQQEIV--LRRKTQEVSALRRLAKPMSER 829

  Fly  1037 TINEMREQMTNLES-ALLEKSVIINKVEDYQRQIESLEKQ-NAEMTMVYEELQDRVTRESSMSES 1099
            ....:..:..|::| |.:..|...::.|...|.:.|:.:| |.:   :...|.|..|.       
  Rat   830 VAGRVGLKPPNMDSGAEVSASTTSSEAESGARSVSSIVRQWNRK---INHFLGDHPTA------- 884

  Fly  1100 LLRVPPDEDTLPGCPTSPSRREQEVATLKTSITELQSQVSDLK-AELENHLRQIQLKDGNIARLQ 1163
                     |:.|  ..|:|::.:    |...::..|:.:.|| ..||..:..|.::...|..|:
  Rat   885 ---------TVNG--ARPARKKFQ----KKGASQSFSKAARLKWQSLERRIIDIVMQRMTIVNLE 934

  Fly  1164 TDFEEM----SERCLSMEV------RL-AELDEDTKQKQEL----------LDRQAQKLSDDLCL 1207
            .|.|.:    .|..|..|.      || ||..|:.|..|||          :|.....::|....
  Rat   935 ADMERLIKKREELFLLQEALRRKRERLQAESPEEEKGLQELAEEIEVLAANIDYINDSITDCQAT 999

  Fly  1208 IDQLQKKNAQLVEQYHKATE------SLSLADAKPDQILLSSQYDSQIEKLNQLLNAAKDELHDV 1266
            |.||::...:|     .:|:      |.|||:|:   :||.:...:.|:|   .|..|:.|. .:
  Rat  1000 IMQLEETKEEL-----DSTDTSVVISSCSLAEAR---LLLDNFLKASIDK---GLQVAQKEA-QI 1052

  Fly  1267 R----RIKDDEISALRMEFLLQIETNEKENQAKFYAELQ------ETKDRYES---NVAELKEKL 1318
            |    |::..:::......||.....||   |:.:.|||      :.::.|.|   .|:|..|..
  Rat  1053 RLLEGRLRQTDMTGSSQNHLLLDALREK---AEAHPELQALIYNVQHENGYASTDEEVSEFSEGS 1114

  Fly  1319 LQVEETLSSVT------VRCQAELEA-LKSAHKENISQAVEERNNLIVQHQAEMETIRE 1370
            .....|:...|      .:.:.:|.| :|:...|.:...::.....|.:..|.:..|:|
  Rat  1115 FSQSFTMKGSTSHDDFKFKGEPKLSAQMKAVSAECLGPPLDSSTKNITKSLASLVEIKE 1173

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cmetNP_524993.3 KISc 8..328 CDD:214526 123/367 (34%)
Motor_domain 8..321 CDD:277568 121/360 (34%)
Smc <680..1449 CDD:224117 160/757 (21%)
TMPIT 779..>867 CDD:285135 20/87 (23%)
Smc 1042..1910 CDD:224117 83/379 (22%)
Kif21bXP_006249915.1 KISc_KIF4 7..372 CDD:276823 122/368 (33%)
KISc 9..378 CDD:214526 124/374 (33%)
PKK 657..791 CDD:289257 26/154 (17%)
JAKMIP_CC3 675..803 CDD:292653 27/152 (18%)
Prefoldin 961..1097 CDD:298833 37/150 (25%)
WD40 1303..1611 CDD:238121
WD40 1304..>1612 CDD:225201
WD40 repeat 1310..1344 CDD:293791
WD40 repeat 1349..1385 CDD:293791
WD40 repeat 1405..1448 CDD:293791
WD40 repeat 1454..1498 CDD:293791
WD40 repeat 1507..1539 CDD:293791
WD40 repeat 1546..1570 CDD:293791
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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