DRSC/TRiP Functional Genomics Resources

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Protein Alignment cmet and Kif5c

DIOPT Version :9

Sequence 1:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster
Sequence 2:NP_032475.2 Gene:Kif5c / 16574 MGIID:1098269 Length:956 Species:Mus musculus


Alignment Length:1229 Identity:309/1229 - (25%)
Similarity:493/1229 - (40%) Gaps:374/1229 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 SIQVCIKVRPCEP-----GLTSLWQVKERRSIHLADSHAEPYVFDYVFDEGASNQEVFDRMAKHI 67
            ||:|..:.||...     |...:.:.|...::.:  ...:|||||.|.....:.::|::..||.|
Mouse     8 SIKVMCRFRPLNEAEILRGDKFIPKFKGEETVVI--GQGKPYVFDRVLPPNTTQEQVYNACAKQI 70

  Fly    68 VHACMQGFNGTIFAYGQTSSGKTYTMMG---DEQNPGVMVLAAKEIFQQISSETER-DFLLRVGY 128
            |...::|:|||||||||||||||:||.|   |.|..|::...|.:||..|.|..|. :|.::|.|
Mouse    71 VKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFHIKVSY 135

  Fly   129 IEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCEECIITSEVDLLRLLCLGNKERTVGETNMNE 192
            .|||.:||.|||:....:|.:||..|.:..| .|.|..::|..:::.::..|...|.|..|||||
Mouse   136 FEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMNE 200

  Fly   193 RSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHINKSLLFL 257
            .|||||:||.|.|   |.::.:.:..:...|.||||||||:..:|||.||.|.|..:|||||..|
Mouse   201 HSSRSHSIFLINI---KQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSAL 262

  Fly   258 SNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPSIMEESQ--STLSFATRAKK 320
            .|||.:|:|..... ..|||||:|||||.|||||..|:|:....||:..|::  |||.|..|||.
Mouse   263 GNVISALAEGTKTH-VPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKT 326

  Fly   321 IRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQKV-EHLERQIKHDMHKIICGHSL 384
            |:....||           ||...:..|.|..:|:.||:..:.| :|||.::..           
Mouse   327 IKNTVSVN-----------LELTAEEWKKKYEKEKEKNKALKSVLQHLEMELNR----------- 369

  Fly   385 SDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTIN 449
                       |   .:|..:...|..:.:|:....|                   .||.|...|
Mouse   370 -----------W---RNGEAVPEDEQISAKDQKSLEP-------------------CDNTPIIDN 401

  Fly   450 ILGSLD-IGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQ 513
            |...:| |..|.....||...                  ..|||.|         ..|:|.::.|
Mouse   402 ITPVVDGISAEKEKYDEEITS------------------LYRQLDD---------KDDEINQQSQ 439

  Fly   514 DLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKER-YDALEKEVTSLRADNEAA 577
                                 |.|||.:....:|.|    ||...| |:.:::|:|.|:.:||||
Mouse   440 ---------------------LAEKLKQQMLDQDEL----LASTRRDYEKIQEELTRLQIENEAA 479

  Fly   578 NSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDD-LLSALLEKESTIESLQ 641
            ..::.|:.:.|..|               .:.::.::.:...|.|.:: |...|.:|.:|:.:.|
Mouse   480 KDEVKEVLQALEEL---------------AVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQ 529

  Fly   642 KSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIADLESKKNSCECDQLRLEIV 706
            :.|..|                                :||..     ..||.:.|...|.|:  
Mouse   530 RELSQL--------------------------------QELSN-----HQKKRATEILNLLLK-- 555

  Fly   707 SVRDKLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTL 771
                                     |...:...:.|:.                       :.||
Mouse   556 -------------------------DLGEIGGIIGTND-----------------------VKTL 572

  Fly   772 HEKHEHVQEKY-------QKLQEEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNERLEEAQ 829
            .:.:..::|::       .|::.|.:.|.:|::...||:    .:.|.|..|     :||     
Mouse   573 ADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQ----MDSNRKMNA-----SER----- 623

  Fly   830 NMLTEVQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLMESVQENDALREEIKQR 894
                     |....:|.|..||  ||||.|....:.|:::    ..||.||   .|:|.||:.: 
Mouse   624 ---------ELAACQLLISQHE--AKIKSLTDYMQNMEQK----RRQLEES---QDSLSEELAK- 669

  Fly   895 PTSHVEESMRSSGISSDFDEQKQDINLLHQFVQLSESVQQIELQHHSGISRLFRANQMKLDQSEP 959
              ...:|.|                   |:.     |.|..|.:|   ::||..|.::|      
Mouse   670 --LRAQEKM-------------------HEV-----SFQDKEKEH---LTRLQDAEEVK------ 699

  Fly   960 GLKLCLESAEYIEEDNRQSDATEPICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQEI 1024
                  ::.|...|.:|::              |:.|:.||..|   :.|::|::|.|..|.|::
Mouse   700 ------KALEQQMESHREA--------------HQKQLSRLRDE---IEEKQRIIDEIRDLNQKL 741

  Fly  1025 EEKSALMEATEATINEMREQMTNLESALLEKSVIIN-KVEDYQRQIESLEKQNAEMTMVYEEL-- 1086
            :.:   .|...:..|:::.:....| ..|||.:::| |.|..:..::.||:..:........|  
Mouse   742 QLE---QERLSSDYNKLKIEDQERE-VKLEKLLLLNDKREQAREDLKGLEETVSRELQTLHNLRK 802

  Fly  1087 ---QDRVTRESSMSESLLRVPPDEDTLPGCPTSPSRREQEVATLKTS---ITELQSQV----SDL 1141
               ||..||.....|.      |.|...|    .:.::|:::.|:.:   :|::..|:    :||
Mouse   803 LFVQDLTTRVKKSVEL------DSDDGGG----SAAQKQKISFLENNLEQLTKVHKQLVRDNADL 857

  Fly  1142 KAELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDE----DTKQKQELLDR 1196
            :.||              .:|:......:||..::|..|.|..|    |.|:.|:.:||
Mouse   858 RCEL--------------PKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQEVDR 902

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cmetNP_524993.3 KISc 8..328 CDD:214526 138/331 (42%)
Motor_domain 8..321 CDD:277568 137/324 (42%)
Smc <680..1449 CDD:224117 107/541 (20%)
TMPIT 779..>867 CDD:285135 22/94 (23%)
Smc 1042..1910 CDD:224117 38/172 (22%)
Kif5cNP_032475.2 KISc_KHC_KIF5 6..327 CDD:276820 137/324 (42%)
KISc 8..334 CDD:214526 138/331 (42%)
Microtubule-binding 174..315 66/144 (46%)
Lebercilin 605..798 CDD:292252 62/287 (22%)
BAR 636..817 CDD:299863 56/252 (22%)
Globular 859..956 14/58 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 910..956
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000669
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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