DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cmet and kif13a

DIOPT Version :9

Sequence 1:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster
Sequence 2:	XP_009291008.1	Gene:	kif13a / 100331282	ZFINID:	ZDB-GENE-090901-1	Length:	1937	Species:	Danio rerio

Alignment Length:	1699	Identity:	374/1699 - (22%)
Similarity:	655/1699 - (38%)	Gaps:	509/1699 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSIQVCIKVRPCEPGLTSLWQVKERRSIHL-----------------------ADSHAEP--YVF 46
            :.::|.::|||           ..||.|.|                       .:|..:|  :.|
Zfish     4 TKVKVAVRVRP-----------MNRREIELNTKCVVEMEDNQTVLHPPPSNAKGESRKQPKVFAF 57

  Fly    47 DYVF---DEG-----ASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMGDEQNPGVM 103
            |:.|   ||.     |..:.||..:.:.|:....||:|..|||||||.|||:::|||....||::
Zfish    58 DHCFWSMDESNIPKYAGQEVVFKCLGEGILQNAFQGYNACIFAYGQTGSGKSFSMMGSGDQPGLI 122

  Fly   104 VLAAKEIFQQISSE--TERDFLLRVGYIEIYNEKIYDLLNKK--NQDLKIHESG------NGIVN 158
            ......:|:::|::  ....|.:.|.|:||||||:.|||:.|  .|.||:.|..      :|:
Zfish   123 PRLCCSLFERVSTQQSDSNSFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGL-- 185

  Fly   159 VNCEECIITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSD-HSDDDAVIQSV 222
               .:..:||..|:..|:..|||.|||..|||||.||||||:|.:|:.....| .|.:.....|.
Zfish   186 ---SQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFSVILTQTLYDLQSGNSGEKVSK 247

  Fly   223 LNLVDLAGSERADQTGARGARLKEGGHINKSLLFLSNVIKSLSE----NADNRFTNYRDSKLTRI 283
            ::|||||||||..:|||.|.|||||.:|||||..|..||.:|::    .:.|:|..||||.||.:
Zfish   248 ISLVDLAGSERVSKTGAAGERLKEGSNINKSLTTLGCVISALADQSAGKSRNKFVPYRDSVLTWL 312

  Fly   284 LQASLGGNAFTSIICTIKPSI--MEESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKV 346
            |:.:||||:.|::|.||.|:.  .||:.|||.:|.|||:|.....||| ..:|.:::.|..|::.
Zfish   313 LKDNLGGNSKTAMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNE-DPNARIIRELREEVEK 376

  Fly   347 LKDKLAEEE--RKNENQQKVEHLERQIKHDM-----HKIICGHSLSDKGQQKRRRTWCPTASGSH 404
            |:::|::.|  :..|.|:|::..|:.|: :|     .|:   ....:..|:::::.   .:.|..
Zfish   377 LREQLSQAESLKAPELQEKLQESEKLIQ-EMTVTWEEKL---RKTEEIAQERQKQL---ESMGIS 434

  Fly   405 LELAETGTTEDR-----IDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSIS 464
            ||.:.....||:     ::..|.::.|   :.::..:..:...:..:.|.:.|   ||.:|.
Zfish   435 LESSGIKVGEDKSFLVNLNADPALNEL---LVYYLKDHTRVGADTTQDIQLFG---IGIQSE--- 490

  Fly   465 EEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTP--------KGPLTTDKI------------- 508
                  .|:             |.:....|:.|||        .|.:...|:
Zfish   491 ------HCV-------------LEVTADGDVTLTPAHNARTCVNGMMVYSKVHVWHGDRILWGNN 536

  Fly   509 ---------KKEIQDLQMFTSLEKHFEVECEEV------QGLKEKLAEV---------------- 542
                     :|..:||...:..|...|.:.|..      |....:.|::
Zfish   537 HFFRVNLPNRKRRKDLDRGSPRESFIEADVETASEASSEQDYSYEFAQMEVMMKALGNNDPMQNA 601

  Fly   543 --TAQRDNLEQESLAEKERYDALEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVENQVA 605
              ..::..:|::.||.:|:....|:|:.|||          .:|..:.:|..|.:
Zfish   602 VQALEKQYVEEKRLALEEQRLMYERELQSLR----------QQLTPERNTQHQRL---------- 646

  Fly   606 VGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLRNS---KEGHMLSIAPEQ 667
                 .:..|...|:||        |..|...|..::||..|...|:|.:   :|.:.||
Zfish   647 -----SYNTHNTHSRLR--------LWTEERDELFRQSLSRLREQVVRANALVREANFLS----- 693

  Fly   668 EDIAGDSICNKCEELEK---LIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQK 729
                        ||::|   ..|.|:....:...::.|..|||        |.|..:...   .|
Zfish   694 ------------EEMQKHTDYQATLQIPAANLSANRKRGAIVS--------EPAIQVRRK---GK 735

  Fly   730 ATDCERLSKELSTSQNAFGQLQERYDALDQQW-QAQQAGITTLHEKHEHVQEKYQKLQEEY---- 789
            .|....:.|    .:|....:::.|    :.| :..|..:..||.|   ..:.:.:.||.:
Zfish   736 GTQVWTIEK----LENKLVDMRDHY----RDWREGAQELVNRLHNK---AGDPFYEAQENHNLIG 789

  Fly   790 --------------------------------------------EQL----ESRARSASSAEFQR 806
                                                        |:|    :|...|:.|:.:..
Zfish   790 VANVFLECLFHDVRLQYAVPIISQQGEVAGRLHVELLRVSGAVPERLCGGDDSSENSSESSGYDF 854

  Fly   807 LQND-NTKFQADIASLNERLEEAQNMLTEVQN-----------SESTVEKLRIQNHELTAKI--K 857
            :.|: .....|...:...|::||..:...:.|           ||.||....:.....||:.  :
Zfish   855 MDNNGEIVHMARKLTCRVRIKEASGLPLHLSNFVFCQYSFWDQSEPTVAPPLVSPDTPTARSHDQ 919

  Fly   858 ELETNFEEMQREYDCLSNQLMESVQENDALREEIKQRPT--------SHVEESMRSSGISSDFDE 914
            |....|...:.....::.:.:|.:.:.....|....|.|        :|..::.:.: :...:.|
Zfish   920 EFTVRFNHCRDFVVQVTEEFLEFISDGALAIEVWGHRYTGNGRSVWETHTLQAKKRT-LRDRWSE 983

  Fly   915 QKQDINLLHQFVQLSESVQQIELQHHS-------GISRLFRANQMKLDQSEPGLKLCLESAEYIE 972
            ..:.|.|.....:|:|..:...::.|:       |:.:|.:.:..:       |::|::..
Zfish   984 VSRSIELWVSIQELNEQGEYSSVELHNTKDSSTGGVFQLRQGHSRR-------LQVCVQPV---- 1037

  Fly   973 EDNRQSDATEPICLKGFLKRHRFQIKRLSQEHVDMG-EEKRLLDIISQLEQEIEEKSALMEATEA 1036
                |...|.|:.::..|.             |.:| ...|...:...|:...||...:....|.
Zfish  1038 ----QHSGTLPLLVEAVLS-------------VSIGCVTARSTKLQRPLDSYQEEDGDMDSYQEE 1085

  Fly  1037 TINEMREQMTNLESALLEK--------SVIINKVEDYQRQIESLEKQNAEMTMVYEELQDRVTRE 1093
            .:|.:|::.::   ||:::        .:|:||.|..:..||...:...:...:.||
Zfish  1086 DLNCVRDRWSD---ALIKRREYLEEQIKIILNKPEKSEEDIEREARLVEQWVGLTEE-------- 1139

  Fly  1094 SSMSESLLRVPPDEDTLPGCP---TSPSRREQEVATLKTSITELQSQVSDLKAE---LENHL--- 1149
                .:.:.||.....:||.|   ..|:..|..:..|          ..||.|:   :.:||
Zfish  1140 ----RNAVLVPAPASGIPGAPAHWVPPAGMEAHIPVL----------FLDLNADNLTVNDHLTGP 1190

  Fly  1150 -----RQIQLKDGN-------IARLQTDFEEMSERC-----LSMEVRLAELDEDTKQKQELLDRQ 1197
                 ..|..|:..       |.|...|  |:|..|     :...:.|..:.. ..::..|:.:.
Zfish  1191 HAAGVNSILPKEHGSSFFYLPIIRHSDD--EVSAVCSWDSSIHDSIHLNRITA-ANERVYLIVKA 1252

  Fly  1198 AQKLSDDLCLIDQLQKKNAQLVEQYHKATESLSLADAKPDQILLSSQYDSQI--EKLNQLLNAAK 1260
            |.:||...|:...|:|:.|  |..|:|.:.:.||   |....|.:..|...:  |.::.:..|::
Zfish  1253 AVQLSHPACVELLLRKRIA--VNIYNKQSFTQSL---KRRMSLKNMLYSCGVTYEIVSNIPKASE 1312

  Fly  1261 DELHDVRRIKDDEISALRMEFLLQIETNEKENQAKFYA--ELQETKD------RYESNVAELKEK 1317
                                     |..|:|..|...|  |.:||:|      :|...|.|: :.
Zfish  1313 -------------------------EPEERETLALMAARGENEETRDGETYIEKYTRGVLEV-DN 1351

  Fly  1318 LLQVEETLSSVTVRCQAELEALKSAHKENISQAVEERNNLIVQH----QAEMETIRETLKNKLAE 1378
            :|.::....:|||:     ||| ||..::|.:::...|   |||    :::..|..|....|::|
Zfish  1352 ILCLDRLRQAVTVK-----EAL-SAKGKHIRRSLSTPN---VQHSSSCKSDGRTGCEDEDVKVSE 1407

  Fly  1379 ASTQQSKMEDAFRAEINEVRA------------------TLMEQLNQ-------TKEDRDKGASK 1418
            .:||...:.|.  .|...|::                  ||..|.::       .||:
Zfish  1408 QTTQCDALPDG--TEDTPVKSRENAGVESPAFFSSAAFKTLSPQTHKFIKSLLPLKEE------- 1463

  Fly  1419 LEEVKKTLE 1427
             |:.::|||
Zfish  1464 -EKTRRTLE 1471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmet	NP_524993.3	KISc	8..328	CDD:214526	138/369 (37%)
		Motor_domain	8..321	CDD:277568	137/362 (38%)
		Smc	<680..1449	CDD:224117	164/907 (18%)
		TMPIT	779..>867	CDD:285135	21/153 (14%)
		Smc	1042..1910	CDD:224117	95/459 (21%)
kif13a	XP_009291008.1	KISc_KIF1A_KIF1B	5..359	CDD:276816	138/369 (37%)
		KISc	6..359	CDD:214526	138/368 (38%)
		Kinesin_assoc	356..468	CDD:292801	24/122 (20%)
		FHA	448..543	CDD:238017	15/122 (12%)
		KIF1B	745..790	CDD:289208	9/51 (18%)
		DUF3585	<1098..1142	CDD:304905	9/55 (16%)
		DUF3694	<1211..1279	CDD:289256	18/72 (25%)
		CAP_GLY	1859..1921	CDD:279625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2883
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.030