Protein Alignment cmet and klp-18

DIOPT Version :9

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: NP_501093.1
• Gene: klp-18 / 177474
• WormBaseID: WBGene00002228
• Length: 932
• Species: Caenorhabditis elegans
• Alignment Length: 1191
• Identity: 280/1191 - (23%)
• Similarity: 487/1191 - (40%)
• Gaps: 361/1191 - (30%)

  Fly    38 DSHAEPYVFDYVFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMG------D 96
            |:.::.|...::||..:|.::||..:||.||..|::|:|||:||||||.||||:||:|      |
 Worm    36 DNGSKRYELHHIFDSSSSQEDVFGTVAKKIVEDCVEGYNGTVFAYGQTGSGKTHTMLGPCDSWTD 100

  Fly    97 EQNPGVMVLAAKEIFQQISSETER----DFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIV 157
            ::..|::..:.:.:||.:.::.:.    .|.:.|.::|:|||.||||||.||: :::.:||..|.
 Worm   101 QELMGLIPRSVEHVFQHLDTKAKECQKLTFSVSVEFVELYNEVIYDLLNAKNK-VQLRDSGKDIQ 164

  Fly   158 NVNCEECIITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQ-- 220
            .|......:.:.:||:.|:..|.:||:.|.|.||..||||||:..|.|   |:.....:.|.:
 Worm   165 LVGALSKNVDNPLDLMHLVQKGWQERSTGSTAMNAESSRSHALLIIRI---KTQERTGELVKERS 226

  Fly   221 SVLNLVDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADNR-FTNYRDSKLTRIL 284
            |:|||||||||||...|.:.|.||||..:||.||..|...|:.|::.:..: ...||||.||.||
 Worm   227 SILNLVDLAGSERQTHTKSSGDRLKEATNINSSLTVLGRCIRLLADPSKAKGHVPYRDSHLTHIL 291

  Fly   285 QASLGGNAFTSIICTIKP--SIMEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVL 347
            :.|||||:.|::|..:.|  ...:||.|||.||                ...||:..:     ..
 Worm   292 KNSLGGNSKTAVIVNMHPDRDFAQESNSTLMFA----------------QSCTMIMNI-----AT 335

  Fly   348 KDKLAEEERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGT 412
            ::::...::::..::.::.|.:::              |:.::|.|     |...|.|:.||
 Worm   336 RNEVMTGDQESSYKKAIQELRQEV--------------DETREKVR-----TEFASQLDEAE--- 378

  Fly   413 TEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNI---PKTINILGSLDIGTESNSISEEFLPAECID 474
                ::|          :...|.|...|.:|:   .|....|....||:|:..|..||
 Worm   379 ----VEQ----------LRLKTENNSLRLENVDLRAKYDFALLKYTIGSENEQIVNEF------- 422

  Fly   475 FGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKL 539
                                              ||.|.:   |::.......||
 Worm   423 ----------------------------------KKIISE---FSAANSSSPFEC---------- 440

  Fly   540 AEVTAQRDNLEQESLAEKERYDALEKEVTSLRADNEAANSKISELEEKL--STLKQTMRIMEVEN 602
              :..:...|:.|..|.::||..|:||.::||          :..:|.|  :.|.||....|
 Worm   441 --IALKNQTLQLEIEASEKRYQELQKETSALR----------NRYQENLDATILMQTPSAKE--- 490

  Fly   603 QVAVGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQ 667
                        .:.||:.:                         .|:.........|...|
 Worm   491 ------------RRSSSRPK-------------------------RRETQYRPSPARMALFA--- 515

  Fly   668 EDIAGDSICNKCEELEKLIADLESKKNSCECDQLRLEIVSVRDKLE-----SVESAFNLASSEII 727
                      :.|..|..:.||:     |:.::|..|:.|::||.|     |:|:. .|...||:
 Worm   516 ----------EVETSEDAVLDLQ-----CQNEKLSCELSSLKDKHEEATSKSIETE-RLLQGEIV 564

  Fly   728 QKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKHEHVQEKYQKLQE-EYEQ 791
            ....:...:|:.|..|:......:|:..|.:          .||.:...|:....:::.| |...
 Worm   565 ALQKEVSIVSESLRKSEAVAEGYKEKVTANN----------LTLDKLLLHIDASRKRIAELELSS 619

  Fly   792 LESRARSASSAEFQRL------QNDNTKFQADIASLNERLEE---AQNML----TEVQNSESTVE 843
            .||..||:...|.|||      ::...|...:.|:|.|.|.:   :.|:|    .|:|.|.:|::
 Worm   620 KESENRSSEELEEQRLYYVSMIEDLERKASDEYAALREELNQKTLSSNLLQVQVDELQLSNATIK 684

  Fly   844 KLRIQNHELTAK---IKELETNFEEMQREYDCLSNQLMESVQENDALREEIKQRPTSHVEESMRS 905
            ||   |.:|:.|   |:.||.:.|:        .:|::..::|...|...
 Worm   685 KL---NADLSTKAGLIRSLEDSIEK--------KSQMITRLEEQAVLDSS--------------- 723

  Fly   906 SGISSDFDEQKQDINLLHQFVQLSESVQQIELQHHSGISRLFRANQMKLDQSEPGLKLCLESAEY 970
                                 :||.:.:|:|   ||.                      ||:.::
 Worm   724 ---------------------ELSSTKRQLE---HSR----------------------LEAIQW 742

  Fly   971 --IEEDNRQSDATEPICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQEIEEKSALMEA 1033
              |.|:...:..|:       ||.|        |:.:|....|:.|:|.| ::..::..:|.::.
 Worm   743 RKISEETTSAMQTQ-------LKDH--------QKDIDQCRHKKKLEIQS-MQLSLDNANARVKE 791

  Fly  1034 TEATINEMRE--------QMTNLESALLEK-SVIINKVED---------YQRQIESLEKQNAEMT 1080
            :||.:.:::.        :|:.:|:...|| ||.:.|.||         .|.::|.:|.:|..::
 Worm   792 SEAMMKKLQNDEKQKFDMKMSEIENTFKEKLSVSLKKQEDTIRRQSLAENQGKLEVMENKNRVLS 856

  Fly  1081 MVYEELQDRVTRESSMSESLLRVPPDEDTLPGCPTSPSRREQEVATLKTSITELQSQVSDLKAEL 1145
            ...|.||.:.::::.:..:.||...|             |...|..|:.....|:..:|.|::|.
 Worm   857 ETIESLQSQHSQDTEVINAGLRTRGD-------------RVGYVDKLRVEKKALEETISQLRSEN 908

  Fly  1146 ENHLRQIQLKDGN--IARLQT 1164
            :...:.::.:..|  :.|.||
 Worm   909 DKLKKIMRGESANKPVLRSQT 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	119/304 (39%)
		Motor_domain	8..321	CDD:277568	119/297 (40%)
		Smc	<680..1449	CDD:224117	110/529 (21%)
		TMPIT	779..>867	CDD:285135	30/104 (29%)
		Smc	1042..1910	CDD:224117	30/143 (21%)
klp-18	NP_501093.1	KISc	5..328	CDD:276812	119/311 (38%)
		SbcC	342..913	CDD:223496	155/842 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000