DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and Kif1b

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	NP_001277924.1	Gene:	Kif1b / 16561	MGIID:	108426	Length:	1816	Species:	Mus musculus

Alignment Length:	2004	Identity:	426/2004 - (21%)
Similarity:	765/2004 - (38%)	Gaps:	552/2004 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NASSIQVCIKVRPCEPGLTSLWQVKERRSIHLADSHA-------------EPYVFDYVFDEG--- 53
            :.:|::|.::|||.....||    ||.:.|.....::             :.:.|||.:...
Mouse     2 SGASVKVAVRVRPFNSRETS----KESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSP 62

  Fly    54 -----ASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMG--DEQNPGVMVLAAKEIF 111
                 ||...|::.:.|.::....:|:|..|||||||.:||:|||||  :|...|::....:|:|
Mouse    63 EDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELF 127

  Fly   112 QQISS--ETERDFLLRVGYIEIYNEKIYDLLNKKNQ-DLKIHES---GNGIVNVNCEECIITSEV 170
            ::|:.  ..|..:.:.|.|:|||.|::.||||.||: :|::.|.   |..:.:::  :..:||..
Mouse   128 EKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLS--KLAVTSYT 190

  Fly   171 DLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQ-SVLNLVDLAGSERA 234
            |:..|:..|||.|||..|||||.||||||:|.|:...:|.|...:.:..: |.::||||||||||
Mouse   191 DIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKQDPETNLSTEKVSKISLVDLAGSERA 255

  Fly   235 DQTGARGARLKEGGHINKSLLFLSNVIKSLSENADN-----------RFTNYRDSKLTRILQASL 288
            |.|||:|.|||||.:|||||..|..||.:|:| .||           .|..||||.||.:|:.:|
Mouse   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAE-VDNCTSKSKKKKKTDFIPYRDSVLTWLLRENL 319

  Fly   289 GGNAFTSIICTIKPSIM--EESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKL 351
            |||:.|:::..:.|:.:  :|:.|||.:|.|||:|:....:|| ..:|.:::.|:.|:..|||.|
Mouse   320 GGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINE-DPNAKLVRELKEEVTRLKDLL 383

  Fly   352 AEEERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDR 416
                       :.:.|...|  |:..:|..:|.|               .|.:|:     ..::.
Mouse   384 -----------RAQGLGDII--DIDPLIDDYSGS---------------GGKYLK-----DFQNN 415

  Fly   417 IDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPD 481
            ..::...|...:|..|.|::.|....: |.:.::...:.: |...||.|..:.
Mouse   416 KHRYLLASENQRPGNFSTASMGSLTSS-PSSCSLNSQVGL-TSVTSIQERIMS------------ 466

  Fly   482 VLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEK----LAE- 541
                            ||.|....:::|   :..::...|.:.:|.:..:.:.::.:    |||
Mouse   467 ----------------TPGGEEAIERLK---ESEKIIAELNETWEEKLRKTEAIRMEREALLAEM 512

  Fly   542 -VTAQRD----------------NLEQESL------------------AEKERYD-------ALE 564
             |..:.|                ||.::.|                  |:.||..       .::
Mouse   513 GVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIK 577

  Fly   565 KEVTSLRADNEAANSKISELE--EKLSTLKQTMRI-----MEVENQVAVGLE--FEFEAHKKSSK 620
            :|....|::.......|..||  |:..|.....|:     :...|::.:|..  |.|. |.:.::
Mouse   578 EEHCLFRSERSNTGEVIVTLEPCERSETYVNGKRVAHPVQLRSGNRIIMGKNHVFRFN-HPEQAR 641

  Fly   621 LRVDDLLSALLEKESTIESLQKSLD--NLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELE 683
                    |..||..:.|:..:.:|  ...|::|  .|:|                 .:..:|:|
Mouse   642 --------AEREKTPSAETPSEPVDWTFAQRELL--EKQG-----------------IDMKQEME 679

  Fly   684 KLIADLE--SKKNSCECD----QLRLEIVSVRDKLESVESAFNLASSEIIQKATDCERLSKELST 742
            |.:.::|  .||...|.|    |.||:..|   ||::::.  .:.:..:..:.|:.|...:|:..
Mouse   680 KRLQEMEILYKKEKEEADLLLEQQRLDYES---KLQALQR--QVETRSLAAETTEEEEEEEEVPW 739

  Fly   743 SQNAFGQLQERYDALDQQWQAQQAGITTLH------------------EKHEHVQEKY------- 782
            :|:.|...|..:    ::|::.|  .|:|.                  |..:.||.::
Mouse   740 TQHEFELAQWAF----RKWKSHQ--FTSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTL 798

  Fly   783 ------QKLQEEYEQL-ESR--ARSASSAEFQRLQNDNTKFQADIASLNERLEEAQNMLTEV--- 835
                  :.|..|.|:. |.|  .|:..:.|.|.|:|..|.:.: :..|.:||:..:.|....
Mouse   799 YSPVPPELLPSEMEKTHEDRPFPRTVVAVEVQDLKNGATHYWS-LDKLKQRLDLMREMYDRAGEV 862

  Fly   836 -----QNSESTV---------------------------EKLRIQNHELT-----AKIKELETNF 863
                 .:||:|:                           |:|..:....|     :.|.||....
Mouse   863 ASSAQDDSETTMTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQ 927

  Fly   864 EEMQREYDCLSNQLMESVQENDALREEIKQRPTSHVEESMRSSGISSDFDEQKQDINLLHQFVQL 928
            ::...::|   ::.......:||..||         ...:.|.|....:|.....|.:...||.|
Mouse   928 QDAMEDFD---DEAFVDDTGSDAGTEE---------GSELFSDGHDPFYDRSPWFILVGRAFVYL 980

  Fly   929 SESVQQIELQHHSGISRLFRANQMKLDQSEPG-----LKLCLESAEYIEE------DNRQSDATE 982
            |..:..:.|.|...|            .||.|     |::.:::....||      ..|||...:
Mouse   981 SNLLYPVPLIHRVAI------------VSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSGTAK 1033

  Fly   983 PICLKGFLKRHRFQIKRLSQEHVDMGEEKRLL-------DIISQLEQ-----EIEEKSALMEATE 1035
            ......:..:..|....:::..:.: ||.|::       ::||..|:     :::.||..:...:
Mouse  1034 ISFDNEYFNQSDFSSAAMTRSGLSL-EELRIVEGQGQSSEVISPPEEVNRMNDLDLKSGTLLDGK 1097

  Fly  1036 ATINEMREQMTN---LESA------LLEKSVIINKVEDYQRQIESLEKQNAEMTM---------- 1081
            ..:....|::.|   |.||      :|:.|.|:.:..|...|...|.:.:...:.
Mouse  1098 MVMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIFCQFNFLHRHDEAFSTEPLKNNGRGS 1162

  Fly  1082 -------------VYEELQDRVTRESSMSESLLRVPPDEDTLPG----CPTSPSRR--------- 1120
                         |.|...|.:..:..:.|...........|.|    .|..||||
Mouse  1163 PLGFYHVQNIAVEVTESFVDYIKTKPIVFEVFGHYQQHPLHLQGQDLNSPPQPSRRFFPPPMPLS 1227

  Fly  1121 ----EQEVATL-KTSITELQSQVSDLK----AELENHLRQIQLKDGNIARLQTDFEEMSERCLSM 1176
                ..::.|: ||::.:..|:...|.    :|||.....|.....:.|.|......:..:.:..
Mouse  1228 KPVPATKLNTMNKTTLGQSMSKYDLLVWFEISELEPTGEYIPAVVDHTAGLPCQGTFLLHQGIQR 1292

  Fly  1177 EVRLAELDEDTKQ------KQELLDRQAQKLSDDLCLIDQLQKKN---AQLVEQYHKATESLSLA 1232
            .:.:..:.|...:      ::.::.|...|...|...:|.:...|   |:.::..|.::.:....
Mouse  1293 RITVTIIHEKGSELHWKDVRELVVGRIRNKPEVDEAAVDAVLSLNIISAKSLKAAHSSSRTFYRF 1357

  Fly  1233 DAKPDQILLSSQYDSQI----EKLNQLLNAAKDELH---------DVRRI---KDDEIS---ALR 1278
            :|..|..|.:|...:::    ||:...|:|..:..|         ||..:   :|.:||   :||
Mouse  1358 EAVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLR 1422

  Fly  1279 MEFLLQIETNEKENQAKFYAELQETK--DRYESNVAELKEKLLQVEETLSSVTVRCQAELEALKS 1341
            ..|......:...|:.....||...|  |.....:...:.|:|..    |...||
Mouse  1423 NLFGSGYSKSPDSNRVTGIYELSLCKMADTGSPGMQRRRRKVLDT----SVAYVR---------- 1473

  Fly  1342 AHKENISQAVEERNNLIVQHQAEMETIRETLKNKLAEASTQQSKMEDAFRAEINEVRAT-----L 1401
             .:||::......::||::||.|:|                  |:|     .::||..|     |
Mouse  1474 -GEENLAGWRPRGDSLILEHQWELE------------------KLE-----LLHEVEKTRHFLLL 1514

  Fly  1402 MEQLNQTKEDRDKGASKLEEVKKTLEQMINGGRVMSDT--IAELEKTKAEQDLA----------- 1453
            .|:|         |.|..:.:..:|...::.|.:.:.|  .:::..|..|..:.
Mouse  1515 RERL---------GDSVPKSLSDSLSPSLSSGTLSTSTSISSQISTTTFESAITPSESSGYDSAD 1570

  Fly  1454 VNKLTKDNIELEKQCSKTQEQLQMESLTRDQISFEIEAHIKKLEL----------IVASSKKRII 1508
            |..|.....||..:|      ||:.:.|.::...::...|...:|          .|:|.....:
Mouse  1571 VESLVDREKELATKC------LQLLTHTFNREFSQVHGSISDCKLSDISPIGRDPSVSSFSSSTL 1629

  Fly  1509 ELEEKCDQQVLELDKCRLEKLSLESEIQKANSEHSCTMEKLQELQ----AEMKVLSNRNEKEKCD 1569
            .....|...|   |.   ...|::.:..:|||..|...::.::.|    .|...|:...:.|
Mouse  1630 TPSSTCPSLV---DS---RSSSMDQKTPEANSRASSPCQEFEQFQIVPTVETPYLARAGKNE--- 1685

  Fly  1570 FETKLETFTFKITDLEEVLKEAQHKVILYDDLVSQHERLKICLAEANELSSNLQKK---VMSLHT 1631
                   |...:.|:|||..         ..:||:    |..|.....||||..|.   |...:.
Mouse  1686 -------FLNLVPDIEEVRA---------GSVVSK----KGYLHFKEPLSSNWAKHFVVVRRPYV 1730

  Fly  1632 ELIDSQK--------GISSRDVEINELREELKAAMDAKATASAEQMTLVTQLKD 1677
            .:.:|.|        .:|:..||.:|.::.:....:..|..:..:..|:..|.|
Mouse  1731 FIYNSDKDPVERGIINLSTAQVEYSEDQQAMVKTPNTFAVCTKHRGVLLQALND 1784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	135/362 (37%)
		Motor_domain	8..321	CDD:277568	134/355 (38%)
		Smc	<680..1449	CDD:224117	175/962 (18%)
		TMPIT	779..>867	CDD:285135	25/143 (17%)
		Smc	1042..1910	CDD:224117	140/763 (18%)
Kif1b	NP_001277924.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	135/363 (37%)
		KISc	5..361	CDD:214526	135/362 (37%)
		Interaction with KBP. /evidence=ECO:0000250	270..350		31/80 (39%)
		Kinesin_assoc	358..555	CDD:292801	41/263 (16%)
		FHA	532..636	CDD:238017	18/104 (17%)
		Prefoldin	662..717	CDD:298833	18/78 (23%)
		KIF1B	845..892	CDD:289208	7/46 (15%)
		DUF3694	1313..1413	CDD:289256	18/99 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1522..1571		5/48 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1620..1659		9/44 (20%)
		PH_KIFIA_KIFIB	1701..1799	CDD:269939	20/88 (23%)
		PH	1702..1795	CDD:278594	20/87 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2883
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030