DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cmet and KIF1B

DIOPT Version :9

Sequence 1:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster
Sequence 2:NP_001352880.1 Gene:KIF1B / 23095 HGNCID:16636 Length:1816 Species:Homo sapiens


Alignment Length:1983 Identity:431/1983 - (21%)
Similarity:766/1983 - (38%) Gaps:533/1983 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 NASSIQVCIKVRPCEPGLTSLWQVKERRSIHLADSHA-------------EPYVFDYVFDEG--- 53
            :.:|::|.::|||.....||    ||.:.|.....::             :.:.|||.:...   
Human     2 SGASVKVAVRVRPFNSRETS----KESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSP 62

  Fly    54 -----ASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMG--DEQNPGVMVLAAKEIF 111
                 ||...|::.:.|.::....:|:|..|||||||.:||:|||||  :|...|::....:|:|
Human    63 EDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELF 127

  Fly   112 QQISS--ETERDFLLRVGYIEIYNEKIYDLLNKKNQ-DLKIHES---GNGIVNVNCEECIITSEV 170
            ::|:.  ..|..:.:.|.|:|||.|::.||||.||: :|::.|.   |..:.:::  :..:||..
Human   128 EKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLS--KLAVTSYT 190

  Fly   171 DLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQ-SVLNLVDLAGSERA 234
            |:..|:..|||.|||..|||||.||||||:|.|:...:|.|:..:.:..: |.::||||||||||
Human   191 DIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLSTEKVSKISLVDLAGSERA 255

  Fly   235 DQTGARGARLKEGGHINKSLLFLSNVIKSLSENADN-----------RFTNYRDSKLTRILQASL 288
            |.|||:|.|||||.:|||||..|..||.:|:| .||           .|..||||.||.:|:.:|
Human   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAE-VDNCTSKSKKKKKTDFIPYRDSVLTWLLRENL 319

  Fly   289 GGNAFTSIICTIKPSIM--EESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKL 351
            |||:.|:::..:.|:.:  :|:.|||.:|.|||:|:....:|| ..:|.:::.|:.|:..|||.|
Human   320 GGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINE-DPNAKLVRELKEEVTRLKDLL 383

  Fly   352 AE-------------EERKNENQQKVEHLERQIKHDMHKIIC-------GH-SLSDKGQQKRRRT 395
            ..             ::......:.:    :..:::.|:.:.       || |.:..|......:
Human   384 RAQGLGDIIDIDPLIDDYSGSGSKYL----KDFQNNKHRYLLASENQRPGHFSTASMGSLTSSPS 444

  Fly   396 WCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLD----- 455
            .|  :..|.:.|....:.::||              ..|....:..:.:.::..|:..|:     
Human   445 SC--SLSSQVGLTSVTSIQERI--------------MSTPGGEEAIERLKESEKIIAELNETWEE 493

  Fly   456 --IGTESNSISEEFLPAECIDFG-SPRPD-----VLKPMLTIRQLPDLPLTPKGPLTTDKIKKEI 512
              ..||:..:..|.|.||   .| :.|.|     |..|    ::.|.|....:.||.::.:...|
Human   494 KLRKTEAIRMEREALLAE---MGVAIREDGGTLGVFSP----KKTPHLVNLNEDPLMSECLLYYI 551

  Fly   513 QDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKERYDALEKEVT---SLRADN 574
            :|     .:.:..:.:.|..|.:....|.:.      |:..:...||.::.|..||   ..|::.
Human   552 KD-----GITRVGQADAERRQDIVLSGAHIK------EEHCIFRSERSNSGEVIVTLEPCERSET 605

  Fly   575 EAANSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDDLLSALLEKESTIES 639
            .....::|:..:    |:...||:..:|.|     |.|. |.:.::        |..||..:.|:
Human   606 YVNGKRVSQPVQ----LRSGNRIIMGKNHV-----FRFN-HPEQAR--------AEREKTPSAET 652

  Fly   640 LQKSLD--NLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIADLE--SKKNSCECD- 699
            ..:.:|  ...|::|  .|:|                 .:..:|:||.:.::|  .||...|.| 
Human   653 PSEPVDWTFAQRELL--EKQG-----------------IDMKQEMEKRLQEMEILYKKEKEEADL 698

  Fly   700 ---QLRLEIVSVRDKLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQW 761
               |.||:..|   ||::::.  .:.:..:..:.|:.|...:|:..:|:.|...|..:    ::|
Human   699 LLEQQRLDYES---KLQALQK--QVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAF----RKW 754

  Fly   762 QAQQAGITTLH------------------EKHEHVQEKY-------------QKLQEEYEQL-ES 794
            ::.|  .|:|.                  |..:.||.::             :.|..|.|:. |.
Human   755 KSHQ--FTSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELLPTEMEKTHED 817

  Fly   795 R--ARSASSAEFQRLQNDNTKFQADIASLNERL-------EEAQNMLTEVQN-SESTV------- 842
            |  .|:..:.|.|.|:|..|.:.: :..|.:||       :.|..|.:..|: ||:||       
Human   818 RPFPRTVVAVEVQDLKNGATHYWS-LEKLKQRLDLMREMYDRAGEMASSAQDESETTVTGSDPFY 881

  Fly   843 --------------------EKLRIQNHELT-----AKIKELETNFEEMQREYDCLSNQLMESVQ 882
                                |:|..:....|     :.|.||.   :|.|.|.:...::......
Human   882 DRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDITELA---DEQQDEMEDFDDEAFVDDA 943

  Fly   883 ENDALREEIKQRPTSHVEESMRSSGISSDFDEQKQDINLLHQFVQLSESVQQIELQHH------- 940
            .:||..||         ...:.|.|....:|.....|.:...||.||..:..:.|.|.       
Human   944 GSDAGTEE---------GSDLFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEK 999

  Fly   941 ---SGISRLFRANQMKLDQSEP--GLKLCLESAEYIEEDN---RQSDATEPICLKGFLKRHRFQI 997
               .|..|: ....:..|:..|  |..:.......|..||   .|||.:.....:..|.....:|
Human  1000 GEVRGFLRV-AVQAIAADEEAPDYGSGIRQSGTAKISFDNEYFNQSDFSSVAMTRSGLSLEELRI 1063

  Fly   998 ---KRLSQEHVDMGEEKRLLDIISQLEQEIEEKSALMEATEATINEMREQMTN---LESA----- 1051
               :..|.|.:...||      ||:: .:::.||:.:...:..:....|::.|   |.||     
Human  1064 VEGQGQSSEVITPPEE------ISRI-NDLDLKSSTLLDGKMVMEGFSEEIGNHLKLGSAFTFRV 1121

  Fly  1052 -LLEKSVIINKVEDYQRQIESLEK------------------------QN--AEMT--------- 1080
             :|:.|.|:.:..|...|...|.:                        ||  .|:|         
Human  1122 TVLQASGILPEYADIFCQFNFLHRHDEAFSTEPLKNNGRGSPLAFYHVQNIAVEITESFVDYIKT 1186

  Fly  1081 --MVYEELQDRVTRESSMSESLLRVPPDEDTL---PGCPTSPSRREQEVATL-KTSITELQSQVS 1139
              :|:|...........:....|..||.....   |..|.|......::.|: |||:.:..|:..
Human  1187 KPIVFEVFGHYQQHPLHLQGQELNSPPQPCRRFFPPPMPLSKPVPATKLNTMSKTSLGQSMSKYD 1251

  Fly  1140 DLK----AELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDEDTKQ------KQELL 1194
            .|.    :|||.....|.....:.|.|......:..:.:...:.:..:.|...:      ::.::
Human  1252 LLVWFEISELEPTGEYIPAVVDHTAGLPCQGTFLLHQGIQRRITVTIIHEKGSELHWKDVRELVV 1316

  Fly  1195 DRQAQKLSDDLCLIDQLQKKN---AQLVEQYHKATESLSLADAKPDQILLSSQYDSQI----EKL 1252
            .|...|...|...:|.:...|   |:.::..|.::.:....:|..|..|.:|...:::    ||:
Human  1317 GRIRNKPEVDEAAVDAILSLNIISAKYLKSSHNSSRTFYRFEAVWDSSLHNSLLLNRVTPYGEKI 1381

  Fly  1253 NQLLNAAKDELH---------DVRRI---KDDEIS---ALRMEFLLQIETNEKENQAKFYAELQE 1302
            ...|:|..:..|         ||..:   :|.:||   :||..|......:...|:.....||..
Human  1382 YMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLRSLFGSGYSKSPDSNRVTGIYELSL 1446

  Fly  1303 TK--DRYESNVAELKEKLLQVEETLSSVTVRCQAELEALKSAHKENISQAVEERNNLIVQHQAEM 1365
            .|  |.....:...:.|:|..    |...||           .:||::......::||::||.|:
Human  1447 CKMSDTGSPGMQRRRRKILDT----SVAYVR-----------GEENLAGWRPRGDSLILEHQWEL 1496

  Fly  1366 ETIRETLKNKLAEASTQQSKMEDAFRAEINEVRAT-----LMEQLNQTKEDRDKGASKLEEVKKT 1425
            |                  |:|     .::||..|     |.|:|         |.|..:.:..:
Human  1497 E------------------KLE-----LLHEVEKTRHFLLLRERL---------GDSIPKSLSDS 1529

  Fly  1426 LEQMINGGRVMSDT--IAELEKTKAEQDLAVNKLTKDNIELEKQCSKTQEQLQMESLTRDQISFE 1488
            |...::.|.:.:.|  .:::..|..|..:..::            |...:...:|||    :..|
Human  1530 LSPSLSSGTLSTSTSISSQISTTTFESAITPSE------------SSGYDSGDIESL----VDRE 1578

  Fly  1489 IEAHIKKLELIVASSKKRIIELEEKCDQQVLELDKCRLEKL------------------------ 1529
            .|...|.|:|:..:..:...::..       .:..|:|..:                        
Human  1579 KELATKCLQLLTHTFNREFSQVHG-------SVSDCKLSDISPIGRDPSESSFSSATLTPSSTCP 1636

  Fly  1530 --------SLESEIQKANSEHSCTMEKLQELQ----AEMKVLSNRNEKEKCDFETKLETFTFKIT 1582
                    ||:.:..:|||..|....:.::.|    .|...|:...:.|          |...:.
Human  1637 SLVDSRSNSLDQKTPEANSRASSPCPEFEQFQIVPAVETPYLARAGKNE----------FLNLVP 1691

  Fly  1583 DLEEV-------------LKE------AQHKVI-------LYDDLVSQHERLKICLAEAN-ELSS 1620
            |:||:             .||      |:|.|:       :|:......||..|.|:.|. |.|.
Human  1692 DIEEIRPSSVVSKKGYLHFKEPLYSNWAKHFVVVRRPYVFIYNSDKDPVERGIINLSTAQVEYSE 1756

  Fly  1621 NLQKKVMSLHT-ELIDSQKGI---SSRDVEINE 1649
            :.|..|.:.:| .:....:|:   :..|.::|:
Human  1757 DQQAMVKTPNTFAVCTKHRGVLLQALNDKDMND 1789

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cmetNP_524993.3 KISc 8..328 CDD:214526 135/362 (37%)
Motor_domain 8..321 CDD:277568 134/355 (38%)
Smc <680..1449 CDD:224117 184/957 (19%)
TMPIT 779..>867 CDD:285135 29/143 (20%)
Smc 1042..1910 CDD:224117 137/766 (18%)
KIF1BNP_001352880.1 KISc_KIF1A_KIF1B 4..361 CDD:276816 135/363 (37%)
Interaction with KBP. /evidence=ECO:0000269|PubMed:16225668 270..350 31/80 (39%)
Kinesin_assoc 358..555 CDD:318424 39/229 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 431..450 3/20 (15%)
FHA 532..636 CDD:238017 24/124 (19%)
Prefoldin 662..717 CDD:324325 18/78 (23%)
KIF1B 845..892 CDD:315155 10/46 (22%)
DUF3694 1266..1413 CDD:315198 22/146 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1550..1570 3/31 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1617..1660 6/42 (14%)
PH_KIFIA_KIFIB 1697..1799 CDD:269939 19/93 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2883
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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