DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and KIF6

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	XP_005248961.1	Gene:	KIF6 / 221458	HGNCID:	21202	Length:	842	Species:	Homo sapiens

Alignment Length:	1026	Identity:	247/1026 - (24%)
Similarity:	416/1026 - (40%)	Gaps:	322/1026 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SIQVCIKVR-PCEPGLTSLWQVKERRSI----------HLAD----SHAEPYVFDY--VFDEGAS 55
            :||:..:|: |.......::.:.|...:          .|||    :..|.|.|.:  :||:.|:
Human     5 TIQIFARVKPPVRKHQQGIYSIDEDEKLIPSLEIILPRDLADGFVNNKRESYKFKFQRIFDQDAN 69

  Fly    56 NQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQ---NPGVMVLAAKEIFQQISSE 117
            .:.||:.:||.:..:.:.|:||||||||||.||||:|:.|..:   :.|::......||:|:..:
Human    70 QETVFENIAKPVAGSVLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTLSYIFEQLQKD 134

  Fly   118 TERDFLLRVGYIEIYNEKIYDLLNKKNQ----------------DLKIHESGNGIVNVNCEECII 166
            :.:.:...:.|:|||||..||||:.:::                |..||     :.|:...:.
Human   135 SSKIYTTHISYLEIYNECGYDLLDPRHEASSLEDLPKVTILEDPDQNIH-----LKNLTLHQA-- 192

  Fly   167 TSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGS 231
            |:|.:.|.||.||:..|.:.||.||:.|:|||.||.|.:.|::...:   .|..:.|:|||||||
Human   193 TTEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTIHLSSKEPGSA---TVRHAKLHLVDLAGS 254

  Fly   232 ERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSI 296
            ||..:||..|..|.|..:||.||.:|..||.:|||...:... ||:|.:|.:|:.|||||..|::
Human   255 ERVAKTGVGGHLLTEAKYINLSLHYLEQVIIALSEKHRSHIP-YRNSMMTSVLRDSLGGNCMTTM 318

  Fly   297 ICT--IKPSIMEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLA--EEERK 357
            |.|  ::...::||.||..||.|...|:.:..:||.::...::|||::||:.|||:||  ..|::
Human   319 IATLSLEKRNLDESISTCRFAQRVALIKNEAVLNEEINPRLVIKRLQKEIQELKDELAMVTGEQR 383

  Fly   358 NENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPK 422
            .|...:.|.|:      :.|:|... |.|:.            |.|.||:..         ...|
Human   384 TEALTEAELLQ------LEKLITSF-LEDQD------------SDSRLEVGA---------DMRK 420

  Fly   423 VSHLPKPVFFHTSNAGKRWDNIPKTIN---ILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLK 484
            |.|.     ||         ::.|.:|   ||       |:|::|.|....:|
Human   421 VHHC-----FH---------HLKKLLNDKKIL-------ENNTVSSESKDQDC------------ 452

  Fly   485 PMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDN- 548
                           :.||..::.:                            ||.::..||||
Human   453 ---------------QEPLKEEEYR----------------------------KLRDILKQRDNE 474

  Fly   549 -------LEQES--------LAEKERYDALEKEVTSLRADN--EAANSKISE----------LEE 586
                   |::|.        ||..:|.:..:.:....|..|  |....::|.          |.:
Human   475 INILVNMLKKEKKKAQEALHLAGMDRREFRQSQSPPFRLGNPEEGQRMRLSSAPSQAQDFSILGK 539

  Fly   587 KLSTLKQTMRIMEVENQVAVGLEFEFEAHKK--SSKLRVDDLLSALLEKESTIESLQKSLDNLTR 649
            :.|.|.:.:.:.|   ::::|.:..||..|:  :..:.:||....|.::.|..::|.:|::.
Human   540 RSSLLHKKIGMRE---EMSLGCQEAFEIFKRDHADSVTIDDNKQILKQRFSEAKALGESINE--- 598

  Fly   650 DVLRNSKEGHM---------------------LSIAPEQEDIAGDSICNKCEELEKLIADLESKK 693
               ..||.||:                     :.:.|:|::             |||.:.||.:|
Human   599 ---ARSKIGHLKEEITQRHIQQVALGISENMAVPLMPDQQE-------------EKLRSQLEEEK 647

  Fly   694 NSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALD 758
            .       |.:.:..|.|...||       .|.:|...|..::            :||:.::.
Human   648 R-------RYKTMFTRLKALKVE-------IEHLQLLMDKAKV------------KLQKEFEV-- 684

  Fly   759 QQWQAQQA--------GITTLHEKHEHVQEKYQKLQEEYEQLESRARSASSAEFQRLQNDNTKFQ 815
              |.|::|        .:.:|......:|.  ...|.|:.||.|. :|:...|.|    |....:
Human   685 --WWAEEATNLQVNSPAVNSLDHTKPFLQT--SDSQHEWSQLLSN-KSSGGWEVQ----DQGTGR 740

  Fly   816 ADIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLMES 880
            .|:..:|.|                                |.|.:         .|.|....:.
Human   741 FDVCDVNAR--------------------------------KILPS---------PCPSPHSQKQ 764

  Fly   881 VQENDALREEIKQRPTSHVE---ESMRSSGISSDFDEQKQDINLLHQFVQL 928
            ...:..|.:.|.:||.|.:.   :|...|.|.: |.:.:|.| |..|::||
Human   765 SSTSTPLEDSIPKRPVSSIPLTGDSQTDSDIIA-FIKARQSI-LQKQYLQL 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	120/357 (34%)
		Motor_domain	8..321	CDD:277568	119/350 (34%)
		Smc	<680..1449	CDD:224117	52/260 (20%)
		TMPIT	779..>867	CDD:285135	15/87 (17%)
		Smc	1042..1910	CDD:224117
KIF6	XP_005248961.1	Motor_domain	5..343	CDD:277568	119/348 (34%)
KIF6	XP_005248961.1	Kinesin	11..345	CDD:278646	117/344 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900