Protein Alignment cmet and Kif22

DIOPT Version :10

• Sequence 1: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Sequence 2: XP_006507264.1
• Gene: Kif22 / 110033
• MGIID: 109233
• Length: 690
• Species: Mus musculus
• Alignment Length: 732
• Identity: 186/732 - (25%)
• Similarity: 309/732 - (42%)
• Gaps: 158/732 - (21%)

  Fly     9 IQVCIKVRPCEPGLTSLWQVKERRSIHLADS------------HAEPYVFDYVFDEGASNQEVFD 61
            ::|.:::||...|.|   :.||...:...||            ....|.||..:.|.::.|||:.
Mouse    39 VRVAVRLRPFMDGET---EAKELPCVRAIDSCSLEVANWKKYQETLKYQFDAFYGEKSTQQEVYV 100

  Fly    62 RMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETER----DF 122
            ...:.|:...::|.|.::.|||.|.:|||:||:|..:.|||:..|..::.|....|:..    |.
Mouse   101 GSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQPGVIPRALMDLLQLAREESAEGRPWDV 165

  Fly   123 LLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNG-IVNVNCEECIITSEVDLLRLLCLGNKERTVG 186
            .:.:.|:|||.||:.|||:..:.||.|.|...| |:.....:..|||..|..:.....::.|.||
Mouse   166 SVAMSYLEIYQEKVLDLLDPASGDLVIREDCRGNILIPGLTQKPITSFSDFEQHFLPASRNRAVG 230

  Fly   187 ETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHIN 251
            .|.:|:|||||||:..:.::.|  :........:..|.|:||||||...:||.:|.||||.|.||
Mouse   231 ATRLNQRSSRSHAVLLVKVDQR--ERLTPFRQREGKLYLIDLAGSEDNRRTGNQGIRLKESGAIN 293

  Fly   252 KSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPS--IMEESQSTLSF 314
            .||..|..|:.:|::....  ..||||||||:||.||||:|.:.:|..|.|.  ..:::.|.|:|
Mouse   294 TSLFVLGKVVDALNQGLPR--IPYRDSKLTRLLQDSLGGSAHSILIANIAPERRFYQDTISALNF 356

  Fly   315 ATRAKKIRIKPQVNEMVSDATM--MKRLEREI----KVLKDKLAEEERKNENQ---------QKV 364
            ..|:|::..:|..||.:....:  :|..::|:    :..|.|..|||.....:         ||:
Mouse   357 TARSKEVINRPFTNESLQPHALAPVKLSQKELLGPSEAKKAKGPEEESTGSPESTAAPASASQKL 421

  Fly   365 EHLERQIKHD---------MHKIICGHSLSDKGQQ---------KRRRTWCPTASGSHLELAETG 411
            ..|::....|         |.::     |..:|.|         :.|.....|....:||:....
Mouse   422 SLLQKLSNMDPAMLENLLSMERL-----LGSQGSQGTPLLNTPKRERMVLMKTVEEKNLEIERLK 481

  Fly   412 TTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFG 476
            ..:..::........|.|         :..:|.|..:....|.. ||.:..:.:.
Mouse   482 MKQKELEAKVLAQEAPDP---------REKENTPTILQPPASYS-GTVAKPLKKA---------- 526

  Fly   477 SPRPDVLKPMLTIRQLPD----LPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKE 537
                 |:.|:..|::..:    :.|..|||      |::::......::||  :.:..|||...|
Mouse   527 -----VVMPLQRIQKQRESSNQIQLLKKGP------KRKLEPSPESEAVEK--DEDYWEVQISPE 578

  Fly   538 KLAEVTAQRDNLEQESLAEKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVEN 602
            .||.             ..|:..|.|          ||.:..::..|:          ||.:.:.
Mouse   579 LLAH-------------GRKKLLDLL----------NEGSARELRSLQ----------RIGQKKA 610

  Fly   603 QVAVGLEFEFEAHKKSSKLRVDDL--LSALLEKESTIESLQKSLDNLT---------------RD 650
            |:.||..   |.|...|:  |:||  :..:..|:  :||..|....|.               .:
Mouse   611 QLIVGWR---ELHGPFSE--VEDLEQVEGISGKQ--VESFLKVRPPLPFLHGVPPPQPTLGCYAN 668

  Fly   651 VLRNSKEGHMLSIAPEQ 667
            ...:|.:.::||:|..|
Mouse   669 ARSSSLQANLLSLAASQ 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	Motor_domain	8..321	CDD:473979	114/330 (35%)
		SMC_prok_B	539..1431	CDD:274008	29/146 (20%)
		SMC_prok_B	1137..1926	CDD:274008
		YhaN	1717..2182	CDD:443752
Kif22	XP_006507264.1	KISc_KID_like	38..361	CDD:276827	113/328 (34%)
		ComEA	591..641	CDD:441164	16/76 (21%)