DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and Kif27

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_932167.1	Gene:	Kif27 / 246209	RGDID:	621071	Length:	1394	Species:	Rattus norvegicus

Alignment Length:	1676	Identity:	387/1676 - (23%)
Similarity:	679/1676 - (40%)	Gaps:	424/1676 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IQVCIKVRP--CEPGLTSLWQVKER---RSIHLADSHAEPYVFDYVFDEGASNQEVFDRMAKHIV 68
            |:|.:::||  |:..|.: .||..|   ::..:.......:.||:||.:.::..||:....|.:|
  Rat     6 IKVAVRIRPLLCKEVLHN-HQVCVRDIPKTQQIIIGRDRVFTFDFVFGKNSTQDEVYSTCIKPLV 69

  Fly    69 HACMQGFNGTIFAYGQTSSGKTYTMMG-------DEQNPGVMVLAAKEIFQQISSETERDFLLRV 126
            .:.::|:|.|:||||||.||||||:.|       |.|. |::..|.:||||.||.....||.::|
  Rat    70 LSLIEGYNATVFAYGQTGSGKTYTIGGGHVASVVDGQK-GIIPRAIQEIFQSISGNPNIDFKIKV 133

  Fly   127 GYIEIYNEKIYDLLNKKN--QDLKIH--ESGNGIVNVNCEECIITSEVDLLRLLCLGNKERTVGE 187
            .|||:|.|.:.|||..:.  :||.|.  |.||.:: |..:||.:.|..|::.||.:||..|..|.
  Rat   134 SYIEVYKEDLRDLLELETSMKDLHIREDEKGNTVI-VGAKECQVDSVEDVMGLLQVGNAARHTGT 197

  Fly   188 TNMNERSSRSHAIFKI-IIESRKSDHSDDDAV------IQSVLNLVDLAGSERADQTGARGARLK 245
            |.|||.||||||||.| :.:..||..:.:|..      |.|..:.||||||||..:||..|.|.|
  Rat   198 TQMNEHSSRSHAIFTISVCQVGKSAEATEDGEWCSHRHIVSKFHFVDLAGSERVTKTGNTGERFK 262

  Fly   246 EGGHINKSLLFLSNVIKSLSE-NADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPSI--MEE 307
            |...||..||.|.|||.:|.: ...:....|||:|:||:|:.||||:|.|.:|..:.||.  .:|
  Rat   263 ESIQINSGLLALGNVISALGDPRRKSSHVPYRDAKITRLLKDSLGGSAKTVMITCVSPSSSDFDE 327

  Fly   308 SQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQKVEHLERQIK 372
            |.::|.:|.||:.||.||.:| ....|..|..:|.|||:|::.|...:.
  Rat   328 SLNSLKYANRARNIRNKPTLN-FSPQADRMDEMEFEIKLLREALQSHQA---------------- 375

  Fly   373 HDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVFFHTSNA 437
                      |:|...|         |||
  Rat   376 ----------SISQTSQ---------TAS------------------------------------ 385

  Fly   438 GKRWDNIPKTINILGSLDIGTESNSISEEF--LPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPK 500
                :|:|....|          :|:.|:.  |..||:.:    .|.::.....  |.||
  Rat   386 ----ENVPDQNRI----------HSLEEQIAQLQEECLGY----QDCIEQAFAF--LVDL----- 425

  Fly   501 GPLTTDKIK---KEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRD--NLEQ--ESLAEKE 558
                .|.::   |:...||.:.|       ..:||:  |..|..:...:.  |||:  :.:...:
  Rat   426 ----KDAVRLNQKQQHKLQQWFS-------RTQEVR--KAVLTPLPGNQSIGNLEEGPQHVTVLQ 477

  Fly   559 RYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVENQ-VAVGLEFEFEAHKKSSKLR 622
            ....|:|...:|.||......|..||||    |::.|::|..|:: .||.|:   ||.|.:.
  Rat   478 LKRELKKYQCALAADQVVFTQKELELEE----LRRQMQLMAQESKGHAVSLK---EAQKVNR--- 532

  Fly   623 VDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIA 687
                    |:.|..||. |..:|.|:.::.:.|.     |:....::..||....:..|.....|
  Rat   533 --------LQNEKIIEQ-QLLVDQLSEELAKRSS-----SMPTSTKESCGDGPDARAPEKRPHTA 583

  Fly   688 DLESK-------------KNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKATDCERL--- 736
            ..:|.             |..|....:.        .|:.|.:.|...|..::....|.:.:
  Rat   584 PFDSHWGHYVYIPSRQDFKKVCSSSPVY--------SLDQVFAGFRTRSQMLMGHLEDQDEVLHC 640

  Fly   737 -SKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKHEHVQEKYQKLQEEYEQLESRARSAS 800
             ..:.|..:::.||.:.|..:....|..:...:.:|.|                       .|.:
  Rat   641 QFSDNSDDEDSEGQEKPRVRSRSHSWVKKPGSVCSLVE-----------------------MSDT 682

  Fly   801 SAEFQR--LQNDNTKFQADIASLNERLEEAQNM-LTEVQNSESTVEKLRIQNHELTAKIKELE-- 860
            .||.||  |.|.:.|.        |.|:|:|.: |.:::.||..:.|.:.:..|||..|:..|
  Rat   683 QAECQRSYLGNGDLKM--------ESLQESQELNLQKLRTSELILNKAKQKMRELTINIRMKEDL 739

  Fly   861 --------TNFEEMQREYDC----LSNQLMESVQENDALREEIKQRPTSHVEESMRSSGISSDF- 912
                    .|.:.:.|:|..    |.::..::..|....|:::::.....:.:......:..:|
  Rat   740 IKELIKTGDNAKSVSRQYSLKVTKLEHEAEQAKVELTETRKQLQELEGKDLSDVALKVKLQKEFR 804

  Fly   913 ---DEQKQDINLLHQFVQLSESVQQIELQHHSGISRLFR-ANQMKLDQSEPGLKLCLESAEYIEE 973
               |..|..:.:|.:..|.|:.:..:.:|:....|.|.: .:.:|..:.:...:|..||     |
  Rat   805 KKMDAAKLRVQVLQKKQQDSKKLASLSIQNEKRASELEQNVDHLKYQKVQLQRRLREES-----E 864

  Fly   974 DNRQSDATEPICLKGFLKRHRFQIKRLSQEHVDMGE----------------EKRLLDIISQLEQ 1022
            ..:|.||.        :||.:.::|.| |.:...||                .|.....:.||::
  Rat   865 KKKQLDAE--------VKRDQQKLKEL-QLNAGQGEGLHPKAEDTDAFNLNRRKGPFRSVDQLQK 920

  Fly  1023 EIEEKSALMEATEATINEMREQMTNLESALLEKSVIINKVEDYQRQIESLE-------------- 1073
            ..|::..|.|..|..::: |:::..||..|.::..|::|.|...::...||
  Rat   921 LDEQRKWLDEEVEKVLSQ-RQELEMLEEELKKREAIVSKKEALLQEKSHLENKKLRSSQALSTDS 984

  Fly  1074 -KQNAEMTMVYEELQDR-VTRESSMSESLLRVPPDEDTLPGCPTSPSRREQEVATLKTSITELQS 1136
             |.:|.:.::.:||.:: :..|:|.:|..:::......|        :||:|         :||.
  Rat   985 LKISARLNLLDQELSEKSLLLENSPTEEKVKISEQVQAL--------QRERE---------QLQR 1032

  Fly  1137 QVSDLKAEL---------ENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDEDTKQKQE 1192
            |.:.:..:|         |.|| ..||::| |..|:...|..:|   |::.|.:.|....   |.
  Rat  1033 QRNSVDEKLRHGRVLSPKEEHL-LFQLEEG-IEALEAAIEFKNE---SIQNRQSSLKSSF---QN 1089

  Fly  1193 LLDRQAQKLSDDLCLIDQLQKKNAQLVEQYHKATESLSLADAKPDQILLSSQYDSQIEKLNQLLN 1257
            |...::..|...:||  .:.:..|.|.:.::|.   ::|.:|:..|.|.:.:...::.:.:.:
  Rat  1090 LSQSESNVLEKLVCL--NIAEIRAILFKYFNKV---INLREAERKQQLQNKEMKMKVLERDNM-- 1147

  Fly  1258 AAKDELHDVRRIKDDEISALRMEFLLQIETNEKENQAKFYAELQ-----------ETKDRYESNV 1311
                 :|::    :..:..||::...::...:||::.|....|.           ||.::||..:
  Rat  1148 -----VHEL----ESALEYLRLQCDRRLTLQQKEHEQKMQLLLHHFKDQDGEGIIETLNKYEDKI 1203

  Fly  1312 AELKEKLLQVEETLSSVTVRCQAELEALKSAHKENISQAVEERNNLIVQHQAEMETIRETLKNKL 1376
            .:|::.|...::|...           ||...|:.:..||:.:..|...|.|....:..
  Rat  1204 QQLEKDLYFYKKTSRD-----------LKKRLKDPVQGAVQWQRTLTEHHDAGDGVLNP------ 1251

  Fly  1377 AEASTQQSKMEDAFRAEINEVRATLMEQLNQTKEDRDKGASKLEEVKKTLEQMINGGRVMSDTIA 1441
            .||:....:::.|.|.|        ..:||..:::.|..:|.|:....| :|::..|   .|::.
  Rat  1252 EEAAVLSEELKWASRTE--------NTKLNGREKEVDNSSSSLKTPPLT-QQILEDG---PDSLP 1304

  Fly  1442 ELEKTKAEQDLAVNKLTKDNIELEKQCSKTQEQLQMESLTRDQISFEIEAHIKKLELIVASSKKR 1506
                       ....|...:.:|:....||:.....:|.:......:....|.:|
  Rat  1305 -----------VCGSLAPSSGQLQSSADKTEAHAFTQSQSPPPPQLQPVRSIAQL---------- 1348

  Fly  1507 IIELEEKCDQQVLELDKCR--LEKLS-LESEIQKAN---SEHSCTMEKLQE 1551
                     |.|..:..||  |.::| ||..:::::   ...|.|.:.|:|
  Rat  1349 ---------QGVKPVKVCRRELRQISALELTLRRSSLGAGVRSVTADSLEE 1390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	138/344 (40%)
		Motor_domain	8..321	CDD:277568	134/337 (40%)
		Smc	<680..1449	CDD:224117	160/859 (19%)
		TMPIT	779..>867	CDD:285135	22/100 (22%)
		Smc	1042..1910	CDD:224117	104/552 (19%)
Kif27	NP_932167.1	KISc_KIF4	4..342	CDD:276823	134/338 (40%)
		KISc	5..348	CDD:214526	138/344 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	551..583		5/36 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	642..664		4/21 (19%)
		SbcC	<702..1222	CDD:223496	112/586 (19%)
		DUF4200	789..>884	CDD:290574	21/108 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1267..1340		15/95 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1375..1394		4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000