DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cmet and kif1aa

DIOPT Version :10

Sequence 1:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster
Sequence 2:XP_021332795.2 Gene:kif1aa / 100330443 ZFINID:ZDB-GENE-100913-3 Length:1898 Species:Danio rerio


Alignment Length:2395 Identity:497/2395 - (20%)
Similarity:829/2395 - (34%) Gaps:811/2395 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SSIQVCIKVRPC---EPGLTSLWQV---------------KERRSIHLAD----SHAEPYVFDYV 49
            :|::|.::|||.   |.|..|...:               ||.:|.:. |    ||..|...:| 
Zfish     4 ASVKVAVRVRPFNSREIGKESKCIIQMSGNTTTIINPKAPKENKSFNF-DYSYWSHTSPEDINY- 66

  Fly    50 FDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMG--DEQNPGVMVLAAKEIFQ 112
                ||.|:|:..:.:.::....:|:|..|||||||.:||:|||||  ::...|::.|..:::|.
Zfish    67 ----ASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPLLCEDLFT 127

  Fly   113 QISSETERD--FLLRVGYIEIYNEKIYDLLNKKNQ-DLKIHES---GNGIVNVNCEECIITSEVD 171
            :|:...:.:  :.:.|.|:|||.|::.||||.||: :|::.|.   |..:.:::  :..:.|..|
Zfish   128 KINENNDNNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLS--KLAVMSYND 190

  Fly   172 LLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSD-HSDDDAVIQSVLNLVDLAGSERAD 235
            :..|:..|||.|||..|||||.||||||:|.||...|:.| .:|:.:...|.::|||||||||||
Zfish   191 IQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQRRHDSETDNTSEKVSKISLVDLAGSERAD 255

  Fly   236 QTGARGARLKEGGHINKSLLFLSNVIKSLSE--NADNR---------FTNYRDSKLTRILQASLG 289
            .|||:|.|||||.:|||||..|..||.:|:|  :..|:         |..||||.||.:|:.:||
Zfish   256 STGAKGTRLKEGANINKSLTTLGKVISALAEVDSGSNKNKKKKKVESFIPYRDSVLTWLLRENLG 320

  Fly   290 GNAFTSIICTIKPSIM--EESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLA 352
            ||:.|:::..:.|:.:  :|:.|||.:|.|||:||....:||..:: .:::.|:.|:..|||   
Zfish   321 GNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNN-RLVRELKDEVSRLKD--- 381

  Fly   353 EEERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAET--GTTED 415
                                     ::....|.|                    :.||  |..||
Zfish   382 -------------------------LLYAQGLGD--------------------IIETFRGPVED 401

  Fly   416 RIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRP 480
                |..:.::         :..|..:|..:.:|..|  |..|.:|:::..          ||.|
Zfish   402 ----FAGLKYI---------SDYKNHNNNGQALNQRG--DFSTVTNAMTGM----------SPSP 441

  Fly   481 DVLKPMLTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQ 545
            .:  ..|:.|         .|.:::      :.|..||:...:      |.::.||| ..::.|:
Zfish   442 SL--SALSSR---------AGSISS------LHDRIMFSPGSE------EAIERLKE-TEKIIAE 482

  Fly   546 RDNLEQESLAEKERYDALEKEVTSLRADNEAANSKIS-ELEEKLSTL-----KQTMRIMEVENQV 604
            .:...:|.|...|          ::|.|.||..:::. .:.|...||     |:|..::      
Zfish   483 LNETWEEKLRRTE----------AIRMDREALLAEMGVAMREDGGTLGVFSPKKTPHLV------ 531

  Fly   605 AVGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTR----------DVLRNS---K 656
                           .|..|.|:|..|        |....|.:||          |::.:.   |
Zfish   532 ---------------NLNEDPLMSECL--------LYYIKDGITRVGREDASSRQDIVLSGHFIK 573

  Fly   657 EGHML---SIAPEQEDIAGDSICNKCEELE-----KLIADLESKKNSCEC-------------DQ 700
            |.|..   :..|..|.:    |...||..|     |.:.:....|:....             :|
Zfish   574 EEHCTFTSTTGPMGEAV----ILEPCEGAETYVNGKRVTEPTVLKSGNRIILGKSHVFRFNHPEQ 634

  Fly   701 LRLEIVSVRDK-------LESVESAFNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALD 758
            .|.|    ||:       :|.|:.||  |..|::.|               ......||    :|
Zfish   635 ARQE----RDRTPCAETPVEPVDWAF--AQRELLDK---------------QGIDMKQE----MD 674

  Fly   759 QQWQAQQAGITTLHEKHEHVQEKYQKLQEEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNE 823
            |:.|              .::::|:|.:||...|..:.|....:..:.||....:...|.|..:|
Zfish   675 QRLQ--------------ELEDQYRKEREEANNLLEQQRLDYESRLEALQKQVDRCYPDAAEEDE 725

  Fly   824 RLEEAQNMLTEVQNSESTVE-------KLRIQNHELTAKIKELETNFEEMQREYDCLSNQLMESV 881
            ..||      |||.:|...|       |.|.  ::.|: :::|........:|.:.:|.:|.:.|
Zfish   726 EPEE------EVQWTERETELAMWAFRKWRC--YQFTS-LRDLLWGNAIFLKEANAISVELKKKV 781

  Fly   882 QENDALREEIKQRPTSHVEESMRSSGISSDFDEQKQDINLLHQFVQLSESVQQIELQHHSGISRL 946
            |                                        .|||.|::::.             
Zfish   782 Q----------------------------------------FQFVLLTDTLY------------- 793

  Fly   947 FRANQMKLDQSEPGLKLCLESAEY------IEEDNRQSDATEPICLKGFLKRHRFQIKRLSQEHV 1005
               :.:..|...|......|.:.:      :|..::::.||           |.:.:::|.|.  
Zfish   794 ---SPLPPDLLPPEAAKDREKSPFPRTIVAVEVQDQKNGAT-----------HYWTLEKLRQR-- 842

  Fly  1006 DMGEEKRLLDIISQLEQEIEEKSALMEATEATINEMREQMTNLESALLE--KSVIINKVEDYQR- 1067
                    ||:                     :.||.::...:.|..:|  .||:......|.| 
Zfish   843 --------LDL---------------------MREMYDRAAEVPSNAVEDCDSVLTGGDPFYDRF 878

  Fly  1068 -QIESLEKQNAEMTMVYEELQDRVTRESSMSESLLRVPPDEDTLPGCPTSPSRREQEVATLKTSI 1131
             ....:.:.....|.:.|:..|                |:....|..|||.|           .:
Zfish   879 PWFRLVGRNPLFSTCLSEQASD----------------PNSSPTPSEPTSTS-----------EL 916

  Fly  1132 TELQSQVSDLK--AELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDEDTKQKQELL 1194
            |||.....|.|  .||::        ||.::         .:.|..:|....:.|:|.....|.|
Zfish   917 TELVQSWPDKKVGTELDD--------DGFLS---------DDPCSDLEEEGEDDDDDDVDDDEEL 964

  Fly  1195 DRQAQKLSDDLCLIDQLQKKNAQLVEQYHKATESLSLADAKPDQILLSSQYDSQIEKLNQLLNAA 1259
            .|.:.|..|..       ...:.|.....:|...||       .:|.......::..:|:     
Zfish   965 CRSSGKAEDPF-------YDRSPLFSVVGRAFVYLS-------NLLYPVPLVHRVAIVNE----- 1010

  Fly  1260 KDELHDVRRIKDDEISALRMEFLLQIETNEKENQAKFYAELQETKDRYESNVAELKEKLLQVE-- 1322
            |.|:....|:....||.                 |..:....|....|.|.|.:.....:..|  
Zfish  1011 KGEVKGFLRVAVQAISG-----------------ALVFPPADEEAPDYGSGVRQSGTAKISFEDQ 1058

  Fly  1323 -------ETLSSVTVRCQAELEALKSAHKENIS-----QAVEERNNLIVQHQAEMETIRETLKNK 1375
                   |:..|...|.....|.|:....|..|     .|.|..||....:..|:::..:|..:.
Zfish  1059 QFEKFQSESCHSGLSRAAVSQEELRIVEGEGQSAEMGLSADEVNNNTCAANPEELDSPVKTGLDG 1123

  Fly  1376 LAEASTQQSKMEDAFRAEINEVRATLMEQLNQTKEDRD-----KGASKLEEVKKTLEQMINGGRV 1435
            :.:.:....::.:.|     ..|.|:::..:.:.|..|     ....:.:|...| |.:.|.||.
Zfish  1124 MLDGALDHLRIGEVF-----TFRVTVLQASSISAEYADIFCQFNFIHRHDEAFST-EPLKNTGRG 1182

  Fly  1436 MSDTIAELEKTKAEQDLAVNKLTKDNIELEKQCSKTQEQLQMESLTRDQISFEIEAHIKKLELIV 1500
            .......:      |::|| ::||..||.    .|||           .|.||:..|.:| :...
Zfish  1183 PPLGFYHV------QNIAV-EVTKSFIEY----IKTQ-----------PIVFEVFGHYQK-QPFP 1224

  Fly  1501 ASSKKRIIELEEKCDQQ---VLELDK------------CRLEKLS-LESEIQKANSEHSCTMEKL 1549
            |..|..|..| ..|.:|   |:.|.|            ..||.:. |..|:...:...|.:...|
Zfish  1225 ALCKDLISPL-RPCRRQFPRVMPLSKPAADNDTPPDREKNLELIRYLLPEVFNGSLVDSLSSHAL 1288

  Fly  1550 QELQAEMKVLSNRNEKEK--------CD-FETKLETFTFKITDLEEVLKEAQHKVILYDDLVSQH 1605
            ......:..|....|:.:        |. .:.:......|:|.|........|  ..||.:|.  
Zfish  1289 NAAGVAVSYLLEGEEQARLPAPPLSICSVIKAQKPVPATKLTALTRPTAGPCH--CKYDLMVF-- 1349

  Fly  1606 ERLKICLAEAN--------------------ELSSNLQKKVMSLHTELIDSQKGISSRDVEINEL 1650
              .:||..|||                    .|...:|::|    |..:..:.|   ||::..|:
Zfish  1350 --FEICELEANGDYIPAVVDHRVGMPCHGTFMLHQGIQRRV----TVTMVHETG---RDIDWKEV 1405

  Fly  1651 REELKAAMDAKATASAEQMTLVTQLKDVEERMANQAEKFTREAANLKGSINELLLKLNSMQETKD 1715
            ||                 .:|.::::..|  |::|            .|:..:|.||       
Zfish  1406 RE-----------------LVVGRIRNTPE--ADEA------------IIDPNILSLN------- 1432

  Fly  1716 MLESGNEELKEQLRNSQNLRNMLDEESKMCISLKEKLVKLEDA-KTSLEQQLRDNKSEIYQRHTE 1779
            :|.:|      .:|.:.:.|..||.:      :.....:.|.| .:|:...|..|:...|.....
Zfish  1433 ILSAG------YIRPTHDDRQFLDSD------MPRTFYRFEAAWDSSMHNSLLLNRVTPYGEKIY 1485

  Fly  1780 LTKEVELGRNRIGELTKKCEELC-------SDLENSDQIR---------------------LDL- 1815
            :|....|......:.|...::||       :.|..|..||                     |.| 
Zfish  1486 MTLSAYLEMENCTQPTVITKDLCMVFHSRDAKLPASRSIRNLFSSGTLRPSEGNRVTGVYELSLC 1550

  Fly  1816 ----------QETKEQLKKTL-------ENNLGWQQKVDEVTR----ECEKLRFDMQSKEVQNES 1859
                      |..:.::..|.       ||..||:.:.|.:..    |.|||..      :|...
Zfish  1551 HLADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSL------LQEVE 1609

  Fly  1860 KVQELISECEELRSTLKSKEASFQSEKESMDRTISSLLEDKRNLEEKLCSANDIVAKLETEIAAL 1924
            |.:..:...|:|.|||...:.|..|                       |.:.|:     ||.::.
Zfish  1610 KTRHYLLLREKLESTLLLGQESLLS-----------------------CGSEDL-----TESSSP 1646

  Fly  1925 RPRKSLDRNPVPRKSITFESE---IRKNRRISVHDERRQSYWNDVREFGIMTDPVDNNCNCAELN 1986
            .....|..||.|......|.:   ..|..|:..|...|                 |.:..|...:
Zfish  1647 STHLGLGHNPGPGPDTPNERQRELAAKCLRLLNHTFNR-----------------DYSHVCVSAS 1694

  Fly  1987 -SKLQDCQRELFIRESQVTALK--------------------------MELDHHPLKDENAQLTK 2024
             |||.         |..||.||                          ...|..|....:..::.
Zfish  1695 ESKLS---------EMSVTLLKDSASVCAESTLTPSSTCPSLVESRYIHNTDLRPPTPRSRAVSP 1750

  Fly  2025 RVIEEQDKAKVEQKRLKMK-----LQDLNARINDLTTASA----KEPESNQMAQAAKPATVAAQT 2080
            ....|.|..|:::.|.:.:     :|::  |::.:.:...    .||.||..   .|...|..:.
Zfish  1751 NPDSETDGKKIQEPRSRTRTFVPDIQEI--RVSPIVSKKGYLHFLEPHSNGW---VKRYVVVRRP 1810

  Fly  2081 QT---ESDLETI------LEKTNVKY---QEAVRMLRYRYHLIQELKEKLRQNEN 2123
            ..   .||.:|:      |....|:|   |:|:....|.:.:..|.:..|.|..|
Zfish  1811 YVYIYNSDRDTVERAILNLSSAQVEYSEDQQAMLKTPYTFAVCTEHRGILLQASN 1865

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cmetNP_524993.3 Motor_domain 8..321 CDD:473979 135/356 (38%)
SMC_prok_B 539..1431 CDD:274008 166/976 (17%)
SMC_prok_B 1137..1926 CDD:274008 166/905 (18%)
YhaN 1717..2182 CDD:443752 93/509 (18%)
kif1aaXP_021332795.2 None

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