DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and unc-116

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_001370811.1	Gene:	unc-116 / 176179	WormBaseID:	WBGene00006840	Length:	815	Species:	Caenorhabditis elegans

Alignment Length:	916	Identity:	249/916 - (27%)
Similarity:	400/916 - (43%)	Gaps:	212/916 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IQVCIKVRPCEPGLTSLWQVKERR------------SIHLADSHAEPYVFDYVFDEGASNQEVFD 61
            :||..::||       |.:.:|:.            ||.|.   .:.||||.||....:.::|:.
Worm    12 VQVFCRIRP-------LNKTEEKNADRFLPKFPSEDSISLG---GKVYVFDKVFKPNTTQEQVYK 66

  Fly    62 RMAKHIVHACMQGFNGTIFAYGQTSSGKTYTM---MGDEQNPGVMVLAAKEIFQQISSETER-DF 122
            ..|.|||...:.|:|||:|||||||||||:||   :||....|::.....:||..|.|..|. .|
Worm    67 GAAYHIVQDVLSGYNGTVFAYGQTSSGKTHTMEGVIGDNGLSGIIPRIVADIFNHIYSMDENLQF 131

  Fly   123 LLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCEECIITSEVDLLRLLCLGNKERTVG 186
            .::|.|.|||||||.|||:.:..:|.|||..|.:..| ...|..:....::|:.:..|...|.|.
Worm   132 HIKVSYYEIYNEKIRDLLDPEKVNLSIHEDKNRVPYVKGATERFVGGPDEVLQAIEDGKSNRMVA 196

  Fly   187 ETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHIN 251
            .|||||.|||||::|.|.:   |.:|......:...|.||||||||:..:|||:|..|:|..:||
Worm   197 VTNMNEHSSRSHSVFLITV---KQEHQTTKKQLTGKLYLVDLAGSEKVSKTGAQGTVLEEAKNIN 258

  Fly   252 KSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPSIMEESQ--STLSF 314
            |||..|..||.:|:|...:. ..|||||||||||.|||||:.|::|....||...|::  |||.|
Worm   259 KSLTALGIVISALAEGTKSH-VPYRDSKLTRILQESLGGNSRTTVIICASPSHFNEAETKSTLLF 322

  Fly   315 ATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQKVEHLERQIKHDMHKII 379
            ..|||.|:...|:||.::.....:|.|:|              .|...::..|.:....::.:..
Worm   323 GARAKTIKNVVQINEELTAEEWKRRYEKE--------------KEKNTRLAALLQAAALELSRWR 373

  Fly   380 CGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNI 444
            .|.|:|:                                                    ..|.|:
Worm   374 AGESVSE----------------------------------------------------VEWVNL 386

  Fly   445 PKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIK 509
            ..:..:..| ::...|..:.|..:        :|.|    ||||         :..||:|.::.|
Worm   387 SDSAQMAVS-EVSGGSTPLMERSI--------APAP----PMLT---------STTGPITDEEKK 429

  Fly   510 K-EIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKERYDALEKEVTSLRAD 573
            | |.:.::::..|::    :.:|:|.:.::|       :.|.|:.|.::|....:.:....:|.:
Worm   430 KYEEERVKLYQQLDE----KDDEIQKVSQEL-------EKLRQQVLLQEEALGTMRENEELIREE 483

  Fly   574 NEAANSKISELEEKLSTLKQTMRIMEVENQVAVGLEF-EFEAHKKSSKLRVDDLLSALLEKESTI 637
            |   |....|.|:|....|:.|..:|   ::||.|:. :.|..|...:|.|      :.|...::
Worm   484 N---NRFQKEAEDKQQEGKEMMTALE---EIAVNLDVRQAECEKLKRELEV------VQEDNQSL 536

  Fly   638 ESLQK---SLDNLTRD----VLRNSKEG--------HMLSIAPEQEDIAGDSICNKCE-ELEKLI 686
            |....   ||.|...|    .:|:.|||        ::..||.:.:.:....:.|... .:.||.
Worm   537 EDRMNQATSLLNAHLDECGPKIRHFKEGIYNVIREFNIADIASQNDQLPDHDLLNHVRIGVSKLF 601

  Fly   687 ADLESKKNSCECDQLRLEIVSVRD--KLESVESAFNL--------ASSEIIQKATDCERLSKELS 741
            ::..:.|.|....:...|.....|  ::||.:.|..:        |:.| |:..||  |::.||:
Worm   602 SEYSAAKESSTAAEHDAEAKLAADVARVESGQDAGRMKQLLVKDQAAKE-IKPLTD--RVNMELT 663

  Fly   742 TSQN-------------AFGQLQERYDALD-----QQWQAQQAGITTLHEKHEHVQEKYQKLQEE 788
            |.:|             ...|..|..|:|.     |:.|..:..:..|.:.|:.:......|:.|
Worm   664 TLKNLKKEFMRVLVARCQANQDTEGEDSLSGPAQKQRIQFLENNLDKLTKVHKQLVRDNADLRVE 728

  Fly   789 YEQLESRAR----------SASSAEFQRLQNDNTKFQADIASLNERLEEA---QNMLTEVQNSES 840
            ..::|:|.|          :|.....||.|.:..|:|.::    ||::||   :||  ...|:..
Worm   729 LPKMEARLRGREDRIKILETALRDSKQRSQAERKKYQQEV----ERIKEAVRQRNM--RRMNAPQ 787

  Fly   841 TVEKLR 846
            .|:.:|
Worm   788 IVKPIR 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	138/337 (41%)
		Motor_domain	8..321	CDD:277568	136/330 (41%)
		Smc	<680..1449	CDD:224117	47/209 (22%)
		TMPIT	779..>867	CDD:285135	20/81 (25%)
		Smc	1042..1910	CDD:224117
unc-116	NP_001370811.1	KISc_KHC_KIF5	9..329	CDD:276820	136/330 (41%)
unc-116	NP_001370811.1	SMC_prok_A	440..>782	CDD:274009	81/373 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910