DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and Kif13b

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	XP_006518682.1	Gene:	Kif13b / 16554	MGIID:	1098265	Length:	1847	Species:	Mus musculus

Alignment Length:	1642	Identity:	373/1642 - (22%)
Similarity:	642/1642 - (39%)	Gaps:	403/1642 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSIQVCIKVRPCEPGLTSLWQVKERRSIHL------------------------ADSHAEPYVFD 47
            |.::|.::|||           ..||.|.|                        .|:..:|.:|.
Mouse     4 SKVKVAVRVRP-----------MNRREIDLHTKCVVDVEANKVILNPVNTNLSKGDARGQPKIFA 57

  Fly    48 Y----------VFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGV 102
            |          |.::.|..::||..:.::|:.....|:|..|||||||.|||:|||||....||:
Mouse    58 YDHCFWSMDESVREKYAGQEDVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGTADQPGL 122

  Fly   103 MVLAAKEIFQQISSE--TERDFLLRVGYIEIYNEKIYDLLNKK--NQDLKIHESG------NGIV 157
            :......:|::...|  .|:.|.:.|.|:||||||:.|||:.|  .|.||:.|..      :|:
Mouse   123 IPRLCSGLFERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLGPYVDGL- 186

  Fly   158 NVNCEECIITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESR----KSDHSDDDAV 218
                .:..:||..|:..|:..|||.|||..|||||.||||||:|||.:...    ||..|.:..
Mouse   187 ----SKLAVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLYDVKSGTSGEKV- 246

  Fly   219 IQSVLNLVDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENA----DNRFTNYRDSK 279
              ..|:||||||||||.:|||.|.|||||.:|||||..|..||.:|::..    .|:|..||||.
Mouse   247 --GKLSLVDLAGSERATKTGAAGDRLKEGSNINKSLTTLGLVISALADQGAGKNKNKFVPYRDSV 309

  Fly   280 LTRILQASLGGNAFTSIICTIKPSI--MEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLER 342
            ||.:|:.|||||:.|:::.|:.|:.  .:|:.|||.:|.|||.|.....||| ..:|.:::.|..
Mouse   310 LTWLLKDSLGGNSKTAMVATVSPAADNYDETLSTLRYADRAKHIVNHAVVNE-DPNARIIRDLRE 373

  Fly   343 EIKVLKDKL--AEEERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHL 405
            |::.|:::|  ||..:..|.:.::|..|:.|:          .::...::|.|:|         .
Mouse   374 EVEKLREQLTKAEAMKSPELKDRLEESEKLIQ----------EMTVTWEEKLRKT---------E 419

  Fly   406 ELAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPA 470
            |:|     ::|..|...:.     :...||......|..     .|.:|:.....|.:...:|..
Mouse   420 EIA-----QERQKQLESLG-----ISLQTSGIKVGDDKC-----FLVNLNADPALNELLVYYLKE 469

  Fly   471 ECIDFGSPRPDVLKPMLTIRQLPD---LPLTPKGP--LTTDK-IKKEIQDLQMFTSLEKH----- 524
            ..:...:...|:  .:..:..||:   :.:||:|.  ||..| .:..:....:.:.::.|
Mouse   470 HTLIGSANSQDI--QLCGMGILPEHGIIDITPEGQVVLTPQKNTRTFVNGSSVSSPIQLHHGDRI 532

  Fly   525 -------FEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKERYDALEKEVTS--LRADNEAANSK 580
                   |.:...:    |:|.||    |::.::|:        :|:.:.:|  |.||.::::..
Mouse   533 LWGNNHFFRLNLPK----KKKKAE----REDEDREA--------SLKNDSSSEQLDADGDSSSEV 581

  Fly   581 ISEL--EEKLSTLKQTMRIM---EVENQVAVGLEFEFEAHKKSS----KLRVDDLLSALLEKEST 636
            .||:  ..:.:.::.||:.:   :....:...||.:.|..|:|:    :|..:..|..|..:.|.
Mouse   582 SSEINFNFEYAQMEVTMKALGSNDPMQSILSSLEQQHEEEKRSALERQRLMYEHELEQLRRRLSP 646

  Fly   637 IESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIADLESKKNSCECDQL 701
            .....:.:|.|:  ....|.:..:...|.|:|....:|:....|::.|  |:|..::.|...::|
Mouse   647 ERQNCRGVDRLS--FHSPSAQQRLKQWAEEREATLNNSLMRLREQIVK--ANLLVREASYIAEEL 707

  Fly   702 --RLEI-VSVRDKLESVESAFNLASSEIIQKATDCERLSK-----ELSTSQNAFGQLQERYDALD 758
              |.|. |:::....|:: |.....|.:.:.|....|..|     .|...:|....:::.|
Mouse   708 DKRTEYKVTLQIPTSSLD-ANRKRGSLLSEPAIQVRRKGKGKQIWSLEKLENRLLDMRDLY---- 767

  Fly   759 QQWQAQQAGITTLHEKHEHVQEKYQKLQEE-YEQLESRARSASSAEFQRLQNDNTKFQADIASLN 822
            |:|:.        .|:...|...|.|..:. |::.|:.:....:..|......:.|.|..:..:|
Mouse   768 QEWKE--------CEEDSPVSRSYFKRADPFYDEQENHSLIGVANVFLETLFYDVKLQYAVPIIN 824

  Fly   823 ERLEEAQNMLTEVQN---------------SESTVEKLRIQNHELTAKIKELE-TNFEE-----M 866
            ::.|.|..:..||..               :|.:.|| ..|.:.|...:|.|: |...:     :
Mouse   825 QKGEVAGRLHVEVMRLSGAIGERIAGGDDPTEVSSEK-EAQENRLVCMVKILQATGLPQHLCHFV 888

  Fly   867 QREYDCLSNQLMESVQENDALREEIKQRPTSHVEESMRSSGISSDFDEQKQDINLLHQFVQ-LSE 930
            ..:||....|...:|    |...:....|||...:.|......|:|     .:|:...|:: |||
Mouse   889 FCKYDFWDQQEPVTV----APEVDTSSSPTSKQPQCMVVFDHCSEF-----SVNITEDFIEYLSE 944

  Fly   931 SVQQIELQHHS-------------GISRLFRANQMKLDQSEPGLKLCLESAEYIEEDNRQSD--A 980
            ....||:..|.             ||.:. :...::...||...|  ||....|.|.|...|  .
Mouse   945 GALAIEVYGHKMNDPRKNPALWDLGIIQA-KTRSLRDRWSEVTRK--LEFWVQILEQNENGDYCP 1006

  Fly   981 TEPICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQEIEEKSALMEATE---------- 1035
            .|.|..|.......||:::        |:.:|:     |:|.:..::|..:...|
Mouse  1007 VEVIAAKDVPTGGIFQLRQ--------GQSRRV-----QVEVKSVQESGTLPLMEECILSVGIGC 1058

  Fly  1036 ------------ATINEMREQMTNLESALLE--KSVIINKVEDYQRQIESLEKQNAEMTMVYEEL 1086
                        ..::|..|.|.:.:...||  :...:|.:...|   |.|::|..::...:::.
Mouse  1059 VKVRPLRSPKIHENVHEEEEDMDSYQDRDLERLRRKWLNALTKRQ---EYLDQQLQKLVSKHDKT 1120

  Fly  1087 QDRVTRESSMSE---------SLLRVPPDEDTLPGCPTS----PSRREQEVATLKTSITELQSQV 1138
            :|...||:.:.|         :.:.||.....:||.|..    |.
Mouse  1121 EDDADREAQLLEMRLTLTEERNAVMVPSAGSGIPGAPAEWTPVPG-------------------- 1165

  Fly  1139 SDLKAELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDEDTKQKQELLDRQAQKLSD 1203
                  :|.|:..|.|                           :|:.|....|:.||
Mouse  1166 ------METHIPVIFL---------------------------DLNADDFSSQDNLD-------- 1189

  Fly  1204 DLCLIDQLQKKNAQLVEQYHKATESLSLADAKPDQILLSSQYDSQIEKLNQLLNA--AKDELHDV 1266
                 |.....:|.|..:..:....|.:......::...:.:||.:....||...  |.:.:..:
Mouse  1190 -----DPEAGWDATLTGEEEEEFFELQIVKQHDGEVKAEASWDSAVHSCPQLSKGTPADERVFLI 1249

  Fly  1267 RRIKDDEISALRMEFLLQIETNEKENQAKFYAELQETKDRYESN----------VAELKEKLLQV 1321
            .|:.........|:.:|:.......:..:.:|:....|..:.|:          |:.:.|....|
Mouse  1250 LRVTVQLSHPADMQLVLRKRICVHVHGRQGFAQSLLKKMSHRSSIPGCGVTFEIVSNIPEDAQGV 1314

  Fly  1322 E--ETLSSVTVRCQAELEALKSAHKENISQAVEERNNLIVQHQAEME-TIRETL--KNKLAEAST 1381
            |  |.|:.:....:....|...|:.|...::|....||:...:...| .::|.|  |.||:..|.
Mouse  1315 EEREALARMAANVENPASADSEAYIEKYLRSVLAVENLLTLDRLRQEVAVKEQLTGKGKLSRRSI 1379

  Fly  1382 QQSKME--DAFRAEI--------NEVRATLMEQLNQTKEDR-------------------DKG-- 1415
            ....|.  ...|.|:        |:.|....:.::||...|                   |.|
Mouse  1380 SSPSMNRLSGSRQELSPSHSLGSNKGRWESQQDVSQTLVSRGIAPGPPALSVSPQNNQSPDPGLG 1444

  Fly  1416 ---ASKLEEVKKTLEQM 1429
               ||.|..||..:.||
Mouse  1445 GVAASYLNPVKSLVPQM 1461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	139/373 (37%)
		Motor_domain	8..321	CDD:277568	138/366 (38%)
		Smc	<680..1449	CDD:224117	163/884 (18%)
		TMPIT	779..>867	CDD:285135	20/109 (18%)
		Smc	1042..1910	CDD:224117	79/454 (17%)
Kif13b	XP_006518682.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	140/374 (37%)
		Kinesin_assoc	357..469	CDD:374417	28/146 (19%)
		FHA	447..544	CDD:238017	15/103 (15%)
		DUF3584	<544..>772	CDD:378817	51/252 (20%)
		KIF1B	756..802	CDD:372100	10/57 (18%)
		C2	<888..>952	CDD:387358	18/72 (25%)
		DUF3585	<1073..1143	CDD:390065	14/72 (19%)
		DUF3694	<1220..1278	CDD:372133	8/57 (14%)
		PHA03247	<1423..1659	CDD:223021	9/39 (23%)
		CAP_GLY	1724..1787	CDD:366568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2883
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940