DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and Kif18a

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	XP_006499322.1	Gene:	Kif18a / 228421	MGIID:	2446977	Length:	919	Species:	Mus musculus

Alignment Length:	1027	Identity:	245/1027 - (23%)
Similarity:	401/1027 - (39%)	Gaps:	294/1027 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IQVCIKVRPCEPGLTSLWQVKER-----RSIHLADSHA---EP---------------------- 43
            ::|.::|||        ...||:     :.:|:.|.|.   :|
Mouse    12 MKVVVRVRP--------ENTKEKAVQFCKVVHVVDKHILSFDPKQEEISFFHRKKTTNFDITKRQ 68

  Fly    44 -----YVFDYVFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVM 103
                 :|||.||||.::..|||:...|.|:|:.:.|:|.|:||||.|.||||:||:|....||||
Mouse    69 NKDLKFVFDAVFDETSTQMEVFEHTTKPILHSFLNGYNCTVFAYGATGSGKTHTMLGSAAEPGVM 133

  Fly   104 VLAAKEIFQQISS-ETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNVNCEECIIT 167
            .|...::|:.|.. :.|::....|.|:|:|||:|.|||..........:|..|:|..........
Mouse   134 YLTMLDLFKCIDEIKEEKECSTAVSYLEVYNEQIRDLLTNSGPLAVREDSQKGVVVQGLTLHQPK 198

  Fly   168 SEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSE 232
            |..::|:||..|||.||...|::|..||||||:|:|.:..:....|.:..|..:.::|:||||||
Mouse   199 SSEEILQLLDNGNKNRTQHPTDVNAVSSRSHAVFQIYLRQQDKTASINQNVRIAKMSLIDLAGSE 263

  Fly   233 RADQTGARGARLKEGGHINKSLLFLSNVIKSLSE-NADNRFTNYRDSKLTRILQASLGGNAFTSI 296
            ||..:||:|:|..||.:||||||.|.|||.:|:. ...|:...||:|||||:|:.|||||..|.:
Mouse   264 RASVSGAKGSRFVEGTNINKSLLALGNVINALANTKRRNQHIPYRNSKLTRLLKDSLGGNCQTIM 328

  Fly   297 ICTIKPSIM--EESQSTLSFATRAKKIR---------IKPQVNEMVSDATMMKRLEREIKVLKDK 350
            |..:.||.:  :::.:||.:|.|||:|:         :...:::.|....|.|   .||.:||:|
Mouse   329 IAAVSPSSLFYDDTYNTLKYANRAKEIKSSLKSNVLNLNSHISQYVKICNMQK---AEILMLKEK 390

  Fly   351 L-AEEERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTE 414
            | |.||:|                         :|||:..       |.....|:.|..||
Mouse   391 LKAYEEQK-------------------------ALSDRND-------CAKLVHSNPEDRET---- 419

  Fly   415 DRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPR 479
               ::|.::                        :|.|..     ....|.:|:|..|.:
Mouse   420 ---ERFQEI------------------------LNCLFQ-----NREGIRQEYLKLEML------ 446

  Fly   480 PDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTA 544
                                   |..:.:|.....     ...|..|:.|.|     :|:.:.|.
Mouse   447 -----------------------LKANALKSSYHQ-----QCHKQIEMMCSE-----DKVEKATC 478

  Fly   545 QRDNLEQESLAEKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVENQVAVGLE 609
            :||:          |.:.|:.....|....|..:.:..|....|..::..||::.....:...|.
Mouse   479 KRDH----------RLEKLKTNSCFLEKKKEEVSKQFDENTNWLHRVENEMRLLGQNGDIPEALN 533

  Fly   610 FEFEAH-----KKSSKLRVDDL--LSALLEKE--STIESLQKSLDNLTRDVLRNSKEGHMLSIAP 665
            .|...|     .|..|.::..:  |:.|.|::  .|...|...|..|.:...:..:.|  ||.|.
Mouse   534 KELHCHHLHLQNKELKTQMAHMTALACLQEQQHKQTEAVLNALLPVLRKQYWKLKETG--LSNAA 596

  Fly   666 EQEDIAGDSICNKCEELEKLIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKA 730
            ...|.         :::|.|:   |.||.....||....  |.|:.|..:.........|.||..
Mouse   597 FDSDF---------KDIEHLV---ERKKVVAWADQTNEH--SNRNDLPGISLLMTFPQLEPIQSI 647

  Fly   731 TDCERLS----------------------KELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHE 773
            :.|..:|                      |...|.::|..:..:..|:..::.|
Mouse   648 SCCTSVSDPNVLKLTPQRRTRRKIIPSPLKVQHTQKSALSESTQLNDSFSKELQ----------- 701

  Fly   774 KHEHVQEKYQKLQEEYEQLESRARSASSAEFQRLQNDNT-KFQADIASLNERLEEAQNMLT---- 833
            ...:..|..:|.|:.:..|     :.:|::...:.|||: |....|.|...|.|..|.:.:
Mouse   702 PIVYTPEDCKKAQDLFPSL-----TRTSSQSANVMNDNSQKALCRIESPLSRTECKQGLYSTSTL 761

  Fly   834 ---------------EVQNSESTVEKLRIQNHELTAKIKELE----------------------- 860
                           .:.:|:|:|.  ||::...:.|....|
Mouse   762 CDSIRGLKNKWPEQEPLASSKSSVH--RIESSSFSTKDSMPESAGVPSYMAMTTAAKRKWKQMSS 824

  Fly   861 TNFEEMQREYDC-------LSNQLMESVQENDALREEIKQRPTSHVEESMRS 905
            |:...::.:..|       ..|..::.:|||..  :.||:.||..::..:.:
Mouse   825 TSNASIKSDESCGFAKRIRRDNSSVKPMQENRL--KAIKEIPTKQIQTCLEN 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	131/366 (36%)
		Motor_domain	8..321	CDD:277568	130/350 (37%)
		Smc	<680..1449	CDD:224117	51/298 (17%)
		TMPIT	779..>867	CDD:285135	22/130 (17%)
		Smc	1042..1910	CDD:224117
Kif18a	XP_006499322.1	KISc_KIP3_like	11..355	CDD:276821	130/350 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810