DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and Kif6

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	XP_006244542.1	Gene:	Kif6 / 171291	RGDID:	621070	Length:	802	Species:	Rattus norvegicus

Alignment Length:	959	Identity:	234/959 - (24%)
Similarity:	409/959 - (42%)	Gaps:	253/959 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SIQVCIKVRPC----EPGLTSLWQVKERRSI-------HLAD----SHAEPYVFDY--VFDEGAS 55
            :||:..:|:|.    :.|:.|:.:.::..|.       .|||    :..|.|.|.:  :||:.|.
  Rat     5 TIQIFARVKPSVRKQQQGIYSIDEDEKLASSLEIVLPRDLADGFVNNKRESYKFKFQRIFDQEAK 69

  Fly    56 NQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQ---NPGVMVLAAKEIFQQISSE 117
            .:.:|:.:||.:..:.:.|:||||||||||.||||:|:.|..:   :.|::......||:|:..:
  Rat    70 QEIIFEIIAKPVAESTLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTLSYIFEQLQKD 134

  Fly   118 TERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIV------NVNCEECII---TSEVDLL 173
            :.:.:...:.|:|||||..||||:.:::..|:.:.....:      |::.:...:   |:|.:.|
  Rat   135 SSKIYTTHISYLEIYNECGYDLLDPRHEASKLEDLPKVTILEDPDQNIHLKNLSLHQATTEEEAL 199

  Fly   174 RLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTG 238
            .||.||:..|.:.||.||:.|:|||.||.:.:.|::...:   .|..:.|:|||||||||..:||
  Rat   200 NLLFLGDTNRMIAETPMNQASTRSHCIFTVHLSSKEPGSA---TVRHAKLHLVDLAGSERVSKTG 261

  Fly   239 ARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTI--- 300
            ..|..|.|..:||.||.:|..||.:|||....... ||:|.:|.:|:.|||||..|::|.|:
  Rat   262 VGGLLLTEAKYINLSLHYLEQVIIALSEKHRTHIP-YRNSMMTSVLRDSLGGNCMTTMIATLSLE 325

  Fly   301 KPSIMEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLA--EEERKNENQQK 363
            |.:| :||.||..||.|...|:.:..:||.:....|:.||::||..||.:||  ..|::.|...:
  Rat   326 KRNI-DESISTCRFAQRVALIKNEAILNEEIDPRLMIVRLQKEIADLKAELAMVTGEQRTEALTE 389

  Fly   364 VEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPK 428
            .|.|:      :.|:|                      .|.:|           ||.|:
  Rat   390 AELLQ------LEKLI----------------------ASFVE-----------DQDPE------ 409

  Fly   429 PVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLP 493
                                   ..|::|.:...|...|
  Rat   410 -----------------------SRLEVGADLRKIHYCF-------------------------- 425

  Fly   494 DLPLTPKGPLTTDKIKKEIQD---LQMFTSLEKHFEVECEEVQGLKE--KLAEVTAQRDN----- 548
                        ...||.:.|   |:...|.|...:..|:|....:|  ||..:..||||
  Rat   426 ------------HHFKKLLNDKKTLENTDSSESTTQQACQEPVKDEEYTKLRSLLKQRDNEINIL 478

  Fly   549 ---LEQESLAEKERYDALEKEVT----------------SLRADNEAANSKISELEEKLSTLKQT 594
               |::|   :|:..|||:...|                |......:.:|.:|:.:: ||..:..
  Rat   479 VNMLKKE---KKKTQDALQYSSTEKSEARPPPNSPFIAGSPAGQRTSFSSSLSQTQD-LSVYRHR 539

  Fly   595 MRIME----VENQVAVGLEFEFEAHKK--SSKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLR 653
            ..::.    :..::::|.:..||..|:  :..:.::|....|.::.|..::|.:|: |..|..:.
  Rat   540 SSLLHKKTGMREEMSLGRQEAFEIFKRDHADSVTIEDNKQVLKQRFSEAKALGESI-NEARSKIG 603

  Fly   654 NSKEG----HM----LSIAPEQEDIAGDSICNKCEELEKLIADLESKKNSCECDQLRLEIVSVRD 710
            ..||.    |:    |.||   |.:|..|..:..|  :||.|.||.:|:..:...:||:.:.|
  Rat   604 QLKEAISQRHLQQVALGIA---ESMAPPSTPDPQE--QKLRAQLEEEKSRYKTTFMRLKALKV-- 661

  Fly   711 KLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKH 775
                        ..|.:|...|..:|            :||:.::|    |.|::|....::...
  Rat   662 ------------EIEHLQLLMDKAKL------------KLQKEFEA----WWAEEASSLQVNSPA 698

  Fly   776 EHVQEKYQKL-QEEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNER-----------LEEA 828
            .::|:..:.. |::..||.|:..|      |.|:.:|...:.|:...|.|           .:|.
  Rat   699 TNLQDAAKPFPQQDQTQLLSKKSS------QGLEVENGAGKLDVCGRNARRILPSPCPSPHSQEP 757

  Fly   829 QNMLTEVQNSESTVEKL--RIQNHELTAKIKELETNFEEMQREYDCLSN 875
            .....::|:..|::...  |..:.::.|.||..::..::     .||.:
  Rat   758 SGSSIQLQDRPSSIPLTGDRQTDSDILAFIKARQSILQK-----KCLGS 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	120/351 (34%)
		Motor_domain	8..321	CDD:277568	119/344 (35%)
		Smc	<680..1449	CDD:224117	41/210 (20%)
		TMPIT	779..>867	CDD:285135	19/101 (19%)
		Smc	1042..1910	CDD:224117
Kif6	XP_006244542.1	KISc_KIF9_like	5..343	CDD:276826	119/342 (35%)
Kif6	XP_006244542.1	Kinesin	28..345	CDD:278646	113/321 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900