DRSC/TRiP Functional Genomics Resources

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Protein Alignment cmet and unc-104

DIOPT Version :9

Sequence 1:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster
Sequence 2:NP_001022041.2 Gene:unc-104 / 174144 WormBaseID:WBGene00006831 Length:1628 Species:Caenorhabditis elegans


Alignment Length:1849 Identity:405/1849 - (21%)
Similarity:708/1849 - (38%) Gaps:530/1849 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SSIQVCIKVRPC---EPGLTS--LWQVKERRSI---HLADSHAEPYVFDYVFDEGASN------- 56
            ||::|.::|||.   |...||  :.||....:.   |..:.....:.||:.:...|.|       
 Worm     2 SSVKVAVRVRPFNQREISNTSKCVLQVNGNTTTINGHSINKENFSFNFDHSYWSFARNDPHFITQ 66

  Fly    57 QEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNP---GVMVLAAKEIFQQISSET 118
            ::|::.:...::....:|:|..|||||||.|||:|||||...:|   |::.....::|.:|.:..
 Worm    67 KQVYEELGVEMLEHAFEGYNVCIFAYGQTGSGKSYTMMGKANDPDEMGIIPRLCNDLFARIDNNN 131

  Fly   119 ERD--FLLRVGYIEIYNEKIYDLLN-KKNQDLKIHES---GNGIVNVNCEECIITSEVDLLRLLC 177
            ::|  :.:.|.|:|||.|::.|||| ....:|::.|.   |..:.::.  :..:.|..|:..|:.
 Worm   132 DKDVQYSVEVSYMEIYCERVKDLLNPNSGGNLRVREHPLLGPYVDDLT--KMAVCSYHDICNLMD 194

  Fly   178 LGNKERTVGETNMNERSSRSHAIFKIII-ESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARG 241
            .|||.|||..||||..||||||:|.|:: :.|....|:.|....|.::||||||||||:.|||.|
 Worm   195 EGNKARTVAATNMNSTSSRSHAVFTIVLTQKRHCADSNLDTEKHSKISLVDLAGSERANSTGAEG 259

  Fly   242 ARLKEGGHINKSLLFLSNVIKSLSENADNRFTN------YRDSKLTRILQASLGGNAFTSIICTI 300
            .|||||.:|||||..|..||..|:|.:..:..:      ||||.||.:|:.:||||:.|:::..:
 Worm   260 QRLKEGANINKSLTTLGLVISKLAEESTKKKKSNKGVIPYRDSVLTWLLRENLGGNSKTAMLAAL 324

  Fly   301 KPSIM--EESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREI----KVLKDK---LAEEER 356
            .|:.:  :|:.|||.:|.|||:|..:..||| ..:|.:::.|..|:    .:||||   :.:.:.
 Worm   325 SPADINFDETLSTLRYADRAKQIVCQAVVNE-DPNAKLIRELNEEVIKLRHILKDKGIDVTDVQE 388

  Fly   357 KNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSH--------------LEL 407
            .....:|...|...:...:.|:    ..|:|...:..:||......:.              |..
 Worm   389 TPGKHKKGPKLPAHVHEQLEKL----QESEKLMAEIGKTWEQKLIHTEEIRKQREEELRDMGLAC 449

  Fly   408 AETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAEC 472
            ||.|||   :..|.     ||              .:|..:|             ::|:.|.:||
 Worm   450 AEDGTT---LGVFS-----PK--------------KLPHLVN-------------LNEDPLMSEC 479

  Fly   473 IDF---------GSP----RPDVLKPMLTIRQLPDLPLTPKGPLT-TDKIKKE--IQDLQMFTSL 521
            :.:         |.|    |||:|.....|.:|....:...|.:| |.|....  |...|:.|..
 Worm   480 LIYYLKEGVTSVGRPEAEHRPDILLSGEAILELHCEFINEDGNVTLTMKPNASCYINGKQVTTPT 544

  Fly   522 EKHFEVECEEVQGLKEKLAEVTAQRDNLEQE---------SLAEK------ERYDALEKEVTSLR 571
            ..|        .|.:..|.|....|.|..||         ::||:      .:.:.|:|:...|:
 Worm   545 VLH--------TGSRVILGEHHVFRYNDPQEARQSRHNLAAIAEQPIDWKYAQQELLDKQGIDLK 601

  Fly   572 ADNEAANSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDD-LLSALLEKES 635
            ||          :|:|:                     .|.|:..:..|:.::. :.....|.||
 Worm   602 AD----------MEKKM---------------------LEMESQYRREKVELEQKMYHQTREYES 635

  Fly   636 TIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIADLESKKNSCECDQ 700
            .||:|||.:| |.:..:  |..|.:.    |.|.:...|:....|||:            ...||
 Worm   636 MIENLQKQVD-LAQSYI--SGGGSIW----EGERMLTSSLLEFPEELK------------WTSDQ 681

  Fly   701 LRL-----------EIVSVRDKLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERY 754
            .|:           :..||||         :|..:.|..|  :...:|.||.             
 Worm   682 KRVVLKAAIKWRYHQFTSVRD---------DLWGNAIFVK--EANAISVELK------------- 722

  Fly   755 DALDQQWQAQQAGITTLHEKHEHVQEKYQKLQEEY----EQLESR--ARSASSAEFQRLQNDNTK 813
                ::.|.|.|.:|         ...|..|..:.    |.|..|  .::..:.:.|.|:|..|.
 Worm   723 ----KKVQFQFALLT---------DTMYSPLPPDLLPPGEDLTLRPYPKTVVAIQVQDLKNGATH 774

  Fly   814 FQADIASLNERLEEAQNMLTEVQNSESTVEKLRI-QNHELTAKIKELETNFEEMQREYDCLSN-- 875
            :.: |..|.:|||:                 :|| .|.||:.....::..:..:...:....|  
 Worm   775 YWS-IEKLKQRLED-----------------MRIFYNSELSVAGTPVDVPYPPVAEGWLAALNRN 821

  Fly   876 --QLMESVQENDALRE----EIKQRPTSHVEESMRSSGISSD--FDEQKQDINLLHQFVQLSESV 932
              :|:...|..:|:|:    :.:..|..  .:.|..:.:.:|  :|.......:...||.|:..:
 Worm   822 SARLIPDRQRLEAMRDMYETDAEMSPAD--GDPMMDALMGTDPFYDRFPWFRMVGRAFVYLNNLL 884

  Fly   933 QQIELQHHSGISRLFRANQMKLDQSEPG-----LKLCLESAEYIEEDNRQSDATEPICL----KG 988
            ..:.|.|...:            .:|.|     ||:.:|..:..|..|::....:...|    :.
 Worm   885 HNVPLIHKVAV------------VNEKGEVKGYLKVAIEPVQKDEVINQKKGVRQTAKLHFRKED 937

  Fly   989 FLKRHRFQIKRLSQEHVDMGE--EKRLLDIISQLEQEIE--EKSALMEATEA--TINEM------ 1041
            |||.|:            .||  :...|.....:::|:|  .:..:::|.:.  |.:::      
 Worm   938 FLKSHK------------NGETSDSDALAFPEHMQEEVEFCFRVVVLQAIDVADTYSDVFCQFNF 990

  Fly  1042 ---------REQMTNLESAL-----------LEKS---------VIINKVEDYQRQIE--SLEKQ 1075
                     .|.|.|.:|.|           :.|:         :|......:|.:.|  :.|:|
 Worm   991 LHRHDEAFSTEPMKNSKSPLTFEHTQNLHIKMSKTFLHYLHHFPIIFEVFGHFQPKSEQFNFERQ 1055

  Fly  1076 NAEMTMVYEELQDRVTRESSMSESLLRVPPDEDTLPGCPTSPSRREQEVATLKTSITELQSQVSD 1140
            |:       .|..|::.:.:..:..|.:           ::|.:.::..|.::.:...::|: .|
 Worm  1056 NS-------ALGRRLSTKLTFQQPSLVI-----------STPVKSKKANAPIQNNNASVKSK-HD 1101

  Fly  1141 LK-----AELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDEDTKQKQELLDRQAQK 1200
            |.     .||.|:...:.....:...|.|....:..:.:...:::....|    |.||..:..|:
 Worm  1102 LLVWFEICELANNGEYVPTIVDHAQGLPTHGIFLLHQGIQRRIKITICHE----KGELKWKDCQE 1162

  Fly  1201 L-------------SDDLCLIDQLQ-----------KKNAQLVEQYHKATES-------LSLADA 1234
            |             .||   :|.|.           ..:.:...|:..|.:|       |:....
 Worm  1163 LVVGRIRAGPEWAGGDD---VDVLSLGLFPGTFMEFSMDDRTFFQFEAAWDSSLHNSPLLNRVSN 1224

  Fly  1235 KPDQILLSSQYDSQIEKLNQLLNAAKDELHDVRRIKDDEISALR---MEFLLQIETNEKENQAKF 1296
            ..|||.::.....:::...|.....|| |..:...:|.:|||..   ...:..|..:.:.|:...
 Worm  1225 YGDQIYMTLSAYMELDGCAQPAVVTKD-LCLLIYARDSKISAASRFCRSLVGGISKSPEMNRVPG 1288

  Fly  1297 YAELQETKDRYESNVAELKEKLLQVEETLSSVTVRCQAELEALKSAHKENISQAVEERNNLIVQH 1361
            ..:|. .||..:|.....:.::|..    ||..||           .:||:.|.....::||.:|
 Worm  1289 VYQLC-LKDGSDSGAIRRQRRVLDT----SSAYVR-----------GEENLGQWRPRGDSLIFEH 1337

  Fly  1362 QAEME---------------TIRETLKNK--LAEASTQQS------------KMEDAFRAEINEV 1397
            |.|:|               .:|:.||.|  ..||.|..|            |:::..:..:.:|
 Worm  1338 QWELEKLTRLQQVERVRLFLRLRDRLKGKKNKGEARTPVSPCDPVCAIPESIKLDEKDKGIVGKV 1402

  Fly  1398 RATLMEQL---------NQTKEDRDKGASKLEEVKKTLEQMINGGRVMSDTIAELEKTKAEQDLA 1453
            ...:..::         |:.:|..|:..|.......:.:.:|...| .||.:.. :|:|::|:||
 Worm  1403 LGLIRRKIPMNKDPPTGNKAQELSDESGSNSITSPVSDKSLIKSSR-SSDLLCR-QKSKSDQNLA 1465

  Fly  1454 VNKLTKDNIELEKQCSKTQEQLQMESLTRDQISFEIEAHIKKLELIVASSKKRIIELEEKCD--- 1515
            .|....||:...|:.......||:..|..:.:...:.        :|.|.|..:..||||..   
 Worm  1466 SNDDIVDNLGGMKRSLSGSRILQLNILVPEVLEERVG--------VVVSKKGYMNFLEEKTQGWT 1522

  Fly  1516 ----------------------QQVLELDKCRLEKLSLESEIQKA-----NSEHSCTMEK----- 1548
                                  :.::.|...|:|    .||.|:|     |:...||.::     
 Worm  1523 RRWVIVRRPYILLFRDDRDLVIRGIINLANARIE----HSEDQQAMVKVPNTFSVCTNQRGFLMQ 1583

  Fly  1549 -------------LQELQA-EMKVLSNRN 1563
                         :..|.| :||:..|:|
 Worm  1584 MMPGDEMYDWLYAINPLMAGQMKLHGNQN 1612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cmetNP_524993.3 KISc 8..328 CDD:214526 127/352 (36%)
Motor_domain 8..321 CDD:277568 126/345 (37%)
Smc <680..1449 CDD:224117 162/925 (18%)
TMPIT 779..>867 CDD:285135 19/94 (20%)
Smc 1042..1910 CDD:224117 123/670 (18%)
unc-104NP_001022041.2 KISc_KIF1A_KIF1B 2..354 CDD:276816 128/353 (36%)
KISc 3..354 CDD:214526 127/352 (36%)
Kinesin_assoc 351..488 CDD:292801 32/176 (18%)
FHA 464..563 CDD:238017 26/119 (22%)
KIF1B 829..874 CDD:289208 7/46 (15%)
DUF3694 1162..1261 CDD:289256 16/102 (16%)
PH_KIFIA_KIFIB 1500..1602 CDD:269939 18/113 (16%)
PH 1505..1602 CDD:278594 17/100 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2883
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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