DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cmet and kif1aa

DIOPT Version :9

Sequence 1:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster
Sequence 2:XP_021332795.1 Gene:kif1aa / 100330443 ZFINID:ZDB-GENE-100913-3 Length:1898 Species:Danio rerio


Alignment Length:2395 Identity:497/2395 - (20%)
Similarity:829/2395 - (34%) Gaps:811/2395 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SSIQVCIKVRPC---EPGLTSLWQV---------------KERRSIHLAD----SHAEPYVFDYV 49
            :|::|.::|||.   |.|..|...:               ||.:|.:. |    ||..|...:| 
Zfish     4 ASVKVAVRVRPFNSREIGKESKCIIQMSGNTTTIINPKAPKENKSFNF-DYSYWSHTSPEDINY- 66

  Fly    50 FDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMG--DEQNPGVMVLAAKEIFQ 112
                ||.|:|:..:.:.::....:|:|..|||||||.:||:|||||  ::...|::.|..:::|.
Zfish    67 ----ASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPLLCEDLFT 127

  Fly   113 QISSETERD--FLLRVGYIEIYNEKIYDLLNKKNQ-DLKIHES---GNGIVNVNCEECIITSEVD 171
            :|:...:.:  :.:.|.|:|||.|::.||||.||: :|::.|.   |..:.:::  :..:.|..|
Zfish   128 KINENNDNNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLS--KLAVMSYND 190

  Fly   172 LLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSD-HSDDDAVIQSVLNLVDLAGSERAD 235
            :..|:..|||.|||..|||||.||||||:|.||...|:.| .:|:.:...|.::|||||||||||
Zfish   191 IQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQRRHDSETDNTSEKVSKISLVDLAGSERAD 255

  Fly   236 QTGARGARLKEGGHINKSLLFLSNVIKSLSE--NADNR---------FTNYRDSKLTRILQASLG 289
            .|||:|.|||||.:|||||..|..||.:|:|  :..|:         |..||||.||.:|:.:||
Zfish   256 STGAKGTRLKEGANINKSLTTLGKVISALAEVDSGSNKNKKKKKVESFIPYRDSVLTWLLRENLG 320

  Fly   290 GNAFTSIICTIKPSIM--EESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLA 352
            ||:.|:::..:.|:.:  :|:.|||.:|.|||:||....:||..:: .:::.|:.|:..|||   
Zfish   321 GNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNN-RLVRELKDEVSRLKD--- 381

  Fly   353 EEERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAET--GTTED 415
                                     ::....|.|                    :.||  |..||
Zfish   382 -------------------------LLYAQGLGD--------------------IIETFRGPVED 401

  Fly   416 RIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRP 480
                |..:.::         :..|..:|..:.:|..|  |..|.:|:::..          ||.|
Zfish   402 ----FAGLKYI---------SDYKNHNNNGQALNQRG--DFSTVTNAMTGM----------SPSP 441

  Fly   481 DVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQ 545
            .:  ..|:.|         .|.:::      :.|..||:...:      |.::.||| ..::.|:
Zfish   442 SL--SALSSR---------AGSISS------LHDRIMFSPGSE------EAIERLKE-TEKIIAE 482

  Fly   546 RDNLEQESLAEKERYDALEKEVTSLRADNEAANSKIS-ELEEKLSTL-----KQTMRIMEVENQV 604
            .:...:|.|...|          ::|.|.||..:::. .:.|...||     |:|..::      
Zfish   483 LNETWEEKLRRTE----------AIRMDREALLAEMGVAMREDGGTLGVFSPKKTPHLV------ 531

  Fly   605 AVGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTR----------DVLRNS---K 656
                           .|..|.|:|..|        |....|.:||          |::.:.   |
Zfish   532 ---------------NLNEDPLMSECL--------LYYIKDGITRVGREDASSRQDIVLSGHFIK 573

  Fly   657 EGHML---SIAPEQEDIAGDSICNKCEELE-----KLIADLESKKNSCEC-------------DQ 700
            |.|..   :..|..|.:    |...||..|     |.:.:....|:....             :|
Zfish   574 EEHCTFTSTTGPMGEAV----ILEPCEGAETYVNGKRVTEPTVLKSGNRIILGKSHVFRFNHPEQ 634

  Fly   701 LRLEIVSVRDK-------LESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALD 758
            .|.|    ||:       :|.|:.||  |..|::.|               ......||    :|
Zfish   635 ARQE----RDRTPCAETPVEPVDWAF--AQRELLDK---------------QGIDMKQE----MD 674

  Fly   759 QQWQAQQAGITTLHEKHEHVQEKYQKLQEEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNE 823
            |:.|              .::::|:|.:||...|..:.|....:..:.||....:...|.|..:|
Zfish   675 QRLQ--------------ELEDQYRKEREEANNLLEQQRLDYESRLEALQKQVDRCYPDAAEEDE 725

  Fly   824 RLEEAQNMLTEVQNSESTVE-------KLRIQNHELTAKIKELETNFEEMQREYDCLSNQLMESV 881
            ..||      |||.:|...|       |.|.  ::.|: :::|........:|.:.:|.:|.:.|
Zfish   726 EPEE------EVQWTERETELAMWAFRKWRC--YQFTS-LRDLLWGNAIFLKEANAISVELKKKV 781

  Fly   882 QENDALREEIKQRPTSHVEESMRSSGISSDFDEQKQDINLLHQFVQLSESVQQIELQHHSGISRL 946
            |                                        .|||.|::::.             
Zfish   782 Q----------------------------------------FQFVLLTDTLY------------- 793

  Fly   947 FRANQMKLDQSEPGLKLCLESAEY------IEEDNRQSDATEPICLKGFLKRHRFQIKRLSQEHV 1005
               :.:..|...|......|.:.:      :|..::::.||           |.:.:::|.|.  
Zfish   794 ---SPLPPDLLPPEAAKDREKSPFPRTIVAVEVQDQKNGAT-----------HYWTLEKLRQR-- 842

  Fly  1006 DMGEEKRLLDIISQLEQEIEEKSALMEATEATINEMREQMTNLESALLE--KSVIINKVEDYQR- 1067
                    ||:                     :.||.::...:.|..:|  .||:......|.| 
Zfish   843 --------LDL---------------------MREMYDRAAEVPSNAVEDCDSVLTGGDPFYDRF 878

  Fly  1068 -QIESLEKQNAEMTMVYEELQDRVTRESSMSESLLRVPPDEDTLPGCPTSPSRREQEVATLKTSI 1131
             ....:.:.....|.:.|:..|                |:....|..|||.|           .:
Zfish   879 PWFRLVGRNPLFSTCLSEQASD----------------PNSSPTPSEPTSTS-----------EL 916

  Fly  1132 TELQSQVSDLK--AELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDEDTKQKQELL 1194
            |||.....|.|  .||::        ||.::         .:.|..:|....:.|:|.....|.|
Zfish   917 TELVQSWPDKKVGTELDD--------DGFLS---------DDPCSDLEEEGEDDDDDEVDDDEEL 964

  Fly  1195 DRQAQKLSDDLCLIDQLQKKNAQLVEQYHKATESLSLADAKPDQILLSSQYDSQIEKLNQLLNAA 1259
            .|.:.|..|..       ...:.|.....:|...||       .:|.......::..:|:     
Zfish   965 CRSSGKAEDPF-------YDRSPLFSVVGRAFVYLS-------NLLYPVPLVHRVAIVNE----- 1010

  Fly  1260 KDELHDVRRIKDDEISALRMEFLLQIETNEKENQAKFYAELQETKDRYESNVAELKEKLLQVE-- 1322
            |.|:....|:....||.                 |..:....|....|.|.|.:.....:..|  
Zfish  1011 KGEVKGFLRVAVQAISG-----------------ALVFPPADEEAPDYGSGVRQSGTAKISFEDQ 1058

  Fly  1323 -------ETLSSVTVRCQAELEALKSAHKENIS-----QAVEERNNLIVQHQAEMETIRETLKNK 1375
                   |:..|...|.....|.|:....|..|     .|.|..||....:..|:::..:|..:.
Zfish  1059 QFEKFQSESCHSGLSRAAVSQEELRIVEGEGQSAEMGLSADEVNNNTCAANPEELDSPVKTGLDG 1123

  Fly  1376 LAEASTQQSKMEDAFRAEINEVRATLMEQLNQTKEDRD-----KGASKLEEVKKTLEQMINGGRV 1435
            :.:.:....::.:.|     ..|.|:::..:.:.|..|     ....:.:|...| |.:.|.||.
Zfish  1124 MLDGALDHLRIGEVF-----TFRVTVLQASSISAEYADIFCQFNFIHRHDEAFST-EPLKNTGRG 1182

  Fly  1436 MSDTIAELEKTKAEQDLAVNKLTKDNIELEKQCSKTQEQLQMESLTRDQISFEIEAHIKKLELIV 1500
            .......:      |::|| ::||..||.    .|||           .|.||:..|.:| :...
Zfish  1183 PPLGFYHV------QNIAV-EVTKSFIEY----IKTQ-----------PIVFEVFGHYQK-QPFP 1224

  Fly  1501 ASSKKRIIELEEKCDQQ---VLELDK------------CRLEKLS-LESEIQKANSEHSCTMEKL 1549
            |..|..|..| ..|.:|   |:.|.|            ..||.:. |..|:...:...|.:...|
Zfish  1225 ALCKDLISPL-RPCRRQFPRVMPLSKPAADNDTPPDREKNLELIRYLLPEVFNGSLVDSLSSHAL 1288

  Fly  1550 QELQAEMKVLSNRNEKEK--------CD-FETKLETFTFKITDLEEVLKEAQHKVILYDDLVSQH 1605
            ......:..|....|:.:        |. .:.:......|:|.|........|  ..||.:|.  
Zfish  1289 NAAGVAVSYLLEGEEQARLPAPPLSICSVIKAQKPVPATKLTALTRPTAGPCH--CKYDLMVF-- 1349

  Fly  1606 ERLKICLAEAN--------------------ELSSNLQKKVMSLHTELIDSQKGISSRDVEINEL 1650
              .:||..|||                    .|...:|::|    |..:..:.|   ||::..|:
Zfish  1350 --FEICELEANGDYIPAVVDHRVGMPCHGTFMLHQGIQRRV----TVTMVHETG---RDIDWKEV 1405

  Fly  1651 REELKAAMDAKATASAEQMTLVTQLKDVEERMANQAEKFTREAANLKGSINELLLKLNSMQETKD 1715
            ||                 .:|.::::..|  |::|            .|:..:|.||       
Zfish  1406 RE-----------------LVVGRIRNTPE--ADEA------------IIDPNILSLN------- 1432

  Fly  1716 MLESGNEELKEQLRNSQNLRNMLDEESKMCISLKEKLVKLEDA-KTSLEQQLRDNKSEIYQRHTE 1779
            :|.:|      .:|.:.:.|..||.:      :.....:.|.| .:|:...|..|:...|.....
Zfish  1433 ILSAG------YIRPAHDDRQFLDSD------MPRTFYRFEAAWDSSMHNSLLLNRVTPYGEKIY 1485

  Fly  1780 LTKEVELGRNRIGELTKKCEELC-------SDLENSDQIR---------------------LDL- 1815
            :|....|......:.|...::||       :.|..|..||                     |.| 
Zfish  1486 MTLSAYLEMENCTQPTVITKDLCMVFHSRDAKLPASRSIRNLFSSGTLRPSEGNRVTGVYELSLC 1550

  Fly  1816 ----------QETKEQLKKTL-------ENNLGWQQKVDEVTR----ECEKLRFDMQSKEVQNES 1859
                      |..:.::..|.       ||..||:.:.|.:..    |.|||..      :|...
Zfish  1551 HLADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSL------LQEVE 1609

  Fly  1860 KVQELISECEELRSTLKSKEASFQSEKESMDRTISSLLEDKRNLEEKLCSANDIVAKLETEIAAL 1924
            |.:..:...|:|.|||...:.|..|                       |.:.|:     ||.::.
Zfish  1610 KTRHYLLLREKLESTLLLGQESLLS-----------------------CGSEDL-----TESSSP 1646

  Fly  1925 RPRKSLDRNPVPRKSITFESE---IRKNRRISVHDERRQSYWNDVREFGIMTDPVDNNCNCAELN 1986
            .....|..||.|......|.:   ..|..|:..|...|                 |.:..|...:
Zfish  1647 STHLGLGHNPGPGPDTPNERQRELAAKCLRLLNHTFNR-----------------DYSHVCVSAS 1694

  Fly  1987 -SKLQDCQRELFIRESQVTALK--------------------------MELDHHPLKDENAQLTK 2024
             |||.         |..||.||                          ...|..|....:..::.
Zfish  1695 ESKLS---------EMSVTLLKDSASVCAESTLTPSSTCPSLVESRYIHNTDLRPPTPRSRAVSP 1750

  Fly  2025 RVIEEQDKAKVEQKRLKMK-----LQDLNARINDLTTASA----KEPESNQMAQAAKPATVAAQT 2080
            ....|.|..|:::.|.:.:     :|::  |::.:.:...    .||.||..   .|...|..:.
Zfish  1751 NPDSETDGKKIQEPRSRTRTFVPDIQEI--RVSPIVSKKGYLHFLEPHSNGW---VKRYVVVRRP 1810

  Fly  2081 QT---ESDLETI------LEKTNVKY---QEAVRMLRYRYHLIQELKEKLRQNEN 2123
            ..   .||.:|:      |....|:|   |:|:....|.:.:..|.:..|.|..|
Zfish  1811 YVYIYNSDRDTVERAILNLSSAQVEYSEDQQAMLKTPYTFAVCTEHRGILLQASN 1865

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cmetNP_524993.3 KISc 8..328 CDD:214526 137/363 (38%)
Motor_domain 8..321 CDD:277568 135/356 (38%)
Smc <680..1449 CDD:224117 139/831 (17%)
TMPIT 779..>867 CDD:285135 22/94 (23%)
Smc 1042..1910 CDD:224117 181/988 (18%)
kif1aaXP_021332795.1 KISc_KIF1A_KIF1B 4..361 CDD:276816 137/364 (38%)
Kinesin_assoc 358..551 CDD:318424 55/329 (17%)
FHA 528..631 CDD:238017 21/135 (16%)
KIF1B 839..885 CDD:315155 12/76 (16%)
DUF3694 1360..1516 CDD:315198 35/212 (17%)
PH_KIFIA_KIFIB 1779..1881 CDD:269939 20/90 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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