Protein Alignment cmet and Kif4

DIOPT Version :10

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: NP_032472.2
• Gene: Kif4 / 16571
• MGIID: 108389
• Length: 1231
• Species: Mus musculus
• Alignment Length: 1595
• Identity: 361/1595 - (22%)
• Similarity: 615/1595 - (38%)
• Gaps: 504/1595 - (31%)

  Fly     9 IQVCIKVRPCEPGLTSLWQVKERRSIHLADSHAEP---------YVFDYVFDEGASNQEVFDRMA 64
            ::|.::.||    |.|. ::||.....|:....||         :.:|:|||.....:|||:...
Mouse    10 VRVALRCRP----LVSK-EIKEGCQTCLSFVPGEPQVVVGNDKSFTYDFVFDPSTEQEEVFNTAV 69

  Fly    65 KHIVHACMQGFNGTIFAYGQTSSGKTYTMMG----DEQNP---GVMVLAAKEIFQQISSETERDF 122
            ..::....:|:|.|:.|||||.|||||:|.|    ::::.   ||:....:.:|::|:.:::.:|
Mouse    70 APLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQEHDSAIGVIPRVIQLLFKEINKKSDFEF 134

  Fly   123 LLRVGYIEIYNEKIYDLL---NKKNQDLKIHES-GNGIVNVNCEECIITSEVDLLRLLCLGNKER 183
            .|:|.|:|||||:|.|||   .:|...:.|.|. ..||..|...|..:....|.:..|..||..|
Mouse   135 TLKVSYLEIYNEEILDLLCSSREKATQINIREDPKEGIKIVGLTEKTVLVASDTVSCLEQGNNSR 199

  Fly   184 TVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEGG 248
            ||..|.||.:||||||||.|.||.||.  :|.::..:|.|:|||||||||..:|.|.|.||:||.
Mouse   200 TVASTAMNSQSSRSHAIFTISIEQRKK--NDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLREGI 262

  Fly   249 HINKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKP--SIMEESQST 311
            :||:.||.|.|||.:|.::....|..||||||||:||.|||||:.|.:|..:.|  |.:||:.:|
Mouse   263 NINRGLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLNT 327

  Fly   312 LSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAE------------EERKN------ 358
            |.:|.||:||:.||.:| :...|..:..|:::::.|:..|.:            |..:|
Mouse   328 LRYADRARKIKNKPIIN-IDPQAAELNHLKQQVQQLQILLLQAHGGTLPGDINVEPSENLQSLME 391

  Fly   359 ENQQKVEHLER----------QIKHDMHKIICGHSLSDKGQQK----RRRTWCPTASGSHLELAE 409
            :||..||..|:          |....:.:||.....::|...|    ||...|..   ...:|.|
Mouse   392 KNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRRHAACKV---DLQKLVE 453

  Fly   410 TGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECID 474
            |...::..:....:.:|.:.:...:..|..   .:..||:..|..|...:|:..:
Mouse   454 TLEDQELKENIEIICNLQQVIAQLSDEAAA---CMTATIDTAGEADTQVQSSPDT---------- 505

  Fly   475 FGSPRPDVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKL 539
              |...||......:||.              ::.||:              :|..:...|||.|
Mouse   506 --SRSSDVFSTQHALRQA--------------QMSKEL--------------IELNKALALKEAL 540

  Fly   540 AEVTAQRDN-LEQESLAEKERYDALEKEVTSLRADNE------------AANSKISELEEKLSTL 591
            |:...|.|| |:......::....||.||.||:.:.|            |..:|:||...|
Mouse   541 AKKMTQNDNQLQPIQFQYQDNIKNLESEVLSLQREKEELVLELQTAKKDANQAKLSERRRK---- 601

  Fly   592 KQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLRNSK 656
                |:.|:|.|:|       :..||             |:::|.:..|::|.:
Mouse   602 ----RLQELEGQIA-------DLKKK-------------LQEQSKLLKLKESTE----------- 631

  Fly   657 EGHMLSIAPEQEDIAGDSICNKCEELEKLIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNL 721
              |.:|                     ||..::...||.      |::::.
Mouse   632 --HTVS---------------------KLNQEIRMMKNQ------RVQLMR-------------- 653

  Fly   722 ASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKHEHVQEKYQKLQ 786
                  |...|.|:.                      :||:.|        :..|.:|.|.:..:
Mouse   654 ------QMKEDAEKF----------------------RQWKQQ--------KDKEVIQLKERDRK 682

  Fly   787 EEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHE 851
            .:||.|:      ....||:..|...:...:.|:.|:||::|      :|..:...||.:
Mouse   683 RQYELLK------LERNFQKQSNVLRRKTEEAAAANKRLKDA------LQKQKEVAEKRK----- 730

  Fly   852 LTAKIKELETNFEEMQREYDCLSNQLMESVQENDALREEIKQRPTSHVEESMRSSGISSDFDEQK 916
                    ||....|:.....:.|.|...:                   |.|.|:      :|.|
Mouse   731 --------ETQSRGMESTAARMKNWLGNEI-------------------EVMVST------EEAK 762

  Fly   917 QDIN-LLHQFVQLSESVQQIELQHHSGISRLFRANQMKLDQSEPGLKLCLESAEYIEEDNRQSDA 980
            :.:| ||.:...|::.|.|::.:..||              ..|.||
Mouse   763 RHLNGLLEERKILAQDVAQLKEKRESG--------------ENPPLK------------------ 795

  Fly   981 TEPICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQEIEEKSALMEATEATINEMREQM 1045
                     |:|..|....:..:  |.|.|..:...|..||.|:|.:||              |:
Mouse   796 ---------LRRRTFSYDEIHGQ--DSGAEDSIAKQIESLETELELRSA--------------QI 835

  Fly  1046 TNLESALLEKSVIINKVEDYQRQIESLEKQNAEMTMVYEELQDRVTRESSMSESLLRVPPDEDTL 1110
            .:|:..||:                             .|.:||
Mouse   836 ADLQQKLLD-----------------------------AESEDR--------------------- 850

  Fly  1111 PGCPTSPSRREQEVATLKTSITELQSQVSDLKAELENHLRQIQLKDGNIARLQTDFEEMSERCLS 1175
                  |.:|.:.:||    |.|.:..:..|..||.:  .:|.     :::|::...:....|:.
Mouse   851 ------PKQRWESIAT----ILEAKCAIKYLVGELVS--SKIL-----VSKLESSLNQSKASCID 898

  Fly  1176 MEVRLAELDE-----DTKQKQELLDRQAQKLSDDLCLIDQLQKKNAQLVEQYHKATESLSLADAK 1235
            ::..|.|...     :|:.|:||:..:.|.....|.|:.|||:  :|:.|:  :..||:|
Mouse   899 VQKMLFEEQNHFAKIETELKEELVKVEQQHQEKVLYLLSQLQQ--SQMTEK--QLEESVS----- 954

  Fly  1236 PDQILLSSQYDSQIEKLNQLLNAAKDELHDVRRIKD---------DEISALRMEF-LLQIETNEK 1290
                          ||..|||:..|.:..::|::::         .|.||::.:. |||:.:.:|
Mouse   955 --------------EKEQQLLSTLKCQEEELRKMQEVCEQNQQLLQENSAIKQKLTLLQVASKQK 1005

  Fly  1291 ENQAKFYAELQETKDRY---ESNVAELKEKLLQVEETLSSVTVRCQAELEALKSAHKENISQAVE 1352
            .:..:...:..::...|   :.....:|||.|  |::.:...::..:|....:..::::...|.|
Mouse  1006 PHLTRNIFQSPDSSFEYIPPKPKPCRIKEKCL--EQSFAVEGLQYYSEPSVAEQDNEDSDDHADE 1068

  Fly  1353 E--RNNLIVQHQAEME--TIRETLKNKLAEASTQQSKMEDAFRAEINEVRATLMEQ-------LN 1406
            |  ...|:...:..::  :.:....||......|:|....:...:..:.|.....|       ||
Mouse  1069 EWIPTKLVKVSKKSIQGCSCKGWCGNKQCGCRKQKSDCNVSCSCDPTKCRNRHQNQDNSDAIELN 1133

  Fly  1407 QTKEDRDKGASKLEE------------------VKKTLEQMINGGRVM--------SDTIAELEK 1445
            |..|:    :.|||:                  ..|.|::|.:..:|.        |....||:.
Mouse  1134 QDSEN----SFKLEDPTEVTSGLSFFHPICATPSSKILKEMCDADQVQLKQPVFVSSSDHPELKS 1194

  Fly  1446 --TKAEQDLAVNKLTK----DNIELEKQCSKTQEQ 1474
              ::::::.|:.|..|    .|......||..||:
Mouse  1195 IASESQENKAIGKKKKRALASNTSFFSGCSPIQEE 1229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	Motor_domain	8..321	CDD:473979	134/333 (40%)
		SMC_prok_B	539..1431	CDD:274008	170/952 (18%)
		SMC_prok_B	1137..1926	CDD:274008	76/399 (19%)
		YhaN	1717..2182	CDD:443752
Kif4	NP_032472.2	KISc_KIF4	8..338	CDD:276823	135/334 (40%)
		Smc	<518..>1005	CDD:440809	150/829 (18%)
		Globular	1001..1231		40/235 (17%)
		Pre-SET	<1082..1120	CDD:461530	5/37 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1189..1212		5/22 (23%)