DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cic and Cic

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	XP_011248998.1	Gene:	Cic / 71722	MGIID:	1918972	Length:	2512	Species:	Mus musculus

Alignment Length:	2703	Identity:	631/2703 - (23%)
Similarity:	899/2703 - (33%)	Gaps:	968/2703 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 STPQQQQPPQPRQHPKKRKFDPAELDKTEQHPQQQQQQQVSLQKQQKPAETTGNGDGLANGNQQH 171
            |....:.||..|....:|: ...|.||.|:..:.|.|:|...::.::..|.....|..|.|....
Mouse    14 SASGSKSPPATRAKALRRR-GAGEGDKPEEEEEAQPQEQAGPEEAEEGEEEEAERDPGAEGTHPE 77

  Fly   172 RMIVSCGAGAGNNSSNSSSSNNSSHSSSDIKQQQQQRIIIASPQHASGSTYKQHVASGNNSHAAT 236
            ..        .|:.:...:.:......:...:....|........|....|.:...:||......
Mouse    78 LQ--------PNDPTPGLTEDPKGDGEAGRWEPSLSRKTATFKSRAPKKKYVEEHGTGNVGVVGA 134

  Fly   237 INHQQRTHTPTTAVYYQQQQQQQQQQQQQRFSFNSNNQQHLQEQHQQQQQ-----------QQSL 290
            ...::||....:|:     ....:.....|.|......:|..:...:..:           ....
Mouse   135 PEERERTPEDASAL-----GVPPRPPTSTRSSSTDTASEHSADLEDEPPEACGPGPWPSTGTSEG 194

  Fly   291 LDLSEWNNTRVLAKIQNN-YAPGIIRHAQEASPDSILVEFDSTDLGLLLYTDVLHQGRNHVILDA 354
            .||.:..:.||||:..:. :.|.::|..:.:  ..:.|:|.. |..|..|..|...|.: |:||.
Mouse   195 YDLRQLRSQRVLARRGDGLFLPAVVRQVRRS--QDLGVQFPG-DRALTFYEGVPGGGVD-VVLDV 255

  Fly   355 SPPMADITLDARVCVRQRVEGRGSGSFVYVEGIITDINQATKQYSVQL----------------- 402
            :||...:.:...||.  .||   .|...|.||::.::......|.|:|
Mouse   256 TPPPGALMVGTAVCT--CVE---PGVAAYREGVVVEVATKPAAYKVRLSPGPSSHAGPPGTLPQA 315

  Fly   403 ---IGDEMATTKVVRRADLRLLQPPWWDEL----------NELTTSGGASAPA-SSAKRKVP--- 450
               :..|......|.|:.||||:|||....          .|....|.|..|. ||.:.|.|
Mouse   316 QQTLHREPEEAVWVTRSSLRLLRPPWEPGALLRKHPAGPEEEQAEPGPALPPCPSSVEPKQPEDA 380

  Fly   451 -----AAGAGAGTGAAGCEAMTVPSGNIVYPKTATGAPLSFVATRYDGKLPTAPPTSSHQQAQQQ 510
                 :.|:..||   .||     .|...:| .:.|.|:         .||..||         |
Mouse   381 EVSNISFGSNLGT---RCE-----EGEEKHP-PSLGTPV---------LLPLPPP---------Q 418

  Fly   511 LVKQEEYYRTTATSPFQTRPPLAGPSHGSEQVVQATQSHPQQYNGLADIVISPCSNGQHLKMQQQ 575
            |:           ||....|...||...|||.                   |||
Mouse   419 LL-----------SPPPKSPAFGGPGRPSEQP-------------------SPC----------- 442

  Fly   576 QQQSSRGYDDYDSDDELKRVGIGYSPAAGDLDTEKMSACSKRSSMQSRGSTSSLLDQRLTPRSHP 640
             |:.|:|                                      .||.|:.:.|::...|.:..
Mouse   443 -QEGSQG--------------------------------------GSRSSSVASLEKGAAPAARA 468

  Fly   641 ATPSAIHRSQATTPHRFKKGDIVESESGVRKKYNGKQWRRLCML--CTKESQRRGYCSRHLNQKG 703
            .||      ......::||||:|.:.:|:|||:|||||||||..  |.|||||||||||||:.:.
Mouse   469 RTP------LTAAQQKYKKGDVVCTPNGIRKKFNGKQWRRLCSRDGCMKESQRRGYCSRHLSMRT 527

  Fly   704 NTSALPSSTGP---GRLLSDSRSSSKTQID--EDTSRDSETSPNYRVKG-------------RYD 750
            ......:.:||   ||....:.....|:.|  ::||||||.| :...:|             |::
Mouse   528 KEMEGLADSGPGGTGRPAGVAAREGSTEFDWGDETSRDSEAS-SVAARGDSRPRLVAPADLSRFE 591

  Fly   751 QEETDAAAMLVSLSSSRSATPSYT--------SPVNHAGASPLNAIAHSPVNVSATHRQNFFTPI 807
            .:|.:||.|||||.||||.|||::        ||......|||  ....|.|.|..:........
Mouse   592 FDECEAAVMLVSLGSSRSGTPSFSPVSTQSPFSPAPSPSPSPL--FGFRPANFSPINASPVIQRT 654

  Fly   808 ANQSQQQQQQQP---VAVPLDSKWKTTPSPVLYNANNNSSNNNTSSSN-------NNNNSNWEVG 862
            |.:|:......|   |..|.|  ....|.|......::|....|..:|       :......|:.
Mouse   655 AVRSRHLSASTPKAGVLTPPD--LGPHPPPPAPRERHSSGILPTFQTNLTFTVPISPGRRKTELL 717

  Fly   863 SNSNTHVAATAAATSTVGAQPLPPQT----TPVSLVMHAPPPQQ-------QPLQQQHHHHQPPP 916
            .:..|..|:.|...   ||.|..|::    :.|..|.|.|.|..       .|........||.|
Mouse   718 PHPGTLGASGAGGG---GAAPDFPKSDSLDSGVDSVSHTPTPSTPAGFRAVSPAVPFSRSRQPSP 779

  Fly   917 ----PPPASL---PAPSA-------------------------PPTSGSSSSHNSVGHATSVIRI 949
                ||||.|   |.||.                         |...|::....:.|...|.
Mouse   780 LLLLPPPAGLTSDPGPSVRRVPAVQRDSPVIVRNPDVPLPSKFPGEVGTAGEARAGGPGRSC--- 841

  Fly   950 SSSQQQHQQQQQHQQQAHPHVVVSGGQTFHPVIVDATQLSVPLP---PTTVSFHQPNTPTSTAAS 1011
                         ::...|..|.||.....|          |||   |.||   .|..||:.|..
Mouse   842 -------------RETPVPPGVASGKPGLPP----------PLPAPVPITV---PPAAPTAVAQP 880

  Fly  1012 VASMSQDKMLAKNGYNAPWF-----KLLPHMTPMSKAS-PAPVTP-------TLTTSASSYNVVM 1063
            :.::.    ||.:.:....|     .|||.:.|.|..| |||...       |:.|:....:|.:
Mouse   881 MPTLG----LASSPFQPVAFHPSPAALLPVLVPSSYPSHPAPKKEVIMGRPGTVWTNVEPRSVAV 941

  Fly  1064 MQQQQQHQQLQQQQQLQQQQQSPPQMPLNHNNNHLIVSAPLSSPGKPLNCSMNDAKVAAAAAAAA 1128
            .........|...|.....|.|..|.|.:|         |::|         |.:|  ..|.:||
Mouse   942 FPWHSLVPFLAPSQPDPSVQPSEAQQPASH---------PVAS---------NQSK--EPAESAA 986

  Fly  1129 VANQRQK----------------QQQEEPDDQLDDDVFETTTPGISANSKKQTAAMRLPTHNSNI 1177
            ||:::..                .:...|...|   ......||.|.....:..|...|......
Mouse   987 VAHEQPPGGTGGADPGRPPGAVCPESPGPGPPL---TLGGVDPGKSLPPTTEEEAPGPPGEPRLD 1048

  Fly  1178 RKLEECHDDGAAGAPATS------AAKRRSQSLSALQQQQQQQQQAGAAGTAAGQPANKK----I 1232
            .:.|..|||......:..      ..|||:||||||.:::....:..      |:..||:    |
Mouse  1049 SETESDHDDAFLSIMSPEIQLPLPPGKRRTQSLSALPKERDSSSEKD------GRSPNKREKDHI 1107

  Fly  1233 RRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHP 1297
            ||||||||||||:||.:||::||||||||||||||||||||.|::|.:||:||..||:||||.||
Mouse  1108 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHP 1172

  Fly  1298 EWKWCSKDRRKSSTSTATP------GG---------KASGAAGTGDAKQRLVSVDGSDSLEHDMC 1347
            :||||:|||:||| |.|.|      ||         ..:|.|........|:||.....|..|
Mouse  1173 DWKWCNKDRKKSS-SEAKPASLGLAGGHKETRERSMSETGTAAAPGVSSELLSVAAQTLLSSD-- 1234

  Fly  1348 PSTPGGSGSCGGQ-------------------GISSDLQGDIIPLTIDNYNSTCD---------- 1383
            ...| |||.||.:                   |:.|...|::....:........
Mouse  1235 TKVP-GSGPCGAERLHAVGAPGSARPRAFSHSGVHSLDGGEVDSQALQELTQMVSGPASYSGPKP 1298

  Fly  1384 ----EAPTTISMKGNG------------------NGKLMKNELPSDEDEQMLVVEEEQQQQTV-- 1424
                .||.:.:..|.|                  :.:....::.||| |:|::.|||.....:
Mouse  1299 SPQYGAPGSFAAPGEGGTLATSGRPPLLPSRASRSQRAASEDMTSDE-ERMVICEEEGDDDVIAD 1362

  Fly  1425 -----KKIDLHCRERVNDSDMDDTPFDYRKQQPEANQ-----------RSAEEH----------- 1462
                 ..|||.|:|||.||:..|:    ..:.||.|:           ||:..|
Mouse  1363 DSFGTTDIDLKCKERVTDSESGDS----SGEDPEGNKGFGRKVFSPVIRSSFTHCRPTLDPEPPG 1423

  Fly  1463 -----------------------------STS---------------------------GANGQA 1471
                                         |||                           ||.|.|
Mouse  1424 PPDPPAAFSKGYGPTPSSSSSPASTSVSVSTSFSLGSGTFKTQESGQGSTAVPLRPPPPGAGGPA 1488

  Fly  1472 ----------------------------------INAPPLSGG-------------EREITLKPK 1489
                                              |.|||..||             :||.|..|.
Mouse  1489 TPSKATRFPPTDSATFRRKRPESVGSLEAPGPSVIAAPPSGGGNLLQTLVLPPSKEDREGTRVPS 1553

  Fly  1490 A--------IKAHPVLESNMLPYTQM--SIYTQYTSPKNPIGVTPFQPTG----------GAFKS 1534
            |        ..|.|:..    |...|  ::....:|...||...||..:|          ||...
Mouse  1554 APAPPLAYGAPAAPLCR----PAATMVTNVVRPVSSTPVPIASKPFPTSGRAEASSNDIAGARTE 1614

  Fly  1535 MPISPKGSGGKPEDAGSLQAHIKQEDIKQEP--------------PSPYKLNN------------ 1573
            |....:..||.|.....:.:..|.......|              .:|..:.|
Mouse  1615 MGTGSRVPGGSPMGVSLVYSDKKSAAAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPA 1679

  Fly  1574 ------------------GSGSASGGG------------------------------------VV 1584
                              |||:::|.|                                    |.
Mouse  1680 SPAVQFIAQGAPGSATPAGSGASTGSGPNGPVPLGILQPGALGKAGGITQVQYILPTLPQQLQVA 1744

  Fly  1585 SAPPPNSGSVGAI---------FNFNVPTATALSQKQFHYPMHHPHRSPTDLRAAHQACVPSSPA 1640
            .||.|..|:..|.         ..|.:|..|:.:.|..      ...:||......|: |||:|.
Mouse  1745 PAPAPAPGTKAAAPSGPAPTTSIRFTLPPGTSTNGKVL------AATAPTAGIPILQS-VPSAPP 1802

  Fly  1641 GMGLGHAANIATP--------------PASAPAQIMGGGPASQKMFFAMT-----------HPYT 1680
            ......:...|||              |.:||:..:.||.|.|.:....:           .|..
Mouse  1803 PKAQSVSPVQATPSGGSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSSPFSVPVQNGAQQPSK 1867

  Fly  1681 LLQRSHQP-GTPS----------------------------LEHLQLDAFAPGGYTLRNHN---- 1712
            ::|.:..| .|||                            :.::|    :.||:||....
Mouse  1868 IIQLTPVPVSTPSGLVPPLSPATMPGPTSQPQKVLLPSSTRITYVQ----SAGGHTLPLGTSSAC 1928

  Fly  1713 -----------------GLSSLPP--PVSAQPTMLLHGYPP-----SHGVE-------PPA---- 1742
                             |.:||.|  |...|| :|..|..|     ..||.       |||
Mouse  1929 SQTGTVTSYGPTSSVALGFTSLGPSGPAFVQP-LLSAGQAPLLAPGQVGVSPVPSPQLPPACTAS 1992

  Fly  1743 ----------RSPSYKSMP------------------STPKSATYLMSAPPERGMDGGMSGCASA 1779
                      .||:..|.|                  :||.:||.|...||           |||
Mouse  1993 GGPVITAFYPGSPAPTSAPLGPPSQAPPSLVYTVATSTTPPAATILPKGPP-----------ASA 2046

  Fly  1780 AASGGDESDIDADGQQFILAPTPAQLGR------AP-LQRRKNLSQSKSESNV------SFGANL 1831
            .|:....|            |.|:..|.      || .||....:..|.::.:      ||.:..
Mouse  2047 TATPAPTS------------PFPSATGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGSFESGT 2099

  Fly  1832 GASNGQHISRKLHSPTMMESSSPIIGHVNSSNLSS-----ALPTPT--------SSTTTPNSDEQ 1883
            ....|....:...|....|.::|      .|.|..     |.|.||        ||...|...|:
Mouse  2100 TGRPGSTPRQSSDSGVAREPAAP------ESELEGQPTPPAPPPPTETWPPTARSSPPPPLPAEE 2158

  Fly  1884 LPLT--PTTS----SSNSNL--------NQQQPKSPMKGAP-------------GSTAAA----- 1916
            .|.|  |.|:    ||:|:.        ::.:|.:|...||             ||:..|
Mouse  2159 RPGTKGPETASKFPSSSSDWRVPGLGLESRGEPPTPPSPAPATGPSGSSSGSSEGSSGRAAGDTP 2223

  Fly  1917 ------------------LKKKNDEMNNSVLKQVDFEKKYKALPQFQPED-CQSPSAIAVPSSPR 1962
                              |||..|.::|.||.:||||:::..||:|:||: ..||:..::.:|||
Mouse  2224 ERKEVTSSGKKMKVRPPPLKKTFDSVDNRVLSEVDFEERFAELPEFRPEEVLPSPTLQSLATSPR 2288

  Fly  1963 VYGTNYRKKNTAPPPVQKLMCEDDSIDEPASAPPTTTQRFFGPDFNNELKDERLAELESS----D 2023
            ....:||||       :|...:.||..|..::|....:|  ....::|....:.|:.|..    |
Mouse  2289 AILGSYRKK-------RKNSTDLDSAPEDPTSPKRKMRR--RSSCSSEPNTPKSAKCEGDIFTFD 2344

  Fly  2024 QTGRSPRT-------PKTPLQSARSDASEKGHRKVLETRRSLVLQLFAEHGNFPTAQATMAFQSK 2081
            :||.....       .|.|..|.         |:.|:.||:||:|||.:||.||:||||.|||::
Mouse  2345 RTGTETEDVLGELEYEKVPYSSL---------RRTLDQRRALVMQLFQDHGFFPSAQATAAFQAR 2400

  Fly  2082 HSDVFPRKQDLQLKIREVRQKLLGQASCTPHSAGPNTP 2119
            ::|:||.|..|||||||||||::..|:.|....|...|
Mouse  2401 YADIFPSKVCLQLKIREVRQKIMQAATPTEQPPGAEAP 2438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708	26/111 (23%)
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	53/74 (72%)
Cic	XP_011248998.1	DUF4819	253..342	CDD:406485	24/93 (26%)
		PHA03247	<647..1061	CDD:223021	97/474 (20%)
		NHP6B	1063..1222	CDD:227935	80/165 (48%)
		SOX-TCF_HMG-box	1106..1177	CDD:238684	53/70 (76%)
		PHA03247	<1671..2172	CDD:223021	102/541 (19%)
		PHA03247	<1979..2464	CDD:223021	136/507 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838556
Domainoid	1	1.000	169	1.000	Domainoid score	I3808
eggNOG	1	0.900	-	-		E1_KOG2746
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	308	1.000	Inparanoid score	I2597
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007200
OrthoInspector	1	1.000	-	-		oto92820
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13059
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3650
SonicParanoid	1	1.000	-	-		X4626
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.970