DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cic and SOX12

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	NP_008874.2	Gene:	SOX12 / 6666	HGNCID:	11198	Length:	315	Species:	Homo sapiens

Alignment Length:	353	Identity:	70/353 - (19%)
Similarity:	119/353 - (33%)	Gaps:	124/353 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1186 DGAAGAPATSAAKRRSQSLSALQQQQQQQQQAGAAGTAAGQPANKKIRRPMNAFMIFSKKHRKMV 1250
            ||....|....|             ::..::.|...|.:|.     |:|||||||::|:..|:.:
Human    12 DGGPPPPGPGPA-------------EEGAREPGWCKTPSGH-----IKRPMNAFMVWSQHERRKI 58

  Fly  1251 HKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKSSTSTAT 1315
            ..:.|:..|..:||.||..|..|:..:|..:...|..::..|...:|::|:             .
Human    59 MDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKY-------------R 110

  Fly  1316 PGGKASGAAGTGDAKQRLVSVDGSDSLEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYNS 1380
            |..|:.||    .||.|               |..|||||  ||..:....|
Human   111 PRKKSKGA----PAKAR---------------PRPPGGSG--GGSRLKPGPQ------------- 141

  Fly  1381 TCDEAPTTISMKGNGNGKLMKNEL------PSDEDEQMLVVEEEQQQQTVKKIDLHCRE------ 1433
                      :.|.|..:.....|      |.|:||     :::::...|:.::...||
Human   142 ----------LPGRGGRRAAGGPLGGGAAAPEDDDE-----DDDEELLEVRLVETPGRELWRMVP 191

  Fly  1434 ------------------------RVNDSDMDDTPFDYRKQQPEANQRSAEEHSTSGAN--GQAI 1472
                                    ..:.:..:|...:..:::..|.:...||...||..  |...
Human   192 AGRAARGQAERAQGPSGEGAAAAAAASPTPSEDEEPEEEEEEAAAAEEGEEETVASGEESLGFLS 256

  Fly  1473 NAPPLSGG------EREITLKPKAIKAH 1494
            ..||...|      :|:..|:|.:..:|
Human   257 RLPPGPAGLDCSALDRDPDLQPPSGTSH 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	23/70 (33%)
SOX12	NP_008874.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		7/45 (16%)
		SOX-TCF_HMG-box	39..110	CDD:238684	23/88 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..288		43/247 (17%)
		Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000250\|UniProtKB:Q04890	283..315		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910