DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cic and Sox12

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	NP_001162121.1	Gene:	Sox12 / 689988	RGDID:	1586313	Length:	314	Species:	Rattus norvegicus

Alignment Length:	245	Identity:	55/245 - (22%)
Similarity:	98/245 - (40%)	Gaps:	64/245 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1218 GAAGTAAGQPA-----NKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQ 1277
            |.|...|.:|.     :..|:|||||||::|:..|:.:..:.|:..|..:||.||..|..|:..:
  Rat    21 GPAAEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSE 85

  Fly  1278 KAQYHELASSVKDAHFKLHPEWKWCSKDRRKSSTSTATP-----GGKAS------------GAAG 1325
            |..:...|..::..|...:|::|:..:.:.|.:.:.|.|     ||..|            |...
  Rat    86 KIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGGGGGGSRLKPGPQLPGRGGRRA 150

  Fly  1326 TG---------------DAKQRLVSVDGSDSLEHDMCPSTPGGSGSCG----GQGISSDLQGDII 1371
            ||               |.::.|:.|...::...::....|.|..:.|    .||.||:
  Rat   151 TGGPLGGGAAAPEDDDEDEEEELLEVRLLETPGRELWRMVPAGRAARGPAERAQGPSSE------ 209

  Fly  1372 PLTIDNYNSTCDEAPTTISMKGNGNGKLMKNELPSDEDEQMLVVEEEQQQ 1421
                   .:....|..|:|          ::|.|.:|:|:....||.:::
  Rat   210 -------GAAASAASPTLS----------EDEEPEEEEEEAATAEEGEEE 242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	23/70 (33%)
Sox12	NP_001162121.1	SOX-TCF_HMG-box	39..110	CDD:238684	23/70 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000