Protein Alignment cic and SOX3

DIOPT Version :9

• Sequence 1: NP_001262755.1
• Gene: cic / 53560
• FlyBaseID: FBgn0262582
• Length: 2150
• Species: Drosophila melanogaster
• Sequence 2: NP_005625.2
• Gene: SOX3 / 6658
• HGNCID: 11199
• Length: 446
• Species: Homo sapiens
• Alignment Length: 489
• Identity: 100/489 - (20%)
• Similarity: 156/489 - (31%)
• Gaps: 151/489 - (30%)

  Fly  1149 VFETTTPGISANSKKQTAAMRLPTHNS-NIRKLEECHDDG------AAGAPATSAAKRRSQSLSA 1206
            :|....|...|.|...|.|..||.... ::.:.|..:..|      ..|.||......:|.:.:|
Human    50 LFTVAAPAPGAPSPPATLAHLLPAPAMYSLLETELKNPVGTPTQAAGTGGPAAPGGAGKSSANAA 114

  Fly  1207 LQQQQQQQQQAGAAGTAAGQPANKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEWWY 1271
            ...........||:|...|...: :::|||||||::|:..|:.:..::|...|..:||.||..|.
Human   115 GGANSGGGSSGGASGGGGGTDQD-RVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRLGADWK 178

  Fly  1272 ALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKSST----------STATPGGKASGAAGT 1326
            .|...:|..:.:.|..::..|.|.:|::|:  :.|||:.|          |...|.|.|:.||..
Human   179 LLTDAEKRPFIDEAKRLRAVHMKEYPDYKY--RPRRKTKTLLKKDKYSLPSGLLPPGAAAAAAAA 241

  Fly  1327 GDAKQRLVSVDGSDSLEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDEAPTTISM 1391
            ..|.               ...|:|.|.|.                 .:|.|        |.::.
Human   242 AAAA---------------AAASSPVGVGQ-----------------RLDTY--------THVNG 266

  Fly  1392 KGNGNGKLMKNELPSDEDEQMLVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRKQQPEANQ 1456
            ..||...|::.:|...:...|...........:.:.|:             ....|....|...|
Human   267 WANGAYSLVQEQLGYAQPPSMSSPPPPPALPPMHRYDM-------------AGLQYSPMMPPGAQ 318

  Fly  1457 R----SAEEHSTSGANGQAINAPPLSG---GEREITLKPKAIKAHPVLESNMLPYTQMSIYTQYT 1514
            .    :|...:.||..|.|.:|...:.   |::..|....|..|           ..||:
Human   319 SYMNVAAAAAAASGYGGMAPSATAAAAAAYGQQPATAAAAAAAA-----------AAMSL----- 367

  Fly  1515 SPKNPIGVTPFQPTGGAFKSMPISPKGS-----------------------GGKPEDAGSLQAHI 1556
                       .|.|...||.|.||..:                       ||...||.|
Human   368 -----------GPMGSVVKSEPSSPPPAIASHSQRACLGDLRDMISMYLPPGGDAADAAS----- 416

  Fly  1557 KQEDIKQEPPSP-------YKLNNGSGSASGGGV 1583
                     |.|       ::...|:|:|..|.|
Human   417 ---------PLPGGRLHGVHQHYQGAGTAVNGTV 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
		SOX-TCF_HMG-box	1231..1302	CDD:238684	23/70 (33%)
SOX3	NP_005625.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..48
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..140		10/53 (19%)
		SOX-TCF_HMG-box	138..209	CDD:238684	23/72 (32%)
		SOXp	208..302	CDD:289133	23/135 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910