DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cmet and CENPE

DIOPT Version :9

Sequence 1:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster
Sequence 2:NP_001804.2 Gene:CENPE / 1062 HGNCID:1856 Length:2701 Species:Homo sapiens


Alignment Length:2589 Identity:654/2589 - (25%)
Similarity:1126/2589 - (43%) Gaps:586/2589 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 SIQVCIKVRPCEPGLTSL-------WQVKERRSIHLADSHAEPYVFDYVFDEGASNQEVFDRMAK 65
            ::.||::|||......||       |:. :...|:..|. ::.:.||.||....:.:.|::.:|.
Human     6 AVAVCVRVRPLNSREESLGETAQVYWKT-DNNVIYQVDG-SKSFNFDRVFHGNETTKNVYEEIAA 68

  Fly    66 HIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVMVLAAKEIFQQISSETERDFLLRVGYIE 130
            .|:.:.:||:||||||||||:|||||||||.|.:.||:..|..:|||:|....:|:|||||.|:|
Human    69 PIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKFPDREFLLRVSYME 133

  Fly   131 IYNEKIYDLL--NKKNQDLKIHESGNGIVNVN--CEECIITSEVDLLRLLCLGNKERTVGETNMN 191
            ||||.|.|||  .:|.:.|.|.|..|..|.|.  .||.:.|||: .|:.:..|.|.|..|||.||
Human   134 IYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEM-ALKWITKGEKSRHYGETKMN 197

  Fly   192 ERSSRSHAIFKIIIESR-KSDHSD-DDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHINKSL 254
            :||||||.||::|:||| |.:.|: :.:|..|.||||||||||||.||||.|.|||||.:||:||
Human   198 QRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSERAAQTGAAGVRLKEGCNINRSL 262

  Fly   255 LFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPSIMEESQSTLSFATRAK 319
            ..|..|||.||:.....|.||||||||||||.||||||.|.|||||.|...:|:.:.|.||:.||
Human   263 FILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPVSFDETLTALQFASTAK 327

  Fly   320 KIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAE-------------------EER----KNENQ 361
            .::..|.|||:.:|..::||..:||..||.:|.|                   ||:    |.:| 
Human   328 YMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQN- 391

  Fly   362 QKVEHLERQIKHDMHKIICGHSLS----DKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPK 422
            :|:|:|.|.       ::...||:    .|.::|||.|||       |.........:..|||  
Human   392 EKIENLTRM-------LVTSSSLTLQQELKAKRKRRVTWC-------LGKINKMKNSNYADQF-- 440

  Fly   423 VSHLPKPVFFHTSNAGKRWDNIPKTINILGSLD--IGTES-------NSISE-EFLPAECI---- 473
              ::|..:...|...         :||:|..:|  :.:||       :::|| |:.||..:    
Human   441 --NIPTNITTKTHKL---------SINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQE 494

  Fly   474 ----DFGSPRPDVLKPMLTIRQL------PDLPLTPKGPL-----TTDKIKKE-----IQDLQMF 518
                :..|.|.|....:|...||      .:|.|..|..|     ...|.||:     |.::...
Human   495 NIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNL 559

  Fly   519 TSLEKHFEVECEEVQG--------LKEKLAEVTAQRDNLEQESL----------------AEKER 559
            .:|.||.||..::::.        |:||..::...::.::.:.|                .::.:
Human   560 KNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMK 624

  Fly   560 YDALEKEVTSLRADNEAA--NSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLR 622
            ....:.|..:|.|..|:|  .|:..||:||:..|..|.:.||.:.|:   .:.:.||.|   |::
Human   625 QTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQL---YQSQLEAKK---KMQ 683

  Fly   623 VDDLLSALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIA 687
            ||      ||||     ||.:.:.:|:  |.:..:|          .:..|.:||.  |||..|.
Human   684 VD------LEKE-----LQSAFNEITK--LTSLIDG----------KVPKDLLCNL--ELEGKIT 723

  Fly   688 DLESKKNS----------------------CECDQLRLEIVSVRDKLESVESAFNLASSEIIQKA 730
            ||:.:.|.                      .|.::||.||....::|..:.|..:...||::.|.
Human   724 DLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKE 788

  Fly   731 TDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLH----EKHEHVQEKYQKLQEEYEQ 791
            :..:.|.:|:..:::.....|..|.:.||::|    ...|||    :|::.|.|:.:::.:|...
Human   789 SRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQ----NFKTLHMDFEQKYKMVLEENERMNQEIVN 849

  Fly   792 LESRAR---SASSAEFQRLQNDNTKFQADIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHELT 853
            |...|:   |:..|....|.....:.|.....:.|||.|.:.:..:::|.:||::.:..:...:|
Human   850 LSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLIT 914

  Fly   854 AKIKELETNFEEMQREYDCLSNQLMESVQ-ENDALREEIKQRPTSHVEESMRSSGISSDFDEQKQ 917
            .|:::.....:.:.:|.|.| .||.||:| |.|.|:.:|......:::...:.........:.::
Human   915 EKLQQTLEEVKTLTQEKDDL-KQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQE 978

  Fly   918 DINLLHQFVQLSESV---------------------------QQIELQHHSGISRLFRANQM--- 952
            .||.|..  ::||.|                           |.:|.::...::...:.|::   
Human   979 TINTLKS--KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQ 1041

  Fly   953 -----KLDQSEPGLKLCLESA----EYIEEDNRQS-----DATEPICLKGFLKRHRFQIKRLSQE 1003
                 .|.|.:..|:..|||.    |.::.|.:::     :..|.:.|.|...:.:.:|....:.
Human  1042 QRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKN 1106

  Fly  1004 HV--DMGEEKRLLDIISQLEQEIEEKSALMEATEATINEMREQMTNLESALLEKSVIINKVEDYQ 1066
            |.  ..||..|..|.::::|::::|||..::..:..:..::|:|:.::..:.|...:.|::::.:
Human  1107 HAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKE 1171

  Fly  1067 RQIESLEKQNAEMTMV----YEELQDRVTRESSMSESLLR-VPPDEDTLPGCPTSPSRREQEVAT 1126
            ..:|.:|.:..|:...    |||::. :|:|..:.:.|.: ...:.|.|.|     ..||.|...
Human  1172 LTLEHMETERLELAQKLNENYEEVKS-ITKERKVLKELQKSFETERDHLRG-----YIREIEATG 1230

  Fly  1127 LKT----------------SITELQSQVSDLKAELEN------------------HLRQIQLKDG 1157
            |:|                :|.||:..||:..|::.|                  |..|..|.  
Human  1231 LQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLP-- 1293

  Fly  1158 NIARLQTDFEEMSERCL--------------SMEVRLAELDEDTKQKQELLDRQAQKLSDDLCLI 1208
            |:..:....|.|:|..|              .:|:....|:|..::.||.: :...|..|:|..|
Human  1294 NVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEI-KSLTKERDNLKTI 1357

  Fly  1209 -DQLQKKNAQLVEQYHKATESLSLADAKPDQILLSSQYDSQIEKLNQLLNAAKDELHDVRRIKDD 1272
             :.|:.|:.||.|...:....:..:.:|.:|.|...:.|::..|:...:...|.        ||.
Human  1358 KEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKP--------KDS 1414

  Fly  1273 EISALRMEFL------------LQIETNEKENQAKFYAELQETKDRYESNVAELKEKLLQVEETL 1325
            .:..:.:|.|            ::....||::..:....||...|:.:.|:.|:..|.|:.||.|
Human  1415 ALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEEL 1479

  Fly  1326 SSVTVRCQAELEALKSAHKENISQAVEERNNLIVQHQAEMETIRETLKNKLAEASTQQSKMEDAF 1390
             .|...|..|.|...:..:.|:|:...|.:.:    |.::|.|.:.|:||:.|.    .:.|:.|
Human  1480 -KVAHCCLKEQEETINELRVNLSEKETEISTI----QKQLEAINDKLQNKIQEI----YEKEEQF 1535

  Fly  1391 R-AEINEVRATLMEQLNQTKEDRDKGASKLEEVKKTLEQMINGGRVMSDTIAELEKTKAEQDLAV 1454
            . .:|:||:..:.| |.|.||.|....|.|:.::..:.::.|          .|::::.|..:.:
Human  1536 NIKQISEVQEKVNE-LKQFKEHRKAKDSALQSIESKMLELTN----------RLQESQEEIQIMI 1589

  Fly  1455 NKLTKDNIELEKQCSKTQEQLQMESLTRDQISFEIEAHIKKLELIVASSKKRIIELEEKCDQQVL 1519
            .:        :::..:.||.||:|   |||:.       :..:.|||..|    |.:|| :.|.|
Human  1590 KE--------KEEMKRVQEALQIE---RDQLK-------ENTKEIVAKMK----ESQEK-EYQFL 1631

  Fly  1520 ELDKCRLEKLSLESEIQKANSEHSCTMEKLQELQAEMKVLSNRNEKEKCDFETKLETFTFKITD- 1583
                    |::..:|.|    |..|.:|.|:|          :.|.:|.:.| .:||...::|. 
Human  1632 --------KMTAVNETQ----EKMCEIEHLKE----------QFETQKLNLE-NIETENIRLTQI 1673

  Fly  1584 LEEVLKEAQHKVILYDDLVSQHERLKICLAEANELSSNLQKKV----------------MSLHTE 1632
            |.|.|:|.:......|||.|..|.||:   |.::|..||::.:                :..|.|
Human  1674 LHENLEEMRSVTKERDDLRSVEETLKV---ERDQLKENLRETITRDLEKQEELKIVHMHLKEHQE 1735

  Fly  1633 LIDSQKGI-SSRDVEINELREELKAAMDAKATAS--------------AEQMTLVTQL------- 1675
            .||..:|| |.:..||:.::::|:.:.||.....              .||...:.:|       
Human  1736 TIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK 1800

  Fly  1676 --------KDVEERMANQAEKFTREAAN------LKGSINELLLKLNSMQETKDMLESGNEELK- 1725
                    ||:|...|...||.....||      ||..:||...|::.|::.|..::..:..|. 
Human  1801 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSK 1865

  Fly  1726 ---EQLRNSQNLRNMLDEESKMCISLKEKLVKLEDAKTSLEQQLRDNKSEIYQRHTELTKEVELG 1787
               |.|..:|.|...| ||.|..:..::.|.::|:.......||:::..|...|..|:.:|::..
Human  1866 LEIENLNLAQKLHENL-EEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTA 1929

  Fly  1788 --------------RNRIGELTKKCEELCSDLENS-DQIRLDLQETKE---QLKKTLEN-NLGWQ 1833
                          |.:|.|.|.:..::..||:.| |:::..:||.::   ||.:..|: |:..:
Human  1930 RMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHK 1994

  Fly  1834 Q--KVDEVTRECEKLRFDMQSKEVQNESKVQELISECEELRSTLKSKEASFQSEKESM----DRT 1892
            :  :::::.::.|.....|||..:.|....::|....||:|...|.:: ..:..|||:    |:.
Human  1995 KINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERD-ELRRIKESLKMERDQF 2058

  Fly  1893 ISSLLE----DKRN--------------------LEEKLCS------------------ANDIVA 1915
            |::|.|    |::|                    |.|| ||                  .|.:..
Human  2059 IATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREK-CSRIKELLKRYSEMDDHYECLNRLSL 2122

  Fly  1916 KLETEI-----AALRPRKSLDRNPVPRKSITFESEIRKNRRISVHDER---------------RQ 1960
            .||.||     .::|.:.:|....:..|.|  |.....|:|.|:...|               ::
Human  2123 DLEKEIEFQKELSMRVKANLSLPYLQTKHI--EKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE 2185

  Fly  1961 SYWNDVREFGIMTDPVDNNCNCAELNSKLQDCQRELFI--RESQVTALKMELDHH---PLKD--- 2017
            .....:.:|.:  |.:|......||..|:|..|::..:  ||.:...|...:|.|   .|||   
Human  2186 EQHESINKFEM--DFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSE 2248

  Fly  2018 --------------ENAQLTKRVIEEQDKAKVEQKRLKMKLQDLNARI-------NDLTTASAKE 2061
                          .|.:...:.:||....:.:.::||..:|..|.||       |:...|... 
Human  2249 SEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMN- 2312

  Fly  2062 PESNQMAQAAKPATVAAQTQTESDLETILEKTNVKYQEAVRMLRYRYHLIQELKEKLRQNENSD- 2125
             ||.:..:  :.||::  .:.|.||:::.|| |.|..:..:.|:.......::....:.|:|.. 
Human  2313 -ESTEFEE--RSATIS--KEWEQDLKSLKEK-NEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHV 2371

  Fly  2126 TSNITSLSAGQTSALKAQCESQKKEILAIKYKYEAAKRILAIRNDDLDALREKL 2179
            ||..|.|:..:...|:......|:..:..:.|....::.|.:.||.:..|:.|:
Human  2372 TSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKV 2425

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cmetNP_524993.3 KISc 8..328 CDD:214526 164/332 (49%)
Motor_domain 8..321 CDD:277568 163/325 (50%)
Smc <680..1449 CDD:224117 189/911 (21%)
TMPIT 779..>867 CDD:285135 17/90 (19%)
Smc 1042..1910 CDD:224117 233/1058 (22%)
CENPENP_001804.2 KISc 6..336 CDD:214526 164/332 (49%)
KISc_CENP_E 6..329 CDD:276825 163/325 (50%)
SbcC 345..915 CDD:223496 142/632 (22%)
Mplasa_alph_rch 660..1366 CDD:275316 157/752 (21%)
NUDE_C 828..>911 CDD:282704 17/82 (21%)
Mplasa_alph_rch 1151..1951 CDD:275316 196/886 (22%)
Smc 1676..2482 CDD:224117 166/767 (22%)
Kinetochore-binding domain 2126..2476 64/311 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2355..2376 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2508..2533
Globular autoinhibitory domain. /evidence=ECO:0000250 2510..2698
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2588..2701
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140817
Domainoid 1 1.000 259 1.000 Domainoid score I1997
eggNOG 1 0.900 - - E2759_KOG0242
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 498 1.000 Inparanoid score I1385
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm40987
orthoMCL 1 0.900 - - OOG6_101662
Panther 1 1.100 - - LDO PTHR47968
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5166
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.790

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