Protein Alignment cmet and Kif11

DIOPT Version :10

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: NP_034745.1
• Gene: Kif11 / 16551
• MGIID: 1098231
• Length: 1052
• Species: Mus musculus
• Alignment Length: 1077
• Identity: 275/1077 - (25%)
• Similarity: 453/1077 - (42%)
• Gaps: 243/1077 - (22%)

  Fly     8 SIQVCIKVRPCEPGLTSLWQVKERRSIHLADSHA------------------------EPYVFDY 48
            :|||.::.||        :.:.||:    |::|:                        :.|.||.
Mouse    17 NIQVVVRCRP--------FNLAERK----ANAHSVVECDHARKEVSVRTAGLTDKTSKKTYTFDM 69

  Fly    49 VFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGD---------EQNP--GV 102
            ||.......:|:..:...|:...:.|:|.||||||||.:|||:||.|:         |::|  |:
Mouse    70 VFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEVYTWEEDPLAGI 134

  Fly   103 MVLAAKEIFQQISSETERDFLLRVGYIEIYNEKIYDLLNKK---NQDLKIHE---SGNGIVNVNC 161
            :.....:||::: ::...:|.::|..:|||||:::|||:..   ::.|::.:   :..|::....
Mouse   135 IPRTLHQIFEKL-TDNGTEFSVKVSLLEIYNEELFDLLSPSSDVSERLQMFDDPRNKRGVIIKGL 198

  Fly   162 EECIITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLV 226
            ||..:.::.::.::|..|..:||...|.||..|||||::|.:.|..:::....::.|....||||
Mouse   199 EEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLV 263

  Fly   227 DLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGN 291
            ||||||...::||...|.:|.|:||:|||.|..||.:|.|...:  ..||:||||||||.||||.
Mouse   264 DLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPH--IPYRESKLTRILQDSLGGR 326

  Fly   292 AFTSIICTIKPSI--MEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEE 354
            ..||||.||.|:.  :||:.|||.:|.|||.|..||:||:.::...::|....||:.||..||..
Mouse   327 TRTSIIATISPASFNLEETLSTLEYAHRAKNIMNKPEVNQKLTKKALIKEYTEEIERLKRDLAAA 391

  Fly   355 ERKN-------------------ENQ-----QKVEHLERQI----------KHDMHKIICGHSLS 385
            ..||                   |.|     :|:..||.::          |:::.:  |...|.
Mouse   392 REKNGVYISEESFRAMNGKVTVQEEQIVELVEKIAVLEEELSKATELFMDSKNELDQ--CKSDLQ 454

  Fly   386 DKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINI 450
            .|.|:  ..|.......:.|:|.:.......:::..|..|         ..|.|..:.:.:|...
Mouse   455 TKTQE--LETTQKHLQETKLQLVKEEYVSSALERTEKTLH---------DTASKLLNTVKETTRA 508

  Fly   451 LGSL-------------------DIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLP 496
            :..|                   ..|...||:....  .|.|..||.:.   |.||      |:.
Mouse   509 VSGLHSKLDRKRAIDEHNAEAQESFGKNLNSLFNNM--EELIKDGSAKQ---KAML------DVH 562

  Fly   497 LTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKER-- 559
            .|..|.|.:..:  ...|....|:||....:. |.|.....:::::.     ||::|||.:.:
Mouse   563 KTLFGNLMSSSV--SALDTITTTALESLVSIP-ENVSARVSQISDMI-----LEEQSLAAQSKSV 619

  Fly   560 ----YDALEKEV-TSLRADNEAANSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSS 619
                .|.|..:: |||:  ...|.|.:|    .|:..||...|....:.||..:|        ..
Mouse   620 LQGLIDELVTDLFTSLK--TIVAPSVVS----ILNINKQLQHIFRASSTVAEKVE--------DQ 670

  Fly   620 KLRVDDLLSALLE-----KESTIESL---QKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSIC 676
            |..:|..||.|..     :|:|:.||   ||...:||.| |:..||.|      .||      :|
Mouse   671 KREIDSFLSILCNNLHELRENTVSSLVESQKLCGDLTED-LKTIKETH------SQE------LC 722

  Fly   677 NKCEELEKLIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKAT--------DC 733
            .......:....||.|..            :::..|.|::....|.|::||.|.|        :.
Mouse   723 QLSSSWAERFCALEKKYE------------NIQKPLNSIQENTELRSTDIINKTTVHSKKILAES 775

  Fly   734 ERLSKELSTSQNAFGQLQE----RYDALDQQWQAQQAGIT----TLHEKHEHVQEKY----QKLQ 786
            :.|.:||........||.|    ...:|:...:.....||    ||:....|..:::    .|.:
Mouse   776 DGLLQELRHFNQEGTQLVEESVGHCSSLNSNLETVSQEITQKCGTLNTSTVHFSDQWASCLSKRK 840

  Fly   787 EEYEQLESRAR---SASSAEFQR--------LQNDNTKFQADIASLNERLEEAQNMLTEVQNSES 840
            ||.|.|.....   .|||:|..:        :.|.::.|.|.:.|..|..:.....|.:...:..
Mouse   841 EELENLMEFVNGCCKASSSEITKKVREQSAAVANQHSSFVAQMTSDEESCKAGSLELDKTIKTGL 905

  Fly   841 TVEKLRIQNHELTAKIK-ELETNFEEMQREYDCLSNQLMESVQENDALREEI-KQRPTSHVEESM 903
            |  ||   |..|...:| ::.|.....:::|  |....:...:..:.|.::: |::|...:..|.
Mouse   906 T--KL---NCFLKQDLKLDIPTGMTPERKKY--LYPTTLVRTEPREQLLDQLQKKQPPMMLNSSE 963

  Fly   904 RSSGISSDFDEQKQDINLLHQFVQLSESVQQIELQHH 940
            .|...|.|.||:::.:.      |.:|.:...|...|
Mouse   964 ASKETSQDMDEEREALE------QCTEELVSPETTEH 994

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	Motor_domain	8..321	CDD:473979	121/355 (34%)
		SMC_prok_B	539..1431	CDD:274008	101/450 (22%)
		SMC_prok_B	1137..1926	CDD:274008
		YhaN	1717..2182	CDD:443752
Kif11	NP_034745.1	KISc_BimC_Eg5	15..367	CDD:276815	126/364 (35%)
		PRK12704	349..>508	CDD:237177	37/171 (22%)
		CCDC158	415..>863	CDD:464943	112/518 (22%)
		Microtub_bind	915..1047	CDD:464048	17/88 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	950..1026		12/51 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1033..1052