DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cmet and Kif13a

DIOPT Version :9

Sequence 1:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster
Sequence 2:XP_036013758.1 Gene:Kif13a / 16553 MGIID:1098264 Length:1840 Species:Mus musculus


Alignment Length:2274 Identity:489/2274 - (21%)
Similarity:811/2274 - (35%) Gaps:705/2274 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SSIQVCIKVRPCEPGLTSLWQVKERRSIHLADS------------HAEP-------------YVF 46
            :.::|.::|||           ..||.:.|...            |..|             :.|
Mouse     4 TKVKVAVRVRP-----------MNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAF 57

  Fly    47 DYVF---DEG-----ASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVM 103
            ||.|   ||.     |..:.||..:.:.|:....||:|..|||||||.|||:::|||..:..|::
Mouse    58 DYCFWSMDESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQLGLI 122

  Fly   104 VLAAKEIFQQISSE--TERDFLLRVGYIEIYNEKIYDLLNKK--NQDLKIHESG------NGIVN 158
            ......:||:|:.|  ..:.|.:.|.|:||||||:.|||:.|  .|.||:.|..      :|:  
Mouse   123 PRLCCALFQRIALEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGL-- 185

  Fly   159 VNCEECIITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSD-HSDDDAVIQSV 222
               .:..:||..|:..|:..|||.|||..|||||.||||||:|.|||.....| .|.:.....|.
Mouse   186 ---SQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSK 247

  Fly   223 LNLVDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENA----DNRFTNYRDSKLTRI 283
            ::|||||||||..:|||.|.|||||.:|||||..|..||.||::.|    .|:|..||||.||.:
Mouse   248 VSLVDLAGSERVSKTGAAGERLKEGSNINKSLTTLGLVISSLADQAAGKGKNKFVPYRDSVLTWL 312

  Fly   284 LQASLGGNAFTSIICTIKPSI--MEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKV 346
            |:.:||||:.||:|.||.|:.  .||:.|||.:|.|||:|.....||| ..:|.:::.|..|::.
Mouse   313 LKDNLGGNSQTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNE-DPNAKVIRELREEVEK 376

  Fly   347 LKDKLAEEE--RKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPT--------AS 401
            |:::|::.|  :..|.::|:|..|:.||          .|:...::|.|:|....        :.
Mouse   377 LREQLSQAEAMKAPELKEKLEESEKLIK----------ELTVTWEEKLRKTEAIAQERQRQLESM 431

  Fly   402 GSHLELAETGTTEDR-----IDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESN 461
            |..||.:.....:|:     ::..|.::.|   :.::..:..:...:..:.|.:.|   ||.:  
Mouse   432 GISLETSGIKVGDDKCYLVNLNADPALNEL---LVYYLKDHTRVGADTSQDIQLFG---IGIQ-- 488

  Fly   462 SISEEFLPAEC-IDFGSPRPDVLKPMLTIRQLPDLPLTPK--------GPLTTDKIKKEIQDLQM 517
                   |..| ||..:.              .|:.||||        |.|.....:....|..:
Mouse   489 -------PEHCEIDIAAD--------------GDITLTPKENARSCVNGTLVCSTTQLWHGDRIL 532

  Fly   518 FTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKERYDAL---EKEVTSLRADNEAANS 579
            :.:  .||                        .:.:|.:::|.|.|   |:|.:|...|.:||:.
Mouse   533 WGN--NHF------------------------FRINLPKRKRRDWLKDFERETSSAEHDLDAASE 571

  Fly   580 KISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSL 644
            ..||.:                      ..:||                      :.:|.:.|:|
Mouse   572 ASSEPD----------------------YNYEF----------------------AQMEVIMKTL 592

  Fly   645 DNLTRDVLRNSKEG----------------HMLSIAP--------EQEDIAGDSICNKCEELEKL 685
                     ||..|                ::..:.|        ..:....|.:.|..:.|||.
Mouse   593 ---------NSNGGFPIVSLSAWWSSPWWSYLKILFPLLWFQTKLVHQHWERDPVQNVVQVLEKQ 648

  Fly   686 IADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQL 750
            .  ||.|:.:.|..:|..|                          .:.|:|.::||..:......
Mouse   649 Y--LEEKRTALEEQRLMYE--------------------------RELEQLRQQLSPERQPPSSA 685

  Fly   751 QERYDALDQQWQAQQAGITTLHEKHEHVQEKYQKLQEEYEQLESRARSAS--SAEFQRLQNDNTK 813
            .:|.....|  .|||.......|:.|..::...||:|:..:..:..|.|:  :.|..:|.:....
Mouse   686 SDRLAYSSQ--TAQQKVTQWAEERDELFRQSLAKLREQLVKANTLVREANFLAEEMSKLTDYQVT 748

  Fly   814 FQADIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLM 878
            .|...|:|:...:....:      ||..::..|.........|::||....:|:..|        
Mouse   749 LQIPAANLSANRKRGAIV------SEPAIQARRKGKGTQVWTIEKLENKLIDMRDLY-------- 799

  Fly   879 ESVQENDALREEIKQRPTSHVEESMRSSGISSD-FDEQKQDINLLHQFVQLSESVQQIELQHHSG 942
                      :|.|:    :|.|:.|..|...| |.|.:::.||:                   |
Mouse   800 ----------QEWKE----NVPEAKRLYGKRGDPFYEAQENHNLI-------------------G 831

  Fly   943 ISRLFRANQMKLDQSEPGLKLCLESAEYIEEDNRQSDATEPICLKGFLKRHRFQIKRLSQEHVDM 1007
            ::.:|                 ||                  ||...:|. ::.:..:||:    
Mouse   832 VANVF-----------------LE------------------CLFCDVKL-QYAVPIISQQ---- 856

  Fly  1008 GEEKRLLDI-ISQLEQEIEEKSALMEATEATINEMREQMTNLESALLE----KSVIINKVEDYQR 1067
            ||....|.: ::::...|.|:.|..:::|          .:.||..||    ...:|::|:....
Mouse   857 GEVAGRLHVEVTRITGTIPERMAEDDSSE----------NSSESGSLEVVDSSGEVIHRVKKLTC 911

  Fly  1068 QIESLEKQNAEMTMVYEELQDRVTRESS---MSESLLRVPPDEDTLPGCPTSPSRREQEVATLKT 1129
            ::...|.....::     |.:.|..:.:   ..||.:..|..:   |..|:..|:..|...|.  
Mouse   912 RVIIKEATGLPIS-----LSNFVFCQYTFWDQCESTVAAPVVD---PDVPSPQSKDAQYTVTF-- 966

  Fly  1130 SITELQSQVSDLKAELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDEDTKQKQELL 1194
                  |...|....:.....:. :.||.:|     .|....||......:.|            
Mouse   967 ------SHCKDYVVTVTEEFLEF-ISDGALA-----IEVWGHRCAGNGSPIWE------------ 1007

  Fly  1195 DRQAQKLSDDLCLIDQLQKKNAQLVEQYHKATESLSLADAKPDQILLSSQYDSQIEKLNQLLNAA 1259
                         :|.|..|...|.:::::.|..:        ::.:|      |.:||:|.:.|
Mouse  1008 -------------VDSLHAKTRTLHDRWNEVTRRI--------EVWIS------ILELNELGDYA 1045

  Fly  1260 KDELHDVRRIKDDEISALRMEFLLQIETNEKENQAKFYAELQETKDRYESNVAELKEKLLQVEET 1324
            ..|||..:.:....:..||.....:::...|..|             :...:..:.|.:|.|  :
Mouse  1046 AVELHQAKDVNTGGVFQLRQGHSRRVQVTVKPVQ-------------HSGTLPLMVEAILSV--S 1095

  Fly  1325 LSSVTVR---CQAELEA----------LKSAHKENISQAVEERNNLIVQHQAEMETIRETLKNKL 1376
            :..||.|   .|..|::          :.|..:|:::...|..::.:::.       ||.|..::
Mouse  1096 IGCVTARSTKLQRGLDSYQRDEEDGGDMDSYQEEDLNCVRERWSDALIKR-------REYLDEQI 1153

  Fly  1377 AEASTQQSKMEDAFRAEINEVRATLMEQLNQTKEDR----------------------------- 1412
            .:.|.::.|.||....|     |.|:||.....|:|                             
Mouse  1154 KKVSNKKEKTEDDMERE-----ARLVEQWVGLTEERNAVLVPAPGSGIPGAPADWVPPPGMETHI 1213

  Fly  1413 -----DKGASKLEEVKKTLEQMI--------------NGGR-----VMSDTIAELEKT-----KA 1448
                 |..|..|    ...||::              :|.:     ::..:..|:..|     ..
Mouse  1214 PVLFLDLNADDL----SANEQLVGPHASGVNSILPKEHGSQFFYLPIIKHSDDEVSATASWDSSV 1274

  Fly  1449 EQDLAVNKLTKDNIELEKQCSKTQEQLQ----MESLTRDQISFEIEAHIKKLELIVASSKKRI-- 1507
            ...|.:|::|..| |......||..||.    ||.:.|.:|:    |:|...:....|.|:||  
Mouse  1275 HDSLHLNRVTPQN-ERIYLIVKTTVQLSHPAAMELVLRKRIA----ANIYNKQSFTQSLKRRISL 1334

  Fly  1508 IELEEKCDQQVLELDKCRLEKLSLESEIQKANSEHSCTMEKLQELQAEMKVLSNRNEKE-KCDFE 1571
            |.:...|.           ....:.|.|.||.       |::::.:. :.:|:.|:|.| ..|.|
Mouse  1335 INICYSCG-----------VTYEIVSNIPKAT-------EEIEDRET-LALLAARSENEGTLDGE 1380

  Fly  1572 TKLETFTFKITDLEEVLKEAQHKVILYDDLVSQHERLKICLAEANELSSNLQKKVMSLHTELIDS 1636
            |.:|.:|..:..:|.:|               ..|||:..:.....||:..:....||.|..:.:
Mouse  1381 TYIEKYTRGVLQVENIL---------------SLERLRQAVTVKEALSTKARHIRRSLSTPNVHN 1430

  Fly  1637 QKGISSRDVEINELREELKA----AMDAKATASAEQMTLV--TQLKDVEERMANQAEKFTREAAN 1695
               :||...:::...|:.|.    .:|....:|:.|....  |..:|...|...........|..
Mouse  1431 ---VSSSRPDLSGFDEDDKGWPENQLDVSDYSSSYQDVACYGTLPRDSPRRSKEGCPSENPHALT 1492

  Fly  1696 LKGSINELLLKLNSMQETK--DMLESGNEELKEQLRNSQNLRNMLDEESKM--------CI---- 1746
            :..      .|..|.|..|  ..|....||.|::|  :...|.:|.:||..        ||    
Mouse  1493 VSP------FKAFSPQPPKFFKPLMPVKEEHKKRL--ALEARPLLSQESMPPSQAHNPGCIVTPG 1549

  Fly  1747 -----------SLKEKLVKLEDAKTSLEQQLRDNKSEIYQRHTELTK---EVELGRNRIGELTKK 1797
                       |..||.:..|:         .:|:.|...|...||:   .||.....:..    
Mouse  1550 SNGSSMPVEHSSKPEKKIDSEE---------EENELEALSRKLMLTQPYVPVEFADFSVYN---- 1601

  Fly  1798 CEELCSDLENSD--QIRLDLQETKEQLKKTLENNLGWQQKVDEVTRECEKLRFDMQSKEVQNESK 1860
                 :.|||.:  ..:.||.::     :.||..:........:|            ....:.|.
Mouse  1602 -----ASLENREWSSSKADLTDS-----RALEKAVSRSPTTSSLT------------SGYFSHSA 1644

  Fly  1861 VQELISECEELRSTLKSKEASFQSEKESMDRTISSLLEDKRNL-EEKLCSANDIVAKLETEIAAL 1924
            ....:|:.....|....:.|....|.|..:....||..|.|.. .::|........|.||....|
Mouse  1645 SNATLSDMAVPSSDSSDQLAVSTKEVECAEPPGPSLAPDVRPASNQELTEVGRGSGKDETIAVPL 1709

  Fly  1925 RPRKSLDRNPVPRKSITFESEIRKNRRISVH--DERRQSYWNDVREF--GIMTDPVDNNCNCAEL 1985
            ....:|.:.....:||..||.....|..|..  |.......:..|||  |.:|  :::..|..|.
Mouse  1710 EENSALPKGTPSPQSIPEESSRMPCRTASCSELDVGPSKDGHQAREFCPGEVT--IEHTTNILED 1772

  Fly  1986 NS--------------KLQDCQRELFIRE-SQVTALKMELDH-------------HPLKDENAQ 2021
            :|              .|.||.    :.| |:..||..|.||             || |.||.|
Mouse  1773 HSFTEFMGVSDGKDFDGLADCS----VGEPSRRRALTNETDHKGIPERPPDADRLHP-KIENDQ 1831

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cmetNP_524993.3 KISc 8..328 CDD:214526 144/369 (39%)
Motor_domain 8..321 CDD:277568 143/362 (40%)
Smc <680..1449 CDD:224117 142/850 (17%)
TMPIT 779..>867 CDD:285135 16/89 (18%)
Smc 1042..1910 CDD:224117 178/989 (18%)
Kif13aXP_036013758.1 KISc_KIF1A_KIF1B 5..359 CDD:276816 144/369 (39%)
Kinesin_assoc 356..468 CDD:406567 25/125 (20%)
FHA 446..543 CDD:238017 20/151 (13%)
Smc <646..811 CDD:224117 41/222 (18%)
KIF1B 788..832 CDD:403579 15/84 (18%)
DUF3694 <1255..1319 CDD:403614 16/68 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2883
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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