DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and tea2

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_596620.1	Gene:	tea2 / 2539857	PomBaseID:	SPBC1604.20c	Length:	628	Species:	Schizosaccharomyces pombe

Alignment Length:	520	Identity:	154/520 - (29%)
Similarity:	258/520 - (49%)	Gaps:	87/520 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSIQVCIKVRPCEPGLTSLWQ-------------VKERRSIHLADSHAEPYVFDYVFDEGASNQE 58
            |.|...|::||.... ..:|.             ::::.|...:....| |:|:.||...:.|.:
pombe   131 SGIITSIRIRPIGKN-QGVWSHGKLSNDPYGREYIRQQTSTSSSTIQQE-YLFNNVFGMESKNYD 193

  Fly    59 VFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETERD-F 122
            ::.|..|.:|.....|:||.:||||.|.:||||:|.|.|..||::.||..::|:.:.:.::.| |
pombe   194 IYKRSVKSVVRNVFSGYNGIVFAYGMTGTGKTYSMQGTENEPGIIPLAMNDLFEMVENNSDDDTF 258

  Fly   123 LLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNVN-CEECIITSEVDLLRLLCLGNKERTVG 186
            .:|:.|:|||||:|.||:...:::.:|.|:.:|.|||. ....::||..::.:::...|..|...
pombe   259 QIRISYLEIYNERIRDLIGNSDEEPRIRENASGEVNVTPLTRVLVTSPEEVSQVIEQCNAIRKTA 323

  Fly   187 ETNMNERSSRSHAIFKI-IIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHI 250
            .|:.|..|||||||.:: :|.:..:.|:..    .|.|:||||||||||   .|...|.|||..|
pombe   324 ATDFNTYSSRSHAILQVFLIRNNPTAHTSQ----ISSLSLVDLAGSERA---SAHHERRKEGAFI 381

  Fly   251 NKSLLFLSNVIKSLSENADNRFTN------YRDSKLTRILQASLGGNAFTSIICT--IKPSIMEE 307
            |||||.|..||..||..|:...|:      ||:|||||:||.||.|.:..|::.|  |:.:...|
pombe   382 NKSLLTLGTVISRLSAAANPSLTSNSGHIPYRESKLTRLLQQSLSGQSQISLLATISIESNHTME 446

  Fly   308 SQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQKVEH---LER 369
            :.:||.||:||:.:   ||   .:..|..:..::.|:..|...|      .:|.|:||:   |.:
pombe   447 TTNTLKFASRAQNL---PQ---DIRQAEAVTNVQAELASLHSAL------EKNAQEVEYYASLVK 499

  Fly   370 QIKHD---------------------------MHKIICGHS-----LSDKGQQKRRRTWCPTASG 402
            |:..|                           |.:::..|:     |.|:.|.|.:..:....:.
pombe   500 QLTSDLEERDTYIAMLEAERSQGTAISRARLRMEELLSDHNFEIADLRDELQDKEQIIYALRYAQ 564

  Fly   403 SHLELAETGTTEDRIDQFP-KVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEE 466
            ...::|:...:   :.:|| |:  |.|.|...:.::..::.|..|| .||......::.:|:::|
pombe   565 KQRDIADFNQS---LAKFPHKI--LKKNVTRGSRSSSDQFSNETKT-EILPDDQQQSKKDSVTQE 623

Fly 467 466
pombe 624 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	122/343 (36%)
		Motor_domain	8..321	CDD:277568	120/336 (36%)
		Smc	<680..1449	CDD:224117
		TMPIT	779..>867	CDD:285135
		Smc	1042..1910	CDD:224117
tea2	NP_596620.1	Motor_domain	133..460	CDD:277568	120/335 (36%)
tea2	NP_596620.1	Kinesin	138..459	CDD:278646	118/329 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101662
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2883
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740