DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cic and SOX4

DIOPT Version :9

Sequence 1:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster
Sequence 2:	NP_003098.1	Gene:	SOX4 / 6659	HGNCID:	11200	Length:	474	Species:	Homo sapiens

Alignment Length:	486	Identity:	106/486 - (21%)
Similarity:	163/486 - (33%)	Gaps:	157/486 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1219 AAGTAAGQPA-----NKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQK 1278
            :.|..|..|:     :..|:|||||||::|:..|:.:.::.|:..|..:||.||:.|..||...|
Human    41 STGGKADDPSWCKTPSGHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDK 105

  Fly  1279 AQYHELASSVKDAHFKLHPEWKWCSKDRRKS----STSTAT----PGGKASGAAGTGDAKQRLVS 1335
            ..:...|..::..|...:|::|:..:.:.||    |:|:|.    ||.|.....|:|........
Human   106 IPFIREAERLRLKHMADYPDYKYRPRKKVKSGNANSSSSAAASSKPGEKGDKVGGSGGGGHGGGG 170

  Fly  1336 VDGSDSLEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDEA-------------PT 1387
            ..||.:       :..||.|:.||...|...|           ..:|...             ..
Human   171 GGGSSN-------AGGGGGGASGGGANSKPAQ-----------KKSCGSKVAGGAGGGVSKPHAK 217

  Fly  1388 TISMKGNGNGKLMKNELPSDEDEQ-----MLVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDY 1447
            .|...|.|.||.......|...||     :|.:.......::                      |
Human   218 LILAGGGGGGKAAAAAAASFAAEQAGAAALLPLGAAADHHSL----------------------Y 260

  Fly  1448 RKQQPEANQRSAEEHSTSGANGQAINAPPLSGGEREITLKPKAIKAHPVLESNMLPYTQMSIYTQ 1512
            :.:.|     ||...::|.|:..|..|.|   |:.   |..|.:|               .:|.
Human   261 KARTP-----SASASASSAASASAALAAP---GKH---LAEKKVK---------------RVYL- 298

  Fly  1513 YTSPKNPIGVTPFQPTGG-AFKSMPISPKGSGGKPEDAGSLQAHIKQEDIKQEPPSPYKLNNGSG 1576
                           .|| ...|.|:...|:|..|.|...|   .::|.....|.:| .|:..|.
Human   299 ---------------FGGLGTSSSPVGGVGAGADPSDPLGL---YEEEGAGCSPDAP-SLSGRSS 344

  Fly  1577 SASGGGVVSAPPPNSGSVGAIFNFNVPTATALSQKQFHYPMHHPHRSPTDLRAAHQACVPSSPAG 1641
            :||.        |.:|...|                       .||....||||..|  |||..
Human   345 AASS--------PAAGRSPA-----------------------DHRGYASLRAASPA--PSSAP- 375

  Fly  1642 MGLGHAANIATPPASAPAQIMGGGPASQKMF 1672
               .||::.|:..:|:.:.  .|..:|...|
Human   376 ---SHASSSASSHSSSSSS--SGSSSSDDEF 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	24/70 (34%)
SOX4	NP_003098.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		3/16 (19%)
		SOX-TCF_HMG-box	58..129	CDD:238684	24/70 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..228		23/117 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..286		8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..416		34/143 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910