Protein Alignment cmet and Kif6

DIOPT Version :10

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: NP_001418110.1
• Gene: Kif6 / 171291
• RGDID: 621070
• Length: 802
• Species: Rattus norvegicus
• Alignment Length: 959
• Identity: 234/959 - (24%)
• Similarity: 409/959 - (42%)
• Gaps: 253/959 - (26%)

  Fly     8 SIQVCIKVRPC----EPGLTSLWQVKERRSI-------HLAD----SHAEPYVFDY--VFDEGAS 55
            :||:..:|:|.    :.|:.|:.:.::..|.       .|||    :..|.|.|.:  :||:.|.
  Rat     5 TIQIFARVKPSVRKQQQGIYSIDEDEKLASSLEIVLPRDLADGFVNNKRESYKFKFQRIFDQEAK 69

  Fly    56 NQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQ---NPGVMVLAAKEIFQQISSE 117
            .:.:|:.:||.:..:.:.|:||||||||||.||||:|:.|..:   :.|::......||:|:..:
  Rat    70 QEIIFEIIAKPVAESTLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTLSYIFEQLQKD 134

  Fly   118 TERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIV------NVNCEECII---TSEVDLL 173
            :.:.:...:.|:|||||..||||:.:::..|:.:.....:      |::.:...:   |:|.:.|
  Rat   135 SSKIYTTHISYLEIYNECGYDLLDPRHEASKLEDLPKVTILEDPDQNIHLKNLSLHQATTEEEAL 199

  Fly   174 RLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTG 238
            .||.||:..|.:.||.||:.|:|||.||.:.:.|::...:   .|..:.|:|||||||||..:||
  Rat   200 NLLFLGDTNRMIAETPMNQASTRSHCIFTVHLSSKEPGSA---TVRHAKLHLVDLAGSERVSKTG 261

  Fly   239 ARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTI--- 300
            ..|..|.|..:||.||.:|..||.:|||....... ||:|.:|.:|:.|||||..|::|.|:
  Rat   262 VGGLLLTEAKYINLSLHYLEQVIIALSEKHRTHIP-YRNSMMTSVLRDSLGGNCMTTMIATLSLE 325

  Fly   301 KPSIMEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLA--EEERKNENQQK 363
            |.:| :||.||..||.|...|:.:..:||.:....|:.||::||..||.:||  ..|::.|...:
  Rat   326 KRNI-DESISTCRFAQRVALIKNEAILNEEIDPRLMIVRLQKEIADLKAELAMVTGEQRTEALTE 389

  Fly   364 VEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPK 428
            .|.|:      :.|:|                      .|.:|           ||.|:
  Rat   390 AELLQ------LEKLI----------------------ASFVE-----------DQDPE------ 409

  Fly   429 PVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLP 493
                                   ..|::|.:...|...|
  Rat   410 -----------------------SRLEVGADLRKIHYCF-------------------------- 425

  Fly   494 DLPLTPKGPLTTDKIKKEIQD---LQMFTSLEKHFEVECEEVQGLKE--KLAEVTAQRDN----- 548
                        ...||.:.|   |:...|.|...:..|:|....:|  ||..:..||||
  Rat   426 ------------HHFKKLLNDKKTLENTDSSESTTQQACQEPVKDEEYTKLRSLLKQRDNEINIL 478

  Fly   549 ---LEQESLAEKERYDALEKEVT----------------SLRADNEAANSKISELEEKLSTLKQT 594
               |::|   :|:..|||:...|                |......:.:|.:|:.:: ||..:..
  Rat   479 VNMLKKE---KKKTQDALQYSSTEKSEARPPPNSPFIAGSPAGQRTSFSSSLSQTQD-LSVYRHR 539

  Fly   595 MRIME----VENQVAVGLEFEFEAHKK--SSKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLR 653
            ..::.    :..::::|.:..||..|:  :..:.::|....|.::.|..::|.:|: |..|..:.
  Rat   540 SSLLHKKTGMREEMSLGRQEAFEIFKRDHADSVTIEDNKQVLKQRFSEAKALGESI-NEARSKIG 603

  Fly   654 NSKEG----HM----LSIAPEQEDIAGDSICNKCEELEKLIADLESKKNSCECDQLRLEIVSVRD 710
            ..||.    |:    |.||   |.:|..|..:..|  :||.|.||.:|:..:...:||:.:.|
  Rat   604 QLKEAISQRHLQQVALGIA---ESMAPPSTPDPQE--QKLRAQLEEEKSRYKTTFMRLKALKV-- 661

  Fly   711 KLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKH 775
                        ..|.:|...|..:|            :||:.::|    |.|::|....::...
  Rat   662 ------------EIEHLQLLMDKAKL------------KLQKEFEA----WWAEEASSLQVNSPA 698

  Fly   776 EHVQEKYQKL-QEEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNER-----------LEEA 828
            .::|:..:.. |::..||.|:..|      |.|:.:|...:.|:...|.|           .:|.
  Rat   699 TNLQDAAKPFPQQDQTQLLSKKSS------QGLEVENGAGKLDVCGRNARRILPSPCPSPHSQEP 757

  Fly   829 QNMLTEVQNSESTVEKL--RIQNHELTAKIKELETNFEEMQREYDCLSN 875
            .....::|:..|::...  |..:.::.|.||..::..::     .||.:
  Rat   758 SGSSIQLQDRPSSIPLTGDRQTDSDILAFIKARQSILQK-----KCLGS 801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	Motor_domain	8..321	CDD:473979	119/344 (35%)
		SMC_prok_B	539..1431	CDD:274008	78/389 (20%)
		SMC_prok_B	1137..1926	CDD:274008
		YhaN	1717..2182	CDD:443752
Kif6	NP_001418110.1	KISc_KIF9_like	5..343	CDD:276826	119/342 (35%)
		GumC	<558..>690	CDD:442439	38/167 (23%)