Protein Alignment cmet and Kif13a

DIOPT Version :10

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: XP_036013758.1
• Gene: Kif13a / 16553
• MGIID: 1098264
• Length: 1840
• Species: Mus musculus
• Alignment Length: 2274
• Identity: 489/2274 - (21%)
• Similarity: 811/2274 - (35%)
• Gaps: 705/2274 - (31%)

  Fly     7 SSIQVCIKVRPCEPGLTSLWQVKERRSIHLADS------------HAEP-------------YVF 46
            :.::|.::|||           ..||.:.|...            |..|             :.|
Mouse     4 TKVKVAVRVRP-----------MNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAF 57

  Fly    47 DYVF---DEG-----ASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVM 103
            ||.|   ||.     |..:.||..:.:.|:....||:|..|||||||.|||:::|||..:..|::
Mouse    58 DYCFWSMDESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQLGLI 122

  Fly   104 VLAAKEIFQQISSE--TERDFLLRVGYIEIYNEKIYDLLNKK--NQDLKIHESG------NGIVN 158
            ......:||:|:.|  ..:.|.:.|.|:||||||:.|||:.|  .|.||:.|..      :|:
Mouse   123 PRLCCALFQRIALEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGL-- 185

  Fly   159 VNCEECIITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSD-HSDDDAVIQSV 222
               .:..:||..|:..|:..|||.|||..|||||.||||||:|.|||.....| .|.:.....|.
Mouse   186 ---SQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSK 247

  Fly   223 LNLVDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENA----DNRFTNYRDSKLTRI 283
            ::|||||||||..:|||.|.|||||.:|||||..|..||.||::.|    .|:|..||||.||.:
Mouse   248 VSLVDLAGSERVSKTGAAGERLKEGSNINKSLTTLGLVISSLADQAAGKGKNKFVPYRDSVLTWL 312

  Fly   284 LQASLGGNAFTSIICTIKPSI--MEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKV 346
            |:.:||||:.||:|.||.|:.  .||:.|||.:|.|||:|.....||| ..:|.:::.|..|::.
Mouse   313 LKDNLGGNSQTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNE-DPNAKVIRELREEVEK 376

  Fly   347 LKDKLAEEE--RKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPT--------AS 401
            |:::|::.|  :..|.::|:|..|:.||          .|:...::|.|:|....        :.
Mouse   377 LREQLSQAEAMKAPELKEKLEESEKLIK----------ELTVTWEEKLRKTEAIAQERQRQLESM 431

  Fly   402 GSHLELAETGTTEDR-----IDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESN 461
            |..||.:.....:|:     ::..|.::.|   :.::..:..:...:..:.|.:.|   ||.:
Mouse   432 GISLETSGIKVGDDKCYLVNLNADPALNEL---LVYYLKDHTRVGADTSQDIQLFG---IGIQ-- 488

  Fly   462 SISEEFLPAEC-IDFGSPRPDVLKPMLTIRQLPDLPLTPK--------GPLTTDKIKKEIQDLQM 517
                   |..| ||..:.              .|:.||||        |.|.....:....|..:
Mouse   489 -------PEHCEIDIAAD--------------GDITLTPKENARSCVNGTLVCSTTQLWHGDRIL 532

  Fly   518 FTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKERYDAL---EKEVTSLRADNEAANS 579
            :.:  .||                        .:.:|.:::|.|.|   |:|.:|...|.:||:.
Mouse   533 WGN--NHF------------------------FRINLPKRKRRDWLKDFERETSSAEHDLDAASE 571

  Fly   580 KISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSL 644
            ..||.:                      ..:||                      :.:|.:.|:|
Mouse   572 ASSEPD----------------------YNYEF----------------------AQMEVIMKTL 592

  Fly   645 DNLTRDVLRNSKEG----------------HMLSIAP--------EQEDIAGDSICNKCEELEKL 685
                     ||..|                ::..:.|        ..:....|.:.|..:.|||.
Mouse   593 ---------NSNGGFPIVSLSAWWSSPWWSYLKILFPLLWFQTKLVHQHWERDPVQNVVQVLEKQ 648

  Fly   686 IADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQL 750
            .  ||.|:.:.|..:|..|                          .:.|:|.::||..:......
Mouse   649 Y--LEEKRTALEEQRLMYE--------------------------RELEQLRQQLSPERQPPSSA 685

  Fly   751 QERYDALDQQWQAQQAGITTLHEKHEHVQEKYQKLQEEYEQLESRARSAS--SAEFQRLQNDNTK 813
            .:|.....|  .|||.......|:.|..::...||:|:..:..:..|.|:  :.|..:|.:....
Mouse   686 SDRLAYSSQ--TAQQKVTQWAEERDELFRQSLAKLREQLVKANTLVREANFLAEEMSKLTDYQVT 748

  Fly   814 FQADIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLM 878
            .|...|:|:...:....:      ||..::..|.........|::||....:|:..|
Mouse   749 LQIPAANLSANRKRGAIV------SEPAIQARRKGKGTQVWTIEKLENKLIDMRDLY-------- 799

  Fly   879 ESVQENDALREEIKQRPTSHVEESMRSSGISSD-FDEQKQDINLLHQFVQLSESVQQIELQHHSG 942
                      :|.|:    :|.|:.|..|...| |.|.:::.||:                   |
Mouse   800 ----------QEWKE----NVPEAKRLYGKRGDPFYEAQENHNLI-------------------G 831

  Fly   943 ISRLFRANQMKLDQSEPGLKLCLESAEYIEEDNRQSDATEPICLKGFLKRHRFQIKRLSQEHVDM 1007
            ::.:|                 ||                  ||...:|. ::.:..:||:
Mouse   832 VANVF-----------------LE------------------CLFCDVKL-QYAVPIISQQ---- 856

  Fly  1008 GEEKRLLDI-ISQLEQEIEEKSALMEATEATINEMREQMTNLESALLE----KSVIINKVEDYQR 1067
            ||....|.: ::::...|.|:.|..:::|          .:.||..||    ...:|::|:....
Mouse   857 GEVAGRLHVEVTRITGTIPERMAEDDSSE----------NSSESGSLEVVDSSGEVIHRVKKLTC 911

  Fly  1068 QIESLEKQNAEMTMVYEELQDRVTRESS---MSESLLRVPPDEDTLPGCPTSPSRREQEVATLKT 1129
            ::...|.....::     |.:.|..:.:   ..||.:..|..:   |..|:..|:..|...|.
Mouse   912 RVIIKEATGLPIS-----LSNFVFCQYTFWDQCESTVAAPVVD---PDVPSPQSKDAQYTVTF-- 966

  Fly  1130 SITELQSQVSDLKAELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDEDTKQKQELL 1194
                  |...|....:.....:. :.||.:|     .|....||......:.|
Mouse   967 ------SHCKDYVVTVTEEFLEF-ISDGALA-----IEVWGHRCAGNGSPIWE------------ 1007

  Fly  1195 DRQAQKLSDDLCLIDQLQKKNAQLVEQYHKATESLSLADAKPDQILLSSQYDSQIEKLNQLLNAA 1259
                         :|.|..|...|.:::::.|..:        ::.:|      |.:||:|.:.|
Mouse  1008 -------------VDSLHAKTRTLHDRWNEVTRRI--------EVWIS------ILELNELGDYA 1045

  Fly  1260 KDELHDVRRIKDDEISALRMEFLLQIETNEKENQAKFYAELQETKDRYESNVAELKEKLLQVEET 1324
            ..|||..:.:....:..||.....:::...|..|             :...:..:.|.:|.|  :
Mouse  1046 AVELHQAKDVNTGGVFQLRQGHSRRVQVTVKPVQ-------------HSGTLPLMVEAILSV--S 1095

  Fly  1325 LSSVTVR---CQAELEA----------LKSAHKENISQAVEERNNLIVQHQAEMETIRETLKNKL 1376
            :..||.|   .|..|::          :.|..:|:::...|..::.:::.       ||.|..::
Mouse  1096 IGCVTARSTKLQRGLDSYQRDEEDGGDMDSYQEEDLNCVRERWSDALIKR-------REYLDEQI 1153

  Fly  1377 AEASTQQSKMEDAFRAEINEVRATLMEQLNQTKEDR----------------------------- 1412
            .:.|.::.|.||....|     |.|:||.....|:|
Mouse  1154 KKVSNKKEKTEDDMERE-----ARLVEQWVGLTEERNAVLVPAPGSGIPGAPADWVPPPGMETHI 1213

  Fly  1413 -----DKGASKLEEVKKTLEQMI--------------NGGR-----VMSDTIAELEKT-----KA 1448
                 |..|..|    ...||::              :|.:     ::..:..|:..|     ..
Mouse  1214 PVLFLDLNADDL----SANEQLVGPHASGVNSILPKEHGSQFFYLPIIKHSDDEVSATASWDSSV 1274

  Fly  1449 EQDLAVNKLTKDNIELEKQCSKTQEQLQ----MESLTRDQISFEIEAHIKKLELIVASSKKRI-- 1507
            ...|.:|::|..| |......||..||.    ||.:.|.:|:    |:|...:....|.|:||
Mouse  1275 HDSLHLNRVTPQN-ERIYLIVKTTVQLSHPAAMELVLRKRIA----ANIYNKQSFTQSLKRRISL 1334

  Fly  1508 IELEEKCDQQVLELDKCRLEKLSLESEIQKANSEHSCTMEKLQELQAEMKVLSNRNEKE-KCDFE 1571
            |.:...|.           ....:.|.|.||.       |::::.:. :.:|:.|:|.| ..|.|
Mouse  1335 INICYSCG-----------VTYEIVSNIPKAT-------EEIEDRET-LALLAARSENEGTLDGE 1380

  Fly  1572 TKLETFTFKITDLEEVLKEAQHKVILYDDLVSQHERLKICLAEANELSSNLQKKVMSLHTELIDS 1636
            |.:|.:|..:..:|.:|               ..|||:..:.....||:..:....||.|..:.:
Mouse  1381 TYIEKYTRGVLQVENIL---------------SLERLRQAVTVKEALSTKARHIRRSLSTPNVHN 1430

  Fly  1637 QKGISSRDVEINELREELKA----AMDAKATASAEQMTLV--TQLKDVEERMANQAEKFTREAAN 1695
               :||...:::...|:.|.    .:|....:|:.|....  |..:|...|...........|..
Mouse  1431 ---VSSSRPDLSGFDEDDKGWPENQLDVSDYSSSYQDVACYGTLPRDSPRRSKEGCPSENPHALT 1492

  Fly  1696 LKGSINELLLKLNSMQETK--DMLESGNEELKEQLRNSQNLRNMLDEESKM--------CI---- 1746
            :..      .|..|.|..|  ..|....||.|::|  :...|.:|.:||..        ||
Mouse  1493 VSP------FKAFSPQPPKFFKPLMPVKEEHKKRL--ALEARPLLSQESMPPSQAHNPGCIVTPG 1549

  Fly  1747 -----------SLKEKLVKLEDAKTSLEQQLRDNKSEIYQRHTELTK---EVELGRNRIGELTKK 1797
                       |..||.:..|:         .:|:.|...|...||:   .||.....:..
Mouse  1550 SNGSSMPVEHSSKPEKKIDSEE---------EENELEALSRKLMLTQPYVPVEFADFSVYN---- 1601

  Fly  1798 CEELCSDLENSD--QIRLDLQETKEQLKKTLENNLGWQQKVDEVTRECEKLRFDMQSKEVQNESK 1860
                 :.|||.:  ..:.||.::     :.||..:........:|            ....:.|.
Mouse  1602 -----ASLENREWSSSKADLTDS-----RALEKAVSRSPTTSSLT------------SGYFSHSA 1644

  Fly  1861 VQELISECEELRSTLKSKEASFQSEKESMDRTISSLLEDKRNL-EEKLCSANDIVAKLETEIAAL 1924
            ....:|:.....|....:.|....|.|..:....||..|.|.. .::|........|.||....|
Mouse  1645 SNATLSDMAVPSSDSSDQLAVSTKEVECAEPPGPSLAPDVRPASNQELTEVGRGSGKDETIAVPL 1709

  Fly  1925 RPRKSLDRNPVPRKSITFESEIRKNRRISVH--DERRQSYWNDVREF--GIMTDPVDNNCNCAEL 1985
            ....:|.:.....:||..||.....|..|..  |.......:..|||  |.:|  :::..|..|.
Mouse  1710 EENSALPKGTPSPQSIPEESSRMPCRTASCSELDVGPSKDGHQAREFCPGEVT--IEHTTNILED 1772

  Fly  1986 NS--------------KLQDCQRELFIRE-SQVTALKMELDH-------------HPLKDENAQ 2021
            :|              .|.||.    :.| |:..||..|.||             || |.||.|
Mouse  1773 HSFTEFMGVSDGKDFDGLADCS----VGEPSRRRALTNETDHKGIPERPPDADRLHP-KIENDQ 1831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	Motor_domain	8..321	CDD:473979	143/362 (40%)
		SMC_prok_B	539..1431	CDD:274008	162/990 (16%)
		SMC_prok_B	1137..1926	CDD:274008	164/903 (18%)
		YhaN	1717..2182	CDD:443752	77/366 (21%)
Kif13a	XP_036013758.1	KISc_KIF1A_KIF1B	5..359	CDD:276816	144/369 (39%)
		Kinesin_assoc	356..468	CDD:465047	25/125 (20%)
		FHA_KIF13A	446..554	CDD:438781	24/162 (15%)
		SMC_prok_B	<646..>801	CDD:274008	37/208 (18%)
		KIF1B	788..832	CDD:463574	15/84 (18%)
		DUF3694	<1255..1319	CDD:463599	16/68 (24%)