DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and Kif22

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	XP_006507264.1	Gene:	Kif22 / 110033	MGIID:	109233	Length:	690	Species:	Mus musculus

Alignment Length:	732	Identity:	186/732 - (25%)
Similarity:	309/732 - (42%)	Gaps:	158/732 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IQVCIKVRPCEPGLTSLWQVKERRSIHLADS------------HAEPYVFDYVFDEGASNQEVFD 61
            ::|.:::||...|.|   :.||...:...||            ....|.||..:.|.::.|||:.
Mouse    39 VRVAVRLRPFMDGET---EAKELPCVRAIDSCSLEVANWKKYQETLKYQFDAFYGEKSTQQEVYV 100

  Fly    62 RMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETER----DF 122
            ...:.|:...::|.|.::.|||.|.:|||:||:|..:.|||:..|..::.|....|:..    |.
Mouse   101 GSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQPGVIPRALMDLLQLAREESAEGRPWDV 165

  Fly   123 LLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNG-IVNVNCEECIITSEVDLLRLLCLGNKERTVG 186
            .:.:.|:|||.||:.|||:..:.||.|.|...| |:.....:..|||..|..:.....::.|.||
Mouse   166 SVAMSYLEIYQEKVLDLLDPASGDLVIREDCRGNILIPGLTQKPITSFSDFEQHFLPASRNRAVG 230

  Fly   187 ETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHIN 251
            .|.:|:|||||||:..:.::.|  :........:..|.|:||||||...:||.:|.||||.|.||
Mouse   231 ATRLNQRSSRSHAVLLVKVDQR--ERLTPFRQREGKLYLIDLAGSEDNRRTGNQGIRLKESGAIN 293

  Fly   252 KSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPS--IMEESQSTLSF 314
            .||..|..|:.:|::....  ..||||||||:||.||||:|.:.:|..|.|.  ..:::.|.|:|
Mouse   294 TSLFVLGKVVDALNQGLPR--IPYRDSKLTRLLQDSLGGSAHSILIANIAPERRFYQDTISALNF 356

  Fly   315 ATRAKKIRIKPQVNEMVSDATM--MKRLEREI----KVLKDKLAEEERKNENQ---------QKV 364
            ..|:|::..:|..||.:....:  :|..::|:    :..|.|..|||.....:         ||:
Mouse   357 TARSKEVINRPFTNESLQPHALAPVKLSQKELLGPSEAKKAKGPEEESTGSPESTAAPASASQKL 421

  Fly   365 EHLERQIKHD---------MHKIICGHSLSDKGQQ---------KRRRTWCPTASGSHLELAETG 411
            ..|::....|         |.::     |..:|.|         :.|.....|....:||:....
Mouse   422 SLLQKLSNMDPAMLENLLSMERL-----LGSQGSQGTPLLNTPKRERMVLMKTVEEKNLEIERLK 481

  Fly   412 TTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFG 476
            ..:..::........|.|         :..:|.|..:....|.. ||.:..:.:.
Mouse   482 MKQKELEAKVLAQEAPDP---------REKENTPTILQPPASYS-GTVAKPLKKA---------- 526

  Fly   477 SPRPDVLKPMLTIRQLPD----LPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKE 537
                 |:.|:..|::..:    :.|..|||      |::::......::||  :.:..|||...|
Mouse   527 -----VVMPLQRIQKQRESSNQIQLLKKGP------KRKLEPSPESEAVEK--DEDYWEVQISPE 578

  Fly   538 KLAEVTAQRDNLEQESLAEKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVEN 602
            .||.             ..|:..|.|          ||.:..::..|:          ||.:.:.
Mouse   579 LLAH-------------GRKKLLDLL----------NEGSARELRSLQ----------RIGQKKA 610

  Fly   603 QVAVGLEFEFEAHKKSSKLRVDDL--LSALLEKESTIESLQKSLDNLT---------------RD 650
            |:.||..   |.|...|:  |:||  :..:..|:  :||..|....|.               .:
Mouse   611 QLIVGWR---ELHGPFSE--VEDLEQVEGISGKQ--VESFLKVRPPLPFLHGVPPPQPTLGCYAN 668

  Fly   651 VLRNSKEGHMLSIAPEQ 667
            ...:|.:.::||:|..|
Mouse   669 ARSSSLQANLLSLAASQ 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	115/337 (34%)
		Motor_domain	8..321	CDD:277568	114/330 (35%)
		Smc	<680..1449	CDD:224117
		TMPIT	779..>867	CDD:285135
		Smc	1042..1910	CDD:224117
Kif22	XP_006507264.1	KISc_KID_like	38..361	CDD:276827	113/328 (34%)
Kif22	XP_006507264.1	ComEA	<591..641	CDD:393460	16/76 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900