DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and MORC3

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_056173.1	Gene:	MORC3 / 23515	HGNCID:	23572	Length:	939	Species:	Homo sapiens

Alignment Length:	1123	Identity:	212/1123 - (18%)
Similarity:	411/1123 - (36%)	Gaps:	347/1123 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   429 PVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLP----AECIDFGSPRPDVLKPMLTI 489
            |.|.||::....|                           |    ||.|| .:..|||....:.|
Human    16 PKFLHTNSTSHTW---------------------------PFSAVAELID-NAYDPDVNAKQIWI 52

  Fly   490 RQ--LPD---LPLTPKG-PLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKL-----AEVT 543
            .:  :.|   |..|..| .:|:||:.|.:.                   .|..:|:     ..|.
Human    53 DKTVINDHICLTFTDNGNGMTSDKLHKMLS-------------------FGFSDKVTMNGHVPVG 98

  Fly   544 AQRDNLEQESLAEKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQT-MRIMEVENQVAVG 607
            ...:..:..|:       .|.|:......:.|:.:         :..|.|| :.:::.|: |.|.
Human    99 LYGNGFKSGSM-------RLGKDAIVFTKNGESMS---------VGLLSQTYLEVIKAEH-VVVP 146

  Fly   608 LEFEFEAHKKSSKLRVDDL-LSALLEKE--STIESLQKSLDNL-----TRDVLRN---------- 654
            : ..|..|::...|..... |:|:||..  ||.:.|...||.:     ||.::.|
Human   147 I-VAFNKHRQMINLAESKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNATEF 210

  Fly   655 --SKEGHMLSIAPEQEDIAGDSICNKCEELEKLIADLE-SKKNSCECDQL--RLEIVSVRDKLES 714
              .|:.:.:.|..:.::|.|.....|.|.::::..:.: |.:..|....|  |::|:....|:::
Human   211 DFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKT 275

  Fly   715 VESAFNLASSEIIQKATDCER---LSKELSTSQNAFG---QLQERYDALDQQWQAQQAGITTLHE 773
                 .|.|..:.....|..|   |||   |.:..||   :.::.|            ||...|.
Human   276 -----QLVSKSLAYIERDVYRPKFLSK---TVRITFGFNCRNKDHY------------GIMMYHR 320

  Fly   774 KHEHVQEKYQKLQEEYEQLESRARSASSA-------EFQRLQNDNTK--------FQADIASLNE 823
                     .:|.:.||::..:.|:.:..       |...|:..:.|        ::..|.:|.|
Human   321 ---------NRLIKAYEKVGCQLRANNMGVGVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGE 376

  Fly   824 RLEEAQNMLTEVQNSE-------STVEKLRIQNH---ELTAKIKELETNFEEMQREYDCLSN--- 875
            :|.:..|.:...:|:|       ..::|...|..   :...|.::|....:::..::.|.:|
Human   377 KLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDP 441

  Fly   876 -----QLMESVQENDAL------------REEIKQR-----PTSHVEESMRSSGISS-DFDEQKQ 917
                 ::.|..::.|.:            :|:.:.|     |..:.|...|.:.:|: .|...|:
Human   442 QFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKE 506

  Fly   918 DINLLHQFVQLSESVQQIELQHHSGISRLFRANQMKLDQSEPGLKLCLESAEYIEEDNRQSDATE 982
            .:...|    |||..       :|..:||...:|:. .||||             |.|.
Human   507 SVPRRH----LSEGT-------NSYATRLLNNHQVP-PQSEP-------------ESNS------ 540

  Fly   983 PICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQEI-------------EEKSALMEAT 1034
                   |||      |||.....:..:.|.|.  ||.|..:             ||.|....|.
Human   541 -------LKR------RLSTRSSILNAKNRRLS--SQFENSVYKGDDDDEDVIILEENSTPKPAV 590

  Fly  1035 EATINEMREQMTNLESALLEKSVIINKVEDYQ---------RQIESLEKQNAEMTMVYEELQDRV 1090
            :..| :|:.:.:::|    :..|.:..|.|.:         ......::.|...|..  |:...|
Human   591 DHDI-DMKSEQSHVE----QGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQT--EVPSLV 648

  Fly  1091 TRESSMSESLLRVPPDEDTLPGCPTSPSR-REQEVATLKTS------ITELQSQVSDLKAELENH 1148
            .::....|..:.|..|...||.|..:.:: .|.:..|.|::      :.||::|:..:..|.||:
Human   649 VKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENY 713

  Fly  1149 LRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDEDTKQKQELLDRQAQKLSDDLCLIDQLQK 1213
            .||..:....|..||....||:::.:               |:|...:..:  :|.:.|::.:..
Human   714 KRQCHMFTDQIKVLQQRILEMNDKYV---------------KKETCHQSTE--TDAVFLLESING 761

  Fly  1214 KNA---QLVEQYHKATESLSLADAKPDQILLSSQYDSQIEKLNQLLNAAKDELHDVRRIKDDEIS 1275
            |:.   .:|.||.:|.|                    :||:|.:..:|.:....:..:..::|..
Human   762 KSESPDHMVSQYQQALE--------------------EIERLKKQCSALQHVKAECSQCSNNESK 806

  Fly  1276 ALRMEFLLQIETNEKENQAKFYAELQE---TKDRYESNVAELKEKLLQVEETLSSVTVRCQ---A 1334
            :...|..:|::        ..:.:|.:   .:|:|:|.|     :||::|:  |.:..:|:   .
Human   807 SEMDEMAVQLD--------DVFRQLDKCSIERDQYKSEV-----ELLEMEK--SQIRSQCEELKT 856

  Fly  1335 ELEALKSAHKE-----NISQAVEERNNLIVQHQAEMETIRETLKNKLA----EASTQQSKME-DA 1389
            |:|.|||.:::     :.|..:||..|.:.....::.::|..:...||    :...||...: |.
Human   857 EVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDV 921

  Fly  1390 FRAEINEVRATLMEQLNQ 1407
                ::|:...::||:::
Human   922 ----VDEILGQVVEQMSE 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526
		Motor_domain	8..321	CDD:277568
		Smc	<680..1449	CDD:224117	157/836 (19%)
		TMPIT	779..>867	CDD:285135	18/112 (16%)
		Smc	1042..1910	CDD:224117	75/401 (19%)
MORC3	NP_056173.1	HATPase_c	29..>127	CDD:294057	24/133 (18%)
		Nuclear matrix binding. /evidence=ECO:0000269\|PubMed:11927593	326..353		4/26 (15%)
		zf-CW	409..446	CDD:284831	4/36 (11%)
		RNA binding domain	500..591		31/136 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	613..640		3/26 (12%)
		HIP1_clath_bdg	769..861	CDD:293123	24/126 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7544
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950