DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cmet and Cenpe

DIOPT Version :9

Sequence 1:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster
Sequence 2:NP_776123.3 Gene:Cenpe / 229841 MGIID:1098230 Length:2471 Species:Mus musculus


Alignment Length:2544 Identity:645/2544 - (25%)
Similarity:1109/2544 - (43%) Gaps:554/2544 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SSIQVCIKVRPC-----EPG-LTSLWQVKERRSIHLADSHAEPYVFDYVFDEGASNQEVFDRMAK 65
            :|:.||::|||.     |.| .|.::...::.:|:.:|. .:.:.||.|||...:.:.|::.:|.
Mouse     5 ASVAVCVRVRPLNSREEELGEATHIYWKTDKNAIYQSDG-GKSFQFDRVFDSNETTKNVYEEIAV 68

  Fly    66 HIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETERDFLLRVGYIE 130
            .|:.:.:||:||||||||||:||||:||||.|...||:..|..:|||:|....||:|||||.|:|
Mouse    69 PIISSAIQGYNGTIFAYGQTASGKTHTMMGSEDCLGVIPRAIHDIFQRIKKFPEREFLLRVSYME 133

  Fly   131 IYNEKIYDLL--NKKNQDLKIHESGNGIVNVN--CEECIITSEVDLLRLLCLGNKERTVGETNMN 191
            ||||.|.|||  .:|.:.|.|.|..|..|.|:  .||.:.|:|: .|:.|..|.|.|..|.|.||
Mouse   134 IYNETITDLLCNAQKMKPLIIREDTNRTVYVSDLTEEVVYTAEM-ALKWLATGEKNRHYGITKMN 197

  Fly   192 ERSSRSHAIFKIIIESR-KSDHSD-DDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHINKSL 254
            :||||||.||::|:||| |::.|: |.:|..|.||||||||||||.||||.|.|||||..||::|
Mouse   198 QRSSRSHTIFRMILESREKAEPSNCDGSVKVSHLNLVDLAGSERAAQTGAEGVRLKEGCFINRNL 262

  Fly   255 LFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPSIMEESQSTLSFATRAK 319
            ..|..|||.||:.....|.||||||||||||.||||||.|.|||||.|:.::|:.:||.||:.||
Mouse   263 FILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPASLDETLTTLQFASTAK 327

  Fly   320 KIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQ-----------------QKVEHL 367
            .::..|.|||:.:|..::||..|||..|:.:|.|...|...|                 |||:  
Mouse   328 YMKNTPYVNEVSNDEALLKRYRREIADLRKQLEEVNTKTRAQEMEKDQLAQLLDEKDLLQKVQ-- 390

  Fly   368 ERQIKHDMHKIICGHSLSDKGQ----QKRRRTWC---------------PTASGSHLELAETGTT 413
            :.:|.:....::...|::.:.:    :|||.|||               ||:..:...  :|..|
Mouse   391 DEKINNLKRMLVTSSSIALQQELEIKRKRRVTWCYGKMKDSNYEKEFKVPTSITTRKR--KTSVT 453

  Fly   414 EDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSP 478
            ..|.:...|         |..|.|...::.:..|:..|..::..:.:..:|||.:.:|.....:.
Mouse   454 SLRENSLMK---------FGESAASSEFEMLNNTLESLAEVEWSSATTLLSEENVESELNSLNAQ 509

  Fly   479 RPDVLKPMLTIRQL----PDLPLTPKGPLTTDKIK-KEIQDLQMFTSLEKHFEVECE-----EVQ 533
            ..|:   :|...||    .||           |:| ||..:|:.|..||:..|.:.|     ||.
Mouse   510 YNDL---VLDYEQLRRENEDL-----------KLKLKEKNELEEFELLEQKEERDQEMQLMHEVS 560

  Fly   534 GLKEKLAEVTAQRDNLEQESLAEKERYDALEKEVTSLRADNEAANSK-----ISELEEKLSTLKQ 593
            .||..:........:||.:..::.:.....|:::.:|:...:|..|:     :|...:....|||
Mouse   561 NLKNLIKHAEEYNQDLENDLSSKVKLLKEKEEQIKNLQEYIDAQKSEKMKIDLSYTSDATEDLKQ 625

  Fly   594 TMRIMEVENQVAVGLEFEFEAHKKSSKLR---------VDDLLSALLEKESTIESLQKSLD---- 645
            .||.:...:.||:      :|.|:|:.||         :::|..:..:.||.|:..|:.|:    
Mouse   626 AMRTLSDLDTVAL------DAKKESAFLRSENLELKEKINELSDSRKQMESDIQMYQRQLEAKKK 684

  Fly   646 ---NLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIADLESKKN-SCECDQLRLEIV 706
               :|.:::....:|...||...:.:.:..:.      ||||.|.||:.:.| ..|..|...|.|
Mouse   685 MQTDLDKELQLAFQEISKLSALVDGKGLLSNL------ELEKRITDLQKELNKEAEEKQTLQEEV 743

  Fly   707 SVRDKLESVESAFNLASSEIIQKA-------TDCERLSKELSTSQN----------------AFG 748
            ::..:|:|:.|.......|:.:|:       |:.|:|..|::...:                |..
Mouse   744 NLLSELKSLPSEVETLRRELYEKSEELHIITTEREKLFSEMAHKDSRIQGLLEEIGNTRDDLATS 808

  Fly   749 QLQERYDALDQQWQAQQAGITTLHEKHEHVQEKYQKLQEEY----EQLESRARSASSAEFQRLQN 809
            ||..|  ..|.:|||.::....|..:|..|.|:.::|::|.    ::.||.|.|..|.:.: |.:
Mouse   809 QLSRR--GSDGEWQALESLHAELEHRHAGVLEERERLKQEIGALSKEAESLAFSLDSVKAE-LSH 870

  Fly   810 DNTKFQADIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLS 874
            ...:.:.......|||.:.:.:..|:::.:|:::.:..:...||.|:::.....:.:.:|...| 
Mouse   871 KTQELEQKTVEGQERLNKMEALREELESRDSSLQSVEKEKVLLTEKLQQALKEVKALTQEKKNL- 934

  Fly   875 NQLMESVQ-ENDALREEIKQRPTSHVEESMRSSGISSDFDEQKQDINLLHQFVQLSESVQQIEL- 937
            .||.||:| |.|.||.:|:..             ::.:.|.|:|.:|.|....|..|::..::: 
Mouse   935 KQLQESLQTERDQLRSDIQDT-------------VNMNIDTQEQLLNALESLKQHQETINMLKMK 986

  Fly   938 ----------------------QHHSGISRLFRA---------------NQMKLD---QSEPGLK 962
                                  |...||.....:               .|.|:|   |...||:
Mouse   987 AAEELSDNLHVKDRGGARDEAQQKMDGIDEQNESAHTLLGGGKDNEVTEEQRKIDSLMQENSGLQ 1051

  Fly   963 LCLESAEYIEEDNRQSDATEPI-----------CLKGFLKRHRFQIKRLSQEHVDMGEEK----- 1011
            ..|||.. .|::..:.|..|.|           .|:..|||.    :.::.:..|...||     
Mouse  1052 QTLESVR-AEKEQLKMDLKENIEMSIENQEELRILRDELKRQ----QEVAAQEKDHATEKTQELS 1111

  Fly  1012 RLLDIISQLEQEIEEKSALMEATEATINEMREQMTNLESALLEKSVIINKVEDYQRQIESLEKQN 1076
            |..:.:::.|:::|||:..::.|:..:...:|.|:.|::.:::...:.|:..:....:|.:|.:.
Mouse  1112 RTQERLAKTEEKLEEKNQKLQETQQQLLSTQEAMSKLQAKVIDMESLQNEFRNQGLALERVETEK 1176

  Fly  1077 AEMTM----VYEELQDRVTRESSMSESLLRVPPDEDTLPGCPTSPSRREQEVATLKTSITELQSQ 1137
            .|:..    .|||::. :|:|                                  :..:.|||..
Mouse  1177 LELAQRLHESYEEVKS-ITKE----------------------------------RNDLKELQES 1206

  Fly  1138 VSDLKAELENHLRQIQ-----------LKDGNIARLQTDFEEMSERCLSMEVRLAELDEDTKQKQ 1191
            ....|.:|:.:.|:|:           :...|:...|....|:.......|.:.|...:..|...
Mouse  1207 FEIEKKQLKEYAREIEAAGLQTKEELNIAHANLKEYQEIITELRGSISENEAQGASTQDTAKSAP 1271

  Fly  1192 ELLDRQAQKLSDDLCLIDQLQKKNAQLVE------QYHKATESLSLADAKPDQILLSSQY-DSQI 1249
            ||   |.:....:|..:.:..:.:|:.|.      .:.:...|:::...:.:.:.|:.:. :||:
Mouse  1272 EL---QGEVPEQELLPVVKEARHSAEKVNGLEPVGAHSRTVHSMTMEGIEIENLRLTKKLEESQM 1333

  Fly  1250 EKLNQLLNAAKDELHDVRRIKDDEISALRMEFLLQIE-TNEKENQAKFYAELQETKDRYESNVAE 1313
            |     ::....|..|:||.::          .||:| |..||:..:..|...||::  |.|:|.
Mouse  1334 E-----ISCLTREREDLRRTQE----------TLQVECTQLKEDARRTLANHLETEE--ELNLAR 1381

  Fly  1314 --LKEKLLQVEETLSSVTVRCQAELE------ALKSAHKENISQAVEERNNLIVQHQ-------- 1362
              |||:..:::..::|::.| :.||.      ||.:|..|...|.:.|:...:.:.:        
Mouse  1382 CCLKEQENKIDTLITSLSQR-ETELSSVRGQLALTTAELERKVQELCEKQEELTRKETSEAQGKM 1445

  Fly  1363 AEMETIRETLKNKLAEASTQQSKMEDAF-------------------RAEINEVRATLMEQLNQT 1408
            :|:|.:||.|   ||:||..|:...|..                   |.|:..::..|..:..|.
Mouse  1446 SELEQLRELL---LAQASALQNAESDRLRLNTQLEESQEEMKTLREEREELRRMQEALHVESEQQ 1507

  Fly  1409 KEDRDKGASKLEEVK---------KTLEQMINGGRVMSDTI-AELEKTKAEQDLAVNKLTKDNIE 1463
            ||...:.:|||:|::         ||:.: ..|.|...|.: .:||..|:    .:.|:..:|:.
Mouse  1508 KESMKEISSKLQELQNKEYECLAMKTINE-TQGSRCEMDHLNQQLEAQKS----TLEKVEMENVN 1567

  Fly  1464 LEKQCSKTQEQLQMESLTRDQI-SFEIEAHIKKLELIVASSKKRIIELEEKCDQQVLELDKCRLE 1527
            |.::..:|.|:::..:..||:: |.|....:::.:|     ||   .|||...:.:.:.::.|:.
Mouse  1568 LTQRLHETLEEMRSVAKERDELWSMEERLTVERDQL-----KK---SLEETVTKGMEKEEELRVA 1624

  Fly  1528 KLSLESEIQKANSEHSCTMEKLQEL-----------QAEMKVLSNRNEKEKCDFETKLETFTFKI 1581
            .:.||        ||..|:.||:::           |.::|..:...|.:..|...|....:...
Mouse  1625 HVHLE--------EHQETINKLRKMVSDYTDEISHTQGDLKHTNAVVEAQNQDLREKEHQLSQVK 1681

  Fly  1582 TDLEEV---LKEAQHKVILYDDLVSQHERLKICLAEANELSSNLQKKVMSLHTELIDSQKGISSR 1643
            .||.|.   :::.:.|:......:...|..|:.|.:  :|:.||:|  ::|.|:..||.|   ..
Mouse  1682 ADLRETVDQMEQLKKKLEAQSSTLESREIEKLELTQ--QLNENLKK--ITLVTKENDSLK---IM 1739

  Fly  1644 DVEINELREELKAAM---DAKATASAEQ-----MTLVTQLKDVEERMANQAEKFTREAANLKGSI 1700
            |..:.|.|::|:.::   :|:...:.|:     |.|....:.::..|...:|| |.|.:|:|..:
Mouse  1740 DEALREERDQLRKSLQQTEARDLENQEKLRIAHMNLKEHQETIDRLMETMSEK-TEEISNMKMEL 1803

  Fly  1701 NELLLKL-NSMQETK-----------DMLESGNEELKEQ-----------LRNSQNLRNMLDEES 1742
            ..:.:|| ..:||.|           |..|: .:|||||           |..:|.:...| ||.
Mouse  1804 ENVNMKLQEKVQELKTSERQRVKLKADASEA-KKELKEQGLTLSKIEMENLNLAQKIHENL-EEM 1866

  Fly  1743 KMCISLKEKLVKLEDAKTSLEQQLRDNKSE----IYQRHTELTK---------EVELGR-----N 1789
            |.....::.|.|||:.......||:||..|    .:|.|.|..|         |...||     .
Mouse  1867 KSVRKERDDLKKLEEILRMERDQLKDNLREAMLKAHQNHEETMKCGKGLLCAGEYCTGRLREKCF 1931

  Fly  1790 RIGELTKKCEELCSDLENSDQIRLDLQ-ETKEQLK----------------KTLENNLGWQQKVD 1837
            ||.:|.|:..|:.:|.|..:::.|||: |||.|.:                |.:|..|...|:..
Mouse  1932 RIEKLLKRYSEMANDYECLNKVSLDLERETKTQKELSVTVRTKLSLPHTQTKEMEKLLTANQRCS 1996

  Fly  1838 -EVTRECEKLRFDMQS----KEVQNES-------------KVQELISECEELRSTLKSKEASFQS 1884
             |..|..::|::.:.|    ||.|:||             |..||..:.:.|..|.:......|.
Mouse  1997 LEFHRALKRLKYVLSSIARIKEEQHESINKREMAFIQEVEKQNELQIQIQSLSQTYRIPARDLQI 2061

  Fly  1885 E-KESMDRTISSLLEDKRNLEEKLCSANDIVAKLETEI-AALRPRKSLDRNPVPRKSITFESE-- 1945
            : .:.||..|..:|:|        .|.||.:. ::||: ..|..||.:........:..|::|  
Mouse  2062 KLSQEMDLHIEEMLKD--------FSENDFLT-IKTEVQQVLNNRKEITEFLGKWLNTLFDTENL 2117

  Fly  1946 ---IRK-NRRISV----HDERRQSYWNDVREF----GIMTDPVDNNCNCAELNSKLQDCQRELFI 1998
               |:| |:.|.:    :..|..:..|:..||    ...:..:|      :....|::...:|..
Mouse  2118 KSTIQKENKSIGLVNNFYHSRITAMINESTEFEERSATRSKDLD------QYLKSLKETTEQLSE 2176

  Fly  1999 RESQVTALKMELDHHPLKDENAQLTKRVIEEQDKAKVEQKRLKMKLQDLNARINDLTTASAKEPE 2063
            ....:||.:..:..||....:.:.::|   .|..:..||...|.|:.        |.....||..
Mouse  2177 VYQTLTASQSVVHLHPTVQPSTRDSER---PQAASGAEQLTSKNKIA--------LGAVPYKEEI 2230

  Fly  2064 SNQMAQAAKPATVAAQTQTESDLETILEKTNVKYQEAVRMLRYRYHLIQELKEKLRQNENS-DTS 2127
            .:...|..|.......|..|.|.:.:..|..|::||         .:|:.|:|.||.::.: |||
Mouse  2231 EDLKMQLVKSDLEKKATAKEFDKKILSLKATVEHQE---------EMIRLLRENLRGHQQAQDTS 2286

  Fly  2128 NITS---------LSAGQTSALKAQCESQKKEILAIKYK---YEAAKRILAIRNDDLDALREKLA 2180
            .|:.         |:.|..|.:   .:|.|..||..:||   .|.:|  |..:|:.|.....:|.
Mouse  2287 MISEQDSQLLSKPLTCGGGSGI---VQSTKALILKSEYKRMGSEISK--LKQQNEQLRKQNNQLL 2346

  Fly  2181 KYETTTSDK 2189
            ...:..|::
Mouse  2347 SDNSQLSNE 2355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cmetNP_524993.3 KISc 8..328 CDD:214526 166/331 (50%)
Motor_domain 8..321 CDD:277568 165/324 (51%)
Smc <680..1449 CDD:224117 191/922 (21%)
TMPIT 779..>867 CDD:285135 17/91 (19%)
Smc 1042..1910 CDD:224117 225/1035 (22%)
CenpeNP_776123.3 KISc 6..336 CDD:214526 166/331 (50%)
KISc_CENP_E 6..329 CDD:276825 165/324 (51%)
SMC_prok_B 586..1436 CDD:274008 189/939 (20%)
DUF972 1041..>1119 CDD:283750 19/82 (23%)
SCP-1 1100..1841 CDD:114219 172/829 (21%)
SbcC 1570..2128 CDD:223496 141/592 (24%)
Kinetochore binding domain. /evidence=ECO:0000250|UniProtKB:Q02224 1959..2249 65/315 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2193..2214 4/23 (17%)
Globular autoinhibitory domain. /evidence=ECO:0000250 2283..2468 20/78 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2368..2438
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167830781
Domainoid 1 1.000 263 1.000 Domainoid score I1916
eggNOG 1 0.900 - - E2759_KOG0242
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 480 1.000 Inparanoid score I1448
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm43058
orthoMCL 1 0.900 - - OOG6_101662
Panther 1 1.100 - - LDO PTHR47968
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5166
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1110.790

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